CN113854623A - Herbal low-temperature atomized electronic cigarette tobacco tar free of nicotine salt - Google Patents

Herbal low-temperature atomized electronic cigarette tobacco tar free of nicotine salt Download PDF

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Publication number
CN113854623A
CN113854623A CN202111259291.2A CN202111259291A CN113854623A CN 113854623 A CN113854623 A CN 113854623A CN 202111259291 A CN202111259291 A CN 202111259291A CN 113854623 A CN113854623 A CN 113854623A
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parts
electronic cigarette
solution
taurine
trehalose
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姜标
周姗妮
周杨
郑锐龙
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Zhongke Molecular Biology Guangdong Co ltd
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Zhongke Molecular Biology Guangdong Co ltd
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/80—Testing

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a herbal low-temperature atomized electronic cigarette tobacco tar without nicotine salt, which is prepared from the following raw materials in parts by weight: 10-80 parts of glycerol (VG), 10-80 parts of Propylene Glycol (PG), 3-25 parts of ginsenoside extract Rb2, 2-5 parts of traditional Chinese medicine full-component molecular essence or natural active ingredients thereof, 1-1.5 parts of taurine, 2-10 parts of flavoring agent and 1-3 parts of trehalose. The invention has the advantages of obviously improving the anti-fatigue effect and preventing the harm caused by high-temperature atomization of the traditional electronic cigarette.

Description

Herbal low-temperature atomized electronic cigarette tobacco tar free of nicotine salt
Technical Field
The invention relates to the field of electronic cigarette oil, in particular to herbal low-temperature atomized electronic cigarette oil without nicotine salt.
Background
With the increasing pressure of modern urban life and the attention to health, more and more people choose to smoke electronic cigarettes to replace traditional cigarettes, on one hand, the pressure and fatigue of work and life can be relieved, on the other hand, the harm and addiction of the traditional cigarettes to the body are reduced, but the existing electronic cigarettes are physically atomized at the high temperature of more than 200 ℃, the tobacco tar is atomized by heating the tobacco tar and is sucked into the lung by suction, and the electronic cigarettes have certain addiction and dependence and even harm to the throat, cardiovascular and the like because the electronic cigarettes contain special tobacco essence and nicotine components. With the rise of the concept of big health and the trend of health care for consumption, higher requirements are put on the formula of the electronic cigarette oil. At present, the formula of the electronic cigarette tobacco tar has many limitations, the electronic cigarette tobacco tar mainly focuses on the simulation of various special flavors, such as fruit flavor type, special flavor type and the like, the research on the functions, stability and the like of functional natural plant extract components in an electronic cigarette atomization solvent is less, and the requirements of refreshing, restoring consciousness, relieving fatigue, pursuing taste and the like of people through an electronic cigarette are not met.
Ginsenoside Rb2(Ginsenoside Rb2) is natural effective constituent extract of Ginseng radix or radix Panacis Quinquefolii, and its molecular formula is C53H90O 22. Ginsenoside Rb2 can inhibit nicotine-stimulated catecholamine secretion, has effects of relieving anxiety and preventing retching of central nervous system, and also has remarkable antifatigue effect, such as increasing spontaneous activity of mouse after forced walking. Taurine (Taurine) is a sulfur-containing amino acid with simple structure in animal bodies, has wide biological functions of regulating nerve conduction, increasing the heart contractility, improving the organism vitality and the like, and is widely applied to medicines and food additives.
Figure 152196DEST_PATH_IMAGE002
Ginsenoside Rb2
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the herbal low-temperature atomized electronic cigarette tobacco tar without nicotine salt, and the atomization temperature is only 70 ℃ through a suction type atomizer, so that the molecular activity of a functional natural plant extract can be kept as far as possible, therefore, the atomized liquid is a natural non-toxic harmless addictive substance (hereinafter referred to as R-T) to replace nicotine, the process of stimulating the brain to generate dopamine after nicotine is inhaled is changed into the process of stimulating the brain to generate dopamine after R-T is inhaled, pituitary hormone secretion is promoted, and the effects of refreshing and relieving fatigue are achieved.
