CN104336777B - A kind of electrospray water medicated cigarette tobacco juice that can improve body immunity and the electrospray water medicated cigarette comprising this tobacco juice - Google Patents
A kind of electrospray water medicated cigarette tobacco juice that can improve body immunity and the electrospray water medicated cigarette comprising this tobacco juice Download PDFInfo
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- CN104336777B CN104336777B CN201410445720.9A CN201410445720A CN104336777B CN 104336777 B CN104336777 B CN 104336777B CN 201410445720 A CN201410445720 A CN 201410445720A CN 104336777 B CN104336777 B CN 104336777B
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- Prior art keywords
- tobacco juice
- ginsenoside
- tobacco
- electronic smoke
- present
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Classifications
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Abstract
The invention belongs to electronic cigarette technical field, disclose a kind of tobacco juice for electronic smoke and the electronic cigarette comprising this tobacco juice.The tobacco juice for electronic smoke that the present invention provides includes saponins compound, tobacco spice and solvent.The electronic cigarette that tobacco juice for electronic smoke provided by the present invention is prepared from can either meet electronic cigarette mouthfeel, can improve again human immunity integration capability, thus reduce harm of smoking, progressively reach the purpose of smoking cessation.
Description
Technical field
The invention belongs to electronic cigarette technical field, particularly to a kind of tobacco juice for electronic smoke and the electronic cigarette that comprises this tobacco juice.
Background technology
Nicotiana tabacum L. is from the 16 incoming China of middle of century, away from the history of existing more than 400 year of the present.At present, China there are about 300,000,000 adults
It is smoker, is affected by second hand smoking more than 700,000,000 people.It is known that Smoking is harmful to your health, multiple disease can be induced, such as: pulmonary carcinoma,
Bronchitis, myocardial infarction, digestive system injury, nerve injury etc.；And light tar, the Asia contained in the smog that medicated cigarette produces
Nitramine, carbon monoxide, radioactive substance etc., more produce greatly infringement to smoker itself and people about.
Along with the development of whole world Tobacco Control campaign, the appearance of " Chinese tobacco controlling planning (2012-2015 ", State Council
The promulgation etc. of public place ban on opium-smoking and the opium trade, smoking is in waning favor with the people.But, due to the long-term smoking formed culture, smoking society
The reason such as sexual function, smoking addiction, the road of ban on opium-smoking and the opium trade must be very long.Based on this type of reason, the product of various simulation Medicated cigarette goes out in succession
Existing, wherein the most prevailing with electronic cigarette (electrospray cigarette).
Electronic cigarette includes tobacco rod, nebulizer, battery component, and its principle is to be atomized by tobacco juice by heating, is directly entered suction
Cigarette person's respiratory tract；Do not burn, do not produce flue dust, be formed without second hand smoking.The taste of electronic cigarette, it is critical only that the composition of tobacco juice；For
Simulating the fragrance of common cigarette, taste as much as possible, having in the tobacco juice for electronic smoke sold in the market, it is certain to add
The nicotine of amount；And nicotine hazard central nervous system, peripheral nervous system, adrenal gland medullary substance etc..In prior art, by
Tobacco juice for electronic smoke adds several kinds of Chinese medicinal materials, such as: Radix Ginseng, the Radix Astragali, Fructus Schisandrae Chinensis, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Cornu Cervi Pantotrichum, Fructus Citri tangerinae
Stalk, Radix Notoginseng, Flos Daturae, Fructus Forsythiae, Radix Asparagi, Radix Bupleuri etc., attempt to improve this shortcoming, but, the practical function of these electronic cigarettes
Average, do not cause concern.So, in addition it is also necessary to provide new tobacco juice for electronic smoke, to realize in the situation meeting electronic cigarette mouthfeel
Under, improve the safety in utilization of electronic cigarette.
Summary of the invention
It is an object of the invention to provide a kind of tobacco juice for electronic smoke and the electronic cigarette comprising this tobacco juice.The electricity that the present invention provides
The electronic cigarette that sub-cigarette tobacco juice is prepared from can meet electronic cigarette mouthfeel, can improve again human body comprehensive immunocompetence, thus drop
Low harm of smoking, progressively reaches the purpose of smoking cessation, the physique that also several hundred million smokers are healthy.
In order to realize the goal of the invention of the present invention, the present invention adopts the following technical scheme that:
The invention provides a kind of tobacco juice for electronic smoke, it includes saponins compound, tobacco spice and solvent.
Preferably, the saponins compound in the tobacco juice for electronic smoke that the present invention provides is ginsenoside Ra1, ginsenoside
Ra2, ginsenoside Ra3, ginsenoside Rb1, ginsenoside Rb2, Ginsenoside Rc, ginsenoside Rd, ginsenoside Re, Radix Ginseng
Saponin Rf, ginsenoside Rg1, ginsenoside Rg2, ginsenoside Rg3, ginsenoside Rh1, ginsenoside Rh2, ginsenoside Rs1、
Ginsenoside Rs2, ginsenoside Rs3, ginseng saponin F1, ginseng saponin F2, ginseng saponin F3, ginseng saponin F5, ginsenoside R0、
Ginseng saponin IH 901, ginsenoside RAO or pseudo-ginsenoside F11In one or both things mixed above.
In some embodiments of the invention, in the tobacco juice for electronic smoke that the present invention provides, saponins compound is by Radix Panacis Quinquefolii
Extract provides.
