CA2867452C - Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta. - Google Patents

Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta. Download PDF

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Publication number
CA2867452C
CA2867452C CA2867452A CA2867452A CA2867452C CA 2867452 C CA2867452 C CA 2867452C CA 2867452 A CA2867452 A CA 2867452A CA 2867452 A CA2867452 A CA 2867452A CA 2867452 C CA2867452 C CA 2867452C
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group
compound
moiety
alkyl
substitutions
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CA2867452A
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English (en)
French (fr)
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CA2867452A1 (en
Inventor
Ram Asrey Vishwakarma
Sanghapal Damodhar Sawant
Parvinder Pal SINGH
Abid Hamid DAR
Parduman Raj SHARMA
Ajit Kumar Saxena
Amit NARGOTRA
Anjaneya Aravind Kumar KOLLURU
Ramesh MUDUDUDDLA
Asif Khurshid QAZI
Aashiq HUSSAIN
Nayan CHANAURIA
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Council of Scientific and Industrial Research CSIR
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Council of Scientific and Industrial Research CSIR
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Publication of CA2867452A1 publication Critical patent/CA2867452A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2867452A 2012-03-19 2013-03-18 Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta. Active CA2867452C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN0794/DEL/2012 2012-03-19
IN794DE2012 IN2012DE00794A (https=) 2012-03-19 2013-03-18
PCT/IN2013/000169 WO2013140417A1 (en) 2012-03-19 2013-03-18 BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF PI3K-α AND/OR β

Publications (2)

Publication Number Publication Date
CA2867452A1 CA2867452A1 (en) 2013-09-26
CA2867452C true CA2867452C (en) 2020-04-14

Family

ID=48464053

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867452A Active CA2867452C (en) 2012-03-19 2013-03-18 Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta.

Country Status (8)

Country Link
US (1) US9206201B2 (https=)
EP (1) EP2828269B1 (https=)
JP (1) JP6126197B2 (https=)
CN (1) CN104395325B (https=)
CA (1) CA2867452C (https=)
IN (1) IN2012DE00794A (https=)
TW (1) TWI577687B (https=)
WO (1) WO2013140417A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3199090B2 (ja) 1993-10-19 2001-08-13 東芝ライテック株式会社 放電灯点灯装置
WO2018203564A1 (ja) 2017-05-02 2018-11-08 国立大学法人東北大学 リファガールの類縁体、及びリファガール又はその類縁体を含む多標的キナーゼ阻害剤
JP2019099537A (ja) * 2017-12-07 2019-06-24 コニカミノルタ株式会社 含窒素複素環化合物の製造方法
WO2024222697A1 (zh) * 2023-04-23 2024-10-31 纽欧申医药(上海)有限公司 一种含氮多元环化合物、其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081659A1 (en) * 2005-02-01 2006-08-10 The University Of British Columbia Meroterpenoid inhibitors of phosphoinositide 3 kinase (pi3k)
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy

Also Published As

Publication number Publication date
IN2012DE00794A (https=) 2015-08-21
US20150051173A1 (en) 2015-02-19
EP2828269A1 (en) 2015-01-28
WO2013140417A4 (en) 2013-11-21
WO2013140417A1 (en) 2013-09-26
JP2015514701A (ja) 2015-05-21
EP2828269B1 (en) 2018-05-16
TW201341391A (zh) 2013-10-16
JP6126197B2 (ja) 2017-05-10
TWI577687B (zh) 2017-04-11
CN104395325B (zh) 2016-12-07
CN104395325A (zh) 2015-03-04
CA2867452A1 (en) 2013-09-26
US9206201B2 (en) 2015-12-08

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