CN104305203A - Preparation for preventing decayed teeth - Google Patents
Preparation for preventing decayed teeth Download PDFInfo
- Publication number
- CN104305203A CN104305203A CN201410633976.2A CN201410633976A CN104305203A CN 104305203 A CN104305203 A CN 104305203A CN 201410633976 A CN201410633976 A CN 201410633976A CN 104305203 A CN104305203 A CN 104305203A
- Authority
- CN
- China
- Prior art keywords
- preparation
- polylysine
- epsilon
- decayed teeth
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 108010039918 Polylysine Proteins 0.000 claims abstract description 24
- 235000013373 food additive Nutrition 0.000 claims abstract description 9
- 239000002778 food additive Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 16
- 208000002925 dental caries Diseases 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 14
- 239000004471 Glycine Substances 0.000 claims description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 13
- 210000000214 mouth Anatomy 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 5
- 230000001013 cariogenic effect Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005115 demineralization Methods 0.000 description 2
- 230000002328 demineralizing effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000019462 natural additive Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 240000004658 Medicago sativa Species 0.000 description 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000007930 Oxalis acetosella Species 0.000 description 1
- 235000008098 Oxalis acetosella Nutrition 0.000 description 1
- 235000010240 Paullinia pinnata Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 102000007365 Sialoglycoproteins Human genes 0.000 description 1
- 108010032838 Sialoglycoproteins Proteins 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007269 microbial metabolism Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 235000019449 other food additives Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation for preventing decayed teeth. The preparation is characterized by comprising Epsilon-polylysine, a food additive and water, wherein the mass percentage of the Epsilon-polylysine is 0.3-2 %. As the Epsilon-polylysine and the food additive which is harmless to safety of human body are added to the preparation, the preparation for preventing the decayed teeth, disclosed by the invention, has a reliable effect and is safe and harmless to human body; when being frequently used, the preparation for preventing the decayed teeth has an effect of preventing the decayed teeth, so that mouth health improving effect is obvious; meanwhile, the taste of the preparation can be also accepted by more people.
Description
Technical field
The present invention relates to a kind of preparation for the prevention of dental caries.
Background technology
Carious tooth is the disease that a kind of incidence of disease of the mankind is very high.Look forward within the scope of All Around The World, carious tooth has the tendency of sharp increase, and according to statistics, Chinese children morbidity of dental caries is up to 70-80%, and adult, the elderly also usually suffers from this disease.Carious tooth not only damages tooth, but also can cause the pathology of other organs of health, increases the misery of patient, seriously affects the health of the people.
But still there is no a kind of convenient and reliable prevention method so far.Trace it to its cause, be engraved in during the cariogenic cause of disease and annoying us.The etiology of dental caries theory of generally acknowledging at present is tetrad factor theory, mainly comprises bacterium, oral environment, host's (namely referring to that parasitic animal and plant comprises the parasitic organism thereon such as parasite, virus) and time.Its basic point is: cariogenicity sugar (particularly sucrose and refining carbon hydrate) is tightly attached at facing, the Acquired Pellicle formed by sialoprotein.This Acquired Pellicle is not only firmly attached to facing, and can under preference temperature, have time enough to produce acid in bacterial plaque deep layer, and invasion and attack tooth, makes it demineralization, and and then destruction of organic material, produce cavity.
In other words, to the generation of the effective caries prevention of energy, acid-producing bacteria multiplying and living in oral cavity will effectively be suppressed.Acid-producing bacteria belongs to streptococcus mutans, actinomyces, carbohydrate breakdown can be made to produce acid, cause the demineralization of tooth inanimate matter; Another kind is GPC, can destruction of organic material, tooth can be made to form cavity through long term.Or improve the external environment of tooth---cleaning of oral cavity, wherein active mainly food and saliva.