In some embodiments of the invention, in the tobacco juice for electronic smoke that the present invention provides, it is used for preparing Radix Panacis Quinquefolii extract
Raw material be one or more in Radix Panacis Quinquefolii stem, leaf, root, rhizome, flower, fruit or Radix Panacis Quinquefolii fermented material.The present invention's
In other embodiment, in the tobacco juice for electronic smoke that the present invention provides, it is Radix Panacis Quinquefolii for preparing the raw material of Radix Panacis Quinquefolii extract
One or more in stem, leaf, root, rhizome, flower or fruit.In the other embodiment of the present invention, it is used for preparing star-spangled banner
The raw material of conopsea extraction is specially one or more in Radix Panacis Quinquefolii stem, leaf, root or rhizome.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
Preparation Method includes:
Take Radix Panacis Quinquefolii to mix with ethanol water, heated, soak, filter after, collect filtrate, concentrated, be dried, i.e.
?.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, Radix Panacis Quinquefolii is 1:(4～6 with the volume ratio of ethanol water).In some embodiments of the invention, Radix Panacis Quinquefolii and ethanol
The volume ratio of water is 1:5.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, with volume percentage, in ethanol water, the content of ethanol is 50%～80%.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, the temperature of heating is 65 DEG C～75 DEG C.In the other embodiment of the present invention, the temperature of heating is 70 DEG C.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, the time of heating is 4h～10h.In the other embodiment of the present invention, the time of heating is 6h.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
Preparation Method includes:
Take Radix Panacis Quinquefolii to mix with water, heated, after filtration, collect filtrate, cross macroporous resin, with volumn concentration be
The ethanol water eluting of 75%～80%, collects elution fraction, concentrated, dry, to obtain final product.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, when Radix Panacis Quinquefolii mixes with water, it is also possible to add ammonium sulfate, add ammonium sulfate and be conducive to improving Radix Panacis Quinquefolii extract
The yield of middle saponins compound.In the other embodiment of the present invention, in the other embodiment that the present invention provides,
With quality volume percentage, ammonium sulfate is 3% with the content of ammonium sulfate in the ammonium sulfate solution of water composition.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, Radix Panacis Quinquefolii is 1:(3～6 with the volume ratio of water).In some embodiments of the invention, Radix Panacis Quinquefolii and the volume of water
Ratio is 1:5.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, the relative density being concentrated into gained extractum is 1.15 (50 DEG C of heat are surveyed).
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, it is dried as being spray-dried.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
In Preparation Method, after collecting filtrate, before mistake resin column, the pH value of regulation filtrate is to 10～12.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the system of Radix Panacis Quinquefolii extract
Preparation Method, for being obtained by Radix Panacis Quinquefolii fermentation, method particularly includes:
Take Radix Panacis Quinquefolii raw material, culture medium, after mixing, inoculated aspergillus niger, fermented after, reclaim fermentation liquid, extract and/or pure
Change, to obtain final product.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, Radix Panacis Quinquefolii extract is by spending
When flag ginseng fermentation obtains, Radix Panacis Quinquefolii raw material used is Radix Panacis Quinquefolii stem, leaf, root, rhizome, flower, fruit, or from any portion of Radix Panacis Quinquefolii
One in the saponins compound that position is extracted or both things mixed above.This saponins compound can be total saponins, monomer
The combination in any of saponin or arbitrarily saponin.
The preparation that Radix Panacis Quinquefolii extract included in the tobacco juice for electronic smoke that the present invention provides can provide according to the present invention
Method prepares, but is not limited to the preparation method that the present invention provides.
Preferably, the tobacco juice for electronic smoke that the present invention provides, wherein the content of saponins compound is 0.734g/L～660g/
L。
Preferably, in the tobacco juice for electronic smoke that the present invention provides, tobacco spice is tobacco extract and/or synthetic perfume.?
In some embodiments of the present invention, tobacco spice is tobacco extract.Tobacco spice in the other embodiment of the present invention
For synthetic perfume.
Tobacco spice in the present invention is the material that can produce tobacco flavor, it include tobacco extract or other can
To produce the material of tobacco flavor.In the present invention, other materials that can produce tobacco flavor are referred to as synthetic perfume, its bag
Include single spice or the combination of more kinds of spice.
In the tobacco juice for electronic smoke that the present invention provides, the raw material preparing tobacco extract is Solanaceae (Solanaceae) Nicotiana
(Nicotiana L.) plant.The raw material preparing tobacco extract in some embodiments of the invention is Solanaceae Nicotiana plant
Leaf.
In some embodiments of the invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation method of tobacco extract
Including:
Take Solanaceae Nicotiana plant, after drying, mix with water, soaking, extract, after filtration, collect filtrate, to obtain final product.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation of tobacco extract
In method, the temperature being dried is 30 DEG C～50 DEG C.In some embodiments of the invention, the temperature being dried is 40 DEG C.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation of tobacco extract
In method, dried Solanaceae Nicotiana plant is 1:(4～6 with the volume ratio of water).In some embodiments of the invention, dry
Solanaceae Nicotiana plant after dry is 1:5 with the volume ratio of water.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation of tobacco extract
In method, the temperature of immersion is 15 DEG C～30 DEG C.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation of tobacco extract
In method, the time of immersion is 40h～55h.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the preparation of tobacco extract
In method, it is extracted as extraction or ultrasonic extraction.
Tobacco extract in the tobacco juice for electronic smoke that the present invention provides can be prepared according to the preparation method that the present invention provides
Obtain, but be not limited to the preparation method that the present invention provides.
In the other embodiment of the present invention, the present invention provide tobacco juice for electronic smoke in, synthetic perfume by coumarin,
Rutin, Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, Salanesol form.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, coumarin in synthetic perfume,
Rutin, Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, the mass ratio of Salanesol are (1～10):
(1～10): (0.1～1): (1～3): (1～3): (1～3): (1～5): (1～5): (1～5).
