CN104324255A - Traditional Chinese medicine for treating heat stress of chicken and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating heat stress of chicken and preparation method of traditional Chinese medicine Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/536—Prunella or Brunella (selfheal)
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Abstract
The invention provides a traditional Chinese medicine for treating heat stress of chicken. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10-80 parts of rhizoma phragmitis, 5-40 parts of lophatherum gracile, 5-40 parts of peppermint, 5-30 parts of talc powder, 5-25 parts of lonicera japonica, 5-40 parts of selfheal, 5-30 parts of licorice root, 5-35 parts of astragalus membranaceus and 5-30 parts of poria cocos. Compared with the prior art, by means of active substances or effective ingredients and the integral regulating effect of the traditional Chinese medicinal materials, the traditional Chinese medicine for treating heat stress of chicken is capable of improving the production performance of chicken and improving the body immunity and stress resistance to guarantee normal metabolism of a body and achieve an excellent effect of resisting heat stress of broilers. The traditional Chinese medicine has the advantages of quick drug effect, good treatment effect, no toxic or side effect and the like, and is simple to prepare and easy to popularize and product.
Description
Technical field
The invention belongs to technical field of Chinese medicine for animals, be specifically related to a kind of Chinese medicine for the treatment of chicken heat shock and preparation method thereof.
Background technology
Heat stress refers to the general name of the nonspecific response reaction that body produces for the disadvantageous thermal environment of its physiology.Heat stress can reduce fertility performance, the feed intake of broiler, make the increases such as mortality rate, broiler is the most directly endangered and shows as fertility performance and chicken meat quality decline, heavy then cause heat cramp and heat exhaustion and dead, mortality rate, up to 25% ~ 30%, has become the major obstacles that restriction broiler breeding industry develops in a healthy way.Along with the development of herding intensive culture industry and the increase of cultivation density, in recent years, the harm that heat stress causes to broiler industry is also more and more outstanding, growth of meat chicken is fast, build is large, skin depth, subcutaneous and stomach fat is many, poor to the resistance of heat stress, hot environment has crushing harm to commercial meat bird.Broiler is the Homoiotherm without sweat gland, and the normal body temperature of Adult Chicken is at about 41 DEG C, and the preference temperature of feeding environment is 21-25 DEG C.In suitable temperature range, growth of meat chicken speed is fast, efficiency of feed utilization is high, mortality rate is low, and when ambient temperature is more than 28 DEG C, broiler starts to occur thermal stress reaction; when ambient temperature is close to 30 DEG C; usually there will be dyspnea, occur heatstroke very soon, even exhaustion is dead.
Heat shock protein (heat shock protein, HSP) is a series of protein with endogenous protection effect synthesized in animal body under high temperature and other stressed conditions, has another name called heat stress proteins.HSP70 is most important a member in HSP family, structurally has well-conserved.Under stress state, HSP70 synthesizes rapidly in cell; the tissue cell insult that opposing stress cause; improve the hot tolerance of body and play the effect protecting body; this hot tolerance is main relevant with HSP70; and be proportionate with the expression of HSP70, some anti-heat stress Chinese medicines improve the ability of body anti-stress by the expression improving HSP.HSP participates in the antibody Monoclonal of cell, reparation and hot tolerance course under stressed condition, Cell protection vital movement.
Under normal physiological conditions, interior free yl produces and removing is in dynamic balance state, and when being subject to heat stress, the generation of body free radical sharply increases, and Scavenging activity deficiency then causes interior free yl to accumulate, and causes tissue oxidizing impaired.Excessive lipid-peroxidative is generated in heat stress inducing cell film, Oxidation is strengthened, destroy the integrity of cell membrane, protein and steatolysis is caused to increase, membrane passage destroys, cytoplasmic osmotic pressure raises, and tissue fluid enters in cell, and moisture in histiocyte is increased, cause a series of pathological changes such as histiocyte generation edema, cause the major injury of cell membrane.SOD activity can reflect the ability of body scavenging activated oxygen indirectly, and the generation of lipid peroxide, improve the oxidation resistance of body, the external source active components of plants exploring excessive free radicals in purged body becomes the focus of current people research.