The technical purpose of the invention is realized by the following technical scheme:
a herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 10-80 parts of glycerol (VG), 10-80 parts of Propylene Glycol (PG), 3-25 parts of ginsenoside extract Rb2, 2-5 parts of traditional Chinese medicine full-component molecular essence or natural active ingredients thereof, 1-1.5 parts of taurine, 2-10 parts of flavoring agent and 1-3 parts of trehalose.
Preferably, the full-component molecular essence or natural active ingredient types of the traditional Chinese medicine comprise one or more of gastrodia elata, lucid ganoderma, honeysuckle, houttuynia cordata, mulberry leaves, polygonatum odoratum, mint, liquorice, ginseng, maca, dried orange peel, chrysanthemum, blueberries, wolfberry fruits, jasmine, green tea, red dates, ginger, black tea, hemp and kenaf.
The traditional Chinese medicine full-component molecular essence or the natural active ingredients thereof in the technical scheme is a traditional Chinese medicine full-component molecular extract or a natural active ingredient molecular extract, and is obtained by low-temperature wall-breaking extraction technology, and the effective ingredients are retained to the maximum extent by low-temperature extraction.
Preferably, the aromatizer comprises one or more of cassia oil, elderberry hydrosol and fruit flavor essence.
Preferably, the preparation method of the herbal low-temperature atomized electronic cigarette liquid without nicotine salt comprises the following steps:
(1) weighing the molecular essence or the natural active ingredients of the full components of the traditional Chinese medicine according to the parts of the formula, and uniformly mixing to prepare a matrix;
(2) dissolving taurine in a part of glycerol, adding the glycerol and stirring to obtain a taurine dissolved solution; dissolving trehalose in a part of glycerol, and stirring while adding to obtain trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding flavoring agent, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
Preferably, the mixing temperature of the raw materials in each step is 20 to 60 ℃.
In summary, compared with the prior art, the beneficial effects of the invention are as follows:
1. the application of the invention adopts ginsenoside Rb2 to act on the central nervous system to have a stabilizing effect, stimulates pituitary receptors to secrete dopamine substances without excessively secreting the dopamine substances, and obviously increases the anti-fatigue effect;
2. the taurine has the effects of remarkably strengthening nerve conduction, refreshing, restoring consciousness, supplementing physical strength and resisting fatigue;
3. the ginsenoside and the taurine, and the full-component molecular essence of the traditional Chinese medicine or natural active ingredients thereof are added into the propylene glycol and the glycerol, so that the electronic cigarette oil has sufficient smoking amount, rich and strong fragrance, moderate strength, good satisfaction and mild and comfortable mouthfeel, guarantees the addiction satisfaction similar to cigarette smoking, achieves the effects of relieving fatigue and refreshing the mind, and prevents the harm caused by high-temperature atomization of the traditional electronic cigarette;
4. the atomization temperature is only 70 ℃ through the suction type atomizer, the activity of full-component molecular essence of traditional Chinese medicines or natural active ingredients thereof can be kept as far as possible, the atomized liquid is a natural non-toxic harmless addictive substance (R-T) and replaces nicotine, so that the process of stimulating the brain to generate dopamine after the nicotine is inhaled is changed into the process of stimulating the brain to generate dopamine after the nicotine is inhaled to promote pituitary hormone secretion, and the effects of refreshing and relieving fatigue are achieved. Meanwhile, the electronic cigarette is embedded with all-component molecular essences of traditional Chinese medicines with various functions (effects) or natural active ingredients thereof, so that the electronic cigarette is a leisure hobby which is non-toxic, harmless and health-preserving, and has great significance for improving the safety, the working efficiency and the health function of consumers.
Detailed Description
Example 1
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 30 parts of glycerol (VG), 50 parts of Propylene Glycol (PG), 4 parts of ginsenoside extract Rb2, 1 part of rhizoma gastrodiae, 0.5 part of hemp, 0.5 part of kenaf, 1 part of taurine, 2 parts of cassia oil and 1 part of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing the gastrodia elata, the hemp and the ambary as matrixes according to the parts of the formula;
(2) dissolving taurine in 10 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 10 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding oleum Cinnamomi, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
The mixing temperature of each raw material in each step above was 20 ℃.
