CN104352983A - Health oral liquid for treatment of qi-stagnancy and blood stasis and preparation method thereof - Google Patents

Abstract

The invention discloses a health oral liquid for the treatment of qi-stagnancy and blood stasis. The oral liquid comprises the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of rhizoma cyperi, 10-20 parts of angelica sinensis, 10-20 parts of poria cocos, 10-20 parts of peach kernels, 10-20 parts of rhizoma ligustici wallichii, 10-20 parts of magnolia officinalis, 10-20 parts of astragalus membranaceus, 10-20 parts of perilla frutescens, 10-20 parts of polygonatum kingianum, 10-20 parts of fructus rubi, 10-20 parts of mulberries, 10-20 parts of charred triplet, 10-20 parts of fructus ligustri lucidi, 10-20 parts of salvia miltiorrhiza, 10-20 parts of flosmume, 10-20 parts of curcuma, 10-20 parts of polygala amflra, 10-20 parts of radix paeoniae rubra, and 10-20 parts of achyranthes bidentata. According to the invention, in the process of treating, by adopting treatment from the liver, and on the basis of treatment based on syndrome differentiation, while a drug for invigorating blood circulation and eliminating stasis is applied, liver-regulating drugs for soothing the liver, warming the liver, nourishing the liver, removing heat from the liver, and the like are respectively added, so that the health oral liquid achieves a good clinical curative effect on affect-mind ill-being together with chest and rib-side distending and distress, and stabbing pain, and Qi-stagnation and blood stasis symptoms such as menstrual disorders, menstrual pain, lassitude in loin and legs, leukorrhea with reddish discharge, lower abdomen deficiency and cold, abdominal pain during menstruation, congealing cold and blood stasis, easily oil face, sterility, and the like.

Description

A kind of health care oral liquid for the treatment of qi depression to blood stasis and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of health care oral liquid for the treatment of qi depression to blood stasis and preparation method thereof.

Background technology

Qi depression to blood stasis, refers to the stagnation of QI and the simultaneous pathological state of blood stasis.Its Deterioration mechanism is: general how first not smooth by the operation of gas, then cause the operation stasis of blood of blood stagnant, first have the stagnation of QI, blood stasis is caused by the stagnation of QI, also by stagnation of blood stasis such as blood circulating out of vessels, can affect the operation of gas, this just first has blood stasis, the stagnation of QI is caused by blood stasis, also can the stagnation of QI and blood stasis be formed simultaneously because of sprain and contusion equivalent damage.

Qi depression to blood stasis disease, is depression and stagnation of QI and hyperamization clots absorbing hinders the sign occurred, how not to be relaxed by feelings will, or exopathogen invasion and attack cause irritability of a specified duration strongly fragrant do not understand caused by.Main clinical manifestation: breast side of body feeling of distension and oppression, walk to alter pain, being irritable and getting angry easily, the lower mass in the abdomen of the side of body, twinge tenderness, the visible menstruation apolipsis of women, or dysmenorrhea, dark menses block, purplish tongue or see ecchymosis, hesitant pulse.

Pathogenic analysis: assertive evidence does not relax with feelings will, simultaneously with breast side of body feeling of distension and oppression, twinge, woman's menoxenia is diagnostic point.Liver controlling conveyance and dispersion and store blood, having bar reaches mechanism of qi, the function of emotion regulation, the unsuccessful or exopathogen invasion and attack the liver pulse then irritability stasis of feelings will, and catharsis is neglected one's duty, therefore is in a very depressed state or irritable, and breast side of body feeling of distension and oppression, walks to alter pain; Qi as the commander of blood, stagnation of QI due to depression of the liver, with the passing of time puzzled, must cause in blood stasis and stop, therefore gradually become the lower mass in the abdomen of the side of body, twinge tenderness; Liver storing blood, be the source of women's menses, the liver blood stasis of blood is stagnant, and blood stasis is stagnated, and amasss in the sea of blood, and hinder menses descending, menses freely then do not cause amenorrhea, dysmenorrhea.Purplish tongue or have ecchymosis, hesitant pulse, is in blood stasis the disease stopped.

The life of qi depression to blood stasis body constitution is taken good care of: research finds, human body is in qi depression to blood stasis state for a long time, tissue ischemia, and state that cell is in " hunger ", can accelerate aging.Therefore, for qi depression to blood stasis body constitution, promoting flow of QI and blood has effect anti-aging in advance.On the living conditions, happy emotion should be kept, contribute to improving QI-blood circulation.Avoid the unhealthy emotions such as rage, terrified, troubled thoughts on the impact of QI-blood circulation.Adhere to sports, quantity of motion varies with each individual.Each motion exercise should reach the degree of slightly perspiring.

In theory of Chinese medical science, " gas " is the life thing extremely micro-to essence be present in human body, be the important substance basis of vital movement, there is very strong vigor, the generation of blood, operation can be promoted, and the effect such as the generation of body fluid, defeated cloth and excretion, there is living matter and physiological function double attribute.The traditional Chinese medical science about the discussion of " the capable then blood of gas, the stagnation of QI is blood stasis then for qi being the governor of blood, blood being the material foundation of QI ", the substantial connection reflecting the interaction of QI and blood in physiological and pathological and mutually cause a disease.The essence of further further investigated gas and qi-blood relationship, can provide new approach for treatment syndrome of blood stasis, have great importance to the research of combination of Chinese and Western medicine syndrome of blood stasis.

The formation of syndrome of qi stagnation and blood stasis is a veryer long process, relevant with factors such as emotion, diet, age, environment, diseases.The traditional Chinese medical science think the activity of spiritual feelings will be with internal organs change the vital essence blood of raw and storage for material base, and liver controlling conveyance and dispersion is anger in will, and anger take blood stored in the liver as material base, liver stored blood, regulating blood flow amount and prevent the hemorrhage liver catharsis mechanism of qi that depends on to be achieved.

