CN104383122A - Traditional Chinese medicine compound lotion for removing free radicals by transdermal absorption and production process thereof - Google Patents
Traditional Chinese medicine compound lotion for removing free radicals by transdermal absorption and production process thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a traditional Chinese medicine compound lotion for removing free radicals by transdermal absorption. The lotion is prepared from the following raw materials in parts by weight: 5-50 parts of GABA tea leaves, 5-45 parts of ganoderma lucidum, 2-20 parts of nacre mother of pearl, 3-20 parts of black bean meal, 5-20 parts of mint, 3-25 parts of olive oil and 80-800 parts of pure water. According to a preparation method of the traditional Chinese medicine compound lotion for removing free radicals by transdermal absorption, extraction is carried out by adopting a microwave extraction device. The lotion can be directly applied to skin surfaces, and effective ingredients in the lotion can quickly go deep in skin and reach peripheral blood circulation by means of the absorption function of skin, so that the effect of neutralizing free radicals in the skin is achieved, elasticity of collagen can be recovered, skin aging can be avoided, and skin health can be improved. Compared with the prior art, the preparation method has the advantages that the process is advanced, the operation is simple and convenient, effective ingredients can be better extracted from medicinal materials, the drug activity can be well protected at a relatively low temperature, and large-scale industrial production can be benefited.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine compound washing liquid of Transdermal absorption scavenging free radicals and production technology thereof.
Background technology
Free radical, is the compound produced in body oxidation reaction, has strong oxidizing property.Under normal circumstances, the free radical in human body is limited in cell mitochondrial.According to modern science checking, free radical is the arch-criminal causing chronic disease and human senility effect.Only there is millions of/mono-second in the life-span of free radical, but they are very easy to be attracted by intracellular genetic stew, chemical reaction occurs, and cause damage, and then cause gene mutation to hereditary material.Free radical is not the exclusive source of gene mutation, other many factors (toxin in such as solar irradiation, smoking, food) are also had to cause gene mutation, but because free radical produces in body intracellular metabolic process, the source of this unavoidable, continual gene mutation that just made them become.Free radical also can cause damage to other biomolecules such as protein.
A kind of popular old and feeble hypothesis is thought, the damage caused just because of free radical is constantly accumulated, result in human body cell, tissue, organ and system occur along with passage of time wearing and tearing, not normal, finally cause aging and death.
Under normal circumstances, free radical constantly produces in human body, is also constantly removed by human body simultaneously.This is inner source free love base scavenging system mainly, and it comprises some antioxidants such as some enzymes and vitamin C, vitamin E, reductive glutathione, carotene and selenium such as superoxide dismutase (SOD), catalase, glutathione peroxidase.
Free radical cannot be avoided, and it is ubiquitous.Inherently free radical is produced in normal metabolic processes in body.And the air polluted, the various biochemical article of everyday exposure, the direct irradiation of sunlight middle-ultraviolet lamp all can make us touch a large amount of free radical.
And skin is as the maximum organ of human body, to expose in such a case for a long time, make a large amount of free radical be attached to skin surface and encroach on skin, destroy the normal configuration of cell, stimulate its gene to morph, this may be the arch-criminal causing skin carcinoma.
Simple skin clean can only dispel the macromolecular substances such as dust, particulate matter that skin surface adheres to, and cannot play desirable purification for free radical and other permeability pollutant.
Transdermal administration is the third generation medication that WHO recommends, transdermal drug delivery system is without " first pass effect " of liver, do not destroyed by pipe intestinal digesting liquid, by directly acting on the cell of skin corium and entering peripheral blood circulation, predetermined, longer action time is provided, reduce drug toxicity and untoward reaction, maintain stable and lasting blood drug level, thus improve curative effect.
In recent years, researcheres more both domestic and external carried out corresponding research with regard to the radical scavenging activity of plant extract component, find that many plant extracts or some compositions wherein have good scavenging action to free radical, utilize natural plant resource to find have anti-oxidation characteristics health material be very likely.
Summary of the invention
The Chinese medicine compound washing liquid of the Transdermal absorption scavenging free radicals that the object of the present invention is to provide a kind of technique advanced, easy and simple to handle and production technology thereof, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A Chinese medicine compound washing liquid for Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 5-50 part, red ganoderma 5-45 part, Concha Margaritifera 2-20 part, black bean powder 3-20 part, Herba Menthae 5-20 part, olive oil 3-25 part, pure water 80-800 part.