Example 2
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 65 parts of glycerol (VG), 10 parts of Propylene Glycol (PG), 12.5 parts of ginsenoside extract Rb2, 5 parts of lucid ganoderma, 1.5 parts of taurine, 5 parts of elderberry hydrosol and 1 part of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing the lucid ganoderma as a matrix according to the parts of the formula;
(2) dissolving taurine in 35 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 30 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding flavoring agent, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
The mixing temperature of each raw material in each step above was 60 ℃.
Example 3
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 30 parts of glycerol (VG), 29 parts of Propylene Glycol (PG), 25 parts of ginsenoside extract Rb2, 3 parts of coriolus versicolor, 1 part of taurine, 10 parts of fruit flavor essence and 2 parts of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing coriolus versicolor as a matrix according to the parts of the formula;
(2) dissolving taurine in 10 parts of glycerol, and stirring while adding to obtain taurine solution; dissolving trehalose in 20 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding fruit flavor essence, taurine solution, ginsenoside solution and trehalose solution into the matrix, and stirring.
The mixing temperature of each raw material in each step above was 40 ℃.
Example 4
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 61 parts of glycerol (VG), 10 parts of Propylene Glycol (PG), 15 parts of ginsenoside extract Rb2, 0.5 part of honeysuckle, 0.5 part of houttuynia cordata, 0.5 part of mulberry leaf, 0.5 part of polygonatum odoratum, 0.5 part of mint, 0.5 part of liquorice, 1.5 parts of taurine, 6.5 parts of elderberry hydrosol and 3 parts of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing honeysuckle, houttuynia cordata, mulberry leaves, polygonatum odoratum, mint and liquorice as matrixes according to the parts of the formula;
(2) dissolving taurine in 20 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 41 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding bone-knitting raspberry hydrolat, taurine solution, ginsenoside solution and trehalose solution into the matrix, and stirring.
The mixing temperature of each raw material in each step above was 30 ℃.
Example 5
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 10 parts of glycerol (VG), 76 parts of Propylene Glycol (PG), 3 parts of ginsenoside extract Rb2, 2.5 parts of ginseng, 2.5 parts of maca, 1 part of taurine, 1 part of cassia oil, 1 part of elderberry hydrosol and 3 parts of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing ginseng and maca as substrates according to the parts of the formula;
(2) dissolving taurine in 4 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 6 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding oleum Cinnamomi, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
The mixing temperature of each raw material in each step above was 50 ℃.
Example 6
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 10 parts of glycerol (VG), 80 parts of Propylene Glycol (PG), 3 parts of ginsenoside extract Rb2, 1.5 parts of ginseng, 1.5 parts of liquorice, 1 part of taurine, 2 parts of fruit flavor essence and 1 part of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing ginseng and liquorice as matrixes according to the parts of the formula;
(2) dissolving taurine in 5 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 5 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding fruit flavor essence, taurine solution, ginsenoside solution and trehalose solution into the matrix, and stirring.
The mixing temperature of each raw material in each step above was 35 ℃.
Example 7
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 80 parts of glycerol (VG), 10 parts of Propylene Glycol (PG), 3 parts of ginsenoside extract Rb2, 1 part of chrysanthemum, 1 part of blueberry, 1 part of medlar, 1 part of taurine, 2 parts of fruit flavor essence and 1 part of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing chrysanthemum, blueberry and medlar as substrates according to the parts of the formula;
(2) dissolving taurine in 40 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 40 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding fruit flavor essence, taurine solution, ginsenoside solution and trehalose solution into the matrix, and stirring.
The mixing temperature of each raw material in each step above was 45 ℃.