Women's feelings will is not relaxed, and simultaneously with breast side of body feeling of distension and oppression, twinge, menoxenia, dysmenorrhea are commonly encountered diseases, affects its physically and mentally healthy and study to a certain extent.Western medical treatment mainly adopts non-steroidal anti-inflammatory drugs and contraceptive treatment, belongs to anti symptom treatment more, though get effect fast, often recur, and side effect is larger after drug withdrawal.Chinese traditional treatment dysmenorrhea accounts for clinically and has great advantage, evident in efficacy and side effect is little.The traditional Chinese medical science about the discussion of " the capable then blood of gas, the stagnation of QI is blood stasis then for qi being the governor of blood, blood being the material foundation of QI ", the substantial connection reflecting the interaction of QI and blood in physiological and pathological and mutually cause a disease.The essence of further further investigated gas and qi-blood relationship, can provide new approach for treatment syndrome of blood stasis, have great importance to the research of combination of Chinese and Western medicine syndrome of blood stasis.But Chinese medicine health-care effect varies with each individual, and specific aim is barely satisfactory, especially abnormal smells from the patient is poor, and mouthfeel is very poor.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of Chinese medicine health-care not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.

Summary of the invention

Technical problem to be solved by this invention is, Chinese medicine health-care effect varies with each individual, and specific aim is barely satisfactory, and especially abnormal smells from the patient is poor, and mouthfeel is very poor.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of Chinese medicine health-care not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.

The formation of syndrome of qi stagnation and blood stasis is a veryer long process, relevant with factors such as emotion, diet, age, environment, diseases.The traditional Chinese medical science think the activity of spiritual feelings will be with internal organs change the vital essence blood of raw and storage for material base, and liver controlling conveyance and dispersion is anger in will, and anger take blood stored in the liver as material base, liver stored blood, regulating blood flow amount and prevent the hemorrhage liver catharsis mechanism of qi that depends on to be achieved.But Chinese medicine health-care effect varies with each individual, specific aim is barely satisfactory, the present invention adopts treat from liver when treating, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, add soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjust liver medicine, do not relax for feelings will, simultaneously with breast side of body feeling of distension and oppression, twinge; Menoxenia, abdominal pain in menstruation, lassitude loin and legs, leucorrhea with red and white discharge, lower abdomen cold caused by deficiency, menalgia, congealing cold with blood stasis, appearance be old, the symptom that do not become the qi depression to blood stasis such as pregnant for a long time easily, clinically obtains good curative effect.

For solving the problems of the technologies described above, the invention provides a kind of health care oral liquid for the treatment of qi depression to blood stasis, the parts by weight of the raw material of oral liquid described in it can be: Radix Bupleuri 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 20 parts, Cortex Magnoliae Officinalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, FLOS MUME 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.

The health care oral liquid of described treatment qi depression to blood stasis, the parts by weight of the raw material of oral liquid described in it can also be: Radix Bupleuri 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, 10 ~ 15 parts, Poria, 10 ~ 15 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 15 parts, Cortex Magnoliae Officinalis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Folium Perillae 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Fructus Rubi 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, FLOS MUME 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.

The health care oral liquid of described treatment qi depression to blood stasis, the parts by weight of the raw material of oral liquid described in it also can be: Radix Bupleuri 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 20 parts, Cortex Magnoliae Officinalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Fructus Rubi 10 ~ 15 parts, Fructus Mori 10 ~ 15 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, FLOS MUME 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the health care oral liquid of qi depression to blood stasis, and described in it, the preparation process of oral liquid comprises:

A, all raw material components to be soaked in ethanol 24 hours;

B, again by crude drug heat extract 2 times, become paste, be component 1;

C, medicinal residues add water and extract, as component 2;

D, above-mentioned two kinds of components to be merged, be condensed into pasty state add Mel or dextrin be in harmonious proportion after canned.

In described step a, all raw material powders can be broken into granule, dry, decontamination of winnowing with a dustpan, then be soaked in ethanol 24 hours.

In described step b, can by soaked heating raw materials reflux, extract, 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, leave standstill 24 hours, remove supernatant, when to put into thickener concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.

In described step c, all the other raw materials can be added 10 times of water gagings, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state, become component 2.

In described steps d, can by component 1 and component also 2-in-1, then put into concentrating under reduced pressure tank, reclaim ethanol, when being concentrated into 90 DEG C, relative density is the extractum of 1.05, is concentrated into every 1ml containing 1g crude drug amount, then adds Mel or dextrin and is in harmonious proportion bottling.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the health care oral liquid of qi depression to blood stasis, and the preparation method of described oral liquid can also be following steps:

All raw materials are put into 10 times amount ethanol to soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2; Merged by above-mentioned two kinds of extracting solution, reducing pressure after reclaiming ethanol, it is concentrated to put into concentrator, then adds dextrin and is in harmonious proportion, pack after ultraviolet radiation for sterilizing and disinfecting.

In above-mentioned steps, two kinds of extracting solution can be merged, after reclaiming ethanol decompression put into concentrator concentrated time, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

Advantageous Effects of the present invention is: the present invention can avoid using the side effect that brings of Western medicine, and the formation of Western medicine syndrome of qi stagnation and blood stasis is a veryer long process, relevant with the factors such as emotion, diet, age, environment, disease.The traditional Chinese medical science think the activity of spiritual feelings will be with internal organs change the vital essence blood of raw and storage for material base, and liver controlling conveyance and dispersion is anger in will, and anger take blood stored in the liver as material base, liver stored blood, regulating blood flow amount and prevent the hemorrhage liver catharsis mechanism of qi that depends on to be achieved.But Chinese medicine health-care effect varies with each individual, specific aim is barely satisfactory, the present invention adopts treat from liver when treating, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, add soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjust liver medicine, do not relax for feelings will, simultaneously with breast side of body feeling of distension and oppression, twinge; Menoxenia, abdominal pain in menstruation, lassitude loin and legs, leucorrhea with red and white discharge, lower abdomen cold caused by deficiency, menalgia, congealing cold with blood stasis, appearance be old, the symptom that do not become the qi depression to blood stasis such as pregnant for a long time easily, clinically obtains good curative effect.The present invention is pure drug matching, without any toxic and side effects, can life-time service, and instant effect, not easily recur after healing.

Detailed description of the invention

The formation of syndrome of qi stagnation and blood stasis is a veryer long process, relevant with factors such as emotion, diet, age, environment, diseases.The traditional Chinese medical science think the activity of spiritual feelings will be with internal organs change the vital essence blood of raw and storage for material base, and liver controlling conveyance and dispersion is anger in will, and anger take blood stored in the liver as material base, liver stored blood, regulating blood flow amount and prevent the hemorrhage liver catharsis mechanism of qi that depends on to be achieved.In this test, rat causes feelings will to change through multifactor combined stimulation, is in rage state for a long time, thus forms this card.

