CN104306542B - 防治猪呼吸道综合征的注射液及其制备方法 - Google Patents

防治猪呼吸道综合征的注射液及其制备方法 Download PDF

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CN104306542B
CN104306542B CN201410531629.9A CN201410531629A CN104306542B CN 104306542 B CN104306542 B CN 104306542B CN 201410531629 A CN201410531629 A CN 201410531629A CN 104306542 B CN104306542 B CN 104306542B
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陈庆忠
安同伟
曹桂敏
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Tianjin Hlinte Biotechnology Co ltd
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Abstract

本发明涉及一种防治猪呼吸道综合征的注射液，其注射液的组分及其重量份数比分别为：替米考星2‑6份；二氧丙嗪1‑5份；蒲公英2‑6份；鱼腥草1‑5份；穿心莲3‑7份；独活1‑5份；乌梅4‑8份；桂枝4‑8份；地黄4‑8份；板蓝根1‑5份；生地1‑5份；玄参1‑5份。本发明配方组成科学合理，工艺简单，使用方便，成本较低，注射液对于猪细菌性呼吸系统疾病、病毒性呼吸系统疾病、细菌和病毒混合感染的呼吸系统疾病、寄生虫性呼吸系统疾病有很好的疗效。

Description

防治猪呼吸道综合征的注射液及其制备方法
技术领域
本发明属于兽药领域，尤其是一种防治猪呼吸道综合征的注射液及其制备方法。
背景技术
近年来呼吸道疾病已成为各大养猪场最常见、危害最严重的疾病之一。这些疾病主要有：猪繁殖与呼吸综合征、猪伪狂犬病、猪瘟、猪气喘病、猪传染性胸膜肺炎、猪传染性萎缩性鼻炎、猪链球菌病、猪肺疫、猪流行性感冒等。这些疾病在临床症状上易于被混淆，诊疗不当常导致猪的大批死亡，给猪场造成严重的经济损失。据报道，美国70%～80%的猪场都存在支原体肺炎。又如1997 年在北美首次发现的猪呼吸道疾病综合征（简称PRDC），多发生于保育期及以后各生长阶段，发病率通常在30%～70%，病死率高达15%～20%。猪瘟也是一种传染性强、致死率高、经济损失严重的病毒性呼吸道疾病。据报道世界范围内约有20 多个国家和地区仍有猪瘟病例存在，如2000 年8 月，英国3 家农场发现猪瘟，致使年出口额为1.26 亿英镑的英国养猪业遭受沉重打击。现阶段，这些疾病的诊断主要依赖于实验室检测，对其治疗并无特别的良方。而中草药是纯天然物质，含有多种生物有效成分，具有抗菌、消炎、不易产生细菌耐药性、低毒、无残留或低残留等特点，兼有药物与营养剂双重功能。应用中草药治疗猪呼吸道疾病，已日益为国内外专家所关注。
发明内容
本发明的目的在于提供一种防治猪呼吸道综合征的注射液，该组合物配方组成科学合理，工艺简单，使用方便，成本较低，注射液对于猪细菌性呼吸系统疾病、病毒性呼吸系统疾病、细菌和病毒混合感染的呼吸系统疾病、寄生虫性呼吸系统疾病有很好的疗效。
本发明的另一个目的在于提供一种防治猪呼吸道综合征的注射液的制备方法。
本发明主要通过以下技术方案实现的：
一种防治猪呼吸道综合征的注射液，该注射液的组分及其重量份数比分别为： 替米考星2份；二氧丙嗪1份；蒲公英2份；鱼腥草1份；穿心莲3份；独活1份；乌梅4份；桂枝4份；地黄4份；板蓝根1份；生地1份；玄参1份。
一种防治猪呼吸道综合征的注射液的制备方法，其制备方法步骤为：
（1）按配比重量称取蒲公英、鱼腥草、穿心莲、独活、乌梅、桂枝、地黄、板蓝根、生地、玄参，经洗净润药烘干后投入中药提取罐内，加1:1 投料量的注射用水，在室温下浸泡18 小时后，再继续加热至水沸腾煎煮6 小时，将提取液0.45μm 过滤后吸入配液罐内储罐；
（2）中药提取罐内再加入2 倍投料量的注射用水，加热至沸腾煎煮2 小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并；
（3）将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa 为宜，蒸发器15 分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次；
（4）提取液浓缩至原生药1ml 将提取液吸入醇沉罐内，室内自然冷却，备用；
（5）将上清液储罐中的提取液过滤后吸入醇沉罐，自然醇沉36 小时收取上清液，弃去残渣，直至原生药1ml，相当于原生药1g；
（6）加入0.3%活性炭，用0.22μm 聚醚砜滤芯过滤；
（7）在称量区称取替米考星、二氧丙嗪，向配液罐内缓慢加入替米考星、二氧丙嗪，再加入80℃的注射水，加至200L，调节药液pH值：5.5-7.0，搅拌15 分钟以上，用0.22μm 聚醚砜滤芯过滤，药液通过管道直接进入灌装机；
（8）打开灌装机进行灌装，灌装到安瓿瓶内，用注射用水清洗安瓿瓶，将安瓿瓶放置于灭菌柜内100℃流通蒸汽灭菌30 分钟，室内自然冷却至室温，即可得到一种防治猪呼吸道综合征的注射液。
本发明的优点及有益效果是：
1.注射液通过杀菌、平喘、化痰、强心、清肺、消炎、解热、排除毒素提升免疫力来达到治疗呼吸系统的疾病。
2.中药成分毒副作用小，不会产生耐药性，应用时强调调节整体功能，提高肌体自身的抗病能力，长期应用安全可靠。
3.西兽药（尤其是抗菌西药）具有收效快、作用强、使用方便等优点。两者相结合，则可以取长补短，内外并重，整体与局部并重，起到相得益彰的效果。
具体实施方式
本发明通过以下实施例进一步详述。需要说明的是：下述实施例是说明性的，不是限定性的，不能以下述实施例来限定本发明的保护范围。
实施例1
一种防治猪呼吸道综合征的注射液，该注射液组分的重量分别为：替米考星2kg、二氧丙嗪1kg、蒲公英2kg、鱼腥草1kg、穿心莲3kg、独活1kg、乌梅4kg、桂枝4kg、地黄4kg、板蓝根1kg、生地1kg、玄参1kg。
一种防治猪呼吸道综合征的注射液的制备方法，该注射液制备工艺步骤如下：
（1）安国市万联中药饮片有限公司采购购筛选净药材，在称重区按配比重量称取蒲公英、鱼腥草、穿心莲、独活、乌梅、桂枝、地黄、板蓝根、生地、玄参，经洗净润药烘干后投入中药提取罐内，加1:1投料量的注射用水，在室温下浸泡18 小时后，再继续加热至水沸腾煎煮6 小时，将提取液0.45μm 过滤后吸入配液罐内储罐；
（2）中药提取罐内再加入2 倍投料量的注射用水，加热至沸腾煎煮2 小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并。
（3）将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa 为宜；蒸发器15 分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次。
（4）提取液浓缩至原生药1ml 相当于原生药1g 将提取液吸入醇沉罐内，室内自然冷却，备用；
（5）将上清液储罐中的提取液过滤后吸入醇醇沉罐，自然醇沉36小时收取上清液，弃去残渣，直至原生药1ml 相当于原生药1g；
（6）加入0.3%活性炭，用0.22μm 聚醚砜滤芯过滤；
（7）在称量区称取替米考星、二氧丙嗪，向配液罐内缓慢加入替米考星、二氧丙嗪，再加入80℃的注射水，加至200L，调节药液pH值：5.5-7.0，搅拌15 分钟以上，用0.22μm 聚醚砜滤芯过滤，药液通过管道直接进入灌装机；
（8）打开灌装机进行灌装，灌装到安瓿瓶内，用注射用水清洗安瓿瓶，将安瓿瓶放置于灭菌柜内100℃流通蒸汽灭菌30 分钟，室内自然冷却至室温，用纯化水清洗安瓿瓶后，印字包装，即可得到一种防治猪呼吸道综合征的注射液。
临床试验
1. 注射液在养猪上的临床试验，病猪表现为呼吸困难，发出喘鸣声、呼吸时呈犬坐姿势，腹式呼吸，有的病猪呼吸时肋骨可见突出外露，呼吸数增加。
2. 试验时间：2014.03.18 日，试验猪群，某养殖厂育肥猪，60头，分为4 组，对照组，试验组，常规治疗I 组，常规治疗II组每组15 只，用法用量：治疗组肌内注射一次量每1kg 体重，猪0.5ml，一日一次，仅用一次。
对照组：为空白组，不使用任何药物治疗。
实验组：为注射液治疗组。1kg 体重0.5ml
常规治疗I 组：为市售药物治疗组，麻杏石甘注射液，1kg 体重0.5ml。
常规治疗II 组：为市售药物治疗组氟苯尼考注射液20%，1kg 体重0.5ml。
试验结果如下：
试验表明：
综上所述，本发明注射液对猪呼吸道综合征见效快，疗效好。

