CN104383122B - A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical - Google Patents
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses the Chinese medicine compound prescription washing lotion that a kind of Transdermal absorption removes free radical, 5 50 parts of GABA tealeaves, 5 45 parts of red ganoderma, 2 20 parts of mother-of-pearl, 3 20 parts of black bean powder, 5 20 parts of peppermint, 3 25 parts of olive oil, 80 800 parts of pure water are made by the raw material of following parts by weight, the preparation method that Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical is extracted using microwave extracting apparatus.The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, active ingredient therein is quickly entered deep skin and reach peripheral blood circulation, reach the effect for neutralizing free radical in skin, recover collagen elasticity, skin ageing is prevented, promotes skin health;Compared with the existing technology, technique is advanced, easy to operate by the present invention, active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to large-scale industrial production.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Transdermal absorption removes Chinese medicine compound prescription washing lotion and its production of free radical
Technique.
Background technology
Free radical, it is caused compound in body oxidation reaction, there is strong oxidizing property.Under normal circumstances, in human body
Free radical is limited in cell mitochondrial.Verified according to modern science, free radical is to cause chronic disease and human senility effect
Arch-criminal.The life-span of free radical only has hundreds of a ten thousandth seconds, but they be very easy to be attracted by intracellular genetic stew,
Chemically react, inhereditary material is caused to damage, and then cause gene mutation.Free radical is not the unique next of gene mutation
Source, there are other many factors (such as toxin in solar irradiation, smoking, food) that gene mutation can be caused, but due to certainly
By base be in internal metabolic processes caused by, this just makes them into unavoidable, continual gene mutation
Source.Free radical also other biomolecules can cause to damage to protein etc..
A kind of popular aging hypothesis thinks, just because of constantly accumulation is damaged caused by free radical, result in people
Body cell, tissue, organ and system elapse over time and occur abrasion, it is not normal, ultimately result in aging and death.
Under normal circumstances, free radical constantly produces in human body, while is also constantly removed by human body.This is mainly inner source
Free love base removes system, it include superoxide dismutase (SOD), catalase, glutathione peroxidase etc. some
Some antioxidants such as enzyme and vitamin C, vitamin E, reductive glutathione, carrotene and selenium.
Free radical can not be avoided, and it is ubiquitous.Free radical is inherently produced in internal normal metabolic processes.It is and dirty
The air of dye, the various biochemical articles of everyday exposure, the direct irradiation of sunlight middle-ultraviolet lamp can all make we touch it is a large amount of from
By base.
And the organ that skin is maximum as human body, permanent exposure is in such a case so that a large amount of free radicals are attached to skin
Skin top layer and encroach on skin, destroy the normal configuration of cell, stimulate its gene to morph, this is probably the member for causing cutaneum carcinoma
It is fierce.
Simple skin cleaning can only dispel the macromolecular substances such as the dust of skin surface adhesion, particulate matter, for freedom
Base and other permeability pollutants can not play preferable catharsis.
Cutaneous penetration be WHO recommend third generation medication, " first pass effect " of the transdermal drug delivery system without liver, not by
Pipe intestinal digesting liquid destroys, by directly acting on the cell of skin corium and entering peripheral blood circulation, there is provided predetermined, longer
Action time, reduce drug toxicity and adverse reaction, stable and lasting blood concentration maintained, so as to improve curative effect.
In recent years, some researchers both domestic and external were carried out corresponding with regard to the radical scavenging activity of plant extract component
Research, it is found that many plant extracts or some of which composition have good scavenging action to free radical, is planted using natural
Goods and materials source is come to find the health material with anti-oxidation characteristics be very likely.
The content of the invention
It is an object of the invention to provide the Chinese medicine that a kind of technique is advanced, Transdermal absorption easy to operate removes free radical to answer
Square washing lotion and its production technology, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme:
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves
5-50 parts, red ganoderma 5-45 parts, mother-of-pearl 2-20 parts, black bean powder 3-20 parts, peppermint 5-20 parts, olive oil 3-25 parts, pure water 80-
800 parts.
As the further scheme of the present invention:The Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, by following heavy
The raw material of amount part is made:GABA tealeaves 5-20 parts, red ganoderma 5-15 parts, mother-of-pearl 2-10 parts, black bean powder 3-10 parts, peppermint 5-10
Part, olive oil 3-15 parts, pure water 80-400 parts.
As the further scheme of the present invention:The Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, by following heavy
The raw material of amount part is made:It is 5 parts of GABA tealeaves, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 6 parts of peppermint, 3 parts of olive oil, pure
85 parts of water.
As the further scheme of the present invention:The GABA tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g.