Qi depression to blood stasis, refers to the stagnation of QI and the simultaneous pathological state of blood stasis.Its Deterioration mechanism is: general how first not smooth by the operation of gas, then cause the operation stasis of blood of blood stagnant, first have the stagnation of QI, blood stasis is caused by the stagnation of QI, also by stagnation of blood stasis such as blood circulating out of vessels, can affect the operation of gas, this just first has blood stasis, the stagnation of QI is caused by blood stasis, also can the stagnation of QI and blood stasis be formed simultaneously because of sprain and contusion equivalent damage.

Qi depression to blood stasis disease, is depression and stagnation of QI and hyperamization clots absorbing hinders the sign occurred, how not to be relaxed by feelings will, or exopathogen invasion and attack cause irritability of a specified duration strongly fragrant do not understand caused by.Main clinical manifestation: breast side of body feeling of distension and oppression, walk to alter pain, being irritable and getting angry easily, the lower mass in the abdomen of the side of body, twinge tenderness, the visible menstruation apolipsis of women, or dysmenorrhea, dark menses block, purplish tongue or see ecchymosis, hesitant pulse.

Pathogenic analysis: assertive evidence does not relax with feelings will, simultaneously with breast side of body feeling of distension and oppression, twinge, woman's menoxenia is diagnostic point.Liver controlling conveyance and dispersion and store blood, having bar reaches mechanism of qi, the function of emotion regulation, the unsuccessful or exopathogen invasion and attack the liver pulse then irritability stasis of feelings will, and catharsis is neglected one's duty, therefore is in a very depressed state or irritable, and breast side of body feeling of distension and oppression, walks to alter pain; Qi as the commander of blood, stagnation of QI due to depression of the liver, with the passing of time puzzled, must cause in blood stasis and stop, therefore gradually become the lower mass in the abdomen of the side of body, twinge tenderness; Liver storing blood, be the source of women's menses, the liver blood stasis of blood is stagnant, and blood stasis is stagnated, and amasss in the sea of blood, and hinder menses descending, menses freely then do not cause amenorrhea, dysmenorrhea.Purplish tongue or have ecchymosis, hesitant pulse, is in blood stasis the disease stopped.

In theory of Chinese medical science, " gas " is the life thing extremely micro-to essence be present in human body, be the important substance basis of vital movement, there is very strong vigor, the generation of blood, operation can be promoted, and the effect such as the generation of body fluid, defeated cloth and excretion, there is living matter and physiological function double attribute.The traditional Chinese medical science about the discussion of " the capable then blood of gas, the stagnation of QI is blood stasis then for qi being the governor of blood, blood being the material foundation of QI ", the substantial connection reflecting the interaction of QI and blood in physiological and pathological and mutually cause a disease.The essence of further further investigated gas and qi-blood relationship, can provide new approach for treatment syndrome of blood stasis, have great importance to the research of combination of Chinese and Western medicine syndrome of blood stasis.

Semen Persicae bitter, sweet, flat.GUIXIN, liver, large intestine channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Semen Persicae extracting solution obviously can increase cerebral blood flow, increases the blood flow of dog femoral artery, reduces vascular resistance, improves hemodynamic situation.Extract can improve the liver surface microcirculation of animal, and promotes bile secretion.Semen Persicae can make the hemorrhage of mice and clotting time obviously extend, and decoct has inhibitory action to external thrombus, and decocting liquid has fiber facilitation.Containing the fatty oil Castor Oil intestinal of 45% in Semen Persicae, be beneficial to defecation.Semen Persicae can promote primipara's uterine contraction and hemorrhage.Water decoction and extract have analgesia, antiinflammatory, antibacterial, anti-allergic effects.Amygdaloside in Semen Persicae has the effect of antitussive and antiasthmatic and anti-hepatic fibrosis." medication heart method ": Semen Persicae, bitter to let out stagnant blood, sweet with tissue regeneration promoting blood, therefore blood coagulation must be used.Heat in dehematizing again." detailed outline ": Semen Persicae promoting the circulation of blood, should use in the life of gross weight point; Moisturizing and invigorate blood circulation, soup leaching should remove the peel sharp parching to brown use, or Testa Tritici is with frying, or charred medicinal herb with its property retained, respectively with we.

Rhizoma Chuanxiong is pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, has the effect of activating blood cirulation to regulate QI flow.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast." detailed outline " carries it: loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Bupleuri clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.The phytomorph of history tree to Radix Bupleuri has description more." book on Chinese herbal medicine is just ": " Radix Bupleuri, cool loose with it with this person, the heat of suppressing the hyperactive liver.It is cool in nature, therefore separates alternate attack of chill and fever, flesh table hectic fever, and liver and gall fire is scorching, and chest and hypochondrium is tied, and doublely controls skin infection, and blood room is heated; Its property is fallen apart, therefore main typhoid fever pathogenic heat are not separated, epidemic febrile disease intenseness of heat, SHAO YANG headache, Liver Channel melancholia.

Folium Perillae: tender leaf is nutritious, containing compositions such as protein, fat, soluble sugar, dietary fiber, carotene, vitamin B1, vitamin B2, vitamin C, potassium, calcium, phosphorus, ferrum, manganese and selenium, in addition, containing volatile oil in leaf, include perillaldehyde, perilla alcohol, menthone, menthol, eugenol and ergomaketon etc., have special fragrance, have antisepsis.Folium Perillae acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae, based on edible tender leaf, can be eaten raw or cook soup.Folium Perillae is edible leaf not only, and its seed also because of the edible containing compositions such as high protein, oryzanol, vitamin E, vitamin B1, linolenic acid, linoleic acid, oleic acid, sterol, phospholipid, and has therapeutical effect to cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation etc.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae property and flavor of peppery and warm, have deliver, cold expelling, the effect of regulating the flow of vital energy and seeking.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen etc.Compendium of Material Medica is carried " promoting the circulation of QI to alleviate the stagnation in middle-JIAO, clearing away phlegm profit lung, and blood, warming middle-JIAO, pain relieving, Dingchuan, antiabortive ".

