CN102188597B - 一种治疗猪喘气病的中药药物 - Google Patents
一种治疗猪喘气病的中药药物 Download PDFInfo
- Publication number
- CN102188597B CN102188597B CN2011101123594A CN201110112359A CN102188597B CN 102188597 B CN102188597 B CN 102188597B CN 2011101123594 A CN2011101123594 A CN 2011101123594A CN 201110112359 A CN201110112359 A CN 201110112359A CN 102188597 B CN102188597 B CN 102188597B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicament
- traditional chinese
- treating
- enzootic pneumonia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 241000282898 Sus scrofa Species 0.000 title claims abstract description 32
- 206010035664 Pneumonia Diseases 0.000 title abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000002347 injection Methods 0.000 claims abstract description 13
- 239000007924 injection Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 24
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 230000008021 deposition Effects 0.000 claims description 2
- 238000012869 ethanol precipitation Methods 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
- 210000004072 lung Anatomy 0.000 abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 13
- 201000010099 disease Diseases 0.000 abstract description 12
- 239000000126 substance Substances 0.000 abstract description 10
- 206010011224 Cough Diseases 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 8
- 208000006673 asthma Diseases 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- 238000000605 extraction Methods 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 241000605447 Anemarrhena Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000003322 Coinfection Diseases 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 244000018633 Prunus armeniaca Species 0.000 abstract 1
- 235000009827 Prunus armeniaca Nutrition 0.000 abstract 1
- 229930191283 anemarrhena Natural products 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 230000002147 killing effect Effects 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000009044 synergistic interaction Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 14
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 239000013558 reference substance Substances 0.000 description 7
- GMBQZIIUCVWOCD-WWASVFFGSA-N Sarsapogenine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@H]4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 GMBQZIIUCVWOCD-WWASVFFGSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000029058 respiratory gaseous exchange Effects 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 238000010992 reflux Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- ATWHGWYKSFRYBN-UHFFFAOYSA-N Amygdaloside Natural products O1C(=O)C2(C)CCCC(C3CC4)(C)C2C1OCC3(C1)CC4C1(O)COC1OC(CO)C(O)C(O)C1O ATWHGWYKSFRYBN-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 description 3
- 241000282894 Sus scrofa domesticus Species 0.000 description 3
- RTMWIZOXNKJHRE-UHFFFAOYSA-N Tigogenin Natural products CC1COC2CC(C)(OC12)C3CCC4C5CCC6CC(O)CCC6(C)C5CCC34C RTMWIZOXNKJHRE-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 229930027917 kanamycin Natural products 0.000 description 3
- 229960000318 kanamycin Drugs 0.000 description 3
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 3
- 229930182823 kanamycin A Natural products 0.000 description 3
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 2
- 239000004100 Oxytetracycline Substances 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 229930194936 Tylosin Natural products 0.000 description 2
- 239000004182 Tylosin Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960005287 lincomycin Drugs 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 229960000625 oxytetracycline Drugs 0.000 description 2
- 235000019366 oxytetracycline Nutrition 0.000 description 2
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 235000019375 tylosin Nutrition 0.000 description 2
- 229960004059 tylosin Drugs 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- YEZWWUMWIFKEQM-UHFFFAOYSA-N O.OC.ClC(Cl)Cl.CCOC(C)=O Chemical compound O.OC.ClC(Cl)Cl.CCOC(C)=O YEZWWUMWIFKEQM-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000006053 animal diet Substances 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- TXHIDIHEXDFONW-UHFFFAOYSA-N benzene;propan-2-one Chemical compound CC(C)=O.C1=CC=CC=C1 TXHIDIHEXDFONW-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001399 clenbuterol hydrochloride Drugs 0.000 description 1