Preferably, the solvent in the tobacco juice for electronic smoke that the present invention provides is organic solvent.It is further preferable that the present invention provides
Tobacco juice for electronic smoke in solvent be the one in sorbitol, glycerol, propylene glycol, water or both things mixed above.At this
In some bright embodiments, in the tobacco juice for electronic smoke that the present invention provides, solvent is glycerol and/or propylene glycol.
Preferably, the present invention provide tobacco juice for electronic smoke, including 0.0734～66 weight portions described saponins compound,
The described tobacco spice of 1～70 weight portions, 26.7～96.5 described solvents of weight portion.
In some embodiments of the invention, in the tobacco juice for electronic smoke that the present invention provides, the content of saponins compound is
0.0734 weight portion, 0.387 weight portion, 0.505 weight portion, 0.765 weight portion, 0.81 weight portion, 1 weight portion, 4.03 weight
Part, 4.57 weight portions, 18.27 weight portions, 66 weight portions.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the content of tobacco spice is 1
Weight portion, 5 weight portions, 20 weight portions, 25 weight portions, 30 weight portions, 70 weight portions.
In the other embodiment of the present invention, in the tobacco juice for electronic smoke that the present invention provides, the content of solvent is 26.7
Weight portion, 66.7 weight portions, 71.7 weight portions, 76.5 weight portions, 96.5 weight portions.
Present invention also offers a kind of electronic cigarette, it includes with lower member: tobacco rod, nebulizer, battery component；Electronic cigarette
Liquid is positioned among nebulizer；
This tobacco juice for electronic smoke includes saponins compound, tobacco spice and solvent.
In the present invention, after the tobacco juice for electronic smoke utilizing the present invention to provide and tobacco rod, nebulizer, battery are integrated, i.e. obtain
Obtain electronic cigarette, we term it " water medicated cigarette ".Correspondingly, this tobacco juice for electronic smoke is also referred to as " water medicated cigarette " cigarette in this application
Liquid.
The invention provides a kind of tobacco juice for electronic smoke and the electronic cigarette comprising this tobacco juice.The tobacco juice for electronic smoke that the present invention provides
Including saponins compound, tobacco spice and solvent.Experimental result confirms, the tobacco juice for electronic smoke that the present invention provides is prepared from
The atomizing effect of electronic cigarette is good, pure in mouth feel, little to throat irritation；And the electronic cigarette using this tobacco juice for electronic smoke to be prepared from can
With useful lung yin, clear asthenic fire, lowering blood pressure and blood fat, raising oxidation resistance, allaying tiredness, with all worries set aside with fixed attention, memory reinforcing,
Human immunity integration capability can be improved, thus reduce harm of smoking, progressively reach the purpose of smoking cessation.
Accompanying drawing explanation
Fig. 1 shows the qualitative detection result of the Radix Panacis Quinquefolii extract that each embodiment prepares, wherein Rb1Represent Radix Ginseng soap
Glycosides Rb1Standard substance, Rc represents Ginsenoside Rc's standard substance, and Re represents ginsenoside Re's standard substance, Rd represents ginsenoside Rd's mark
Quasi-product, Rg1Represent ginsenoside Rg1Standard substance, Rh1Represent ginsenoside Rh1Standard substance, Rg3Represent ginsenoside Rg3Standard
Product, Rh2Represent ginsenoside Rh2Standard substance；Wherein 1 represent Radix Panacis Quinquefolii extract that embodiment 1 prepares, 2 represent embodiment
Radix Panacis Quinquefolii extract that 2 prepare, 3 represent Radix Panacis Quinquefolii extract that embodiment 3 prepares, 4 represent embodiment 4 preparation and obtain
Radix Panacis Quinquefolii extract, 5 represent the Radix Panacis Quinquefolii extract that embodiment 5 prepares, 7 represent the flower that embodiment 7 prepares
Flag conopsea extraction, 8 represent the Radix Panacis Quinquefolii extract that embodiment 8 prepares.
Detailed description of the invention
The invention discloses a kind of tobacco juice for electronic smoke and the electronic cigarette comprising this tobacco juice.Those skilled in the art are referred to
Present disclosure, it is thus achieved that this tobacco juice for electronic smoke, it is accordingly required in particular to it is noted that all similar replacements and change are to people in the art
Being apparent from for Yuan, they are considered as being included in the present invention.The preparation method and application of the present invention has been passed through
Preferred embodiment is described, and related personnel substantially can be to making herein in without departing from present invention, spirit and scope
Preparation Method and application are modified or suitably change and combine, and realize and apply the technology of the present invention.
A kind of tobacco juice for electronic smoke that the present invention provides and in comprising the electronic cigarette of this tobacco juice used reagent and raw material equal
Can be buied by market.
In order to make those skilled in the art better understood when technical scheme, below in conjunction with enforcement
Example, is expanded on further the present invention:
The preparation of embodiment 1 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: Radix Panacis Quinquefolii root is cut into the segment of 0.5～1.0cm, with the body of 5 times of volumes
Long-pending percentage composition is the ethanol mixing of 75%, is incubated 6 hours afterwards, is stirred continuously during insulation under the conditions of 70 DEG C；Stand, take
Supernatant；Gained precipitation mixes with the ethanol that volumn concentration is 75% of 5 times of volumes, extracts afterwards, so repeats 3
Secondary.Merge supernatant, concentrating under reduced pressure, hot blast drying, obtain Radix Panacis Quinquefolii extract.