Rhizoma Polygonati: Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.For alleviating weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, and slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas, obtain dizzy, soreness of the waist and knees for deficiency of kidney essence, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, then body is from light, sends out in vain also.Respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main settling five organs, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence.

Fructus Mori nourishing YIN and benefiting blood medicine; Promote the production of body fluid medicine; Aperitive.To enrich blood YIN nourishing, promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science thinks the acid of Fructus Mori sweet in the mouth, and cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effects such as intestine moistening is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Asparagi, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The micro-acid of FLOS MUME, puckery, nontoxic.Soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula.FLOS MUME pattern is pure white, and fragrance is extremely dense, has the laudatory title of " spending middle gentleman ".Its property is put down, and maximum feature can be regulated the flow of vital energy exactly, and function of spleen and stomach regulating unclogs and readjusts QI and blood, but can not impairment of YIN, very seldom.So be no matter the old man of family, or immature baby, can keep healthy by FLOS MUME.Be usually used in gloomy vexed, the disease such as stomachache due to hyperactive liver-QI attacking the stomach, inappetence.The external of FLOS MUME water can also prevent facial blood stasis to form speckle.Supplementary Amplifications of the Compendium of Materia Medica: " " all sorts of flowers mirror ": powder for improving appetite is evil, and food of cooking congee, help the gas of sun clearly to rise, distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." " decoction pieces is newly joined ": " FLOS MUME suppressing the hyperactive liver and easing the stomach, only gastralgia, dizziness, enter diet.”

Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine." property of medicine opinion ": control woman's stagnated blood epigastric pain caused by emotional factors, cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound." book on Chinese herbal medicine just ": emesis blood, epistaxis; Alonely control married woman's cold air accumulation of blood, knot gather qi together is stagnant, and trusted subordinate has a pain." book on Chinese herbal medicine is stated ": control heating, strongly fragrant, cough, bleeding from the gum, cough blood, hematuria, has a headache dizzy, mad epilepsy, dysentery, drenches, and the cards such as eyes nose glossopharyngeum larynx.

Radix Polygalae (Radix Polygalae) is conventional Chinese medicine, be recorded in Shennong's Herbal the earliest, be classified as top grade, and be regarded as supporting life key medicine, derive from the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. and ovum leaf Radix Polygalae P.sibirica L..Warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Shennong's Herbal: main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency, except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.There is the function of clearing away heat and cooling blood, eliminating stasis to stop pain.Raw Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.The fever of the body being used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Wine Radix Paeoniae Rubra: with promoting blood circulation to remove blood stasis power victory, clearing away heat and cooling blood effect is more weak.Be used for amenorrhea or dysmenorrhea, traumatic injury.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Radix Achyranthis Bidentatae invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.Radix Achyranthis Bidentatae, walks and can mend, and property is apt to descending, therefore enters Liver and kidney.Main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia unable to flex and stretch the extremities person, liver spleen is suffered from a deficiency of the kidney, then cold-damp heresy visitor form numbness, and sick spasm of the limbs, gonalgia unable to flex and stretch the extremities.This property of medicine is walked and descending, and it can also must by eliminating impediment by cold-damp.Top capping liver then muscle is relaxed, descending, manages knee joint, and promoting the circulation of blood then pain stops.By vim and vigour, still cloud can lead to qi stagnation hemagglutination also." not Lu ": middle weak breath of curing the wound, male kidney yin disappears, and old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration, and benefit essence, Li Yin gas, only turns white.The effect of have diuresis, by force essence, stimulating the menstrual flow.Energy relaxing muscles and tendons to promote blood circulation, specially controls lumbocrural pain.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is three taste medicines, i.e. Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown).This three tastes medicine all has the stagnant function of good removing food stagnancyization, but has features different separately.Fructus Hordei Germinatus (parched to brown) has the effect of good digestible starch group food; Fructus Crataegi (parched to brown) is good at treating meat or greasy too much caused dyspepsia; Massa Medicata Fermentata (parched to brown) is then beneficial to digestion rice and flour food.Three medicines share, and can strengthen digestive function significantly.Therefore, three medicines often share and are called " JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) " by doctor clinically.

Fructus Hordei Germinatus, forms through barley germination, and Fructus Hordei Germinatus is put micro-stir-fry extremely yellow in pot, spray clear water, taking-up is dried, and is Fructus Hordei Germinatus (parched to brown).Fructus Hordei Germinatus (parched to brown) has the stagnant merit of invigorating the spleen and regulating the stomach, soothing liver-QIization, is used for the treatment of that food stagnation does not disappear, the disease such as distension and fullness in the abdomen, inappetence, vomiting are had loose bowels.Modern study is thought, in Fructus Hordei Germinatus, rich in starch catabolic enzyme, conversion carbohydrase, esterified enzyme, vitamin B etc., have good digestion-aid effect.

Fructus Crataegi, section is dried, and put in pot large stir-fry of useing force and be degree to outer wrinkly face brown, inner yellowish-brown, spray clear water, taking-up is dried, and is Fructus Crataegi (parched to brown).Oral Fructus Crataegi can increase digestive enzyme, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, Fructus Crataegi has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increases myocardial contraction, to arrhythmia.Therefore, be conducive to preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.

Massa Medicata Fermentata is the processed goods through fermentation after whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mixing.Get Massa Medicata Fermentata to put in pot and fry to appearance be coke black, inner coke yellow, take out, sprinkling disappears water, cools, is Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, and therefore, bad, feeling of stuffiness in chest abdominal distention for the digestion caused by diet internal injury quite have effect.

Cortex Magnoliae Officinalis is bitter; Pungent; Warm in nature.Gui Jing: spleen channel; Stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Against relievining asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough, and removing dampness by means of aromatics Chinese medicine, cures mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.Come from Shennong's Herbal.Bencao Jingshu ": Cortex Magnoliae Officinalis, main apoplexy, cold headache, cold and heat, the dead flesh person of QI and blood numbness, covers with wind and cold exopathogen, hinders and divide in sun, be then cold and heat headache; Wind and cold wets into space between skin and muscles, then QI and blood is coagulated and puckeryly formed numbness, very then numbness, and this medicine is pungent can eliminating stagnation, bitterly can bath wet, warm can cold-dispelling, therefore know main also." not Lu " main warming middle-JIAO, expectorant, therapeutic method to keep the adverse QI flowing downwards again, treats cholera, and stomachache distension, and cold in the stomach is inverse, vomits in the heart more than, lets out the vexed full person of dysentery, and what is is it possible that flatus is inverse stops up stagnant, and phlegm retention stays knot, caused by diet raw food.