- OPXKTCUYRHXSBK-UHFFFAOYSA-N clenbuterol hydrochloride Chemical compound Cl.CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 OPXKTCUYRHXSBK-UHFFFAOYSA-N 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000005560 droplet transmission Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- KXUYYFNHOZRVKP-UHFFFAOYSA-N ethanol;4-hydroxy-3-methoxybenzaldehyde Chemical compound CCO.COC1=CC(C=O)=CC=C1O KXUYYFNHOZRVKP-UHFFFAOYSA-N 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- -1 from natural goods Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 230000001830 phrenic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
分组 | 试验数 | 治愈数 | 显效数 | 无效死亡 | 治愈率 |
止咳灵注射液组 | 3438 | 3130 | 308 | 0 | 91.04% |
泰乐菌素组 | 19 | 16 | 1 | 2 | 84.21% |
卡那霉素组 | 22 | 18 | 2 | 2 | 81.81% |
林可霉素组 | 17 | 12 | 2 | 3 | 70.58% |
土霉素组 | 24 | 18 | 4 | 2 | 75% |
对照组 | 6 | 1 | 1 | 4 | 17% |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101123594A CN102188597B (zh) | 2011-05-03 | 2011-05-03 | 一种治疗猪喘气病的中药药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101123594A CN102188597B (zh) | 2011-05-03 | 2011-05-03 | 一种治疗猪喘气病的中药药物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102188597A CN102188597A (zh) | 2011-09-21 |
CN102188597B true CN102188597B (zh) | 2012-08-15 |
Family
ID=44598032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011101123594A Expired - Fee Related CN102188597B (zh) | 2011-05-03 | 2011-05-03 | 一种治疗猪喘气病的中药药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102188597B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103768239A (zh) * | 2012-10-24 | 2014-05-07 | 天津中敖生物科技有限公司 | 防治猪支原体肺炎的中药组合物及其制备方法 |
CN103202946B (zh) * | 2013-04-15 | 2014-06-25 | 西安医学院 | 治疗猪气喘病的中药及其注射液的制备方法 |
CN104324209B (zh) * | 2014-10-21 | 2017-09-15 | 张其星 | 一种治疗猪喘气的中药组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1336214A (zh) * | 2001-08-08 | 2002-02-20 | 曹怀坤 | 治疗慢性支气管炎的中成药 |
CN101062318A (zh) * | 2007-05-21 | 2007-10-31 | 王军 | 金银止咳汤 |
CN101167944A (zh) * | 2007-10-25 | 2008-04-30 | 张津 | 清痰止咳的中药方剂 |
-
2011
- 2011-05-03 CN CN2011101123594A patent/CN102188597B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1336214A (zh) * | 2001-08-08 | 2002-02-20 | 曹怀坤 | 治疗慢性支气管炎的中成药 |
CN101062318A (zh) * | 2007-05-21 | 2007-10-31 | 王军 | 金银止咳汤 |
CN101167944A (zh) * | 2007-10-25 | 2008-04-30 | 张津 | 清痰止咳的中药方剂 |
Non-Patent Citations (2)
Title |
---|
付新成.猪喘气病研究现状.《国外畜牧学-猪与禽》.2009,第29卷(第5期),80-82页. * |
朱小龙 等.中药验方治疗猪喘气病及禽慢性呼吸道病.《中兽医学杂志》.2004,(第118期),41页右栏. * |
Also Published As
Publication number | Publication date |
---|---|
CN102188597A (zh) | 2011-09-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101209294A (zh) | 一种具有止咳平喘功效的兽用中药颗粒剂 | |
CN102188597B (zh) | 一种治疗猪喘气病的中药药物 | |
CN105169017A (zh) | 一种治疗肾结石的中药及其制备方法 | |
CN102847021B (zh) | 一种治疗溃疡性结肠炎的灌肠剂及其制备方法 | |
CN102302504A (zh) | 高纯度黄芩苷或黄芩素在制备吸入式平喘药物的应用 | |
CN118001231A (zh) | 一种兽用抗病毒中药口服液及其制备方法 | |
CN102188494B (zh) | 一种治疗猪高热病的中药药物 | |
CN101703572B (zh) | 用于畜禽类呼吸道疾病的中药组合物的制备方法及其应用 | |
CN103494927B (zh) | 一种用于治疗鸡呼吸道疾病的中药组合物及其制备方法 | |
CN101537055A (zh) | 猪喘气病的治疗配方、制作方法及药液使用方法 | |
CN1608654A (zh) | 一种治疗肺内感染及防治非典型肺炎的中药 | |
CN108272874A (zh) | 用于蛋鸡的中药制剂及其制备方法 | |
CN102698158B (zh) | 防治鸡肾型传染性支气管炎的中药、制备方法和饲料 | |
CN106389562A (zh) | 一种蒲地蓝消炎颗粒及其制备方法和产品质量控制方法 | |
CN101757106B (zh) | 一种用于清热解毒的注射液及其制备方法 | |
CN103341154B (zh) | 一种复方兽用清热解毒注射液 | |
CN105832848A (zh) | 一种用于禽类呼吸道疾病的中药组方及制备方法 | |
CN104922258B (zh) | 一种马腺疫散剂及在制备防治马腺疫及脓肿药物中的应用 | |
CN106728010A (zh) | 一种用于畜禽咳喘的药物组合物及其制备工艺 | |
CN102258620B (zh) | 治疗猪链球菌和猪瘟混合感染的中药注射剂及其制备方法 | |
CN113350429A (zh) | 一种防治非洲猪瘟疾病的中药组合物及其制备方法与应用 | |
CN106138665A (zh) | 一种用于治疗鸡肺炎的中药组合物 | |
CN103721058A (zh) | 用于预防流感病毒的中药制剂 | |
CN104887945B (zh) | 一种用于治疗羔羊肺炎的中药组合物及其制备方法和应用 | |
CN107929415A (zh) | 一种治疗上呼吸道感染的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: ZHAO FENG SUN TAIRAN WANG LI Effective date: 20130724 Owner name: HEBEI RUIGAO ANIMAL PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHAO ZHIMIN Effective date: 20130724 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100098 HAIDIAN, BEIJING TO: 071200 BAODING, HEBEI PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130724 Address after: 071200 in Anguo City of Hebei Province Chinese Medicine Industry Park Patentee after: Hebei ruigao Animal Pharmaceutical Co. Ltd. Address before: 100098 Beijing Dazhong Temple Sun Park 12-603 Patentee before: Zhao Zhimin Patentee before: Zhao Feng Patentee before: Sun Tairan Patentee before: Wang Li |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120815 Termination date: 20150503 |
|
EXPY | Termination of patent right or utility model |