CN105639655A - Health care product capable of promoting proliferation of intestinal bifidobacteria and application - Google Patents
Health care product capable of promoting proliferation of intestinal bifidobacteria and application Download PDFInfo
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- CN105639655A CN105639655A CN201610109344.5A CN201610109344A CN105639655A CN 105639655 A CN105639655 A CN 105639655A CN 201610109344 A CN201610109344 A CN 201610109344A CN 105639655 A CN105639655 A CN 105639655A
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- propagation
- intestinal bifidobacteria
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- intestinal
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- 230000000968 intestinal effect Effects 0.000 title claims abstract description 88
- 241000186000 Bifidobacterium Species 0.000 title claims abstract description 74
- 230000036541 health Effects 0.000 title claims abstract description 52
- 230000001737 promoting effect Effects 0.000 title claims abstract description 27
- 230000035755 proliferation Effects 0.000 title abstract 4
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 28
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 28
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 24
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 24
- 239000000945 filler Substances 0.000 claims abstract description 15
- 229940046011 buccal tablet Drugs 0.000 claims description 34
- 239000006189 buccal tablet Substances 0.000 claims description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 14
- 241000196324 Embryophyta Species 0.000 claims description 14
- 230000002378 acidificating effect Effects 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 14
- 235000013355 food flavoring agent Nutrition 0.000 claims description 14
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 12
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 12
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 12
- 229940013618 stevioside Drugs 0.000 claims description 12
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- 239000003795 chemical substances by application Substances 0.000 claims description 10
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- 238000000748 compression moulding Methods 0.000 claims description 7
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 6
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- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 6
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- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 6
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- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims description 4
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 229930014669 anthocyanidin Natural products 0.000 claims description 4
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 4
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- 235000013361 beverage Nutrition 0.000 claims description 4
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 4
- 235000020357 syrup Nutrition 0.000 claims description 4
- 239000006188 syrup Substances 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000007938 effervescent tablet Substances 0.000 claims description 2
- 239000007941 film coated tablet Substances 0.000 claims description 2
- 235000013373 food additive Nutrition 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007902 hard capsule Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 8
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 6
- 239000004310 lactic acid Substances 0.000 abstract description 4
- 235000014655 lactic acid Nutrition 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 150000004666 short chain fatty acids Chemical class 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 21
- 210000003608 fece Anatomy 0.000 description 10
- 230000000813 microbial effect Effects 0.000 description 10
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 6
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- 238000010521 absorption reaction Methods 0.000 description 5
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- 231100000252 nontoxic Toxicity 0.000 description 5
- 230000003000 nontoxic effect Effects 0.000 description 5
- 239000006041 probiotic Substances 0.000 description 4
- 230000000529 probiotic effect Effects 0.000 description 4
- 235000018291 probiotics Nutrition 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
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- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Abstract
The invention belongs to the technical field of biological food and health care products and particularly relates to a health care product capable of promoting proliferation of intestinal bifidobacteria and an application. The health care product capable of promoting proliferation of the intestinal bifidobacteria comprises following components: 30%-60% of oligosaccharide, 0.4%-7.5% of a sweetener, 1.5%-2.5% of an acidulant, 10%-30% of plant polyphenol and the balance of filler. The health care product contains the oligosaccharide and the plant polyphenol, and after the health care product is taken by a human body, the plant polyphenol has an antioxidation function and can react with a large amount of hydrogen peroxide produced by lactic acid bacteria, so that bifidobacterium growth is protected directly; further, the plant polyphenol can inhibit a large quantity of harmful intestinal bacteria and has the function of regulating intestinal flora; besides, the intestinal pH value is reduced through short-chain fatty acid produced by bifidobacterium fermenting oligosaccharide, not only is bifidobacterium proliferation obtained, but also harmful bacteria are inhibited. The health care product can be used for preparing lozenges or capsules.
Description
Technical field
The invention belongs to biological food health product technology field, be specifically related to a kind of health product promoting intestinal bifidobacteria to breed and application.