As the further scheme of the present invention: the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 5-20 part, red ganoderma 5-15 part, Concha Margaritifera 2-10 part, black bean powder 3-10 part, Herba Menthae 5-10 part, olive oil 3-15 part, pure water 80-400 part.
As the further scheme of the present invention: the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 5 parts, red ganoderma 5 parts, Concha Margaritifera 2 parts, black bean powder 3 parts, Herba Menthae 6 parts, 3 parts, olive oil, pure water 85 parts.
As the further scheme of the present invention: described GABA Folium Camelliae sinensis refers to the Folium Camelliae sinensis of GABA content at more than 1.5mg/g.
As the present invention's further scheme: described olive oil is Pure Olive Oil.
The production technology of the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, concrete steps are as follows:
(1) take GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera, Herba Menthae and black bean powder according to above-mentioned weight portion, after GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera and Herba Menthae being pulverized with pulverizer, cross 14-20 mesh sieve.
(2) get the material powder after above-mentioned pulverizing, add black bean powder and mix and be placed in large beaker, then add pure water dissolving, leave standstill 23-25h with ParafilmTM beaker mouth.
(3) above-mentioned medicinal liquid is put into microwave extracting apparatus, setting extraction temperature is 60-80 DEG C, and microwave power is 500-2000w, and each microwave irradiation time is 30-50s, and it is 4-6 time that microwave adds up radiation number of times, and microwave radiation is complete, insulation extraction 40-60min.
(4) by the medicinal liquid that extracted through 10-15 order sock filtration, collect filtrate, in filtrate, add olive oil, ultrasonic mixing, obtain Chinese medicine compound washing liquid.
Pharmacological action: GABA Folium Camelliae sinensis is rich in γ mono-amido butanoic acid, confirms through lot of documents, and this material can effective defying age, also has and prevents skin aging, function such as elimination body odor, fat-reducing etc.; Compared by the antioxidation of Black Ganoderma with red ganoderma extract, reach a conclusion: to DPPH free radical scavenging activity, more than the antioxidant effect of 5mg/mlBHT when the extract concentrations of red ganoderma reaches 3mg/ml, a little less than the antioxidant effect of the ascorbic acid of 0.5mg/ml; Semen sojae atricolor is also containing a large amount of antioxidants, and containing vitamin E2 1.9mg in every 100g black bean powder, vitamin E has stronger oxidation resistance; Vitamin E can free radical effectively in purged body, the tissues such as Cell protection film, skin, blood vessel, heart, eyes, liver and breast; Anthocyanidin, as the main component of Testa sojae atricolor pigment, is a kind of well antioxidant; Black bean peel anthocyanidin is hydroxyl donor, is also simultaneously a kind of free radical scavenger, can not only prevents peroxidating with protein bound, also with the chelating such as Cu2+, prevents VC peroxidating, regeneration VC, thus regeneration VE, also can singlet-oxygen quenching; Herba Menthae comprises menthol, Herba Menthae wet goods material, soluble in water, and numerous experimentatioies confirms, the medicine of Folium Menthae extract to numerous species has to be urged to ooze effect.
Compared with prior art, the invention has the beneficial effects as follows:
Chinese medicine compound washing liquid of the present invention is directly applied in skin surface, percutaneous absorption function, effective ingredient is wherein made to enter deep skin rapidly and arrive peripheral blood circulation, reach the effect with free radical in skin, recover collagen protein elasticity, prevent skin ageing, impel skin health; Compared with the existing technology, technique is advanced, easy and simple to handle, can extract effective ingredient better from medicine in the present invention, and extraction can protect pharmaceutically active well at a lower temperature, is easy to large-scale industrial production.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
A Chinese medicine compound washing liquid for Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 5 parts, red ganoderma 5 parts, Concha Margaritifera 2 parts, black bean powder 3 parts, Herba Menthae 5 parts, 3 parts, olive oil, pure water 80 parts.
The production technology of the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, concrete steps are as follows:
(1) take GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera, Herba Menthae and black bean powder according to above-mentioned weight portion, after GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera and Herba Menthae being pulverized with pulverizer, cross 14 mesh sieves.
(2) get the material powder after above-mentioned pulverizing, add black bean powder and mix and be placed in large beaker, then add pure water dissolving, leave standstill 23h with ParafilmTM beaker mouth.
(3) above-mentioned medicinal liquid is put into microwave extracting apparatus, setting extraction temperature is 60 DEG C, and microwave power is 500w, and each microwave irradiation time is 30s, and it is 4 times that microwave adds up radiation number of times, and microwave radiation is complete, insulation extraction 40min.