The specific embodiment of the invention

Specific embodiment 1

The preparation of oral liquid of the present invention: get Radix Bupleuri 1500g, Rhizoma Cyperi 1500g, Radix Angelicae Sinensis 1500g, Poria 1500g, Semen Persicae 1500g, Rhizoma Chuanxiong 1500g, Cortex Magnoliae Officinalis 1500g, Radix Astragali 1500g, Folium Perillae 1500g, Rhizoma Polygonati 1500g, Fructus Rubi 1500g, Fructus Mori 1500g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 1500g, Fructus Ligustri Lucidi 1500g, Radix Salviae Miltiorrhizae 1500g, FLOS MUME 1500g, Radix Curcumae 1500g, Radix Polygalae 1500g, Radix Paeoniae Rubra 1500g, Radix Achyranthis Bidentatae 1500g.All raw material powders are broken into granule, dry, decontamination of winnowing with a dustpan, and to be then soaked in ethanol 24 hours.Heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.Merged by the extractum of component 1 and component 2, then put into concentrating under reduced pressure tank, being evaporated to relative density is 1.20, then takes out, and adding dextrin or Mel, to reconcile into oral liquid canned.

Specific embodiment 2

The preparation of oral liquid of the present invention:

Get Radix Bupleuri 1200g, Rhizoma Cyperi 1300g, Radix Angelicae Sinensis 1100g, Poria 1100g, Semen Persicae 1200g, Rhizoma Chuanxiong 1100g, Cortex Magnoliae Officinalis 1200g, Radix Astragali 1100g, Folium Perillae 1200g, Rhizoma Polygonati 1100g, Fructus Rubi 1200g, Fructus Mori 1300g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 1200g, Fructus Ligustri Lucidi 1200g, Radix Salviae Miltiorrhizae 1100g, FLOS MUME 1200g, Radix Curcumae 1200g, Radix Polygalae 1100g, Radix Paeoniae Rubra 1100g, Radix Achyranthis Bidentatae 1200g.All raw material powders are broken into granule, dry, decontamination of winnowing with a dustpan, to be then soaked in ethanol 24 hours.By soaked heating raw materials reflux, extract, 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, leaves standstill 24 hours, removes supernatant, when to put into thickener concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.The medicinal residues of the raw material crossed by above-mentioned ethanol extraction add 10 times of water gagings, then put into extraction pot heated and boiled 1 hour, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state, become component 2.Merged by the extractum of component 1 and component 2, then put into concentrating under reduced pressure tank, reclaim ethanol, being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, then takes out, and adding dextrin or Mel, to reconcile into oral liquid canned.

Specific embodiment 3

The preparation of oral solutions of the present invention:

Get Radix Bupleuri 1300g, Rhizoma Cyperi 1300g, Radix Angelicae Sinensis 1100g, Poria 1100g, Semen Persicae 1200g, Rhizoma Chuanxiong 1300g, Cortex Magnoliae Officinalis 1200g, Radix Astragali 1300g, Folium Perillae 1100g, Rhizoma Polygonati 1200g, Fructus Rubi 1100g, Fructus Mori 1300g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 1200g, Fructus Ligustri Lucidi 1200g, Radix Salviae Miltiorrhizae 1100g, FLOS MUME 1200g, Radix Curcumae 1200g, Radix Polygalae 1300g, Radix Paeoniae Rubra 1100g, Radix Achyranthis Bidentatae 1200g.All raw material powders are broken into granule, dry, decontamination of winnowing with a dustpan, to be then soaked in ethanol 24 hours.Heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Pharmacological toxicity is tested

One, skin irritation test

1, experimental technique

Depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, often organize Cavia porcellus and be coated with the present invention's (pill) 4,8 and 12g respectively, respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and the present invention, without local irritant effect, also has no general toxicity performance.Show invention formulation use safety.

Two, animal acute toxicity test research:

The present invention, through trial test, can not measure LD 50, therefore measures maximum dosage-feeding.Adopt rectal delivery, the maximum dosage-feeding on the one recording mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about 1567.5 times that intend clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.At the end of experiment, all healthy survival of animal, body weight increases.

Three, long-term toxicity test for animals research:

One, test material and method

(1) test medicine: the tablet that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, strengthens the drug effects such as metabolism, avirulence.

Medicine and clinical experiment

Syndrome of qi stagnation and blood stasis refers to mechanism of qi retardance and hyperamization clots absorbing hinders the syndrome showed.Often because feelings will is unsuccessful, caused by sprain and contusion wound or cold-evil's internal resistance etc.Clinical manifestation fullness and distention in the chest and hypochondrium or walk to alter pain, irascible temperament, the lower mass in the abdomen of the side of body, twinge tenderness, enters Night Watch very, or dysmenorrhes, and dark menses, accompanies stasis of blood block, and purplish tongue is dark or have ecchymosis etc.

Gas is to essence to micro-living matter in human body, is the important substance basis of vital movement, have promote blood generation, operation, and the function such as the generation of body fluid, defeated cloth and excretion.The more difficult assurance of concept of the traditional Chinese medical science " gas ", but " gas " is material after all, has its material base just can complete its critical function.In order to the essence of Primary Study " gas " and the dependency of gaseous signal molecule, this experiment copies qi depression to blood stasis disease model, observe the situation of change of gaseous signal molecule NO in its model body, examine whether to there is dependency with " gas " in theory of Chinese medical science, the research for syndrome of blood stasis and Blood-Activating-and-Stasis-Removing medicine provides a new thinking.

1 materials and methods

1.1 reagent N O test kits (20111123), NOS test kit (20111123) (Bioengineering Research Institute is built up in Nanjing), Trizol (D9108A), RT-PCR kit (DRR019A), agarose (D601), Marker (D526A) primer (precious biological engineering (Dalian) company limited).

1.2 laboratory animals and the healthy wistar rat of grouping SPF level, male and female half and half, body weight 180g mono-200g, is divided into 4 groups at random, is respectively matched group, model group, low dose group of the present invention and high dose group.

