CN104378976B - 人源化il-7啮齿动物 - Google Patents

人源化il-7啮齿动物 Download PDF

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Publication number
CN104378976B
CN104378976B CN201380031333.4A CN201380031333A CN104378976B CN 104378976 B CN104378976 B CN 104378976B CN 201380031333 A CN201380031333 A CN 201380031333A CN 104378976 B CN104378976 B CN 104378976B
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China
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human
rodent
humanized
gene
locus
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Expired - Fee Related
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CN201380031333.4A
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English (en)
Chinese (zh)
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CN104378976A (zh
Inventor
A·J·莫菲
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
CN201380031333.4A 2012-06-18 2013-06-14 人源化il-7啮齿动物 Expired - Fee Related CN104378976B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US61/660,976 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US61/740,074 2012-12-20
US13/795,765 2013-03-12
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610168011.XA Division CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Publications (2)

Publication Number Publication Date
CN104378976A CN104378976A (zh) 2015-02-25
CN104378976B true CN104378976B (zh) 2016-03-23

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380031333.4A Expired - Fee Related CN104378976B (zh) 2012-06-18 2013-06-14 人源化il-7啮齿动物
CN201610168011.XA Pending CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610168011.XA Pending CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Country Status (27)

Country Link
US (7) US8962913B2 (https=)
EP (2) EP2861063A1 (https=)
JP (1) JP6174134B2 (https=)
KR (1) KR20150027752A (https=)
CN (2) CN104378976B (https=)
AU (1) AU2013277457B2 (https=)
BR (1) BR112014029892A2 (https=)
CA (1) CA2873134A1 (https=)
CY (1) CY1119071T1 (https=)
DK (1) DK2859793T3 (https=)
ES (1) ES2626965T3 (https=)
HK (1) HK1203761A1 (https=)
HR (1) HRP20170974T1 (https=)
HU (1) HUE034592T2 (https=)
IL (3) IL235773B (https=)
IN (1) IN2014DN10189A (https=)
LT (1) LT2859793T (https=)
MX (1) MX363540B (https=)
NZ (1) NZ702943A (https=)
PL (1) PL2859793T3 (https=)
PT (1) PT2859793T (https=)
RS (1) RS56039B1 (https=)
RU (1) RU2654565C2 (https=)
SG (3) SG10201609569PA (https=)
SI (1) SI2859793T1 (https=)
SM (1) SMT201700313T1 (https=)
WO (1) WO2013192030A1 (https=)

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BR112014006394A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
US9001798B2 (en) * 2012-03-05 2015-04-07 Samsung Electronics Co., Ltd. HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
CN105592695B (zh) 2013-09-23 2018-04-10 瑞泽恩制药公司 具有人源化信号调节蛋白基因的非人动物
DE112014004537T5 (de) 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
ES2715949T3 (es) 2013-10-15 2019-06-07 Regeneron Pharma Animales con IL-15 humanizada
SG10201811701YA (en) 2013-11-19 2019-01-30 Regeneron Pharma Non-human animals having a humanized a proliferation-inducing ligand gene
SG10202003996YA (en) 2014-05-05 2020-06-29 Regeneron Pharma Humanized c5 and c3 animals
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SI3086637T1 (sl) 2014-12-05 2019-04-30 Regeneron Pharmaceuticals, Inc. Nehumane živali s humaniziranim označevalcem diferenciacije gena CD47
KR102658190B1 (ko) * 2015-04-13 2024-04-17 리제너론 파마슈티칼스 인코포레이티드 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법
MX2018009513A (es) 2016-02-04 2019-01-31 Regeneron Pharma Animales no humanos que tienen un gen angptl8 modificado genéticamente.
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
MX394999B (es) 2017-09-29 2025-03-24 Regeneron Pharma Animales no humanos que comprenden un locus ttr humanizado y metodos de uso
IL278267B2 (en) 2018-07-16 2025-02-01 Regeneron Pharma Non-human animal models of DITRA disease and their uses
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
US11891618B2 (en) 2019-06-04 2024-02-06 Regeneron Pharmaceuticals, Inc. Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
EP4096396A1 (en) * 2020-01-28 2022-12-07 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR102316506B1 (ko) 2020-02-26 2021-10-22 차의과학대학교 산학협력단 동물 면역계의 인간화 활성을 촉진하는 방법
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
KR20230124973A (ko) * 2020-12-21 2023-08-28 리제너론 파마슈티칼스 인코포레이티드 인간화 tslp 유전자, 인간화 tslp 수용체 유전자, 및/또는인간화 il7ra 유전자를 갖는 비인간 동물
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Publication number Publication date
JP2015523863A (ja) 2015-08-20
RU2654565C2 (ru) 2018-05-21
US9232776B2 (en) 2016-01-12
US20130340104A1 (en) 2013-12-19
SG10201609576YA (en) 2016-12-29
BR112014029892A2 (pt) 2017-07-25
EP2859793A1 (en) 2015-04-15
EP2861063A1 (en) 2015-04-22
MX363540B (es) 2019-03-27
HK1203761A1 (en) 2015-11-06
NZ702943A (en) 2017-07-28
US20170064932A1 (en) 2017-03-09
MX2014015679A (es) 2015-04-08
CA2873134A1 (en) 2013-12-27
HRP20170974T1 (hr) 2017-09-22
US9737059B2 (en) 2017-08-22
CN105779467A (zh) 2016-07-20
ES2626965T3 (es) 2017-07-26
AU2013277457A1 (en) 2015-01-22
WO2013192030A1 (en) 2013-12-27
IN2014DN10189A (https=) 2015-08-21
SMT201700313T1 (it) 2017-07-18
IL260250B (en) 2019-08-29
PT2859793T (pt) 2017-07-06
RS56039B1 (sr) 2017-09-29
IL235773B (en) 2018-07-31
HK1203302A1 (en) 2015-10-30
US20150082469A1 (en) 2015-03-19
DK2859793T3 (en) 2017-06-19
HUE034592T2 (en) 2018-02-28
RU2014148107A (ru) 2016-08-10
CY1119071T1 (el) 2018-01-10
US20160052986A1 (en) 2016-02-25
EP2859793B1 (en) 2017-04-05
IL235773A0 (en) 2015-01-29
KR20150027752A (ko) 2015-03-12
PL2859793T3 (pl) 2017-09-29
CN104378976A (zh) 2015-02-25
IL268674A (en) 2019-10-31
SG11201407370QA (en) 2014-12-30
US20170311581A1 (en) 2017-11-02
US10314298B2 (en) 2019-06-11
US9974291B2 (en) 2018-05-22
US20180360007A1 (en) 2018-12-20
US20190343093A1 (en) 2019-11-14
SG10201609569PA (en) 2016-12-29
JP6174134B2 (ja) 2017-08-02
LT2859793T (lt) 2017-07-10
AU2013277457B2 (en) 2018-03-15
US8962913B2 (en) 2015-02-24
SI2859793T1 (sl) 2017-07-31

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