CN104334571B - 重楼皂苷i的酰化衍生物、及其制备方法和应用 - Google Patents

重楼皂苷i的酰化衍生物、及其制备方法和应用 Download PDF

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Publication number
CN104334571B
CN104334571B CN201380024577.XA CN201380024577A CN104334571B CN 104334571 B CN104334571 B CN 104334571B CN 201380024577 A CN201380024577 A CN 201380024577A CN 104334571 B CN104334571 B CN 104334571B
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CN
China
Prior art keywords
arabinofuranosyl
saponin
acylated
pharmaceutically acceptable
rhizoma paridis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380024577.XA
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English (en)
Chinese (zh)
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CN104334571A (zh
Inventor
徐荣臻
荣风光
谢福文
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Priority to CN201380024577.XA priority Critical patent/CN104334571B/zh
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Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201380024577.XA 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用 Expired - Fee Related CN104334571B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201380024577.XA CN104334571B (zh) 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/076840 2012-06-13
CN2012076840 2012-06-13
CN201380024577.XA CN104334571B (zh) 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用
PCT/CN2013/077165 WO2013185613A1 (zh) 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用

Publications (2)

Publication Number Publication Date
CN104334571A CN104334571A (zh) 2015-02-04
CN104334571B true CN104334571B (zh) 2016-08-31

Family

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Family Applications (1)

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CN201380024577.XA Expired - Fee Related CN104334571B (zh) 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用

Country Status (6)

Country Link
US (1) US9353146B2 (cg-RX-API-DMAC7.html)
EP (1) EP2862869B1 (cg-RX-API-DMAC7.html)
JP (1) JP2015523349A (cg-RX-API-DMAC7.html)
CN (1) CN104334571B (cg-RX-API-DMAC7.html)
DK (1) DK2862869T3 (cg-RX-API-DMAC7.html)
WO (1) WO2013185613A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104098646B (zh) * 2014-07-17 2017-01-11 云南省药物研究所 纤细薯蓣皂苷衍生物及其抗肿瘤活性应用
CN107619427B (zh) * 2017-11-03 2020-09-15 广西南宁成远科技有限公司 一种从重楼中提取纯化重楼皂苷ⅰ的方法
CN112402438B (zh) * 2020-12-05 2022-01-11 中南大学 重楼皂苷ⅶ在制备msn蛋白抑制剂中的应用
CN113694046B (zh) * 2021-08-27 2023-04-07 广东药科大学 一种重楼皂苷纳米脂质体粉雾剂的制备方法及其应用
CN115429759B (zh) * 2022-08-24 2023-07-21 中国人民解放军空军军医大学 以重楼皂苷活性提取物为膜材的脂质体的制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1322729A (zh) * 2001-05-11 2001-11-21 中国科学院上海有机化学研究所 薯蓣皂甙的酰基化衍生物、制备方法及用途
CN101143148A (zh) * 2007-10-16 2008-03-19 浙江大学 重楼皂甙ⅰ及其衍生物的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1322729A (zh) * 2001-05-11 2001-11-21 中国科学院上海有机化学研究所 薯蓣皂甙的酰基化衍生物、制备方法及用途
CN101143148A (zh) * 2007-10-16 2008-03-19 浙江大学 重楼皂甙ⅰ及其衍生物的应用

Also Published As

Publication number Publication date
WO2013185613A1 (zh) 2013-12-19
US9353146B2 (en) 2016-05-31
CN104334571A (zh) 2015-02-04
US20150152133A1 (en) 2015-06-04
EP2862869B1 (en) 2018-08-08
DK2862869T3 (en) 2018-10-29
EP2862869A1 (en) 2015-04-22
JP2015523349A (ja) 2015-08-13
EP2862869A4 (en) 2015-11-11

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Granted publication date: 20160831