Example 8
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 30 parts of glycerol (VG), 40 parts of Propylene Glycol (PG), 18 parts of ginsenoside extract Rb2, 2 parts of jasmine, 2 parts of green tea, 1 part of taurine, 3 parts of elderberry hydrosol, 2 parts of fruit flavor essence and 2 parts of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing jasmine and green tea as matrix according to the parts of the formula;
(2) dissolving taurine in 10 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 20 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding fruit flavor essence, taurine solution, ginsenoside solution and trehalose solution into the matrix, and stirring.
The mixing temperature of each raw material in each step above was 55 ℃.
Example 9
A herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is prepared from the following raw materials in parts by weight: 45 parts of glycerol (VG), 18 parts of Propylene Glycol (PG), 20 parts of ginsenoside extract Rb2, 1 part of red dates, 1 part of ginger, 1 part of black tea, 1 part of taurine, 10 parts of cassia oil and 3 parts of trehalose.
The preparation method of the electronic cigarette oil of the embodiment is as follows:
(1) weighing red dates, ginger and black tea as a matrix according to the parts of the formula;
(2) dissolving taurine in 10 parts of glycerol, and stirring while adding to obtain a taurine dissolved solution; dissolving trehalose in 35 parts of glycerol, and stirring while adding the trehalose to obtain a trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding oleum Cinnamomi, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
The mixing temperature of each raw material in each step above was 55 ℃.
Example 10 sensory test
1. Subject: the E-liquid of examples 1-9 were the test sample, control 1 general E-liquid, control 2 conventional cigarette
2. The experimental contents are as follows: randomly selecting 50 volunteers of smokers, wherein the volunteers are 25-45 years old and randomly divided into 10 groups of 5 persons, each group uses the same test sample every day in a mode of twice a day, and after ten days, performing usage evaluation record on the volunteers; the sensory evaluation is 5 items, each item is divided into 20 points and 100 points, and the five items are respectively: comfortable taste, satisfaction, irritation, fragrance, and smoking amount.
TABLE 1 sensory evaluation value of E-cigarette tobacco tar
Evaluation index Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Control 1 Control 2
Has comfortable taste 19 19 18 19 19 18 18 18 18 17 17
Satisfaction feeling 18 19 19 19 18 18 18 17 18 18 19
Irritation property 18 18 19 18 18 17 17 18 18 16 15
Fragrance 19 18 19 18 18 19 17 19 17 15 15
Amount of smoke generated 18 19 18 19 19 19 18 19 18 18 19
Total score 92 93 93 93 92 91 88 91 89 84 85
As can be seen from Table 1, the effects of examples 1-5 are better than those of examples 6-9, wherein examples 2, 3, 4 and 6 are the most preferred examples, while the formulations of examples 6-7 contain higher amounts of glycerin (VG) and Propylene Glycol (PG), and are more irritating to throat than other examples, and examples 8-9 contain lower amounts of essence of Chinese medicinal molecules, and are slightly inferior to other examples in taste, aroma and satisfaction, but the combined scores of examples 1-9 are higher than those of control 1 (ordinary E-liquid cigarette) and control 2 (conventional cigarette), which indicates that the ginsenoside Rb2+ taurine extracted from ginsenoside and the essence of Chinese medicinal constituents added in the present invention are more similar to genuine cigarette in taste of E-liquid cigarette, and no nicotine component is added, thereby avoiding nicotine affecting nervous system, The respiratory system and the digestive system.
Example 11 test for nicotine addiction withdrawal
1. Laboratory animal preparation and grouping
The rat body weight of an SPF-level adult male SD (Sprague-Dawley) rat is 300-400 g, the body weight is provided by the Guangdong province medical experimental animal center, the rat is bred adaptively for 7 d, and the rat body circulates naturally day and night, lives under indirect illumination, is well ventilated, and can eat and drink freely. Before grouping the experimental animals, rats with position preference are rejected through a Conditional Place Preference (CPP) experiment. 180 rats were randomly divided into 12 groups and subjected to a plant extract addiction test and a nicotine addiction withdrawal test using the plant extracts. The specific groups are plant extract addiction experiments, a blank control group (normal saline), a nicotine addiction control group and examples 1-9 groups.