Because oral cavity is a special organ, in oral cavity, use any bactericide or bacteriostatic agent not only will have reliable effect, first it will consider especially to the security of human body; Its flavour also wants people happyly to accept simultaneously.
Summary of the invention
For solving the problem in background technology, the invention provides one not only has and kills (pressing down) bacterium effect reliably, harmless to human-body safety again, while its flavour people preparation for the prevention of dental caries that also can accept.
Technical scheme of the present invention is:
For a preparation for the prevention of dental caries, it is characterized in that: comprise epsilon-polylysine, glycine and other food additives and water, wherein the mass percent of epsilon-polylysine is 0.3%-2%.
As a kind of technical scheme of optimization, described food additives comprise in sorbierite, glycine, citric acid, malic acid, starch, Aspartame, flavoring essence one or several.
Epsilon-polylysine is a kind of natural microbial metabolism product, forms the homopolymers that amido link is formed by connecting, have 25 ~ 35 lysine monomers by essential amino acid lysine residue by Alpha-hydroxy and epsilon-amino.Within 1989, first Japanese a company uses biological technique method suitability for industrialized production polylysine, and is classified as natural additive, allows to use.In January, 2004, U.S. FDA official approval epsilon-polylysine is as natural additive for foodstuff.Epsilon-polylysine can be decomposed into lysine in human body, can be completely digested, and lysine is one of needed by human 8 seed amino acid, allows strengthening in food to use.Epsilon-polylysine does not only have toxic and side effect, and can be used as a kind of lysine source.People's Republic of China's national health and Family Planning Committee " bulletins (2014 No. 5) about 4 kinds of food additives new varieties such as approval epsilon-polylysine etc. ".Therefore the security of this product can be considered food, confirm that through zoopery the effect of the generation of its caries prevention is very remarkable.
Epsilon-polylysine is with the addition of in preparation of the present invention, and the food additives harmless to human-body safety, be not only provided with reliable effect, harmless to human-body safety, often use said preparation, effectively can play the effect of caries prevention.
Product of the present invention both can be developed as medicine, also can be developed as functional food even bread and cheese.
Detailed description of the invention
Embodiment
For a preparation for the prevention of dental caries, it is characterized in that: comprise the corresponding binder such as epsilon-polylysine, food additives and water and flavor enhancement, wherein the mass percent of epsilon-polylysine is 0.3%-2%.Described food additives comprise in sorbierite, glycine, citric acid, malic acid, starch, Aspartame, flavoring essence one or several.
Present invention also offers relevant tablet and the preparation technology of liquid preparation.
Tablet producing technology 1
1, take epsilon-polylysine 10g, sorbierite (solid) 980g respectively, dolomol 10g is for subsequent use.
2, first epsilon-polylysine, sorbierite are fully mixed, cross 60 mesh sieves, the carrying out do not passed through is pulverized, till passing through completely.
3, get above-mentioned ready material to mix with dolomol.
4, load tablet press machine and carry out compressing tablet, sheet weight, size, thickness are all adjustable.
Tablet producing technology 2
1, epsilon-polylysine 20g, glycine 15g, sorbierite (solid) 939g, citric acid 12g, menthol 1g, silica 5g, dolomol 8g is taken respectively, stand-by.
2, first epsilon-polylysine, glycine, citric acid, sorbierite are fully mixed, 85% ethanol that takes a morsel dissolves proper amount of edible pigment and is evenly spilled in compound above, then adds ethanol in proper amount stirring, until material is tightly collected together agglomerating, unclamp and can fall apart, cross 16 mesh sieves and granulate.
3, dry, control temperature is no more than 70 DEG C, and diligent stirring makes to be heated evenly, and treats that moisture reaches 6%, and cooling crosses the whole grain of 60 mesh sieve, by pulverizing again of not passing through, till passing through completely.
4, menthol, silica and dolomol is added and the mixing of materials that makes evenly can carry out compressing tablet above.