1.3 duplicating models adopt the modeling of multifactor combined stimulation method.Stimulating factor comprises sound, optical, electrical, ice-water bath, constraint, folder tail, stimulates 2 every day, continues 5 Zhou Shiwen.

1.4 NO content in plasma measure after NO produces and transform rapidly nitrite (NO in vivo ^2-) and nitrate (NO ^3-), and NO ^2-one is further converted to NO again ^3-.Utilize nitrate reductase specifically by NO ^3-reductive NO ^2-, measure NO by the colour developing depth ^2-one concentration level.

The operation of NO and NOS detection kit description is pressed in 1.5 hepatic tissue TNOS and iNOS determination of activity, measure NO synthase (TNOS), inducible NO-synthase (iNOS) is active, the active iNOS of structural type NO synthase (eNOS) activity=TNOS is active.

1.6RT-PCR method measures hepatic tissue eNOS gene expression reference literature and adopts Trizol reagent to extract total serum IgE, carries out reverse transcription synthesis cDNA, carry out pcr amplification as template according to Reverse Transcriptase kit description.Reaction condition eNOS, B-actin annealing temperature 65 DEG C.Employing gel image analyser scans, and measures the A of genes of interest and B-actin amplification, calculates the ratio of itself and B-actin, in table 1.

Table 1eNOS and actin gene primer sequence

1.7 common carotid artery eNOS immunohistochemical analysis common carotid artery paraffin section routine dewaxing aquations, endogenous peroxydase 15min eliminated by 3% hydrogen peroxide, microwave method antigen retrieval 10min, drip primary antibodie, 4 ~ C spends the night, and next day, order added two anti-and three to resist, hatch 30min for 37 DEG C respectively, DAB develops the color, haematoxylin redyeing, light Microscopic observation eNOS expression J in common carotid artery endotheliocyte.The painted grey decision-making of eNOS positive cell is measured by color pathological analytical system.Grey decision-making is less, illustrates painted darker, and reflection eNOS expression is more, carries out quantizing rear row statistical analysis with grey decision-making.

1.8 statistical data analysis represents with (± s), application SPSS 17.0 processes, and many group sample averages compare employing One-way ANOVA variance analysis, and compare between two between group, the neat person of variance checks by LSD method, and heterogeneity of variance person checks with Tamhane s12.

2 results

2.1 blood plasma and Enzyme assay in liver NO content and hepatic tissue are compared with matched group, in model group blood plasma and hepatic tissue, NO content obviously reduces (P < 0.01), and in low dose group blood plasma and hepatic tissue, NO content is apparently higher than model group (P < 0.05).Compared with matched group, model group TNOS, cNOS activity all obviously reduce (P < 0.01), and low dose group TNOS, cNOS are active in model group (P < 0.05), in table 2.

NO content in table 2 syndrome of qi stagnation and blood stasis rat plasma and liver

And the change of enzymatic activity (n=8, x ± s)

Note: compare .**P < 0.01 with matched group; Compare with model group, Δ p < 0.01, Δ Δ p < 0.05.

3 discuss

Nitric oxide is the more active lipophilic small molecule compound of a kind of chemical property, finally generated under NOS effect by L-arginine in vivo, can continue produce and through biomembrane free diffusing, there is vasodilator, the physiological function such as reduce blood pressure, and plays an important role in cardiovascular system, immune system and nervous system.Apply existing more than 100 year of nitro class vasodilator medicine clinically, along with going deep into of research, people understand its mechanism of action, are actually as NO donor.The drug-induced vasorelaxation action of nitro class vasodilator directly depends on the growing amount of NO, and amount effect relationship, be played a role by gaseous signal molecule to syndrome of blood stasis medicative nitro class vasodilator medicine essence.

The formation of syndrome of qi stagnation and blood stasis is a veryer long process, relevant with factors such as emotion, diet, age, environment, diseases.The traditional Chinese medical science think the activity of spiritual feelings will be with internal organs change the vital essence blood of raw and storage for material base, and liver controlling conveyance and dispersion is anger in will, and anger take blood stored in the liver as material base, liver stored blood, regulating blood flow amount and prevent the hemorrhage liver catharsis mechanism of qi that depends on to be achieved.In this test, rat causes feelings will to change through multifactor combined stimulation, is in rage state for a long time, thus establishes qi depression to blood stasis model.Experimental result display syndrome of qi stagnation and blood stasis NO content and NOS expression obviously reduce (P < 0.01), after giving promoting flow of QI and blood medicine, NO content and NOS expression significance increase (P < 0.01), the two variation tendency is consistent, this also demonstrates NO vasodilator function, and research discloses circulation of qi promoting blood circulation promoting medicine can raise NO/NOS system.There are some researches show Endothelial dysfunction after body tissue ischemia-reperfusion; histiocyte can form irreversible damage; after tissue ischemia, eNOS activity, eNOS gene expression dose and NO content all obviously reduce; after perfusion recovers in ischemic tissue; eNOS activity, eNOS gene expression dose and NO content are lower than basic value; recover perfusion 2h, These parameters is close to basic value, and this is a process of body self-protection.In theory of Chinese medical science, " gas " is the life thing extremely micro-to essence be present in human body, be the important substance basis of vital movement, there is very strong vigor, the generation of blood, operation can be promoted, and the effect such as the generation of body fluid, defeated cloth and excretion, there is living matter and physiological function double attribute.The traditional Chinese medical science about the discussion of " the capable then blood of gas, the stagnation of QI is blood stasis then for qi being the governor of blood, blood being the material foundation of QI ", the substantial connection reflecting the interaction of QI and blood in physiological and pathological and mutually cause a disease.The essence of further further investigated gas and qi-blood relationship, can provide new approach for treatment syndrome of blood stasis, have great importance to the research of combination of Chinese and Western medicine syndrome of blood stasis.

Clinical trial:

Dysmenorrhes is commonly encountered diseases, affects its physically and mentally healthy and study to a certain extent.Western medical treatment mainly adopts non-steroidal anti-inflammatory drugs and contraceptive treatment, belongs to anti symptom treatment more, though get effect fast, often recur, and side effect is larger after drug withdrawal.Chinese traditional treatment dysmenorrhea accounts for clinically and has great advantage, evident in efficacy and side effect is little.This research purpose probes into the common TCM Syndrome Type of the dysmenorrhea that qi depression to blood stasis causes and effective Therapeutic Method.

