CN104383122B - A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical - Google Patents

A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical Download PDF

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CN104383122B
CN104383122B CN201410621003.7A CN201410621003A CN104383122B CN 104383122 B CN104383122 B CN 104383122B CN 201410621003 A CN201410621003 A CN 201410621003A CN 104383122 B CN104383122 B CN 104383122B
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chinese medicine
free radical
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田胜利
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SHANGHAI SHIDAO HEALTH TECHNOLOGY Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
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    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
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    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses the Chinese medicine compound prescription washing lotion that a kind of Transdermal absorption removes free radical, 5 50 parts of GABA tealeaves, 5 45 parts of red ganoderma, 2 20 parts of mother-of-pearl, 3 20 parts of black bean powder, 5 20 parts of peppermint, 3 25 parts of olive oil, 80 800 parts of pure water are made by the raw material of following parts by weight, the preparation method that Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical is extracted using microwave extracting apparatus.The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, active ingredient therein is quickly entered deep skin and reach peripheral blood circulation, reach the effect for neutralizing free radical in skin, recover collagen elasticity, skin ageing is prevented, promotes skin health;Compared with the existing technology, technique is advanced, easy to operate by the present invention, active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to large-scale industrial production.

Description

A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Transdermal absorption removes Chinese medicine compound prescription washing lotion and its production of free radical Technique.
Background technology
Free radical, it is caused compound in body oxidation reaction, there is strong oxidizing property.Under normal circumstances, in human body Free radical is limited in cell mitochondrial.Verified according to modern science, free radical is to cause chronic disease and human senility effect Arch-criminal.The life-span of free radical only has hundreds of a ten thousandth seconds, but they be very easy to be attracted by intracellular genetic stew, Chemically react, inhereditary material is caused to damage, and then cause gene mutation.Free radical is not the unique next of gene mutation Source, there are other many factors (such as toxin in solar irradiation, smoking, food) that gene mutation can be caused, but due to certainly By base be in internal metabolic processes caused by, this just makes them into unavoidable, continual gene mutation Source.Free radical also other biomolecules can cause to damage to protein etc..
A kind of popular aging hypothesis thinks, just because of constantly accumulation is damaged caused by free radical, result in people Body cell, tissue, organ and system elapse over time and occur abrasion, it is not normal, ultimately result in aging and death.
Under normal circumstances, free radical constantly produces in human body, while is also constantly removed by human body.This is mainly inner source Free love base removes system, it include superoxide dismutase (SOD), catalase, glutathione peroxidase etc. some Some antioxidants such as enzyme and vitamin C, vitamin E, reductive glutathione, carrotene and selenium.
Free radical can not be avoided, and it is ubiquitous.Free radical is inherently produced in internal normal metabolic processes.It is and dirty The air of dye, the various biochemical articles of everyday exposure, the direct irradiation of sunlight middle-ultraviolet lamp can all make we touch it is a large amount of from By base.
And the organ that skin is maximum as human body, permanent exposure is in such a case so that a large amount of free radicals are attached to skin Skin top layer and encroach on skin, destroy the normal configuration of cell, stimulate its gene to morph, this is probably the member for causing cutaneum carcinoma It is fierce.
Simple skin cleaning can only dispel the macromolecular substances such as the dust of skin surface adhesion, particulate matter, for freedom Base and other permeability pollutants can not play preferable catharsis.
Cutaneous penetration be WHO recommend third generation medication, " first pass effect " of the transdermal drug delivery system without liver, not by Pipe intestinal digesting liquid destroys, by directly acting on the cell of skin corium and entering peripheral blood circulation, there is provided predetermined, longer Action time, reduce drug toxicity and adverse reaction, stable and lasting blood concentration maintained, so as to improve curative effect.
In recent years, some researchers both domestic and external were carried out corresponding with regard to the radical scavenging activity of plant extract component Research, it is found that many plant extracts or some of which composition have good scavenging action to free radical, is planted using natural Goods and materials source is come to find the health material with anti-oxidation characteristics be very likely.
The content of the invention
It is an object of the invention to provide the Chinese medicine that a kind of technique is advanced, Transdermal absorption easy to operate removes free radical to answer Square washing lotion and its production technology, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme:
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves 5-50 parts, red ganoderma 5-45 parts, mother-of-pearl 2-20 parts, black bean powder 3-20 parts, peppermint 5-20 parts, olive oil 3-25 parts, pure water 80- 800 parts.
As the further scheme of the present invention:The Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, by following heavy The raw material of amount part is made:GABA tealeaves 5-20 parts, red ganoderma 5-15 parts, mother-of-pearl 2-10 parts, black bean powder 3-10 parts, peppermint 5-10 Part, olive oil 3-15 parts, pure water 80-400 parts.
As the further scheme of the present invention:The Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, by following heavy The raw material of amount part is made:It is 5 parts of GABA tealeaves, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 6 parts of peppermint, 3 parts of olive oil, pure 85 parts of water.
As the further scheme of the present invention:The GABA tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g.
As further scheme of the invention:The olive oil is Pure Olive Oil.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, Red ganoderma, mother-of-pearl and peppermint cross 14-20 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water Solution, 23-25h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60-80 DEG C, microwave power 500- 2000w, each microwave irradiation time are 30-50s, and the accumulative radiation number of microwave is 4-6 times, and microwave radiation is complete, insulation extraction 40- 60min。
(4) decoction extracted is passed through into 10-15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound Mix, produce Chinese medicine compound prescription washing lotion.