Background technology
Bacillus bifidus is acknowledged as human body intestinal canal probiotic bacteria, it is possible to promote that human body intestinal canal is healthy. There are a large amount of probiotic bacteria and prebiotics product on the market at present, including various oligosaccharides and probiotic bacteria beverage etc. We are found by In vivo study laboratory early stage, and the facilitation of intestinal bifidobacteria is not had continuous action by oligosaccharide such as oligofructose and oligomeric xylose, and the facilitation of bacillus bifidus is also not as notable by some oligosaccharide; And probiotic bacteria beverage processes through gastric juice after human body is taken in, the viable count entering intestinal leaves a question open. Therefore, all there is each different shortcomings in existing product.
Summary of the invention
In order to overcome shortcoming and the deficiency of prior art, the primary and foremost purpose of the present invention is in that to provide a kind of health product promoting intestinal bifidobacteria to breed.
It is still another object of the present invention to provide the application of the health product of above-mentioned promotion intestinal bifidobacteria propagation.
The goal of the invention of the present invention is achieved through the following technical solutions:
A kind of health product promoting intestinal bifidobacteria to breed, comprise following composition by mass percentage:
Described oligosaccharide is at least one in oligofructose, oligomeric xylose, oligomeric isomaltose, soybean oligo saccharide and oligomeric galactose, however not excluded that other oligosaccharide and combination thereof;
Described sweeting agent is at least one in stevioside, sucrose and maltose syrup, it is preferred to stevioside, however not excluded that other sweeting agent and combination thereof;
Described acidic flavoring agent is at least one in citric acid, malic acid and phosphoric acid, it is preferred to citric acid, however not excluded that other acidic flavoring agent and combination thereof;
Described plant polyphenol is at least one in Quercetin, tea polyphenols, catechin and anthocyanidin, it is preferred to Quercetin or catechin, however not excluded that other polyphenol and combination thereof;
Described filler is preferably microcrystalline Cellulose, but is not excluded for other filler or its combination;
The preparation method of the described health product promoting intestinal bifidobacteria propagation, comprises the steps of:
Each component mixing of the health product bred by above-mentioned promotion intestinal bifidobacteria, is promoted the health product of intestinal bifidobacteria propagation;
The described health product promoting intestinal bifidobacteria propagation promote the application in intestinal bifidobacteria propagation product in preparation;
Described product is preferably liquid beverage, granule, soft capsule, hard capsule, effervescent tablet, buccal tablet, Film coated tablets;
The described health product promoting intestinal bifidobacteria propagation also can make an addition to as food additive in milk powder or other food and use;
A kind of buccal tablet promoting intestinal bifidobacteria to breed, comprises the health product of above-mentioned promotion intestinal bifidobacteria propagation;
The preparation method of a kind of buccal tablet promoting intestinal bifidobacteria to breed, comprises the steps of
The component botanical polyphenol of health product, oligosaccharide, acidic flavoring agent and the filler that above-mentioned promotion intestinal bifidobacteria is bred, mixed compression molding, is promoted the buccal tablet of intestinal bifidobacteria propagation successively;
The described buccal tablet promoting intestinal bifidobacteria propagation is preferably 1g/ sheet;
The buccal tablet of described promotion intestinal bifidobacteria propagation can store and transport by room temperature; And can according to using method difference select canned, flexible plastic is packed or plastic bottle;
The described eating method containing the buccal tablet promoting intestinal bifidobacteria propagation: daily intake 6��8 for benefit;
Effect mechanism of the health product of promotion intestinal bifidobacteria of the present invention propagation is: oligosaccharide can promote the growth of bacillus bifidus and lactic acid bacteria at human body intestinal canal, but when taking in for a long time, lactic acid bacteria produces again a large amount of hydrogen peroxide, causes that the growth of bacillus bifidus is suppressed. Plant polyphenol has antioxidation, can react with a large amount of hydrogen peroxide that lactic acid bacteria produces, thus the indirect protection growth of bacillus bifidus; Secondly, plant polyphenol can suppress a large amount of harmful intestinal tract bacteria, has the function of regulating intestinal canal flora; 3rd, the short-chain fatty acid that bifidobacterium fermentation oligosaccharide produces reduces gut pH, acquisition propagation of not only controlling oneself, and inhibits the growth of noxious bacteria. Therefore, these health product or buccal tablet have the effect promoting intestinal bifidobacteria.