How to improve body antioxidant levels by means such as Chinese medicines; suppress the liver cell apoptosis that heat stress causes; reach the effect of repairing heat stress damaged cell; become the important topic of molecular biology research; the stress that its achievement in research will cause for ischemia-reperfusion in the pathological processes such as anti-wound, surgical operation, provides a new effective way to the protection of cell and organ.
Summary of the invention
The technical problem to be solved in the present invention is fertility performance and the feed intake reduction of the broiler caused by heat stress, the increases such as mortality rate, the quality of Carnis Gallus domesticus declines, even because of heat cramp and heat exhaustion and death etc., for solving the problem, the invention provides a kind of Chinese medicine for the treatment of chicken heat shock and preparation method thereof.
The object of the invention is to realize in the following manner:
A kind of Chinese medicine for the treatment of chicken heat shock, be made up of the raw material of following parts by weight: Rhizoma Phragmitis 10 ~ 80 parts, Herba Lophatheri 5 ~ 40 parts, Herba Menthae 5 ~ 40 parts, Pulvis Talci 5 ~ 30 parts, Flos Lonicerae 5 ~ 25 parts, Spica Prunellae 5 ~ 40 parts, Radix Glycyrrhizae 5 ~ 30, the Radix Astragali 5 ~ 35 parts, 5 ~ 30 parts, Poria.
The Chinese medicine of described treatment chicken heat shock, the parts by weight of raw material are preferably: Rhizoma Phragmitis 30 ~ 60 parts, Herba Lophatheri 15 ~ 30 parts, Herba Menthae 15 ~ 30 parts, Pulvis Talci 12 ~ 21 parts, Flos Lonicerae 9 ~ 15 parts, Spica Prunellae 9 ~ 24 parts, 9 ~ 15 parts, Radix Glycyrrhizae, the Radix Astragali 9 ~ 21 parts, 9 ~ 21 parts, Poria.
The Chinese medicine of described treatment chicken heat shock, parts by weight the best of raw material is: Rhizoma Phragmitis 45 parts, Herba Lophatheri 18 parts, Herba Menthae 18 parts, Pulvis Talci 15 parts, Flos Lonicerae 12 parts, Spica Prunellae 12 parts, 9 parts, Radix Glycyrrhizae, the Radix Astragali 15 parts, 12 parts, Poria.
A preparation method for the Chinese medicine of above-mentioned treatment chicken heat shock, concrete steps are:
(1) take each raw material by weight, after pulverizing, cross 40 mesh sieves;
(2) insert in mixer and stir, fully mix;
(3) 300 orders are crushed to through superfine communication technique, mix homogeneously.
Division of traditional Chinese drugs of the present invention divides composition principle:
(1) Rhizoma Phragmitis: clearing heat and relieving fidgetness, promoting the production of body fluid to quench thirst, diuresis.
(2) Herba Lophatheri: the relieving restlessness that clears away heart-fire, promote the production of body fluid, diuresis.
(3) Herba Menthae: dispelling wind and heat pathogens, refresh oneself.
(4) Pulvis Talci: clearing away summer-heat, inducing diuresis for treating stranguria syndrome.Pulvis Talci is cold in nature and slide, the heat clearing away of cold energy, and the sharp key of sliding energy, again can removing summer-heat.
(5) Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating.Wherein Volatile Components of Honeysuckle can clearing away summer-heat, and refresh oneself.
(6) Spica Prunellae: improving eyesight of relieving inflammation or internal heat, mass dissipating and swelling eliminating.This product energy clearing away liver-fire, refresh oneself.
(7) Radix Glycyrrhizae: invigorating the spleen and replenishing QI, for weakness of the spleen and stomach, deficiency of QI in middle-JIAO, shortness of breath and fatigue.
(8) Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis, for deficiency of spleen-QI and stomach-QI or sinking of QI of middle-JIAO.