5, load tablet press machine and carry out compressing tablet, sheet weight, size, thickness are all adjustable.
Liquid preparation embodiment 3
1, first in container, add appropriate pure water, in container, then drop into epsilon-polylysine 10 grams, glycine 8 grams, citric acid 9 grams, malic acid 7 grams, Aspartame 0.6 gram, sorbierite 50 grams, 0.5 gram, soluble fruit essence;
2, in container, then add pure water to 1000ml place, namely obtain the mouthwash with caries prevention effect of 1000ml.
Also have a kind of embodiment in addition, namely in toothpaste, add epsilon-polylysine, both can obtain and prevent the putrid and deteriorated effect of toothpaste from also can play disinfective action to oral cavity outward.
The present invention also lists an experiment material.
Experiment material: cleaning grade kunming mice, the cariogenic feed of Keyes (1958) 2000# (sucrose 56%, wholemeal 6%, milk powder 28%, alfalfa meal 3%, dewater full hepar siccatum 1%, yeast 4%, salt 2%), toothbrush, magnifying glass.
Experimental technique: get 7 weeks mouse 30, random crawl is divided into three points.Control group, administration 1 group, administration 2 groups.The cariogenic feed of control group feeding Keyes (1958) 2000#, drinks water for ordinary tap water; Administration 1 group in the cariogenic feed of Keyes (1958) 2000# every kilogram add 10 grams, embodiment 1 preparation, mixing make pellet; Drinking-water also adds 10 grams, embodiment 1 preparation for ordinary tap water often rises, and dissolving shakes up, and crosses and filters water-fast dolomol (or silica).Administration 2 groups in the cariogenic feed of Keyes (1958) 2000# every kilogram add 10 grams, embodiment 2 preparation, drinking water also adds 10 grams, embodiment 2 preparation for ordinary tap water often rises, and concrete operations are the same.Feed and drinking-water are not all sterilized.Feed 45 days respectively under field conditions (factors).Put to death, get its oral cavity and clean and observe, in oral cavity all have one and above tooth to occur the corrosion of tooth glaze or cavity generate is positive findings.Result is as follows:
Through statistical procedures: control group compares with two administration groups.Compare with administration 1 group, the free degree=1, card side=5.49,0.01 < p < 0.05; Compare with administration 2 groups, the free degree=1, card side=7.50, p < 0.01.
Result shows to take epsilon-polylysine as the effect that the preparation of the main caries prevention made has caries prevention really.Epsilon-polylysine and glycine with the use of effect better.
The present invention is not limited to above-mentioned preferred embodiment, and anyone should learn the structure change made under enlightenment of the present invention, and every have identical or akin technical scheme with the present invention, all belongs to protection scope of the present invention.
Claims (2)
1. for a preparation for the prevention of dental caries, it is characterized in that: comprise epsilon-polylysine, food additives and water, wherein the mass percent of epsilon-polylysine is 0.3%-2%.