(2) qualitative detection (qualitative checking method) of saponins compound in Radix Panacis Quinquefolii extract:
Use thin layer chromatography.Take ginsenoside Rb1、Rc、Rd、Re、Rg1、Rg3、Rh1、Rh2Each 10mg, is dissolved in 2mL respectively
Methanol, makes standard substance liquid.Draw standard substance liquid and Radix Panacis Quinquefolii extract liquid respectively with micro-sampling device, put in thin layer chromatography
On plate, dry up with air duct, be subsequently placed in the layer filling developing solvent [V (chloroform): V (methanol): V (water)=65:35:10 (lower floor)]
Analysis cylinder launches, launches about to take out when top edge 2～3mm, volatilize solvent, spray 10%H2SO4After-ethanol solution, at 105 DEG C
Observe after heating 3min colour developing.Testing result is shown in Fig. 1, wherein Rb1Represent ginsenoside Rb1Standard substance, Rc represents Ginsenoside Rc
Standard substance, Re represents ginsenoside Re's standard substance, Rd represents ginsenoside Rd's standard substance, Rg1Represent ginsenoside Rg1Standard substance,
Rh1Represent ginsenoside Rh1Standard substance, Rg3Represent ginsenoside Rg3Standard substance, Rh2Represent ginsenoside Rh2Standard substance；Wherein
1 represent Radix Panacis Quinquefolii extract that embodiment 1 prepares, 2 represent Radix Panacis Quinquefolii extract that embodiment 2 prepares, 3 represent real
Execute Radix Panacis Quinquefolii extract that example 3 prepares, 4 represent Radix Panacis Quinquefolii extract that embodiment 4 prepares, 5 represent embodiment 5 and make
The standby Radix Panacis Quinquefolii extract obtained, 7 represent the Radix Panacis Quinquefolii extract that embodiment 7 prepares, and 8 represent embodiment 8 prepares
Radix Panacis Quinquefolii extract.
Comparison according to sample spot with standard substance position understands (see Fig. 1), saponins compound in this Radix Panacis Quinquefolii extract
Predominantly ginsenoside Rb1、Rc、Re、Rd、Rg1、Rh1。
(3) mensuration (quantitative detecting method) of the mass percent of saponins compound in Radix Panacis Quinquefolii extract:
A. the drafting of standard curve: precision weighing ginsenoside Re's reference substance 16.3 mg, is placed in 10 mL volumetric flasks, adds
Enter methanol to scale, shake up, to obtain final product.Respectively precision measure ginsenoside Re's standard solution 10,20,40,60,80,100 μ L in
In tool plug test tube, by methanol constant volume to 1 mL, it is made into control series solution.The most accurately add the vanillin second of 0.5 mL 8%
Alcoholic solution (now joining with dehydrated alcohol), the sulfuric acid solution of 5 mL 77%, mix homogeneously, it is placed in constant temperature 10 min in 60 DEG C of water-baths,
Taking out immediately after, put into ice-water bath 15 min, take out and place to room temperature, chromophoric solution measures absorbance at 544 nm, with
Saponins compound concentration (C) is made regression treatment by absorbance (A), obtains regression equation: C=0.2305A-0.0045, r=
0.999.Result shows, ginsenoside Re is good linear relationship at 16.3～163 μ g range internal absorbances and concentration.
B. take Radix Panacis Quinquefolii extract 0.5g, be dissolved in 5mL volumetric flask, take 20 μ L solution totally 3 parts, be respectively placed in 3 10mL
In ground test tube with ground stopper, chromogenic assay absorbance as stated above, regression equation calculation obtain, soap in this Radix Panacis Quinquefolii extract
The average percentage by mass of glycosides compound is 7.34%.
(4) preparation of leaf tobacco extract: dried at 40 DEG C by Nicotiana tabacum L., be cooled to room temperature, pulverizes, with going of 5 times of volumes
Ionized water mixes, and 15 DEG C of immersions are irregularly stirred, sucking filtration after 48 hours, are evaporated to, about 1/2 volume, obtain Nicotiana tabacum L. and carry
Take thing.
(5) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 1 part (be equivalent to saponins compound 0.0734 part,
Every part of 1g meter), gained leaf tobacco extract 20 parts, glycerol 11.5 parts, propylene glycol 65 parts, mix homogeneously, fully dissolve, obtain electric
Sub-cigarette tobacco juice 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 0.734 g/L.Referred to as " water is fragrant for the present invention
Cigarette " tobacco juice.
The preparation of embodiment 2 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: Radix Panacis Quinquefolii root is cut into the segment of 0.5～1.0cm, with the body of 4 times of volumes
Long-pending percentage composition is the ethanol mixing of 80%, is incubated 4 hours afterwards, is stirred continuously during insulation under the conditions of 65 DEG C；Stand, take
Supernatant；Gained precipitation mixes with the ethanol that volumn concentration is 80% of 4 times of volumes, extracts afterwards, so repeats 3
Secondary.Merge supernatant, concentrating under reduced pressure, hot blast drying, obtain Radix Panacis Quinquefolii extract.According to embodiment 1 provide qualitative and quantitative
Detection method carries out qualitative and quantitative determination, obtains: in this Radix Panacis Quinquefolii extract, the mass percent of saponins compound is
7.65%, it is mainly composed of ginsenoside Rb1、Rc、Re、Rd、Rg1(see Fig. 1).