(9) Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Heat stress is called as febrile disease due to summer-heat pathogen or heatstroke, is that pathogenic summer-heat and the damp and hot machine seizing the opportunity the positive QI-insufficiency of body are invaded caused by body, belongs to damp-heat syndrome.To touch upon science of prescription monarch, minister, the principles of formulating prescriptions of helping, making according to Chinese veterinarian's pharmacology, should with tonifying QI to produce body fluid, the relieving restlessness that clears away heart-fire, the dampness removing that drives away summer heat for Therapeutic Principle, the Radix Astragali, Radix Codonopsis yang invigorating QI invigorating in side, keep fit strengthening superficial resistance to stop perspiration for monarch; The Rhizoma Atractylodis Macrocephalae, Poria replenishing QI to invigorate the spleen, infiltration wet, and let out summer-heat, Rhizoma Phragmitis, Herba Lophatheri, Pulvis Talci clearing away summer-heat, promoting the production of body fluid to quench thirst or diuresis are minister, and Spica Prunellae clearing away liver-fire is adjuvant drug, and the refrigerant pathogenic fire purging of Radix Glycyrrhizae is for making medicine.
Relative to prior art, the Chinese medicine for the treatment of chicken heat shock provided by the invention, by the active substance of Chinese medicine or effective ingredient and integrally-regulated effect, improves the fertility performance of chicken, enhancing human body immunity function and anti-stress ability effect, to ensure body eubolism, reach the good result of dorking heat-resistant stress, there is drug effect fast, therapeutic effect is good, have no side effect, preparation method is simple, is easy to promote the advantages such as production.
Detailed description of the invention
Embodiment 1:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, raw material primarily of following parts by weight is made: Rhizoma Phragmitis 10 ~ 80 parts, Herba Lophatheri 5 ~ 40 parts, Herba Menthae 5 ~ 40 parts, Pulvis Talci 5 ~ 30 parts, Flos Lonicerae 5 ~ 25 parts, Spica Prunellae 5 ~ 40 parts, 5 ~ 30 parts, Radix Glycyrrhizae, the Radix Astragali 5 ~ 35 parts, 5 ~ 30 parts, Poria.
Concrete operation step:
(1) take each raw material by weight, after pulverizing, cross 40 mesh sieves;
(2) insert in mixer and stir, fully mix;
(3) 300 orders are crushed to through superfine communication technique, mix homogeneously.
Embodiment 2:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, the raw material primarily of following parts by weight is made: Rhizoma Phragmitis 100g, Herba Lophatheri 50g, Herba Menthae 50g, Pulvis Talci 50g, Flos Lonicerae 50g, Spica Prunellae 50g, Radix Glycyrrhizae 50g, Radix Astragali 50g, Poria 50g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Embodiment 3:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, the raw material primarily of following parts by weight is made: Rhizoma Phragmitis 300g, Herba Lophatheri 150g, Herba Menthae 150g, Pulvis Talci 120g, Flos Lonicerae 90g, Spica Prunellae 90g, Radix Glycyrrhizae 90g, Radix Astragali 90g, Poria 90g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Embodiment 4:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, raw material primarily of following parts by weight is made: Rhizoma Phragmitis 450g, Herba Lophatheri 180g, Herba Menthae 180g, Pulvis Talci 150g, Flos Lonicerae 120g, Spica Prunellae 120g, Radix Glycyrrhizae 250g, Radix Astragali 150g, Poria 120g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Embodiment 5:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, raw material primarily of following parts by weight is made: Rhizoma Phragmitis 600g, Herba Lophatheri 300g, Herba Menthae 300g, Pulvis Talci 210g, Flos Lonicerae 150g, Spica Prunellae 240g, Radix Glycyrrhizae 150g, Radix Astragali 210g, Poria 210g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Embodiment 6:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, raw material primarily of following parts by weight is made: Rhizoma Phragmitis 800g, Herba Lophatheri 400g, Herba Menthae 400g, Pulvis Talci 300g, Flos Lonicerae 250g, Spica Prunellae 400g, Radix Glycyrrhizae 300g, Radix Astragali 350g, Poria 300g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Embodiment 7:
The Chinese medicine being used for the treatment of chicken heat shock of the present embodiment, raw material primarily of following parts by weight is made: Rhizoma Phragmitis 150, 200, 250, 350, 400, 500, 550, 650, 700, 750g, Herba Lophatheri 80, 100, 120, 200, 230, 270, 330, 370g, Herba Menthae 80, 100, 120, 200, 230, 270, 330, 370g, Pulvis Talci 80, 135, 170, 190, 230, 250, 270, 290g, Flos Lonicerae 70, 100, 110, 130, 140, 170, 190, 210, 230g, Spica Prunellae 70, 110, 140, 160, 180, 200, 220, 260, 300, 320, 350, 380g, Radix Glycyrrhizae 70, 100, 120, 140, 160, 180, 200, 220, 240, 260, 280g, the Radix Astragali 70, 120, 140, 160, 180, 200, 220, 240, 260, 280, 300, 320, 340g, Poria 70, 100, 140, 160, 180, 200, 220, 240, 260, 280g.