2., according to the preparation for the prevention of dental caries described in claim 1, it is characterized in that: described food additives comprise in sorbierite, glycine, citric acid, malic acid, starch, Aspartame, flavoring essence one or several.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410633976.2A CN104305203A (en) | 2014-11-12 | 2014-11-12 | Preparation for preventing decayed teeth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410633976.2A CN104305203A (en) | 2014-11-12 | 2014-11-12 | Preparation for preventing decayed teeth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104305203A true CN104305203A (en) | 2015-01-28 |
Family
ID=52360638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410633976.2A Pending CN104305203A (en) | 2014-11-12 | 2014-11-12 | Preparation for preventing decayed teeth |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104305203A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620891A (en) * | 2016-11-25 | 2017-05-10 | 北京刷新活力健康科技有限公司 | A bioactive mineral powder intertooth healthcare floss brush and applications thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05310544A (en) * | 1992-05-14 | 1993-11-22 | Chisso Corp | Antidental carious and antiperiodontotic agent |
| JP2004107309A (en) * | 2002-09-13 | 2004-04-08 | Lion Corp | Composition for oral cavity |
| JP2004123630A (en) * | 2002-10-03 | 2004-04-22 | Chisso Corp | Cariostatic and antiperiodontic composition |
| WO2006117029A1 (en) * | 2005-04-29 | 2006-11-09 | Lucas Huybrechts | Use of polylysine in combination with either green tea or olive extracts or both for use against halitosis |
| CN103974688A (en) * | 2011-12-15 | 2014-08-06 | 高露洁-棕榄公司 | Oral care compositions |
-
2014
- 2014-11-12 CN CN201410633976.2A patent/CN104305203A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05310544A (en) * | 1992-05-14 | 1993-11-22 | Chisso Corp | Antidental carious and antiperiodontotic agent |
| JP2004107309A (en) * | 2002-09-13 | 2004-04-08 | Lion Corp | Composition for oral cavity |
| JP2004123630A (en) * | 2002-10-03 | 2004-04-22 | Chisso Corp | Cariostatic and antiperiodontic composition |
| WO2006117029A1 (en) * | 2005-04-29 | 2006-11-09 | Lucas Huybrechts | Use of polylysine in combination with either green tea or olive extracts or both for use against halitosis |
| CN103974688A (en) * | 2011-12-15 | 2014-08-06 | 高露洁-棕榄公司 | Oral care compositions |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620891A (en) * | 2016-11-25 | 2017-05-10 | 北京刷新活力健康科技有限公司 | A bioactive mineral powder intertooth healthcare floss brush and applications thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105685342A (en) | Probiotic buccal tablet and preparation method thereof | |
| KR101467316B1 (en) | Oral cleansing composition fermented taraxacum extract-containing complex herbal extract | |
| CN105410365B (en) | A kind of feed addictive of alternative antibiotic and its application | |
| KR101773249B1 (en) | The manufacturing method of Herbal Food Products from the Leaves and Berries of Korean Cudrania tricuspidata | |
| JP2006333842A (en) | Compounding agent for fodder | |
| US20030108627A1 (en) | Cranberry based dietary supplement and dental hygiene product | |
| CN106509855A (en) | Edible fungus sugar-free nutrition powder and preparation method thereof | |
| CN110140773A (en) | A kind of probiotics solid beverage, preparation method and applications | |
| CN105639655A (en) | Health care product capable of promoting proliferation of intestinal bifidobacteria and application | |
| CN1969681A (en) | Buccal tablet prepared by fruits and royal jelly and production process thereof | |
| JP2011125323A (en) | Method for producing functional antioxidation tea | |
| CN112889924A (en) | Milk tablet for preventing dental caries and its preparation method | |
| CN105640828A (en) | Application of durian shell extract in oral care products | |
| KR101472190B1 (en) | Composition for preventing, treating or improving constipation comprising plant originated tyndalized lactic acid bacteria, Lactobacillus plantarum PMO08 dead cell as an active ingredient | |
| CN105832614B (en) | A kind of edible natural children's toothpaste and preparation method | |
| CN104305203A (en) | Preparation for preventing decayed teeth | |
| JP2014187949A (en) | Fermented fig product and beverage blended therewith | |
| CN104146312B (en) | The health products of regulating gastointestinal function | |
| CN102907676A (en) | Preparation method of sea-buckthorn chewable tablet | |
| CN105767419A (en) | Production method of caries-prevention candies | |
| CN103892028B (en) | Chewing gum capable of resisting oral helicobacter pylori, and preparation method thereof | |
| CN102783551A (en) | Chewing gum and preparation method thereof | |
| KR101902313B1 (en) | Composition of baby food and nourishing food for pet | |
| CN104012848A (en) | Mantis shrimp healthcare freshness-retaining rice cake and preparation method thereof | |
| JP2019041661A (en) | Health food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150128 |