DK2862869T3 - ACYLATED DERIVATIVES OF POLYPHYLLINE I, METHOD OF PREPARING IT AND USING THEREOF - Google Patents

ACYLATED DERIVATIVES OF POLYPHYLLINE I, METHOD OF PREPARING IT AND USING THEREOF Download PDF

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Publication number
DK2862869T3
DK2862869T3 DK13805106.5T DK13805106T DK2862869T3 DK 2862869 T3 DK2862869 T3 DK 2862869T3 DK 13805106 T DK13805106 T DK 13805106T DK 2862869 T3 DK2862869 T3 DK 2862869T3
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DK
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Prior art keywords
arabinofuranosyl
rhamnopyranosyl
polyphylline
acylated
derivative
Prior art date
Application number
DK13805106.5T
Other languages
Danish (da)
English (en)
Inventor
Rongzhen Xu
Fuwen Xie
Frank Rong
Original Assignee
Hangzhou Bensheng Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Bensheng Pharmaceutical Co Ltd filed Critical Hangzhou Bensheng Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK2862869T3 publication Critical patent/DK2862869T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DK13805106.5T 2012-06-13 2013-06-13 ACYLATED DERIVATIVES OF POLYPHYLLINE I, METHOD OF PREPARING IT AND USING THEREOF DK2862869T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012076840 2012-06-13
PCT/CN2013/077165 WO2013185613A1 (zh) 2012-06-13 2013-06-13 重楼皂苷i的酰化衍生物、及其制备方法和应用

Publications (1)

Publication Number Publication Date
DK2862869T3 true DK2862869T3 (en) 2018-10-29

Family

ID=49757536

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13805106.5T DK2862869T3 (en) 2012-06-13 2013-06-13 ACYLATED DERIVATIVES OF POLYPHYLLINE I, METHOD OF PREPARING IT AND USING THEREOF

Country Status (6)

Country Link
US (1) US9353146B2 (cg-RX-API-DMAC7.html)
EP (1) EP2862869B1 (cg-RX-API-DMAC7.html)
JP (1) JP2015523349A (cg-RX-API-DMAC7.html)
CN (1) CN104334571B (cg-RX-API-DMAC7.html)
DK (1) DK2862869T3 (cg-RX-API-DMAC7.html)
WO (1) WO2013185613A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104098646B (zh) * 2014-07-17 2017-01-11 云南省药物研究所 纤细薯蓣皂苷衍生物及其抗肿瘤活性应用
CN107619427B (zh) * 2017-11-03 2020-09-15 广西南宁成远科技有限公司 一种从重楼中提取纯化重楼皂苷ⅰ的方法
CN112402438B (zh) * 2020-12-05 2022-01-11 中南大学 重楼皂苷ⅶ在制备msn蛋白抑制剂中的应用
CN113694046B (zh) * 2021-08-27 2023-04-07 广东药科大学 一种重楼皂苷纳米脂质体粉雾剂的制备方法及其应用
CN115429759B (zh) * 2022-08-24 2023-07-21 中国人民解放军空军军医大学 以重楼皂苷活性提取物为膜材的脂质体的制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1153779C (zh) * 2001-05-11 2004-06-16 中国科学院上海有机化学研究所 薯蓣皂甙的酰基化衍生物、制备方法及用途
CN101143148B (zh) 2007-10-16 2010-12-08 浙江大学 重楼皂甙ⅰ及其衍生物的应用

Also Published As

Publication number Publication date
CN104334571B (zh) 2016-08-31
WO2013185613A1 (zh) 2013-12-19
US9353146B2 (en) 2016-05-31
CN104334571A (zh) 2015-02-04
US20150152133A1 (en) 2015-06-04
EP2862869B1 (en) 2018-08-08
EP2862869A1 (en) 2015-04-22
JP2015523349A (ja) 2015-08-13
EP2862869A4 (en) 2015-11-11

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