The preparation method of above-mentioned Chinese medicine is undertaken by embodiment 1.
Clinical experimental study
1 materials and methods
1.1 test specimen
By traditional Chinese medicine sample prepared by embodiment 4,5,6 method.
The selection of 1.2 test chickens and grouping
Father and mother Dai Nike Red Indian race chicken 192 in 48 week age is selected under chicken house working condition is planted by Northwest Agricultural University, be divided at random 4 groups (matched group, embodiment 1 group, embodiment 2 groups and embodiments 3 groups), often group establishes 6 repetitions, each repetition 8, through 10d preliminary trial period, plant chicken healthy, 4 group laying rate differences not significantly (P>0.05), then carry out formal test 30d.
1.3 feedstuff
Preliminary trial period 4, group all fed the full price laying hen material (basal diet) of this autogamy, experimental period, embodiment 1 group feed to add in basal diet daily ration weight based on weight 0.5% the traditional Chinese medicine sample prepared of embodiment 4, embodiment 2 groups feed to add in basal diet daily ration weight based on weight 0.5% the traditional Chinese medicine sample prepared of embodiment 5, embodiment 3 groups feed to add in basal diet daily ration weight based on weight 0.5% the traditional Chinese medicine sample prepared of embodiment 6, control group fed basal diet.
1.4 observation test projects
1.4.1 observed and recorded respectively organizes the spirit of chicken, appetite, morbidity and death condition.
1.4.2 fertility performance
Every day respectively organized egg number, egg size, soft-shelled egg number, amount of livestock on hand, death toll, feed consumption rate in record, calculates laying rate and feed conversion rate.
1.4.3 the mensuration of some biochemical and inorganic ions
Experimental period, divides and carries out for 2 times, and mesophase spherule is every 7d.Often organize and select the wing quiet blood sampling 5ml on an empty stomach in 8 chicken mornings at random, 0.5% heparin sodium anticoagulant, leaves standstill the centrifugal 5min of 3min, 3000 turns/min, and the penicillin bottle that separated plasma is displaced to cleaning is jumped a queue, and to be stored in 4 DEG C of refrigerators for subsequent use.T-CHOL measures: sulfur ferrophosphorus method; Triglyceride measures: by test kit supplying method; Serium inorganic phosphorus measures: colorimetric analysis; Blood calcium determination: EDTA compleximetry; Blood sugar detection: glucose oxidase method.
2 results
2.1 clinical observation
Duration of test 4 group the searching for food of chicken, feces, spiritual Non Apparent Abnormality.Embodiment 1 group, embodiment 2 groups, embodiment 3 groups have no dead, dead 1 of matched group.
2.2 fertility performance
The laying rate that embodiment is 1,2,3 groups improves 6.14% than matched group respectively, 3.49%, 4.59%, difference is (P<0.01) and significant difference (P<0.05) extremely significantly; Egg material than raising 3.9%, 1.0%, 1.8%, significant difference (P<0.05); Soft-shelled egg rate reduces by 0.8%, 0.7%, 0.5%; Mortality rate reduces by 2.1%, refers to table 1.