The present invention has such advantages as relative to prior art and effect:
(1) many oligosaccharide are in the news and have the effect promoting beneficial bacteria of intestinal tract, but major part all exists the long-term shortcoming taking in poor effect. After these health product or buccal tablet are taken in, the content that the content ratio of bacillus bifidus only takes in oligosaccharide is high at least one times; And can ensure that intestinal bifidobacteria is in higher level distribution for a long time.
(2) promote intestinal bifidobacteria propagation health product or buccal tablet in plant polyphenol, also there is plurality of health care functions in vivo simultaneously, also make product health-care effect variation, be different from the product only based on oligosaccharide.
(3) health product of promotion intestinal bifidobacteria of the present invention propagation or the preparation method of buccal tablet are simple, and processing cost is relatively low, but added value is high.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
(1) promote the preparation of the health product of intestinal bifidobacteria propagation: take the oligosaccharide (oligofructose) of mass percent 30%, the sweeting agent stevioside of mass percent 0.4%, the acidic flavoring agent citric acid of mass percent 1.5%, the plant polyphenol Quercetin of mass percent 30% and the filler microcrystalline Cellulose of 38.1% and mix successively, be promoted the health product of intestinal bifidobacteria propagation;
(2) preparation of the buccal tablet of intestinal bifidobacteria propagation is promoted: health product compression molding step (1) prepared, bottling, it is promoted the buccal tablet of intestinal bifidobacteria propagation;Wherein, the summation of oligosaccharide, sweeting agent, acidic flavoring agent, plant polyphenol and filler is mass percent 100%, and every weight is 1g;
(3) efficacy detection: be divided into A/B/C tri-groups to carry out double blind experiment for object with 30 male volunteers of 25��30 years old, often group 10. Wherein, A group is taken in glucose 0.6g, B group and is taken in the buccal tablet 2 that the present embodiment prepares, and C group takes in oligofructose 0.6g, daily intakes three times. It is consecutively ingested 30 days, and the feces of absorption person was collected in the 15th day and the 30th day, carrying out quantitatively to the bacillus bifidus in feces and total bacterium, result display A, B and C group accounts for the 8.5% of total intestinal microbial population, 26.8% and 15.9% respectively at the content of the bacillus bifidus of the 15th day; The bacillus bifidus of the 30th day account for the 9.1% of total intestinal microbial population, 26.4% and 13.4% respectively.
The buccal tablet Nantural non-toxic promoting intestinal bifidobacteria propagation prepared by the present embodiment, and has several functions: such as fat-reducing, blood pressure lowering, antioxidation and anti-ageing wait for a long time.
Embodiment 2
(1) promote the preparation of health product of intestinal bifidobacteria propagation: take the oligomeric xylose of mass percent 40%, the stevioside of mass percent 0.10% and 7.4% sucrose, mass percent 2.5% acidic flavoring agent (citric acid and malic acid etc. quality mixture), the catechin of mass percent 16%, mass percent 34% filler microcrystalline Cellulose mix successively, be promoted intestinal bifidobacteria propagation health product;
(2) promote the preparation of the buccal tablet of intestinal bifidobacteria propagation: health product compression molding step (1) prepared, be promoted the buccal tablet of intestinal bifidobacteria propagation; Wherein, the summation of oligosaccharide, sweeting agent, acidic flavoring agent, plant polyphenol and filler is mass percent 100%, and every weight is 1g;
(2) efficacy detection: be divided into A/B/C tri-groups to carry out double blind experiment for object with 30 male volunteers of 25��30 years old, often group 10. Wherein, A group is taken in glucose 0.94g, B group and is taken in the buccal tablet 2 that the present embodiment prepares, and C group takes in oligomeric xylose 0.94g, daily intakes three times. It is consecutively ingested 30 days, and the feces of absorption person was collected in the 15th day and the 30th day, carrying out quantitatively to the bacillus bifidus in feces and total bacterium, result display A, B and C group accounts for the 7.8% of total intestinal microbial population, 27.1% and 16.6% respectively at the content of the bacillus bifidus of the 15th day; The bacillus bifidus of the 30th day account for the 8.3% of total intestinal microbial population, 26.5% and 12.9% respectively.
The buccal tablet Nantural non-toxic promoting intestinal bifidobacteria propagation prepared by the present embodiment, and has several functions: such as fat-reducing, blood pressure lowering, antioxidation and anti-ageing wait for a long time.
