BR112014029892A2 - animal não humano e roedor geneticamente modificados, método para preparar um animal não humano, locus de il-7 humanizada, e, célula ou tecido - Google Patents

animal não humano e roedor geneticamente modificados, método para preparar um animal não humano, locus de il-7 humanizada, e, célula ou tecido

Info

Publication number
BR112014029892A2
BR112014029892A2 BR112014029892A BR112014029892A BR112014029892A2 BR 112014029892 A2 BR112014029892 A2 BR 112014029892A2 BR 112014029892 A BR112014029892 A BR 112014029892A BR 112014029892 A BR112014029892 A BR 112014029892A BR 112014029892 A2 BR112014029892 A2 BR 112014029892A2
Authority
BR
Brazil
Prior art keywords
humanized
human animal
human
genetically modified
rodent
Prior art date
Application number
BR112014029892A
Other languages
English (en)
Portuguese (pt)
Inventor
J Murphy Andrew
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112014029892A2 publication Critical patent/BR112014029892A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
BR112014029892A 2012-06-18 2013-06-14 animal não humano e roedor geneticamente modificados, método para preparar um animal não humano, locus de il-7 humanizada, e, célula ou tecido BR112014029892A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Publications (1)

Publication Number Publication Date
BR112014029892A2 true BR112014029892A2 (pt) 2017-07-25

Family

ID=49757275

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014029892A BR112014029892A2 (pt) 2012-06-18 2013-06-14 animal não humano e roedor geneticamente modificados, método para preparar um animal não humano, locus de il-7 humanizada, e, célula ou tecido

Country Status (27)

Country Link
US (7) US8962913B2 (https=)
EP (2) EP2859793B1 (https=)
JP (1) JP6174134B2 (https=)
KR (1) KR20150027752A (https=)
CN (2) CN104378976B (https=)
AU (1) AU2013277457B2 (https=)
BR (1) BR112014029892A2 (https=)
CA (1) CA2873134A1 (https=)
CY (1) CY1119071T1 (https=)
DK (1) DK2859793T3 (https=)
ES (1) ES2626965T3 (https=)
HK (1) HK1203761A1 (https=)
HR (1) HRP20170974T1 (https=)
HU (1) HUE034592T2 (https=)
IL (3) IL235773B (https=)
IN (1) IN2014DN10189A (https=)
LT (1) LT2859793T (https=)
MX (1) MX363540B (https=)
NZ (1) NZ702943A (https=)
PL (1) PL2859793T3 (https=)
PT (1) PT2859793T (https=)
RS (1) RS56039B1 (https=)
RU (1) RU2654565C2 (https=)
SG (3) SG10201609576YA (https=)
SI (1) SI2859793T1 (https=)
SM (1) SMT201700313T1 (https=)
WO (1) WO2013192030A1 (https=)

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BR112014006394A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
AU2013228185B2 (en) * 2012-03-05 2016-11-03 Samsung Electronics Co., Ltd. HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
TR201901782T4 (tr) 2013-09-23 2019-03-21 Regeneron Pharma İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar.
AU2014330922A1 (en) 2013-10-01 2016-03-03 Kymab Limited Animal models and therapeutic molecules
ES2613379T3 (es) 2013-10-15 2017-05-24 Regeneron Pharmaceuticals, Inc. Animales con IL-15 humanizada
RU2671101C1 (ru) 2013-11-19 2018-10-29 Регенерон Фармасьютикалс, Инк. Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда
EP3636073B1 (en) 2014-05-05 2023-11-15 Regeneron Pharmaceuticals, Inc. Humanized c5 and c3 animals
NO2785538T3 (https=) * 2014-05-07 2018-08-04
HUE064960T2 (hu) 2014-12-05 2024-04-28 Regeneron Pharma Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok
ES2950399T3 (es) * 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos
SG11201806176PA (en) 2016-02-04 2018-08-30 Regeneron Pharma Non-human animals having an engineered angptl8 gene
DK3422845T3 (da) 2016-02-29 2021-08-30 Regeneron Pharma Gnavere med et humaniseret tmprss-gen
US20190098879A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use
HRP20240999T1 (hr) 2018-07-16 2024-10-25 Regeneron Pharmaceuticals, Inc. Glodavački modeli bolesti ditra i njihova upotreba
CN114107385A (zh) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
KR102661779B1 (ko) 2019-04-04 2024-04-30 리제너론 파마슈티칼스 인코포레이티드 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물
US11891618B2 (en) 2019-06-04 2024-02-06 Regeneron Pharmaceuticals, Inc. Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
MX2021015122A (es) 2019-06-07 2022-04-06 Regeneron Pharma Animales no humanos que comprenden un locus de albumina humanizado.
WO2021027737A1 (en) * 2019-08-09 2021-02-18 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
WO2021154791A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR102316506B1 (ko) 2020-02-26 2021-10-22 차의과학대학교 산학협력단 동물 면역계의 인간화 활성을 촉진하는 방법
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
JP2024500153A (ja) * 2020-12-21 2024-01-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物
WO2022247936A1 (en) * 2021-05-28 2022-12-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric cd36
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Also Published As

Publication number Publication date
RU2654565C2 (ru) 2018-05-21
RU2014148107A (ru) 2016-08-10
US20190343093A1 (en) 2019-11-14
US20150082469A1 (en) 2015-03-19
IN2014DN10189A (https=) 2015-08-21
WO2013192030A1 (en) 2013-12-27
IL235773B (en) 2018-07-31
MX2014015679A (es) 2015-04-08
EP2859793A1 (en) 2015-04-15
US20170311581A1 (en) 2017-11-02
US10314298B2 (en) 2019-06-11
CY1119071T1 (el) 2018-01-10
US20160052986A1 (en) 2016-02-25
IL268674A (en) 2019-10-31
SI2859793T1 (sl) 2017-07-31
SG10201609569PA (en) 2016-12-29
DK2859793T3 (en) 2017-06-19
AU2013277457B2 (en) 2018-03-15
NZ702943A (en) 2017-07-28
US8962913B2 (en) 2015-02-24
PT2859793T (pt) 2017-07-06
JP6174134B2 (ja) 2017-08-02
IL260250B (en) 2019-08-29
CN104378976A (zh) 2015-02-25
HK1203761A1 (en) 2015-11-06
CN105779467A (zh) 2016-07-20
EP2861063A1 (en) 2015-04-22
KR20150027752A (ko) 2015-03-12
US9232776B2 (en) 2016-01-12
US20180360007A1 (en) 2018-12-20
SG11201407370QA (en) 2014-12-30
SG10201609576YA (en) 2016-12-29
PL2859793T3 (pl) 2017-09-29
US9737059B2 (en) 2017-08-22
JP2015523863A (ja) 2015-08-20
CN104378976B (zh) 2016-03-23
US9974291B2 (en) 2018-05-22
HK1203302A1 (en) 2015-10-30
US20170064932A1 (en) 2017-03-09
HUE034592T2 (en) 2018-02-28
RS56039B1 (sr) 2017-09-29
HRP20170974T1 (hr) 2017-09-22
LT2859793T (lt) 2017-07-10
MX363540B (es) 2019-03-27
SMT201700313T1 (it) 2017-07-18
AU2013277457A1 (en) 2015-01-22
CA2873134A1 (en) 2013-12-27
EP2859793B1 (en) 2017-04-05
ES2626965T3 (es) 2017-07-26
IL235773A0 (en) 2015-01-29
US20130340104A1 (en) 2013-12-19

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