As further scheme of the invention:The olive oil is Pure Olive Oil.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves,
Red ganoderma, mother-of-pearl and peppermint cross 14-20 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water
Solution, 23-25h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60-80 DEG C, microwave power 500-
2000w, each microwave irradiation time are 30-50s, and the accumulative radiation number of microwave is 4-6 times, and microwave radiation is complete, insulation extraction 40-
60min。
(4) decoction extracted is passed through into 10-15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound
Mix, produce Chinese medicine compound prescription washing lotion.
Pharmacological action:GABA tealeaves is rich in the amido butyric acid of γ mono-, is confirmed through lot of documents, the material can effective anti-aging,
Also having prevents skin aging, eliminates the functions such as body odor, fat-reducing;Pass through Black Ganoderma and the antioxidation ratio of red ganoderma extract
Compared with, it was therefore concluded that:From the point of view of DPPH free radical scavenging activities, more than 5mg/ when the extract concentrations of red ganoderma reach 3mg/ml
The antioxidant effect of the ascorbic acid of mlBHT antioxidant effect, slightly below 0.5mg/ml;Black soya bean is also containing substantial amounts of anti-oxidant
Property material, per 100g black bean powders in 1.9mg containing vitamin E2, vitamin E has stronger oxidation resistance;Vitamin E can have
Effect removes the tissue such as internal free radical, protection cell membrane, skin, blood vessel, heart, eyes, liver and breast;Anthocyanidin conduct
The main component of black soya bean skin pigment, it is a kind of good antioxidant;Black bean peel anthocyanidin is hydroxyl donor, while is also one kind
Free radical scavenger, can not only be combined with protein prevents peroxidating, is also chelated with Cu2+ etc., prevents VC peroxidating, regenerates VC,
, also can singlet-oxygen quenching so as to regenerate VE;Peppermint includes the materials such as menthol, peppermint oil, and soluble in water, numerous experiments are ground
Study carefully confirmation, mint extract has the rush effect of oozing to the medicine of numerous species.
Compared with prior art, the beneficial effects of the invention are as follows:
The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, made therein
Active ingredient quickly enters deep skin and reaches peripheral blood circulation, reaches the effect for neutralizing free radical in skin, recovers glue
Former albumen elasticity, prevents skin ageing, promotes skin health;Compared with the existing technology, technique is advanced, easy to operate by the present invention,
Active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to advise greatly
Mould industrialized production.
Embodiment
The technical scheme of this patent is described in more detail with reference to embodiment.
Embodiment 1
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves 5
Part, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 5 parts of peppermint, 3 parts of olive oil, 80 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves,
Red ganoderma, mother-of-pearl and peppermint cross 14 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water
Solution, 23h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60 DEG C, microwave power 500w, every time
Microwave irradiation time is 30s, and the accumulative radiation number of microwave is 4 times, and microwave radiation is complete, insulation extraction 40min.
(4) decoction extracted is passed through into 10 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed
It is even, produce Chinese medicine compound prescription washing lotion.
Embodiment 2
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves
20 parts, 25 parts of red ganoderma, 12 parts of mother-of-pearl, 12 parts of black bean powder, 13 parts of peppermint, 12 parts of olive oil, 400 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves,
Red ganoderma, mother-of-pearl and peppermint cross 16 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water
Solution, 24h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 70 DEG C, microwave power 1200w, every time
Microwave irradiation time is 40s, and the accumulative radiation number of microwave is 5 times, and microwave radiation is complete, insulation extraction 50min.
(4) decoction extracted is passed through into 12 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed
It is even, produce Chinese medicine compound prescription washing lotion.
Embodiment 3
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves
50 parts, 45 parts of red ganoderma, 20 parts of mother-of-pearl, 20 parts of black bean powder, 20 parts of peppermint, 25 parts of olive oil, 800 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves,
Red ganoderma, mother-of-pearl and peppermint cross 20 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water
Solution, 25h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 80 DEG C, microwave power 2000w, every time
Microwave irradiation time is 50s, and the accumulative radiation number of microwave is 6 times, and microwave radiation is complete, insulation extraction 60min.
(4) decoction extracted is passed through into 15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed
It is even, produce Chinese medicine compound prescription washing lotion.
GABA tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g in above example, and the olive oil is pure olive
Olive oil.
Embodiment 4
Clinical test:
This group of case totally 60,60 patients are divided into treatment group and control group by the method for random table.Treatment group 30,
Wherein man 18, female 12, average age 39.25 ± 5.36 years old;Control group 30, wherein man 16, female 14, average age
40.29 ± 2.35 years old.The sex of two groups of cases, age compare, and are statistically analyzed no significant difference, P > 0.05, having can
Compare property.