Embodiment 3
(1) promote the preparation of health product of intestinal bifidobacteria propagation: take the oligosaccharide (oligofructose and oligomeric isomaltose etc. quality mixture) of mass percent 50%, the stevioside of mass percent 0.35% and 4% sucrose, the acidic flavoring agent (citric acid and malic acid etc. quality mixture) of mass percent 2.5%, the plant polyphenol (catechin and tea polyphenols etc. quality mixture) of mass percent 20% and the filler microcrystalline Cellulose of mass percent 23.15% mix successively, be promoted the health product that intestinal bifidobacteria is bred;
(2) promote the preparation of the buccal tablet of intestinal bifidobacteria propagation: health product compression molding step (1) prepared, be promoted the buccal tablet of intestinal bifidobacteria propagation; Wherein, the summation of oligosaccharide, sweeting agent, acidic flavoring agent, plant polyphenol and filler is mass percent 100%, and every tablet quality is 1g;
(3) efficacy detection: be divided into A/B/C tri-groups to carry out double blind experiment for object with 30 male volunteers of 25��30 years old, often group 10. Wherein, A group is taken in glucose 1.62g, B group and is taken in the buccal tablet 3 that the present embodiment prepares, C group takes in oligosaccharide and sweeting agent mixture (oligofructose and each 0.75g of oligomeric isomaltose of and equivalent identical with B group, stevioside 0.0105g, sucrose 0.12g), daily intake three times. It is consecutively ingested 30 days, and the feces of absorption person was collected in the 15th day and the 30th day, carrying out quantitatively to the bacillus bifidus in feces and total bacterium, result display A, B and C group accounts for the 9.1% of total intestinal microbial population, 26.6% and 15.2% respectively at the content of the bacillus bifidus of the 15th day; The bacillus bifidus of the 30th day account for the 8.8% of total intestinal microbial population, 26.9% and 13.7% respectively.
The tablet Nantural non-toxic promoting intestinal bifidobacteria propagation prepared by the present embodiment, and has several functions: such as fat-reducing, blood pressure lowering, antioxidation and anti-ageing wait for a long time.
Embodiment 4
(1) promote the preparation of health product of intestinal bifidobacteria propagation: take the oligosaccharide (the equivalent mixture of oligofructose and oligomeric xylose) of mass percent 30%, the stevioside of mass percent 0.35% and 5% sucrose, the malic acid of mass percent 1.8%, the plant polyphenol (the equivalent mixture of catechin, Quercetin and anthocyanidin) of mass percent 30%, mass percent be 32.85% filler microcrystalline Cellulose mix successively, be promoted the health product of intestinal bifidobacteria propagation;
(2) promote the preparation of the buccal tablet of intestinal bifidobacteria propagation: health product compression molding step (1) prepared, be promoted the buccal tablet of intestinal bifidobacteria propagation; Wherein, the summation of oligosaccharide, sweeting agent, acidic flavoring agent, plant polyphenol and filler is mass percent 100%, and every weight is 1g;
(2) efficacy detection: be divided into A/B/C tri-groups to carry out double blind experiment for object with 30 male volunteers of 25��30 years old, often group 10. Wherein, A group takes in glucose 0.7g, B group takes in the buccal tablet 2 that the present embodiment prepares, C group takes in the oligosaccharide mixture of and equivalent identical with B group and stevioside and sucrose mixture (oligofructose and each 0.3g of oligomeric xylose, stevioside 0.007g, sucrose 0.1g), daily intake three times. It is consecutively ingested 30 days, and the feces of absorption person was collected in the 15th day and the 30th day, carrying out quantitatively to the bacillus bifidus in feces and total bacterium, result display A, B and C group accounts for the 7.3% of total intestinal microbial population, 26.5% and 17.2% respectively at the content of the bacillus bifidus of the 15th day; The bacillus bifidus of the 30th day account for the 7.2% of total intestinal microbial population, 27.4% and 14.8% respectively.
The buccal tablet Nantural non-toxic promoting intestinal bifidobacteria propagation prepared by the present embodiment, and has several functions: such as fat-reducing, blood pressure lowering, antioxidation and anti-ageing wait for a long time.