Table 1 Chinese medicine of the present invention is on the impact of performance in layers
| Group | Laying rate/% | Egg size/% | Egg material ratio/% | Soft-shelled egg rate/% | Mortality rate/% |
| Embodiment 1 group | 80.11±0.87 | 66.55±1.21 | 50.5±2.7 | 1.4 | 0 |
| Embodiment 2 groups | 77.46±0.99 | 67.62±1.29 | 47.6±1.4 | 1.5 | 0 |
| Embodiment 3 groups | 78.56±0.99 | 68.32±1.09 | 48.4±1.4 | 1.7 | 0 |
| Matched group | 73.97±1.21 | 66.29±1.56 | 46.6±1.7 | 2.2 | 2.1 |
2.3 some biochemical inorganic ionss
As can be seen from Table 2, when giving up temperature and rising to 24 ~ 29 DEG C from 21 ~ 26 DEG C, blood glucose, triglyceride, T-CHOL, blood calcium and serium inorganic phosphorus have a declining tendency, but, within the scope of same temperature, feed the some biochemical inorganic ion content of the test chicken of the basal diet being added with Chinese medicine and the test chicken of embodiment 1,2,3 groups except blood glucose, all higher than the test chicken of matched group.
The change of table 2 some biochemical inorganic ions
3 discuss
Result of the test shows, Chinese medicine provided by the invention can reach the good result improving chicken anti-heat stress, alleviate the mechanism of heat stress and can be summed up as in Chinese medicine some active substance or effective ingredient by integrally-regulated effect, improve the fertility performance of chicken, enhancing human body immunity function and anti-stress ability effect, to ensure body eubolism, reach the good result of chicken anti-heat stress, enhance the adaptive capacity to heat stress, significantly improve production capacity and economic benefit.
Claims (4)
1. treat the Chinese medicine of chicken heat shock for one kind, it is characterized in that, be made up of the raw material of following parts by weight: Rhizoma Phragmitis 10 ~ 80 parts, Herba Lophatheri 5 ~ 40 parts, Herba Menthae 5 ~ 40 parts, Pulvis Talci 5 ~ 30 parts, Flos Lonicerae 5 ~ 25 parts, Spica Prunellae 5 ~ 40 parts, Radix Glycyrrhizae 5 ~ 30, the Radix Astragali 5 ~ 35 parts, 5 ~ 30 parts, Poria.
2. the Chinese medicine for the treatment of chicken heat shock according to claim 1, it is characterized in that, the parts by weight of raw material are preferably: Rhizoma Phragmitis 30 ~ 60 parts, Herba Lophatheri 15 ~ 30 parts, Herba Menthae 15 ~ 30 parts, Pulvis Talci 12 ~ 21 parts, Flos Lonicerae 9 ~ 15 parts, Spica Prunellae 9 ~ 24 parts, Radix Glycyrrhizae 9 ~ 15, the Radix Astragali 9 ~ 21 parts, 9 ~ 21 parts, Poria.
3. the Chinese medicine for the treatment of chicken heat shock according to claim 2, it is characterized in that, parts by weight the best of raw material is: Rhizoma Phragmitis 45 parts, Herba Lophatheri 18 parts, Herba Menthae 18 parts, Pulvis Talci 15 parts, Flos Lonicerae 12 parts, Spica Prunellae 12 parts, 9 parts, Radix Glycyrrhizae, the Radix Astragali 15 parts, 12 parts, Poria.
4. according to the preparation method of the Chinese medicine of the treatment chicken heat shock described in claim 1,2 or 3, it is characterized in that: concrete steps are:
(1) take each raw material by weight, after pulverizing, cross 40 mesh sieves;
(2) insert in mixer and stir, fully mix;
(3) 300 orders are crushed to through superfine communication technique, mix homogeneously.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105233098A (en) * | 2015-11-11 | 2016-01-13 | 郑州后羿制药有限公司 | Veterinary herbal medicine capable of improving summer productivity of laying hens and preparing method thereof |
| CN108902537A (en) * | 2018-09-17 | 2018-11-30 | 辽宁农业职业技术学院 | The Chinese herbal feed additive and preparation method thereof for preventing and treating chicken heat shock |
| CN109512959A (en) * | 2018-12-28 | 2019-03-26 | 广东海洋大学 | A kind of breeding period rabbit anti-heat stress preparation and its preparation method and application |
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| CN109512959A (en) * | 2018-12-28 | 2019-03-26 | 广东海洋大学 | A kind of breeding period rabbit anti-heat stress preparation and its preparation method and application |
| CN109512959B (en) * | 2018-12-28 | 2021-08-27 | 广东海洋大学 | Heat stress resistant preparation for breeding-stage rabbits as well as preparation method and application thereof |
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