(2) preparation of synthetic perfume: be 6:2:1:1:1:3:5:1:1 according to mass ratio；Take respectively coumarin, rutin,
Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, Salanesol, mix homogeneously, to obtain final product.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 10 parts (be equivalent to saponins compound 0.765 part,
Every part of 1g meter), gained synthetic perfume 20 parts, deionized water 5 parts, glycerol 11.5 parts, propylene glycol 80 parts, mix homogeneously, fully
Dissolving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 7.65g/L.The present invention claims
Be " water medicated cigarette " tobacco juice.
The preparation of embodiment 3 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: Radix Panacis Quinquefolii root is cut into the segment of 0.5～1.0cm, with the body of 6 times of volumes
Long-pending percentage composition is the ethanol mixing of 50%, is incubated 10 hours afterwards, is stirred continuously during insulation under the conditions of 75 DEG C；Stand,
Take supernatant；Gained precipitation mixes with the ethanol that volumn concentration is 50% of 6 times of volumes, extracts afterwards, so repeats 3
Secondary.Merge supernatant, concentrating under reduced pressure, hot blast drying, obtain Radix Panacis Quinquefolii extract.According to embodiment 1 provide qualitative and quantitative
Detection method carries out qualitative and quantitative determination, obtains: in this Radix Panacis Quinquefolii extract, the mass percent of saponins compound is
7.73%, it is mainly composed of ginsenoside Rb1、Rc、Re、Rd、Rg1、Rh1(see Fig. 1).
(2) source of leaf tobacco extract: Shenzhen's Perry irrigates bio tech ltd.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 5 parts (be equivalent to saponins compound 0.387 part,
Every part of 1g), gained tobacco extract 30 parts, deionized water 5 parts, sorbitol 6.7 parts, propylene glycol 55 parts, mix homogeneously, the most molten
Solving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 3.87g/L.The present invention is referred to as
For " water medicated cigarette " tobacco juice.
The preparation of embodiment 4 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: take Radix Panacis Quinquefolii stem and leaf, adds the distilled water of 5 times of volumes, decocts 3 times, each 3,3,
2 hours, filtering by several times, merging filtrate, stand 24 hours, take supernatant, hydro-oxidation sodium regulation pH value is to 10, by macropore tree
Fat post adsorbs, and washes post with water to after neutrality, use 75% ethanol elution, eluent recovery ethanol, be concentrated into relative density 1.15 (50
DEG C heat survey) extractum, be spray-dried, obtain Radix Panacis Quinquefolii extract.Qualitative and the quantitative detecting method provided according to embodiment 1 enters
Row is qualitative and quantitative determines, and obtains: in this Radix Panacis Quinquefolii extract, the mass percent of saponins compound is 81.02%, mainly
Composition is ginsenoside Rb1、Rc、Re、Rd、Rg1、Rh1(see Fig. 1).
(2) preparation of leaf tobacco extract: dried at 30 DEG C by Nicotiana tabacum L., be cooled to room temperature, pulverizes, with going of 6 times of volumes
Ionized water mixes, and 30 DEG C of immersions are irregularly stirred, sucking filtration after 40 hours, are evaporated to 1/2 volume, obtain leaf tobacco extract.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 1 part and (be equivalent to saponins compound 0.81 part, often
Part 1g), gained leaf tobacco extract 25 parts, deionized water 5 parts, propylene glycol 60 parts, sorbitol 6.7 parts, mix homogeneously, the most molten
Solving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 8.1g/L.The present invention is referred to as
For " water medicated cigarette " tobacco juice.
The preparation of embodiment 5 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: take Radix Panacis Quinquefolii stem and leaf, adds 3% (W/V) ammonium sulfate of 3 times of volumes, decocts
3 times, each 3,3,2 hours, filtering by several times, merging filtrate, stand 24 hours, take supernatant, hydro-oxidation sodium regulation pH value is extremely
12, adsorbed by macroporous resin column, wash post with water to after neutrality, use 80% ethanol elution, eluent reclaims ethanol, is concentrated into phase
Extractum to density 1.15 (50 DEG C of heat are surveyed), is spray-dried, obtains Radix Panacis Quinquefolii extract.According to embodiment 1 provide qualitative and
Quantitative detecting method carries out qualitative and quantitative determination and obtains: in this Radix Panacis Quinquefolii extract, the mass percent of saponins compound is
91.33%, it is mainly composed of ginsenoside Rb1、Rc、Re、Rd、Rg1、Rh1(see Fig. 1).
(2) preparation of synthetic perfume: be 1:10:0.5:3:3:1:1:2:5 according to mass ratio；Take coumarin, Folium Symplocoris Caudatae respectively
Glycosides, Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, Salanesol, mix homogeneously, to obtain final product.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 5 parts (be equivalent to the saponins compound of 4.57 parts,
Every part of 1g), gained synthetic perfume 5 parts, deionized water 15 parts, propylene glycol 70 parts, glycerol 11.5 parts, mix homogeneously, the most molten
Solving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 45.7g/L.The present invention is referred to as
For " water medicated cigarette " tobacco juice.
The preparation of embodiment 6 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: the preparation method that embodiment 5 provides prepares, gained Radix Panacis Quinquefolii extract
The mass percent of middle saponins compound is 91.33%, is mainly composed of ginsenoside Rb1、Rc、Re、Rd、Rg1、Rh1(see
Fig. 1).
(2) preparation of leaf tobacco extract: dried at 50 DEG C by Nicotiana tabacum L., be cooled to room temperature, pulverizes, with going of 4 times of volumes
Ionized water mixes, and 25 DEG C of immersions are irregularly stirred, sucking filtration after 55 hours, are evaporated to 1/2 volume, obtain leaf tobacco extract.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 20 parts and (be equivalent to the saponins chemical combination of 18.27 parts
Thing, every part of 1g), gained leaf tobacco extract 20 parts, propylene glycol 65 parts, glycerol 11.5 parts, mix homogeneously, fully dissolve, to obtain final product
Tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 182.7g/L.The present invention is referred to as " water
Medicated cigarette " tobacco juice.