Embodiment 5
(1) promote the preparation of health product of intestinal bifidobacteria propagation: take the oligofructose of mass percent 40%, the stevioside of mass percent 0.6% and 1% maltose syrup, the acidic flavoring agent (citric acid and malic acid etc. quality mixture) of mass percent 2.5%, mass percent 18% plant polyphenol (Quercetin and anthocyanidin etc. quality mixture) and the filler microcrystalline Cellulose that mass percent is 37.9% mix successively, be promoted the health product of intestinal bifidobacteria propagation;
(2) promote the preparation of the buccal tablet of intestinal bifidobacteria propagation: health product compression molding step (1) prepared, be promoted the buccal tablet of intestinal bifidobacteria propagation;Wherein, oligosaccharide, sweeting agent, acidic flavoring agent, plant polyphenol and filler summation are mass percent 100%, and every tablet quality is 1g;
(2) efficacy detection: be divided into A/B/C tri-groups to carry out double blind experiment for object with 30 male volunteers of 25��30 years old, often group 10. Wherein, A group is taken in glucose 0.83g, B group and is taken in the buccal tablet 2 that the present embodiment prepares, C group takes in the low fructose of and equivalent identical with B group and sweet taste inulin and malt syrup mixture (oligofructose 0.8g, stevioside 0.012g, maltose syrup 0.02g), daily intake three times. It is consecutively ingested 30 days, and the feces of absorption person was collected in the 15th day and the 30th day, carrying out quantitatively to the bacillus bifidus in feces and total bacterium, result display A, B and C group accounts for the 6.9% of total intestinal microbial population, 24.8% and 15.5% respectively at the content of the bacillus bifidus of the 15th day; The bacillus bifidus of the 30th day account for the 7.5% of total intestinal microbial population, 26.7% and 14.5% respectively.
The buccal tablet Nantural non-toxic promoting intestinal bifidobacteria propagation prepared by the present embodiment, and has several functions: such as fat-reducing, blood pressure lowering, antioxidation and anti-ageing wait for a long time.
Above-described embodiment is the present invention preferably embodiment; but embodiments of the present invention are also not restricted to the described embodiments; the change made under other any spirit without departing from the present invention and principle, modification, replacement, combination, simplification; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1. the health product promoting intestinal bifidobacteria to breed, it is characterised in that comprise following composition by mass percentage:
2. the health product of promotion intestinal bifidobacteria according to claim 1 propagation, it is characterised in that:
Described oligosaccharide is at least one in oligofructose, oligomeric xylose, oligomeric isomaltose, soybean oligo saccharide and oligomeric galactose.
3. the health product of promotion intestinal bifidobacteria according to claim 1 propagation, it is characterised in that:
Described sweeting agent is at least one in stevioside, sucrose and maltose syrup.
4. the health product of promotion intestinal bifidobacteria according to claim 1 propagation, it is characterised in that:
Described acidic flavoring agent is at least one in citric acid, malic acid and phosphoric acid.
5. the health product of promotion intestinal bifidobacteria according to claim 1 propagation, it is characterised in that:
Described plant polyphenol is at least one in Quercetin, tea polyphenols, catechin and anthocyanidin.
6. the health product promoting intestinal bifidobacteria propagation described in any one of Claims 1 to 5 promote the application in intestinal bifidobacteria propagation product in preparation.
7. the health product of promotion intestinal bifidobacteria according to claim 6 propagation promote the application in intestinal bifidobacteria propagation product in preparation, it is characterised in that:
Described product is liquid beverage, granule, soft capsule, hard capsule, effervescent tablet, buccal tablet or Film coated tablets.
8. the health product of promotion intestinal bifidobacteria according to claim 6 propagation promote the application in intestinal bifidobacteria propagation product in preparation, it is characterised in that:
The described health product promoting intestinal bifidobacteria propagation make an addition in milk powder as food additive.
9. the buccal tablet promoting intestinal bifidobacteria to breed, it is characterised in that: comprise the health product promoting intestinal bifidobacteria propagation described in any one of Claims 1 to 5.
10. the preparation method of the buccal tablet promoting intestinal bifidobacteria propagation described in claim 9, it is characterised in that comprise the steps of
By the component botanical polyphenol of health product of promotion intestinal bifidobacteria propagation described in any one of Claims 1 to 5, oligosaccharide, acidic flavoring agent and filler, mixed compression molding, is promoted the buccal tablet of intestinal bifidobacteria propagation successively.
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