Pharmacological action:GABA tealeaves is rich in the amido butyric acid of γ mono-, is confirmed through lot of documents, the material can effective anti-aging, Also having prevents skin aging, eliminates the functions such as body odor, fat-reducing;Pass through Black Ganoderma and the antioxidation ratio of red ganoderma extract Compared with, it was therefore concluded that:From the point of view of DPPH free radical scavenging activities, more than 5mg/ when the extract concentrations of red ganoderma reach 3mg/ml The antioxidant effect of the ascorbic acid of mlBHT antioxidant effect, slightly below 0.5mg/ml;Black soya bean is also containing substantial amounts of anti-oxidant Property material, per 100g black bean powders in 1.9mg containing vitamin E2, vitamin E has stronger oxidation resistance;Vitamin E can have Effect removes the tissue such as internal free radical, protection cell membrane, skin, blood vessel, heart, eyes, liver and breast;Anthocyanidin conduct The main component of black soya bean skin pigment, it is a kind of good antioxidant;Black bean peel anthocyanidin is hydroxyl donor, while is also one kind Free radical scavenger, can not only be combined with protein prevents peroxidating, is also chelated with Cu2+ etc., prevents VC peroxidating, regenerates VC, , also can singlet-oxygen quenching so as to regenerate VE;Peppermint includes the materials such as menthol, peppermint oil, and soluble in water, numerous experiments are ground Study carefully confirmation, mint extract has the rush effect of oozing to the medicine of numerous species.
Compared with prior art, the beneficial effects of the invention are as follows:
The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, made therein Active ingredient quickly enters deep skin and reaches peripheral blood circulation, reaches the effect for neutralizing free radical in skin, recovers glue Former albumen elasticity, prevents skin ageing, promotes skin health;Compared with the existing technology, technique is advanced, easy to operate by the present invention, Active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to advise greatly Mould industrialized production.
Embodiment
The technical scheme of this patent is described in more detail with reference to embodiment.
Embodiment 1
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves 5 Part, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 5 parts of peppermint, 3 parts of olive oil, 80 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, Red ganoderma, mother-of-pearl and peppermint cross 14 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water Solution, 23h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60 DEG C, microwave power 500w, every time Microwave irradiation time is 30s, and the accumulative radiation number of microwave is 4 times, and microwave radiation is complete, insulation extraction 40min.
(4) decoction extracted is passed through into 10 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed It is even, produce Chinese medicine compound prescription washing lotion.
Embodiment 2
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves 20 parts, 25 parts of red ganoderma, 12 parts of mother-of-pearl, 12 parts of black bean powder, 13 parts of peppermint, 12 parts of olive oil, 400 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, Red ganoderma, mother-of-pearl and peppermint cross 16 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water Solution, 24h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 70 DEG C, microwave power 1200w, every time Microwave irradiation time is 40s, and the accumulative radiation number of microwave is 5 times, and microwave radiation is complete, insulation extraction 50min.
(4) decoction extracted is passed through into 12 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed It is even, produce Chinese medicine compound prescription washing lotion.
Embodiment 3
A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, is made up of the raw material of following parts by weight:GABA tealeaves 50 parts, 45 parts of red ganoderma, 20 parts of mother-of-pearl, 20 parts of black bean powder, 20 parts of peppermint, 25 parts of olive oil, 800 parts of pure water.
The Transdermal absorption removes the production technology of the Chinese medicine compound prescription washing lotion of free radical, comprises the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, Red ganoderma, mother-of-pearl and peppermint cross 20 mesh sieves after being crushed with pulverizer.
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, it is molten to add pure water Solution, 25h is stood with ParafilmTM beaker mouth.
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 80 DEG C, microwave power 2000w, every time Microwave irradiation time is 50s, and the accumulative radiation number of microwave is 6 times, and microwave radiation is complete, insulation extraction 60min.
(4) decoction extracted is passed through into 15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed It is even, produce Chinese medicine compound prescription washing lotion.
GABA tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g in above example, and the olive oil is pure olive Olive oil.
Embodiment 4
Clinical test:
This group of case totally 60,60 patients are divided into treatment group and control group by the method for random table.Treatment group 30, Wherein man 18, female 12, average age 39.25 ± 5.36 years old;Control group 30, wherein man 16, female 14, average age 40.29 ± 2.35 years old.The sex of two groups of cases, age compare, and are statistically analyzed no significant difference, P > 0.05, having can Compare property.
Selected case with situations below person to being excluded:(1) vitals such as the heart, liver, kidney and lung exist serious Disease;(2) there is active hemorrhage tendency person;(3) hypertension, diabetes and other patients with chronic diseases;In (4) one years Once operator is carried out.
Treatment group's Chinese medicine compound prescription washing lotion as made from the methods described of above-described embodiment one, be applied to 3 times a day patient back, At belly and calf skin, coordinate popular treatment for sunstroke by scraping the patient's neck, chest or back, massage manipulation, promote to absorb;Control group gives vitamin E, 30mg/ times, and daily 3 Secondary, postprandial half an hour takes.The course for the treatment of 12 weeks.Before on-test and after end, SOD, MDA are detected, testing result is as described in Table 1.
Statistical method carries out statistical analysis using statistic software SPSS ll.0.Measurement data is recorded using x ± s methods, Measurement data compares using t inspections before and after treatment and between group;Ranked data compare using in non-parametric test before and after treatment Ridit is examined, and two groups of treated effects use Chi-square Test.
The treatment group of table 1, control group pretherapy and post-treatment SOD, MDA compare (X ± S)
Upper table data show that two groups are pretherapy and post-treatment, and SOD has rise, MDA to have decline, and difference has statistical significance, The Chinese medicine compound prescription finish prepared as can be seen here using preparation method in the present invention can effectively reduce the content of people's interior free yl, promote Enter body health.
The Chinese medicine compound prescription washing lotion of the present invention is applied directly to skin surface, percutaneous absorption function, made therein Active ingredient quickly enters deep skin and reaches peripheral blood circulation, reaches the effect for neutralizing free radical in skin, recovers glue Former albumen elasticity, prevents skin ageing, promotes skin health.Compared with the existing technology, technique is advanced, easy to operate by the present invention, Active ingredient can be preferably extracted from medicine, and extraction can protect pharmaceutical activity well at a lower temperature, be easy to advise greatly Mould industrialized production.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party Formula, can also be on the premise of this patent objective not be departed from one skilled in the relevant art's possessed knowledge Various changes can be made.