The preparation of embodiment 7 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: take Radix Panacis Quinquefolii stem and leaf, adds the distilled water of 6 times of volumes, decocts 3 times, each 3,3,
2 hours, filtering by several times, merging filtrate, stand 24 hours, take supernatant, hydro-oxidation sodium regulation pH value is to 11, by macropore tree
Fat post adsorbs, and washes post with water to after neutrality, use 78% ethanol elution, eluent recovery ethanol, be concentrated into relative density 1.15 (50
DEG C heat survey) extractum, be spray-dried, obtain Radix Panacis Quinquefolii extract.Qualitative and the quantitative detecting method provided according to embodiment 1 is surveyed
Determine to obtain: in this Radix Panacis Quinquefolii extract, the mass percent of saponins compound is 80.56%, is mainly composed of ginsenoside
Rb1、Rc、Re、Rd、Rg1、Rh1(see Fig. 1).
(2) source of tobacco extract: Guangdong Hua Bang spice Science and Technology Ltd..
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 5 parts (be equivalent to the saponins compound of 4.03 parts,
Every part of 1g), gained tobacco extract 70 parts, deionized water 5 parts, propylene glycol 15 parts, sorbitol 6.7 parts, mix homogeneously, the most molten
Solving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 40.03g/L.The present invention claims
Be " water medicated cigarette " tobacco juice.
The preparation of embodiment 8 tobacco juice for electronic smoke
(1) preparation of Radix Panacis Quinquefolii extract: take Radix Panacis Quinquefolii root 10g and be loaded in 250mL conical flask, adds 20mL deionization
Water, sealing, 121 DEG C of high pressure steam sterilization 30min.After cooling after superclean bench medium ultraviolet sterilizing 30min, inoculated aspergillus niger
(Aspergillus nige, derive from Yiyuan Kangyuan Bio-Technology Co., Ltd.) 5mL, 37 DEG C of constant temperature culture 7d.By cultivation well
Fermentation liquid in 121 DEG C of high pressure steam sterilization 30min, add the water-saturated n-butanol of equal volume, ultrasonic extraction 30min, mistake
Filter, centrifugal (5000r/min, 10min), take supernatant.By supernatant concentrating under reduced pressure, hot blast drying, obtain Radix Panacis Quinquefolii extract.Press
The qualitative detection provided according to embodiment 1 and quantitative detecting method carry out qualitative and quantitative determination and obtain: in this Radix Panacis Quinquefolii extract
The mass percent of saponins compound is 10.09%, is mainly composed of ginsenoside Rb1、Rc、Re、Rd、Rg1、Rg3、Rh1、
Rh2(see Fig. 1).
(2) preparation of synthetic perfume: be 10:1:0.1:1:1:1:5:5:5 according to mass ratio；Take coumarin, Folium Symplocoris Caudatae respectively
Glycosides, Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, Salanesol, mix homogeneously, to obtain final product.
(3) preparation of tobacco juice for electronic smoke: take gained Radix Panacis Quinquefolii extract 5 parts (be equivalent to saponins compound 0.505 part,
Every part of 1g), gained synthetic perfume 5 parts, deionized water 15 parts, propylene glycol 70 parts, glycerol 11.5 parts, mix homogeneously, the most molten
Solving, obtain tobacco juice for electronic smoke 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 5.05 g/L.The present invention claims
Be " water medicated cigarette " tobacco juice.
The preparation of embodiment 9 tobacco juice for electronic smoke
(1) preparation of saponins compound: be 1:1:1 according to mass ratio, takes ginsenoside Rb respectively1, Ginsenoside Rc,
Ginsenoside Rd (derives from Chengdu Han He biochemical product company limited), and mix homogeneously to obtain final product.
(2) preparation of synthetic perfume: be 1:5:0.5:2:2:2:4:4:4 according to mass ratio；Take coumarin, Folium Symplocoris Caudatae respectively
Glycosides, Quercetin, chlorogenic acid, isovaleric acid, Beta-methyl valeric acid, geranial, catechol, Salanesol, mix homogeneously, to obtain final product.
(3) preparation of tobacco juice for electronic smoke: take gained saponins compound 66 parts, gained synthetic perfume 1 part, deionized water 15
Part, propylene glycol 70 parts, sorbitol 11.5 parts, mix homogeneously, fully dissolve, and obtains tobacco juice for electronic smoke 100mL, gained electronic cigarette
In liquid, the content of saponins compound is 660g/L.The present invention is referred to as " water medicated cigarette " tobacco juice.
The preparation of embodiment 10 tobacco juice for electronic smoke
(1) preparation of tobacco extract: dried at 40 DEG C by Nicotiana tabacum L., be cooled to room temperature, pulverizes, with going of 4 times of volumes
Ionized water mixes, and 30 DEG C of immersions are irregularly stirred, sucking filtration after 40 hours, are evaporated to 1/2 volume, obtain leaf tobacco extract.
(2) preparation of tobacco juice for electronic smoke: take ginsenoside Re's (deriving from Chengdu Han He biochemical product company limited) 1 part
(every part of 1g), gained leaf tobacco extract 25 parts, propylene glycol 65 parts, sorbitol 6.7 parts, mix homogeneously, fully dissolve, and obtains electronics
Cigarette tobacco juice 100mL, in gained tobacco juice for electronic smoke, the content of saponins compound is 10g/L.The present invention is referred to as " water medicated cigarette " cigarette
Liquid.