Selected case with situations below person to being excluded:(1) vitals such as the heart, liver, kidney and lung exist serious
Disease;(2) there is active hemorrhage tendency person;(3) hypertension, diabetes and other patients with chronic diseases;In (4) one years
Once operator is carried out.
Treatment group's Chinese medicine compound prescription washing lotion as made from the methods described of above-described embodiment one, be applied to 3 times a day patient back,
At belly and calf skin, coordinate popular treatment for sunstroke by scraping the patient's neck, chest or back, massage manipulation, promote to absorb;Control group gives vitamin E, 30mg/ times, and daily 3
Secondary, postprandial half an hour takes.The course for the treatment of 12 weeks.Before on-test and after end, SOD, MDA are detected, testing result is as described in Table 1.
Statistical method carries out statistical analysis using statistic software SPSS ll.0.Measurement data is recorded using x ± s methods,
Measurement data compares using t inspections before and after treatment and between group;Ranked data compare using in non-parametric test before and after treatment
Ridit is examined, and two groups of treated effects use Chi-square Test.
The treatment group of table 1, control group pretherapy and post-treatment SOD, MDA compare (X ± S)
Upper table data show that two groups are pretherapy and post-treatment, and SOD has rise, MDA to have decline, and difference has statistical significance,
The Chinese medicine compound prescription finish prepared as can be seen here using preparation method in the present invention can effectively reduce the content of people's interior free yl, promote
Enter body health.
The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, made therein
Active ingredient quickly enters deep skin and reaches peripheral blood circulation, reaches the effect for neutralizing free radical in skin, recovers glue
Former albumen elasticity, prevents skin ageing, promotes skin health.Compared with the existing technology, technique is advanced, easy to operate by the present invention,
Active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to advise greatly
Mould industrialized production.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, can also be on the premise of this patent objective not be departed from one skilled in the relevant art's possessed knowledge
Various changes can be made.
Claims (6)
1. a kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that is made up of the raw material of following parts by weight:
GABA tealeaves 5-50 parts, red ganoderma 5-45 parts, mother-of-pearl 2-20 parts, black bean powder 3-20 parts, peppermint 5-20 parts, olive oil 3-25
Part, pure water 80-800 parts.
2. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that by following heavy
The raw material of amount part is made:GABA tealeaves 5-20 parts, red ganoderma 5-15 parts, mother-of-pearl 2-10 parts, black bean powder 3-10 parts, peppermint 5-10
Part, olive oil 3-15 parts, pure water 80-400 parts.
3. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that by following heavy
The raw material of amount part is made:It is 5 parts of GABA tealeaves, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 6 parts of peppermint, 3 parts of olive oil, pure
85 parts of water.
4. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that the GABA
Tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g.
5. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that the olive
Oil is Pure Olive Oil.
6. a kind of Transdermal absorption using described in one of claim 1-5 removes the production work of the Chinese medicine compound prescription washing lotion of free radical
Skill, it is characterised in that comprise the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, red spirit
Sesame, mother-of-pearl and peppermint cross 14-20 mesh sieves after being crushed with pulverizer;
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, add pure water dissolving, with
ParafilmTM beaker mouth stands 23-25h;
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60-80 DEG C, microwave power 500-2000w,
Each microwave irradiation time is 30-50s, and the accumulative radiation number of microwave is 4-6 times, and microwave radiation is complete, insulation extraction 40-60min;
(4) decoction extracted is passed through into 10-15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed
It is even, produce Chinese medicine compound prescription washing lotion.
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CN101911989A (en) * | 2010-08-03 | 2010-12-15 | 马伟光 | Truffle health-care tea and preparation method thereof |
CN102885747A (en) * | 2011-07-22 | 2013-01-23 | 方樱翰 | Black bean powder ageing-resistant facial mask |
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2014
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101911989A (en) * | 2010-08-03 | 2010-12-15 | 马伟光 | Truffle health-care tea and preparation method thereof |
CN102885747A (en) * | 2011-07-22 | 2013-01-23 | 方樱翰 | Black bean powder ageing-resistant facial mask |
Non-Patent Citations (3)
Title |
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γ-氨基丁酸的药理作用;郑红发等;《茶叶通讯》;20041231(第4期);第14-18页 * |
γ-氨基丁酸茶的研究进展;王芳等;《武夷学院学报》;20091031;第28卷(第5期);第39-43页 * |
皮肤的生理特点与透皮吸收;马庆晏等;《生物学通报》;19971231;第32卷(第10期);第24-26页 * |
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