1 data and method

1.1 physical data

My 200, Out-patient Department gynecological of random selecting, the age is in (17.35 ± 0.27) ~ (21.74 ± 0.12) year.Rejecting data is not enough, and getting rid of pelvic cavity has positive discovery, finally filters out eligible person totally 160 people.Wherein dysmenorrheal caused by qi stagnation and blood stasis totally 80 examples.Be divided into two groups, treatment group of the present invention and matched group are without significant difference.

1.2 deliberated index

1. pain degree criteria for classification adopts visual analogue scales (VAS scoring), can be divided into 3 degree by pain degree: slight: 1 ~ 3 point; Moderate: 4 ~ 6 points; Severe: 7 ~ 10 points.2. Standards of Chinese Medical Syndrome Differentiation is with reference to " Gynecology of Chinese Medicine dysmenorrhea " typing.3. symptom integral: with reference to the standards of grading of " new Chinese medicine guideline of clinical investigations ", dysmenorrhea symptom integral >=14 point severe; Dysmenorrhea symptom integral 8 ~ 13.5 points of moderates: dysmenorrhea symptom integral < 8 points is slight.4. clinical efficacy is cured: pain degree returns to 0 point, other transference cure, follows up a case by regular visits to the no recurrence of 3 menstrual cycle; Effective: integration is reduced to 1/2 of the front integration for the treatment of, and symptom takes a turn for the better, and refuses to obey that analgesic can adhere to work; Effective: integration is reduced to 1/2 ~ 3/4 of the front integration for the treatment of, and symptom takes a turn for the better, and taking analgesic can adhere to work; Invalid: stomachache and other symptom are without change.5. lab testing: empty stomach extracting vein blood 4ml detection prostaglandin in morning (F2a) in menstrual onset 24 ~ 48h.

1.3 method

The above academic title of traditional Chinese medical science attending doctor, carries out pattern of syndrome judgement to MethodsThe cases enrolled by above standard.By qi stagnation and blood stasis type patient 80 people maximum for pattern of syndrome, be divided into 2 groups, often organize 40 people.Treatment group adopts the present invention to treat.Fang Yong: Radix Bupleuri 15g, Rhizoma Cyperi 12g, Radix Angelicae Sinensis 12g, Poria 12g, Semen Persicae 13g, Rhizoma Chuanxiong 13g, Cortex Magnoliae Officinalis 12g, Radix Astragali 13g, Folium Perillae 13g, Rhizoma Polygonati 12g, Fructus Rubi 11g, Fructus Mori 12g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 13g, Fructus Ligustri Lucidi 12g, Radix Salviae Miltiorrhizae 13g, FLOS MUME 12g, Radix Curcumae 12g, Radix Polygalae 12g, Radix Paeoniae Rubra 12g, Radix Achyranthis Bidentatae 11g.Contrast groups decoction for removing blood stasis is treated.

Treatment in 1 week before menstrual onset, later monthly treatment in premenstrual 1 week, treats, is for 9 times 1 course for the treatment of, treat statistical correlation data after 1 course for the treatment of for continuous 3 months.

1.4 statistical procedures

Data information adopts S to represent, t and X 2 test, and P < 0.05 has significant for difference.

2 results

Treat after 3 months, 80 routine patients symptomatic's integrations, pain scores obviously reduce before all comparatively treating.In table 1.The evaluation for the treatment of clinical efficacy, treatment group cures 29 examples, effective 10 examples, invalid 1 example; Contrast groups, healing is 21 examples, effective 10 examples, and invalid is 9 examples.The state of an illness be light, in, between severe patient, effective percentage is poor apart from without significant.

Compare (X ± S) before and after the routine patient's indices treatment of table 180

Project	N	Before treatment	After treatment
				Symptom integral	80	10.35±2.36	6.87±2.22*
Pain scores	80	7.21±2.34	4.24±1.98*
				PGF2a(mmol/l)	80	128.56±41.85	88.54±33.78**

Note; * P < is compared O.05, * * P < 0.01 with before treatment.

3 discuss

Dysmenorrhea is that endometrium synthesis and release PGF2a increase, and causes hysterospasm shrink and produce pain.Women be in go to school, take an advanced study, choose a job, marriage, many-sided unstable factor such as emotion the emotion changeable phase, abnormal emotion-thought and affect zang-fu organs qi movement, cause QI and blood transporting disorderly, impact punching is appointed and causes pain, " stagnation of QI and blood may bring about pain ".Patient is anxiety-depression because of long pain, therefore the normal life of impact, lack human communication etc., this has increased the weight of again depressive anxiety state further, has occurred the disease due to stagnation of QI-blood, the vicious cycle of stagnation of QI-blood due to disease.Woman is congenital with liver, and the disgruntled thing of normal susceptible will causes functional activity of QI being not smooth, qi being the governor of blood, and the capable then blood of gas, the stagnation of QI is blood stasis then, and married woman's qi stagnation and blood stasis type proportion is maximum.

The author carries out treatment by the method to the court qi stagnation and blood stasis type primary dysmenorrhea women and achieves good curative effect, thinks that this method is worth at clinical further genralrlization.

Specific embodiment 1: Lee, female, 29 years old, white collar, abdominal pain during menstruation companion did not practise contraception unpregnancy more than 2 years.Dysmenorrhea generally at premenstrual 1 ~ 2 day to menstruation the 2nd day obviously, treats that menstrual blood volume is gradually many, pain relief after having large clot to discharge.Menstruation 30 days one tide, measure medium, color is purple, have clot, with distention and pain of breast before menstruation, there is purple gas on red tongue limit, wiry and frequent pulse.Tcm diagnosis is dysmenorrhea, and card belongs to stagnation of liver-QI blood stasis.Control with dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, side's Xuefu Zhuyu Decoction, but always intermittent, DeGrain.Use oral liquid of the present invention instead, Fang Yong: Radix Bupleuri 12g, Rhizoma Cyperi 12g, Radix Angelicae Sinensis 12g, Poria 12g, Semen Persicae 13g, Rhizoma Chuanxiong 12g, Cortex Magnoliae Officinalis 12g, Radix Astragali 13g, Folium Perillae 13g, Rhizoma Polygonati 12g, Fructus Rubi 11g, Fructus Mori 12g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 13g, Fructus Ligustri Lucidi 12g, Radix Salviae Miltiorrhizae 13g, FLOS MUME 12g, Radix Curcumae 12g, Radix Polygalae 12g, Radix Paeoniae Rubra 12g, Radix Achyranthis Bidentatae 11g.Make oral liquid, every day 2 bottles.Advise premenstrual 1 week clothes, serve on 7 days.Patient's continuous 3 cycles.Within premenstrual 1 week, take medicine, symptom is obviously alleviated, and successful pregnancies.