Claims (6)

1. a kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that is made up of the raw material of following parts by weight: GABA tealeaves 5-50 parts, red ganoderma 5-45 parts, mother-of-pearl 2-20 parts, black bean powder 3-20 parts, peppermint 5-20 parts, olive oil 3-25 Part, pure water 80-800 parts.
2. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that by following heavy The raw material of amount part is made:GABA tealeaves 5-20 parts, red ganoderma 5-15 parts, mother-of-pearl 2-10 parts, black bean powder 3-10 parts, peppermint 5-10 Part, olive oil 3-15 parts, pure water 80-400 parts.
3. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that by following heavy The raw material of amount part is made:It is 5 parts of GABA tealeaves, 5 parts of red ganoderma, 2 parts of mother-of-pearl, 3 parts of black bean powder, 6 parts of peppermint, 3 parts of olive oil, pure 85 parts of water.
4. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that the GABA Tealeaves refers to tealeaves of the GABA content in more than 1.5mg/g.
5. Transdermal absorption according to claim 1 removes the Chinese medicine compound prescription washing lotion of free radical, it is characterised in that the olive Oil is Pure Olive Oil.
6. a kind of Transdermal absorption using described in one of claim 1-5 removes the production work of the Chinese medicine compound prescription washing lotion of free radical Skill, it is characterised in that comprise the following steps that:
(1) GABA tealeaves, red ganoderma, mother-of-pearl, peppermint and black bean powder are weighed according to above-mentioned parts by weight, by GABA tealeaves, red spirit Sesame, mother-of-pearl and peppermint cross 14-20 mesh sieves after being crushed with pulverizer;
(2) material powder after above-mentioned crushing is taken, black bean powder mixing is added and is placed in large beaker, add pure water dissolving, with ParafilmTM beaker mouth stands 23-25h;
(3) above-mentioned decoction is put into microwave extracting apparatus, sets extraction temperature as 60-80 DEG C, microwave power 500-2000w, Each microwave irradiation time is 30-50s, and the accumulative radiation number of microwave is 4-6 times, and microwave radiation is complete, insulation extraction 40-60min;
(4) decoction extracted is passed through into 10-15 mesh sock filtrations, collects filtrate, olive oil is added into filtrate, ultrasound is mixed It is even, produce Chinese medicine compound prescription washing lotion.
CN201410621003.7A 2014-11-07 2014-11-07 A kind of Transdermal absorption removes the Chinese medicine compound prescription washing lotion and its production technology of free radical Active CN104383122B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN102885747A (en) * 2011-07-22 2013-01-23 方樱翰 Black bean powder ageing-resistant facial mask

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101911989A (en) * 2010-08-03 2010-12-15 马伟光 Truffle health-care tea and preparation method thereof
CN102885747A (en) * 2011-07-22 2013-01-23 方樱翰 Black bean powder ageing-resistant facial mask

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
γ-氨基丁酸的药理作用;郑红发等;《茶叶通讯》;20041231(第4期);第14-18页 *
γ-氨基丁酸茶的研究进展;王芳等;《武夷学院学报》;20091031;第28卷(第5期);第39-43页 *
皮肤的生理特点与透皮吸收;马庆晏等;《生物学通报》;19971231;第32卷(第10期);第24-26页 *

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