CN104379164A - 治疗狗中的莱姆病的疫苗和方法 - Google Patents

治疗狗中的莱姆病的疫苗和方法 Download PDF

Info

Publication number
CN104379164A
CN104379164A CN201380030342.1A CN201380030342A CN104379164A CN 104379164 A CN104379164 A CN 104379164A CN 201380030342 A CN201380030342 A CN 201380030342A CN 104379164 A CN104379164 A CN 104379164A
Authority
CN
China
Prior art keywords
seq
construct
protein
cyclic peptide
helical peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380030342.1A
Other languages
English (en)
Chinese (zh)
Inventor
R.M.洛瑟
P.F.M.缪斯
J.J.米勒希普
Z.许
R.T.马科尼
C.厄恩哈特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
University of Virginia UVA
Original Assignee
Pfizer Inc
University of Virginia UVA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, University of Virginia UVA filed Critical Pfizer Inc
Publication of CN104379164A publication Critical patent/CN104379164A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0225Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380030342.1A 2012-04-18 2013-04-18 治疗狗中的莱姆病的疫苗和方法 Pending CN104379164A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261635031P 2012-04-18 2012-04-18
US61/635,031 2012-04-18
PCT/US2013/037063 WO2013158818A2 (en) 2012-04-18 2013-04-18 Vaccines and methods to treat lyme disease in dogs

Publications (1)

Publication Number Publication Date
CN104379164A true CN104379164A (zh) 2015-02-25

Family

ID=48193279

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380030342.1A Pending CN104379164A (zh) 2012-04-18 2013-04-18 治疗狗中的莱姆病的疫苗和方法

Country Status (10)

Country Link
EP (1) EP2838555A2 (es)
JP (1) JP2015514776A (es)
CN (1) CN104379164A (es)
AR (1) AR090726A1 (es)
AU (1) AU2013249229A1 (es)
BR (1) BR112014025740A2 (es)
CA (1) CA2870179C (es)
EA (1) EA201491668A1 (es)
UY (1) UY34745A (es)
WO (1) WO2013158818A2 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483624A (zh) * 2019-08-22 2019-11-22 中国疾病预防控制中心传染病预防控制所 伽氏疏螺旋体OspA蛋白C端肽段及其应用
CN111432835A (zh) * 2017-12-04 2020-07-17 英特维特国际股份有限公司 犬莱姆病疫苗

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3204404A4 (en) 2014-10-08 2018-06-06 Virginia Commonwealth University Stage specific diagnostic antigens, assay and vaccine for lyme disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004175A1 (en) * 1991-08-15 1993-03-04 Smithkline Beecham Biologicals (S.A.) Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines
WO2009135118A2 (en) * 2008-05-02 2009-11-05 Virginia Commonwealth University Lyme disease vaccine
WO2010132758A2 (en) * 2009-05-14 2010-11-18 Gomes-Solecki Maria J Ospc-based diagnostic test for lyme disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567043A (en) 1983-06-15 1986-01-28 American Home Products Corporation (Del.) Canine corona virus vaccine
US4567042A (en) 1983-06-15 1986-01-28 American Home Products Corporation Inactivated canine coronavirus vaccine
US6872550B1 (en) 1991-07-11 2005-03-29 Baxter Vaccine Ag Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
WO2000006745A1 (en) 1998-07-31 2000-02-10 Gundersen Lutheran Medical Foundation, Inc. Uses of the borreliacidal epitope(s) of borrelia burgdorferi outer surface protein c (ospc) as vaccine
EP3029073B1 (en) * 2010-10-20 2019-09-04 Virginia Commonwealth University Polyvalent chimeric ospc vaccinogen and diagnostic antigen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004175A1 (en) * 1991-08-15 1993-03-04 Smithkline Beecham Biologicals (S.A.) Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines
WO2009135118A2 (en) * 2008-05-02 2009-11-05 Virginia Commonwealth University Lyme disease vaccine
WO2010132758A2 (en) * 2009-05-14 2010-11-18 Gomes-Solecki Maria J Ospc-based diagnostic test for lyme disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER G. EARNHART等: "OspC Phylogenetic Analyses Support the Feasibility of a Broadly Protective Polyvalent Chimeric Lyme Disease Vaccine", 《CLIN VACCINE IMMUNOL.》 *
EARNHART CG等: "An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences", 《HUM VACCIN.》 *
IVANOVA L等: "Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design", 《CLIN IMMUNOL.》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111432835A (zh) * 2017-12-04 2020-07-17 英特维特国际股份有限公司 犬莱姆病疫苗
US11883476B2 (en) 2017-12-04 2024-01-30 Intervet Inc. Canine lyme disease vaccine
CN110483624A (zh) * 2019-08-22 2019-11-22 中国疾病预防控制中心传染病预防控制所 伽氏疏螺旋体OspA蛋白C端肽段及其应用

Also Published As

Publication number Publication date
WO2013158818A2 (en) 2013-10-24
CA2870179A1 (en) 2013-10-24
EA201491668A1 (ru) 2015-08-31
AR090726A1 (es) 2014-12-03
UY34745A (es) 2013-11-29
EP2838555A2 (en) 2015-02-25
BR112014025740A2 (pt) 2017-07-04
AU2013249229A1 (en) 2014-10-23
JP2015514776A (ja) 2015-05-21
CA2870179C (en) 2018-09-04
WO2013158818A3 (en) 2014-04-17

Similar Documents

Publication Publication Date Title
JP6965417B2 (ja) Ospaキメラおよびそのワクチンでの使用法
JP4301415B2 (ja) ライム病組み合せ組成物とその使用
CA2565925C (en) Vaccine for periodontal disease
US8986704B2 (en) Mutant fragments of OspA and methods and uses relating thereto
CN104379164A (zh) 治疗狗中的莱姆病的疫苗和方法
EP2877206B1 (en) Compositions comprising chimeric ospa molecules and methods of use thereof
GB2551984A (en) Fish virus
ES2684556T3 (es) Vacunas de mannheimia haemolytica atenuadas y procedimientos de fabricación y uso
Lo et al. Characterization of two lipoproteins in Pasteurella multocida
Register et al. Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene
US9562079B2 (en) Vaccines and methods to treat lyme disease in dogs
US6096323A (en) Vaccine against papillomatous digital dermatitis (PDD)
WO2021099458A1 (en) A novel vaccine against heamophilus parasuis
EP4061413A1 (en) A novel vaccine against heamophilus parasuis
US9175049B2 (en) Recombinant mycobacterium avium subsp. paratuberculosis proteins induce immunity and protect against infection
RU2773402C2 (ru) Химерные гены ospa, белки и способы их применения
Thomas Development of vaccines for Ehrlichiosis
Farahi et al. Cloning and Expression of Brucella abortus Omp19 an Immunogenic Minor Outer Membrane Protein
CN115057944A (zh) 一种针对所有gbs血清型的多表位亚单位疫苗
Song et al. Expression of Clostridium perfringens alpha-epsilon soluble fusion toxin gene in Escherichia coli and its immunogenicity in mice.
JP2008546637A (ja) ルデテラ・ブロンキセプチカp68抗原及びワクチン製造のための製剤及び製法プロセス
JP2010505792A (ja) マイコバクテリアの熱ショックタンパク質70を含む治療用ワクチン

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150225