Specific embodiment 2: the Qin, female, 34 years old.The first visit time: on February 15th, 2012.Main suit: more than 10 years of menstruation menoxenia.History of present illness: menstrual cycle 20-25 days, menstrual period general 4-5 days, the last menstrual period time: on February 15th, 2009.This time menstruation shifts to an earlier date 5 days, and have clot, in 5 days menstrual period, leucorrhea amount holds the blood streak under the arm more.Lumbago between menstrual period, two lower limb cold type of pain.Bilateral cheekbone portion acne, premenstruum increases the weight of.Tired weak, anorexia, peace of sleeping, two just adjust.The micro-Huang of light red tongue tongue, stringy and thready pulse.Dialectical: depression of liver-QI, deficiency of spleen-YANG and kidneyYANG.Method for the treatment of: dispersing the stagnated live-QI to relieve the stagnation of QI, invigorate the spleen and warm the kidney.Fang Yong: Radix Bupleuri 12g, Rhizoma Cyperi 12g, Radix Angelicae Sinensis 12g, Poria 12g, Semen Persicae 13g, Rhizoma Chuanxiong 12g, Cortex Magnoliae Officinalis 12g, Radix Astragali 13g, Folium Perillae 13g, Rhizoma Polygonati 12g, Fructus Rubi 11g, Fructus Mori 12g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 13g, Fructus Ligustri Lucidi 12g, Radix Salviae Miltiorrhizae 13g, FLOS MUME 12g, Radix Curcumae 12g, Radix Polygalae 12g, Radix Paeoniae Rubra 12g, Radix Achyranthis Bidentatae 11g.Make oral liquid, every day 2 bottles.Two examine the time: on March 5th, 2012.Behind patient's readme clothes top, symptom alleviates.Existing disease stool is shapeless, day a line.Lassitude loin and legs's pain, fear of cold.The micro-Huang of light red tongue tongue is greasy, and Sublingual is livid purple, stringy and thready pulse.Continue to take 1 week.Three examine the time: on March 12nd, 2012.Behind patient's readme clothes top, symptom alleviates.The existing micro-Huang of light red tongue tongue, stringy and thready pulse.Further consultation after serveing on March, private prosecution disappears through row or postmenstrual abdominal pain, and follow-up study 3 months, has no recurrence.

Claims (10)

1. treat the health care oral liquid of qi depression to blood stasis for one kind, it is characterized in that, the parts by weight of the raw material of described oral liquid comprise: Radix Bupleuri 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 20 parts, Cortex Magnoliae Officinalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, FLOS MUME 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.

2. treat the health care oral liquid of qi depression to blood stasis according to claim 1, it is characterized in that, the parts by weight of the raw material of described oral liquid comprise: Radix Bupleuri 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, 10 ~ 15 parts, Poria, 10 ~ 15 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 15 parts, Cortex Magnoliae Officinalis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Folium Perillae 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Fructus Rubi 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, FLOS MUME 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.

3. treat the health care oral liquid of qi depression to blood stasis according to claim 1, it is characterized in that, the parts by weight of the raw material of described oral liquid comprise: Radix Bupleuri 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, Poria, 10 ~ 20 parts, Semen Persicae, Rhizoma Chuanxiong 10 ~ 20 parts, Cortex Magnoliae Officinalis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Fructus Rubi 10 ~ 15 parts, Fructus Mori 10 ~ 15 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, FLOS MUME 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat a preparation method for the health care oral liquid of qi depression to blood stasis, it is characterized in that, the preparation process of described oral liquid comprises:

A, all raw material components to be soaked in ethanol 24 hours;

B, again by crude drug heat extract 2 times, become paste, be component 1;

C, medicinal residues add water and extract, as component 2;

D, above-mentioned two kinds of components to be merged, be condensed into pasty state add Mel or dextrin be in harmonious proportion after canned.

5. treat the preparation method of the health care oral liquid of qi depression to blood stasis according to claim 4, it is characterized in that, in described step a, all raw material powders are broken into granule, dry, decontamination of winnowing with a dustpan, to be then soaked in ethanol 24 hours.

6. treat the preparation method of the health care oral liquid of qi depression to blood stasis according to claim 4, it is characterized in that, in described step b, by soaked heating raw materials reflux, extract, 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, leave standstill 24 hours, remove supernatant, when to put into thickener concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.

7. treat the preparation method of the health care oral liquid of qi depression to blood stasis according to claim 4, it is characterized in that, in described step c, medicinal residues are added 10 times of water gagings, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state, become component 2.

8. treat the preparation method of the health care oral liquid of qi depression to blood stasis according to claim 4, it is characterized in that, in described steps d, by component 1 and component also 2-in-1, then put into concentrating under reduced pressure tank, reclaim ethanol, when being concentrated into 90 DEG C, relative density is the extractum of 1.05, be concentrated into every 1ml containing 1g crude drug amount, then add Mel or dextrin mediation bottling.

9. according to any one of claims 1 to 3, treat a preparation method for the health care oral liquid of qi depression to blood stasis, it is characterized in that, the preparation method of described oral liquid can also be following steps:

All raw materials are put into 10 times amount ethanol to soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, remove supernatant, merge extractive liquid, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2; Merged by above-mentioned two kinds of extracting solution, reducing pressure after reclaiming ethanol, it is concentrated to put into concentrator, then adds dextrin and is in harmonious proportion, pack after ultraviolet radiation for sterilizing and disinfecting.

10. the preparation method of the Semen Cuscutae oral liquid of the kidney invigorating and essence nourishing according to claim 9, it is characterized in that: in above-mentioned steps, two kinds of extracting solution are merged, reclaim decompression after ethanol put into concentrator concentrated time, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.