(4) by the medicinal liquid that extracted through 10 order sock filtration, collect filtrate, in filtrate, add olive oil, ultrasonic mixing, obtain Chinese medicine compound washing liquid.
Embodiment 2
A Chinese medicine compound washing liquid for Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 20 parts, red ganoderma 25 parts, Concha Margaritifera 12 parts, black bean powder 12 parts, Herba Menthae 13 parts, 12 parts, olive oil, pure water 400 parts.
The production technology of the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, concrete steps are as follows:
(1) take GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera, Herba Menthae and black bean powder according to above-mentioned weight portion, after GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera and Herba Menthae being pulverized with pulverizer, cross 16 mesh sieves.
(2) get the material powder after above-mentioned pulverizing, add black bean powder and mix and be placed in large beaker, then add pure water dissolving, leave standstill 24h with ParafilmTM beaker mouth.
(3) above-mentioned medicinal liquid is put into microwave extracting apparatus, setting extraction temperature is 70 DEG C, and microwave power is 1200w, and each microwave irradiation time is 40s, and it is 5 times that microwave adds up radiation number of times, and microwave radiation is complete, insulation extraction 50min.
(4) by the medicinal liquid that extracted through 12 order sock filtration, collect filtrate, in filtrate, add olive oil, ultrasonic mixing, obtain Chinese medicine compound washing liquid.
Embodiment 3
A Chinese medicine compound washing liquid for Transdermal absorption scavenging free radicals, comprises according to the raw material of weight portion: GABA Folium Camelliae sinensis 50 parts, red ganoderma 45 parts, Concha Margaritifera 20 parts, black bean powder 20 parts, Herba Menthae 20 parts, 25 parts, olive oil, pure water 800 parts.
The production technology of the Chinese medicine compound washing liquid of described Transdermal absorption scavenging free radicals, concrete steps are as follows:
(1) take GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera, Herba Menthae and black bean powder according to above-mentioned weight portion, after GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera and Herba Menthae being pulverized with pulverizer, cross 20 mesh sieves.
(2) get the material powder after above-mentioned pulverizing, add black bean powder and mix and be placed in large beaker, then add pure water dissolving, leave standstill 25h with ParafilmTM beaker mouth.
(3) above-mentioned medicinal liquid is put into microwave extracting apparatus, setting extraction temperature is 80 DEG C, and microwave power is 2000w, and each microwave irradiation time is 50s, and it is 6 times that microwave adds up radiation number of times, and microwave radiation is complete, insulation extraction 60min.
(4) by the medicinal liquid that extracted through 15 order sock filtration, collect filtrate, in filtrate, add olive oil, ultrasonic mixing, obtain Chinese medicine compound washing liquid.
In above embodiment, GABA Folium Camelliae sinensis refers to the Folium Camelliae sinensis of GABA content at more than 1.5mg/g, and described olive oil is Pure Olive Oil.
Embodiment 4
Clinical trial:
This group case is totally 60 examples, and 60 routine patients are divided into treatment group and matched group by the method for random table.Treatment group 30 example, wherein man 18 example, female 12 example, 39.25 ± 5.36 years old mean age; Matched group 30 example, wherein man 16 example, female 14 example, 40.29 ± 2.35 years old mean age.Sex, the age of two groups of cases compare, and through statistical procedures no significant difference, P > 0.05, has comparability.
Selected case is got rid of having following situation person: the vitals such as (1) heart, liver, kidney and lung exist serious disease patient; (2) there is active hemorrhage tendency person; (3) hypertension, diabetes and other patients with chronic diseases; Once operator was carried out in (4) one years.
Treatment group presses the obtained Chinese medicine compound washing liquid of method described in above-described embodiment one, is applied in patient back, abdominal part and calf skin place every day for 3 times, coordinates scrape therapy, massage manipulation, penetration enhancement; Matched group gives vitamin E, 30mg/ time, every day 3 times, takes half an hour after the meal.12 weeks courses for the treatment of.Before on-test and after terminating, detect SOD, MDA, testing result is as described in Table 1.
Statistical method adopts statistic software SPSS ll.0 to carry out statistical analysis.Measurement data all adopts x ± s method record, contrasts and adopt t inspection before and after measurement data treatment and between group; Ranked data treatment cross-reference adopts the Ridit inspection in non parametric tests, and two groups of treated effects adopt X 2 test.
Before and after table 1 treatment group, treatment of control group, SOD, MDA compare (X ± S)
Upper table data display, before and after two groups of treatments, SOD all has rising, MDA all has decline, and difference has statistical significance, and the Chinese medicine compound oil preparation that in application the present invention prepared by preparation method as can be seen here effectively can reduce the content of people's interior free yl, promotes body health.