2. Blank control group
Saline was nebulized at 70 ℃ and this group of rats was subjected to smoke exposure: 3 times/d, 40 min/time, and the interval between the two times is 3 h.
3. Control group of nicotine addiction
Rats were exposed to smoke: 3 times/d, 40 min/time, two times interval 3h, lasting 20 days. The nicotine was ignited each time of smoke exposure, and placed in a box in which the rats of the experimental group were placed, the box being placed in a windless environment, with a certain air circulation being maintained. After 20 days, a withdrawal evaluation experiment and a CPP test are carried out to detect the addiction.
TABLE 2 analysis of addiction withdrawal of tobacco tar in electronic cigarettes
Recipe number Assessment of physical withdrawal response (symptom score: 4-fold) Degree; 3-moderate; 2-mild degree; 1-none) CPP (preference degree) The value: 1-10) Dopaminergic nerve endings The damage rate of the tip is% Fatigue relieving effect (symptom) And (4) score: 1-4) Analgesic Effect (symptom score) The value: 1-4)
Model group (Nicotine control group) 4 10 50 4 4
Example 1 2 3 12.5 1 1
Example 2 2 4 12.5 3 2
Example 3 2 5 12.5 3 2
Example 4 1 2 12.5 1 1
Example 5 1 2 12.5 1 1
Example 6 2 4 12.5 1 1
Example 7 2 3 12.5 1 1
Example 8 2 2 12.5 1 1
Example 9 2 2 12.5 1 1
The results in the table show that the model group (nicotine control group) has better fatigue relieving and pain easing effects than the embodiment of the invention, but has stronger body withdrawal response, high dopaminergic nerve ending damage rate and larger harm to human health. Therefore, the electronic cigarette oil disclosed by the invention is low in addiction withdrawal property and can achieve the effect of relieving fatigue, and meanwhile, the ginsenoside extract Rb2+ taurine and the whole-component molecular essence of the traditional Chinese medicine can also improve the immunity of a human body.
Example 12 fatigue relief test
Healthy ICR female mice, weighing 20 + -2 g, 100 test animals in total, were taken, and were randomly divided into 10 groups 2 days after adaptive feeding, 10 animals in each group, namely, a blank control group and 9 test animal groups (compositions 1 to 9 obtained by preparation of examples 1 to 9), and were gavaged with 15mg/kg daily, fed freely, and then, after four weeks, the test animals were subjected to the test.
2. Procedure of the test
30min after the last administration, the mice with 5% weight lead skin loaded on the tail root are placed in a swimming box for swimming, the water depth in the box is not less than 30cm, the water temperature is 25 +/-1 ℃, and the time from swimming to death of the mice is recorded.
TABLE 3 mouse swimming test results
Group of Initial body weight (g) Middle-term body weight (g) Swimming time(s)
Control group 20.2±1.03 26.2±1.65 305.5±54.2
1 20.1±1.25 27.3±1.24 413.5±65.9
2 20.2±1.16 27.5±1.26 435.5±65.9
3 20.1±1.09 27.4±1.11 425.5±68.2
4 20.2±1.13 27.1±1.42 414.6±43.9
5 20.2±1.36 27.7±1.38 421.5±46.5
6 20.1±1.29 26.8±1.22 411.7±45.2
7 20.2±1.32 27.7±1.17 423.2±53.3
8 20.1±1.30 27.7±1.25 419.8±64.1
9 20.2±1.17 27.7±1.21 424.0±61.6
The results in table 3 show that the experimental group can obviously prolong the swimming time of the mice compared with the control group, so the electronic cigarette oil of the embodiment of the invention can achieve the effect of relieving fatigue.
The above description is intended to be illustrative of the present invention and not to limit the scope of the invention, which is defined by the claims appended hereto.

