CN104395325B - 带有硼酸的LIPHAGANE化合物作为PI3K-α和/或β的抑制剂 - Google Patents

带有硼酸的LIPHAGANE化合物作为PI3K-α和/或β的抑制剂 Download PDF

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Publication number
CN104395325B
CN104395325B CN201380026291.5A CN201380026291A CN104395325B CN 104395325 B CN104395325 B CN 104395325B CN 201380026291 A CN201380026291 A CN 201380026291A CN 104395325 B CN104395325 B CN 104395325B
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compound
methyl
general formula
cdcl
nmr
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Expired - Fee Related
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CN201380026291.5A
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Chinese (zh)
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CN104395325A (zh
Inventor
R·A·维施瓦卡玛
S·D·萨万特
P·P·辛格
A·H·达尔
P·R·夏尔马
A·K·萨克斯纳
A·纳戈特拉
A·A·K·科尔卢勒
R·马杜杜德拉
A·K·卡齐
A·赫塞恩
N·查纳尤里亚
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Council of Scientific and Industrial Research CSIR
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380026291.5A 2012-03-19 2013-03-18 带有硼酸的LIPHAGANE化合物作为PI3K-α和/或β的抑制剂 Expired - Fee Related CN104395325B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN0794/DEL/2012 2012-03-19
IN794DE2012 IN2012DE00794A (https=) 2012-03-19 2013-03-18
PCT/IN2013/000169 WO2013140417A1 (en) 2012-03-19 2013-03-18 BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF PI3K-α AND/OR β

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CN104395325A CN104395325A (zh) 2015-03-04
CN104395325B true CN104395325B (zh) 2016-12-07

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CN201380026291.5A Expired - Fee Related CN104395325B (zh) 2012-03-19 2013-03-18 带有硼酸的LIPHAGANE化合物作为PI3K-α和/或β的抑制剂

Country Status (8)

Country Link
US (1) US9206201B2 (https=)
EP (1) EP2828269B1 (https=)
JP (1) JP6126197B2 (https=)
CN (1) CN104395325B (https=)
CA (1) CA2867452C (https=)
IN (1) IN2012DE00794A (https=)
TW (1) TWI577687B (https=)
WO (1) WO2013140417A1 (https=)

Families Citing this family (4)

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JP3199090B2 (ja) 1993-10-19 2001-08-13 東芝ライテック株式会社 放電灯点灯装置
WO2018203564A1 (ja) 2017-05-02 2018-11-08 国立大学法人東北大学 リファガールの類縁体、及びリファガール又はその類縁体を含む多標的キナーゼ阻害剤
JP2019099537A (ja) * 2017-12-07 2019-06-24 コニカミノルタ株式会社 含窒素複素環化合物の製造方法
WO2024222697A1 (zh) * 2023-04-23 2024-10-31 纽欧申医药(上海)有限公司 一种含氮多元环化合物、其制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081659A1 (en) * 2005-02-01 2006-08-10 The University Of British Columbia Meroterpenoid inhibitors of phosphoinositide 3 kinase (pi3k)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081659A1 (en) * 2005-02-01 2006-08-10 The University Of British Columbia Meroterpenoid inhibitors of phosphoinositide 3 kinase (pi3k)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A concise synthesis of the bioactive meroterpenoid natural product (±)-liphagal,a potent PI3K inhibitor;Goverdhan Mehta等;《Tetrahedron Letters》;20090709;第50卷(第37期);第5260-5262页 *
Liphagal,a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge Aka coralliphaga:Structure Elucidation and Biomimetic Synthesis;Frederic Marion等;《Org.Lett.》;20051218;第8卷(第2期);第321-324页 *
Synthesis of Phosphatidylinositol 3-Kinase (PI3K) Inhibitory Analogues of the Sponge Meroterpenoid Liphagal;Alban R.Pereira等;《J.Med.Chem.》;20101201;第53卷(第24期);第8523-8533页 *
The Catalytic Enantioselective Total Synthesis of (+)-Liphagal;Joshua J.Day等;《Angew.Chem.Int.Ed.》;20110610;第50卷(第30期);第6814-6818页 *

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Publication number Publication date
IN2012DE00794A (https=) 2015-08-21
US20150051173A1 (en) 2015-02-19
CA2867452C (en) 2020-04-14
EP2828269A1 (en) 2015-01-28
WO2013140417A4 (en) 2013-11-21
WO2013140417A1 (en) 2013-09-26
JP2015514701A (ja) 2015-05-21
EP2828269B1 (en) 2018-05-16
TW201341391A (zh) 2013-10-16
JP6126197B2 (ja) 2017-05-10
TWI577687B (zh) 2017-04-11
CN104395325A (zh) 2015-03-04
CA2867452A1 (en) 2013-09-26
US9206201B2 (en) 2015-12-08

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