Chinese medicine compound washing liquid of the present invention is directly applied in skin surface, percutaneous absorption function, effective ingredient is wherein made to enter deep skin rapidly and arrive peripheral blood circulation, reach the effect with free radical in skin, recover collagen protein elasticity, prevent skin ageing, impel skin health.Compared with the existing technology, technique is advanced, easy and simple to handle, can extract effective ingredient better from medicine in the present invention, and extraction can protect pharmaceutically active well at a lower temperature, is easy to large-scale industrial production.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (6)
1. the Chinese medicine compound washing liquid of a Transdermal absorption scavenging free radicals, it is characterized in that, comprise according to the raw material of weight portion: GABA Folium Camelliae sinensis 5-50 part, red ganoderma 5-45 part, Concha Margaritifera 2-20 part, black bean powder 3-20 part, Herba Menthae 5-20 part, olive oil 3-25 part, pure water 80-800 part.
2. the Chinese medicine compound washing liquid of Transdermal absorption scavenging free radicals according to claim 1, it is characterized in that, comprise according to the raw material of weight portion: GABA Folium Camelliae sinensis 5-20 part, red ganoderma 5-15 part, Concha Margaritifera 2-10 part, black bean powder 3-10 part, Herba Menthae 5-10 part, olive oil 3-15 part, pure water 80-400 part.
3. the Chinese medicine compound washing liquid of Transdermal absorption scavenging free radicals according to claim 1, it is characterized in that, comprise according to the raw material of weight portion: GABA Folium Camelliae sinensis 5 parts, red ganoderma 5 parts, Concha Margaritifera 2 parts, black bean powder 3 parts, Herba Menthae 6 parts, 3 parts, olive oil, pure water 85 parts.
4. the Chinese medicine compound washing liquid of Transdermal absorption scavenging free radicals according to claim 1, is characterized in that, described GABA Folium Camelliae sinensis refers to the Folium Camelliae sinensis of GABA content at more than 1.5mg/g.
5. the Chinese medicine compound washing liquid of Transdermal absorption scavenging free radicals according to claim 1, is characterized in that, described olive oil is Pure Olive Oil.
6. a production technology for the Chinese medicine compound washing liquid of the Transdermal absorption scavenging free radicals adopting one of claim 1-5 described, it is characterized in that, concrete steps are as follows:
(1) take GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera, Herba Menthae and black bean powder according to above-mentioned weight portion, after GABA Folium Camelliae sinensis, red ganoderma, Concha Margaritifera and Herba Menthae being pulverized with pulverizer, cross 14-20 mesh sieve;
(2) get the material powder after above-mentioned pulverizing, add black bean powder and mix and be placed in large beaker, then add pure water dissolving, leave standstill 23-25h with ParafilmTM beaker mouth;
(3) above-mentioned medicinal liquid is put into microwave extracting apparatus, setting extraction temperature is 60-80 DEG C, and microwave power is 500-2000w, and each microwave irradiation time is 30-50s, and it is 4-6 time that microwave adds up radiation number of times, and microwave radiation is complete, insulation extraction 40-60min;
(4) by the medicinal liquid that extracted through 10-15 order sock filtration, collect filtrate, in filtrate, add olive oil, ultrasonic mixing, obtain Chinese medicine compound washing liquid.
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| CN201410621003.7A CN104383122B (en) | 2014-11-07 | 2014-11-07 | A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical |
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| CN201410621003.7A CN104383122B (en) | 2014-11-07 | 2014-11-07 | A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101911989A (en) * | 2010-08-03 | 2010-12-15 | 马伟光 | Truffle health-care tea and preparation method thereof |
| CN102885747A (en) * | 2011-07-22 | 2013-01-23 | 方樱翰 | Black bean powder ageing-resistant facial mask |
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2014
- 2014-11-07 CN CN201410621003.7A patent/CN104383122B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101911989A (en) * | 2010-08-03 | 2010-12-15 | 马伟光 | Truffle health-care tea and preparation method thereof |
| CN102885747A (en) * | 2011-07-22 | 2013-01-23 | 方樱翰 | Black bean powder ageing-resistant facial mask |
Non-Patent Citations (3)
| Title |
|---|
| 王芳等: "γ-氨基丁酸茶的研究进展", 《武夷学院学报》 * |
| 郑红发等: "γ-氨基丁酸的药理作用", 《茶叶通讯》 * |
| 马庆晏等: "皮肤的生理特点与透皮吸收", 《生物学通报》 * |
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