Claims (5)

1. The herbal low-temperature atomization electronic cigarette tobacco tar free of nicotine salt is characterized by comprising the following raw materials in parts by weight: 10-80 parts of glycerol (VG), 10-80 parts of Propylene Glycol (PG), 3-25 parts of ginsenoside extract Rb2, 2-5 parts of traditional Chinese medicine full-component molecular essence or natural active ingredients thereof, 1-1.5 parts of taurine, 2-10 parts of flavoring agent and 1-3 parts of trehalose.
2. The herbal low-temperature atomized electronic cigarette liquid without nicotine salt according to claim 1, wherein the full-ingredient molecular essence of traditional Chinese medicine or natural active ingredient thereof comprises one or more of gastrodia elata, ganoderma lucidum, honeysuckle, houttuynia cordata, mulberry leaves, polygonatum odoratum, mint, liquorice, ginseng, maca, dried orange peel, chrysanthemum, blueberry, medlar, jasmine, green tea, red dates, ginger, black tea, hemp and kenaf.
3. The herbal low-temperature atomized electronic cigarette liquid without nicotine salt as claimed in claim 1, wherein the flavoring agent comprises one or more of cassia oil, elderberry hydrosol and fruit-flavored essence.
4. The method for preparing the herbal low-temperature atomized electronic cigarette liquid without nicotine salt according to claim 1, comprising the following steps:
(1) weighing the molecular essence or the natural active ingredients of the full components of the traditional Chinese medicine according to the parts of the formula, and uniformly mixing to prepare a matrix;
(2) dissolving taurine in a part of glycerol, adding the glycerol and stirring to obtain a taurine dissolved solution; dissolving trehalose in a part of glycerol, and stirring while adding to obtain trehalose solution; dissolving ginsenoside extract in propylene glycol under stirring, and filtering with 15 μm membrane to obtain ginsenoside solution;
(3) sequentially adding flavoring agent, taurine solution, ginsenoside solution and trehalose solution into the matrix under stirring.
5. The method for preparing the herbal low-temperature atomized electronic cigarette liquid without the nicotine salt as claimed in claim 4, wherein the mixing temperature of the raw materials in each step is 20-60 ℃.
CN202111259291.2A 2021-10-28 2021-10-28 Herbal low-temperature atomized electronic cigarette tobacco tar free of nicotine salt Pending CN113854623A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104664588A (en) * 2014-12-31 2015-06-03 广东金成生物科技工程有限公司 Nebulized liquid containing ginseng and preparing method thereof
CN105146733A (en) * 2015-08-13 2015-12-16 深圳市施美乐科技股份有限公司 Electronic cigarette atomization liquid with anti-aging function and preparation method thereof
WO2016034100A1 (en) * 2014-09-03 2016-03-10 美国豪顿水香烟科技（香港）有限公司 E-liquid for water-atomizing electronic cigarette and water-atomizing electronic cigarette comprising the e-liquid
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN106805287A (en) * 2017-03-27 2017-06-09 刘国钦 A kind of electronic cigarette tobacco tar with healthcare function
CN112971199A (en) * 2021-02-20 2021-06-18 深圳市真味生物科技有限公司 Electronic cigarette tobacco tar helpful for relieving fatigue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016034100A1 (en) * 2014-09-03 2016-03-10 美国豪顿水香烟科技（香港）有限公司 E-liquid for water-atomizing electronic cigarette and water-atomizing electronic cigarette comprising the e-liquid
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN104664588A (en) * 2014-12-31 2015-06-03 广东金成生物科技工程有限公司 Nebulized liquid containing ginseng and preparing method thereof
CN105146733A (en) * 2015-08-13 2015-12-16 深圳市施美乐科技股份有限公司 Electronic cigarette atomization liquid with anti-aging function and preparation method thereof
CN106805287A (en) * 2017-03-27 2017-06-09 刘国钦 A kind of electronic cigarette tobacco tar with healthcare function
CN112971199A (en) * 2021-02-20 2021-06-18 深圳市真味生物科技有限公司 Electronic cigarette tobacco tar helpful for relieving fatigue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张伯礼 等主编: "《中药现代化二十年1996-2015》", 31 October 2016, 上海科学技术出版社 *

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Application publication date: 20211231