The quality evaluation of embodiment 11 tobacco juice for electronic smoke
The acquisition of matched group tobacco juice for electronic smoke:
(1) preparation of leaf tobacco extract: dried at 40 DEG C by Nicotiana tabacum L., be cooled to room temperature, pulverizes, with going of 5 times of volumes
Ionized water mixes, and 15 DEG C of immersions are irregularly stirred, sucking filtration after 48 hours, are evaporated to 1/2 volume, obtain leaf tobacco extract.
(2) preparation of tobacco juice for electronic smoke: take gained leaf tobacco extract 20 parts, glycerol 11.5 parts, propylene glycol 65 parts, mixing
Uniformly, fully dissolve, to obtain final product.
The tobacco juice for electronic smoke that Example 1 to embodiment 10, the tobacco juice for electronic smoke prepared, matched group provide respectively.
Sensory quality assessment is tested:
The electronic cigarette that the tobacco juice for electronic smoke prepared by the embodiment of the present invention 1 to embodiment 10 is made as experimental group,
The electronic cigarette made with the tobacco juice for electronic smoke without Radix Panacis Quinquefolii extract is as a control group.Gained electronic cigarette sample is by domestic tool
There are smoke panel test 20 professional and technical personnel of credentials of national or provincial Sensory Quality of Cigarette to smoke panel test, and then carry out sense organ matter
Amount Evaluation, sensory quality assessment standard is shown in Table 1.Result of the test of smokeing panel test is shown in Table 2.
Table 1 electronic cigarette sensory quality assessment standard
Table 2 is smoked panel test result of the test
| Project | Fragrance | Harmony | Zest | Pleasant impression | Amount of smoke | Add up to |
| Matched group | 24.46 | 4.75 | 16.10 | 21.15 | 8 | 74.46 |
| Embodiment 1 | 31.56 | 5.35 | 19.90 | 24.15 | 8.35 | 89.31 |
| Embodiment 2 | 30.15 | 4.85 | 19.60 | 23.05 | 8.30 | 85.95 |
| Embodiment 3 | 31.30 | 5.15 | 19.00 | 24.15 | 8 | 87.60 |
| Embodiment 4 | 30.85 | 5.20 | 18.75 | 23.55 | 8 | 86.35 |
| Embodiment 5 | 30.55 | 5.45 | 19.00 | 23.70 | 8 | 86.70 |
| Embodiment 6 | 31.20 | 5.15 | 18.60 | 24.00 | 8 | 86.95 |
| Embodiment 7 | 31.60 | 5.25 | 18.55 | 23.90 | 8 | 87.30 |
| Embodiment 8 | 30.15 | 5.55 | 18.95 | 23.45 | 8 | 86.10 |
| Embodiment 9 | 29.75 | 4.75 | 18.95 | 23.40 | 8.20 | 85.05 |
| Embodiment 10 | 30.25 | 5.65 | 18.25 | 24.00 | 8 | 86.15 |
According to experimental result, comparing matched group, the electronic cigarette product of experimental group is (i.e. by the embodiment of the present invention 1 to reality
Execute the electronic cigarette that the tobacco juice for electronic smoke that example 10 prepares is made) fragrance, pleasant impression be further improved, and zest
It is substantially reduced, significant difference (P ＜ 0.05), hence it is evident that improve the electronic cigarette zest to throat.Compare amount of smoke, matched group with
Experimental group experimental result is suitable, illustrates that adding Radix Panacis Quinquefolii extract in tobacco juice for electronic smoke does not affect atomizing effect.
In sum, the present invention provide tobacco juice for electronic smoke atomizing effect is good, pure in mouth feel, significantly reduce throat
Zest.
The tobacco juice for electronic smoke impact on human normal function:
Take the electronic cigarette that the tobacco juice for electronic smoke prepared by the embodiment of the present invention 1 is made, investigate it to human normal machine
The impact of energy.
In northeast, the whole nation, North China, southwest choose suction Medicated cigarette more than 3 years, and nearest 3 monthly average inhale every day 0.5～
Smoker 150 people of 2 winding cigarettes, it is provided that the electronic cigarette that the tobacco juice for electronic smoke that the preparation method that embodiment 1 provides prepares is made.
Using method is identical: experimenter 1.5mL every day, uses 3 months continuously.Respectively use the present invention provide electronic cigarette before and
Use detection experimenter after 3 months to cardiovascular system, blood system, index that oxidation resistance is relevant: blood pressure, total gallbladder
Sterin, triglyceride, low density lipoprotein, LDL, high density lipoprotein, malonaldehyde, superoxide dismutase, glutathion peroxidating
Thing enzyme, lipid peroxide.Detect macrophage quantity and function simultaneously, carry out vitro lymphocyte proliferation test to check body
Immunity.
Result shows, after using the tobacco juice for electronic smoke that the present invention provides, and the blood pressure (blood markers) of 94.67% experimenter
Be significantly improved (P ＜ 0.05)；Blood fat (T-CHOL, triglyceride, low density lipoprotein, LDL, the high density of 90.67% experimenter
Lipoprotein index) be significantly improved (P ＜ 0.05)；Oxidation resistance (malonaldehyde, superoxide dismutase in 92% subject
Enzyme, glutathion peroxidase, lipid peroxide index) be significantly increased (P ＜ 0.05).Macrophage number in subject
Amount shows with Function detection test, vitro lymphocyte proliferation result of the test, and the immunity of experimenter obtains and significantly improves (P ＜
0.05)。
The electronic cigarette that the tobacco juice for electronic smoke that Example 2 to embodiment 10 prepares is made, according to identical experiment side
Method, the tobacco juice for electronic smoke that the investigation present invention the provides impact on human normal function, it is thus achieved that similar experimental result, i.e. through making
After the tobacco juice for electronic smoke prepared by the embodiment of the present invention 2 to embodiment 10, the blood pressure of experimenter is significantly improved, blood fat obtains
To significantly improving, oxidation resistance significantly improves, and combined immune power is significantly improved.