Claims (2)

1.一种防治猪呼吸道综合征的注射液，其特征在于，该注射液的组分及其重量份数比分别为： 替米考星2份；二氧丙嗪1份；蒲公英2份；鱼腥草1份；穿心莲3份；独活1份；乌梅4份；桂枝4份；地黄4份；板蓝根1份；生地1份；玄参1份。
2.如权利要求1所述的一种防治猪呼吸道综合征的注射液的制备方法，其特征在于，制备方法步骤为：
（1）按配比重量称取蒲公英、鱼腥草、穿心莲、独活、乌梅、桂枝、地黄、板蓝根、生地、玄参，经洗净润药烘干后投入中药提取罐内，加1:1 投料量的注射用水，在室温下浸泡18 小时后，再继续加热至水沸腾煎煮6 小时，将提取液0.45μm 过滤后吸入配液罐内储罐；
（2）中药提取罐内再加入2 倍投料量的注射用水，加热至沸腾煎煮2 小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并；
（3）将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa 为宜，蒸发器15 分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次；
（4）提取液浓缩至原生药1ml 将提取液吸入醇沉罐内，室内自然冷却，备用；
（5）将上清液储罐中的提取液过滤后吸入醇沉罐，自然醇沉36 小时收取上清液，弃去残渣，直至原生药1ml，相当于原生药1g；
（6）加入0.3%活性炭，用0.22μm 聚醚砜滤芯过滤；
（7）在称量区称取替米考星、二氧丙嗪，向配液罐内缓慢加入替米考星、二氧丙嗪，再加入80℃的注射水，加至200L，调节药液pH值：5.5-7.0，搅拌15 分钟以上，用0.22μm 聚醚砜滤芯过滤，药液通过管道直接进入灌装机；
（8）打开灌装机进行灌装，灌装到安瓿瓶内，用注射用水清洗安瓿瓶，将安瓿瓶放置于灭菌柜内100℃流通蒸汽灭菌30 分钟，室内自然冷却至室温，即可得到一种防治猪呼吸道综合征的注射液。
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