Therefore, the electronic cigarette life-time service that the tobacco juice for electronic smoke utilizing the present invention to provide is prepared, can blood pressure lowering, fall blood
Fat, resisting fatigue, slow down aging, reach to improve effect of combined immune power.
Below it is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred implementation is not construed as
The restriction of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, it is also possible to make some improvements and modifications, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (7)
1. a tobacco juice for electronic smoke, it is characterised in that it includes saponins compound, tobacco spice and solvent；
Described tobacco spice is synthetic perfume；Described synthetic perfume by coumarin, rutin, Quercetin, chlorogenic acid, isovaleric acid,
Beta-methyl valeric acid, geranial, catechol, Salanesol form.
Tobacco juice for electronic smoke the most according to claim 1, it is characterised in that described saponins compound is ginsenoside Ra1、
Ginsenoside Ra2, ginsenoside Ra3, ginsenoside Rb1, ginsenoside Rb2, Ginsenoside Rc, ginsenoside Rd, ginsenoside
Re, ginsenoside Rf, ginsenoside Rg1, ginsenoside Rg2, ginsenoside Rg3, ginsenoside Rh1, ginsenoside Rh2, Radix Ginseng
Saponin Rs1, ginsenoside Rs2, ginsenoside Rs3, ginseng saponin F1, ginseng saponin F2, ginseng saponin F3, ginseng saponin F5, people
Ginseng saponin R0, ginseng saponin IH 901, ginsenoside RAO or pseudo-ginsenoside F11In one or both things mixed above.
Tobacco juice for electronic smoke the most according to claim 1, it is characterised in that described saponins compound is by Radix Panacis Quinquefolii extract
There is provided.
Tobacco juice for electronic smoke the most according to claim 1, it is characterised in that the content of wherein said saponins compound is
0.734g/L～660g/L.
Tobacco juice for electronic smoke the most according to claim 1, it is characterised in that described solvent be sorbitol, glycerol, the third two
One in alcohol, water or both things mixed above.
Tobacco juice for electronic smoke the most according to claim 1, it is characterised in that it includes the described soap of 0.0734～66 weight portions
Glycosides compound, 1～70 described tobacco spice, 26.7～96.5 described solvents of weight portion of weight portion.
7. an electronic cigarette, it is characterised in that it includes with lower member: tobacco rod, nebulizer, battery component；As claim 1 to
In 6, the tobacco juice for electronic smoke described in any one is positioned among described nebulizer.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410445720.9A CN104336777B (en) | 2014-09-03 | 2014-09-03 | A kind of electrospray water medicated cigarette tobacco juice that can improve body immunity and the electrospray water medicated cigarette comprising this tobacco juice |
| PCT/CN2015/088730 WO2016034100A1 (en) | 2014-09-03 | 2015-09-01 | E-liquid for water-atomizing electronic cigarette and water-atomizing electronic cigarette comprising the e-liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410445720.9A CN104336777B (en) | 2014-09-03 | 2014-09-03 | A kind of electrospray water medicated cigarette tobacco juice that can improve body immunity and the electrospray water medicated cigarette comprising this tobacco juice |
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Country Status (2)
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| WO (1) | WO2016034100A1 (en) |
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| US10980273B2 (en) | 2013-11-12 | 2021-04-20 | VMR Products, LLC | Vaporizer, charger and methods of use |
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| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
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| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
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| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| CN104336777B (en) * | 2014-09-03 | 2016-11-16 | 美国豪顿水香烟科技（香港）有限公司 | A kind of electrospray water medicated cigarette tobacco juice that can improve body immunity and the electrospray water medicated cigarette comprising this tobacco juice |
| AU2015357509B2 (en) | 2014-12-05 | 2021-05-20 | Juul Labs, Inc. | Calibrated dose control |
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| CN105268007A (en) * | 2015-10-23 | 2016-01-27 | 吕其镁 | Smoker's powder |
| CN105341995A (en) * | 2015-10-27 | 2016-02-24 | 深圳瀚星翔科技有限公司 | Electronic cigarette liquid and preparation method thereof |
| CN105394808A (en) * | 2015-12-17 | 2016-03-16 | 立场电子科技发展（上海）有限公司 | Atomization liquid for electronic cigarette |
| WO2017139595A1 (en) | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
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| KR20180000379A (en) | 2016-06-22 | 2018-01-03 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | Composition for enhancing immune response comprising ginsenoside F1 |
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| CN109619656A (en) * | 2019-01-18 | 2019-04-16 | 薪火高科(深圳)有限公司 | It is a kind of to have effects that the tobacco juice for electronic smoke of antiphlogistic antibacterial |
| WO2021102652A1 (en) * | 2019-11-25 | 2021-06-03 | 深圳雾芯科技有限公司 | E-liquid |
| CN111802687B (en) * | 2020-07-27 | 2022-04-29 | 湖北中烟工业有限责任公司 | Atomizing agent containing conjugated linoleic acid and saponin and cigarette without burning during heating |
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