CN104288376A - 一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 - Google Patents
一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN104288376A CN104288376A CN201410563724.7A CN201410563724A CN104288376A CN 104288376 A CN104288376 A CN 104288376A CN 201410563724 A CN201410563724 A CN 201410563724A CN 104288376 A CN104288376 A CN 104288376A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- traditional chinese
- leptospirosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 56
- 241000772415 Neovison vison Species 0.000 title claims abstract description 25
- 206010024238 Leptospirosis Diseases 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 25
- 239000000706 filtrate Substances 0.000 claims abstract description 18
- 239000000047 product Substances 0.000 claims abstract description 16
- 239000008187 granular material Substances 0.000 claims abstract description 13
- 239000000454 talc Substances 0.000 claims abstract description 13
- 229910052623 talc Inorganic materials 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 229920002472 Starch Polymers 0.000 claims abstract description 9
- 239000011812 mixed powder Substances 0.000 claims abstract description 9
- 235000019698 starch Nutrition 0.000 claims abstract description 9
- 239000008107 starch Substances 0.000 claims abstract description 9
- 241000222640 Polyporus Species 0.000 claims description 13
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 13
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 claims description 13
- 210000000582 semen Anatomy 0.000 claims description 12
- 235000012222 talc Nutrition 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims 1
- 208000004880 Polyuria Diseases 0.000 abstract description 13
- 230000001737 promoting effect Effects 0.000 abstract description 13
- 230000035619 diuresis Effects 0.000 abstract description 12
- 206010023126 Jaundice Diseases 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 230000001939 inductive effect Effects 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 3
- 238000005303 weighing Methods 0.000 abstract 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 abstract 1
- 244000144730 Amygdalus persica Species 0.000 abstract 1
- 235000003097 Artemisia absinthium Nutrition 0.000 abstract 1
- 240000001851 Artemisia dracunculus Species 0.000 abstract 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 abstract 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000222684 Grifola Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 239000001138 artemisia absinthium Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000021552 granulated sugar Nutrition 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000010446 mirabilite Substances 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 206010010774 Constipation Diseases 0.000 description 5
- 241001508687 Mustela erminea Species 0.000 description 5
- 210000000232 gallbladder Anatomy 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 201000003126 Anuria Diseases 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000589902 Leptospira Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010030302 Oliguria Diseases 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 239000011280 coal tar Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 210000000795 conjunctiva Anatomy 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000003640 drug residue Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009313 farming Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001215120 Leptospirales Species 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 201000001505 hemoglobinuria Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000010726 hind limb paralysis Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 210000000244 kidney pelvis Anatomy 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗水貂钩端螺旋体病的中药组合物，由茵陈、栀子、大黄、甘草、桃仁、芒硝、猪苓、茯苓、滑石、泽泻制备而成。该中药组合物可以是颗粒剂，其制备步骤是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。本发明所提供的中药组合物可有效治疗水貂钩端螺旋体病，治愈率95％以上。本组方具有清热利湿，利胆退黄，利尿通淋的功效。
Description
技术领域
本发明属于中兽药制剂领域，尤其是一种治疗水貂钩端螺旋体病的中药组合物及其制备方法。
背景技术
钩端螺旋体病是由各种致病性钩端螺旋体引起的人兽共患的一种急性传染病，在世界各地均有发生。各种年龄动物均易感，其中以幼龄动物最易感，发病率和死亡率也最高。本病一年四季均有发生，但以夏秋季节高发。传播方式多种多样，经消化道感染是主要的感染途径。由于本病病原最终定位于肾脏，所以尿液在本病的蔓延扩散上有重要作用。如尿液接触破伤的皮肤和黏膜就可以感染，如尿液污染了饲料和水源也能造成本病的传播。钩端螺旋体经消化道或外伤进入机体，通过血液侵入器官组织内繁殖，主要在肝脏积聚和肾脏定位。菌体进入血液、组织，并在其中繁殖，形成菌血症。钩端螺旋体的代谢产物引起动物体温升高，血糖降低，红细胞被破坏崩解等病理过程，临床表现为发烧、体温升高、贫血、黄疸等。病原体在肝脏增殖，引起肝细胞变性坏死，导致胆红素蓄积，发生黄疸。在肾脏定位增殖造成肾脏细胞变性坏死，出血，出现血红蛋白尿。急性型表现为体温升高，采食减少，精神沉郁，粪便由病初的黄色逐渐变为淡绿色，最后呈煤焦油状。可视黏膜黄染，严重者皮肤也呈黄色。一般在停止采食后1-2天死亡。慢性型表现为食欲减退，喝水猛增，可视粘膜充血，淤血，并有出血斑。肾功能障碍者出现少尿、无尿或尿液粘稠呈黄色，亦可出现血尿，表现尿毒症症状。本病给水貂养殖业带来了巨大的经济损失。
现代兽医主要采用抗生素药物进行预防和治疗，如：青霉素、链霉素、强力霉素和阿莫西林。但不可避免的会产生药物残留。随着国际上对抗生素药物的控制标准越来越严格，选择纯天然的绿色中药替代抗生素药物，成为新的发展方向。
发明内容
本发明要解决的问题是：克服现有技术的不足，提供一种疗效好、无药残、安全可靠的中药组合物。
本发明要解决的另一技术问题是：提供一种治疗水貂钩端螺旋体病的中药配方。
本发明要解决的另一技术问题是：提供上述中药组合物的颗粒剂的制备方法。
为解决上述技术问题，本发明采用的技术方案是：一种治疗水貂钩端螺旋体病的中药组合物，其特征在于：由如下质量份数的原料制备而成：茵陈10～20份、栀子10～20份、大黄5～15份、甘草5～10份、桃仁5～15份、芒硝5～15份、猪苓5～20份、茯苓5～15份、滑石5～10份、泽泻5～10份。
进一步地，该中药组合物的最佳原料的质量份数如下：
茵陈15份、栀子15份、大黄10份、甘草5份、桃仁10份、芒硝5份、猪苓15份、茯苓10份、滑石10份、泽泻5份。
进一步地，该中药组合物是含有或不含有药用辅料的各种常规中药口服药物制剂形式。
进一步地，所述制剂可以是颗粒剂。
进一步地，该组合物的颗粒剂的制备方法是：
(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
本发明具有的优点和积极效果是：
(1)本发明针对抗生素药物残留问题，发明了一种纯天然、无污染、无残留的绿色中兽药。本组方依据中药理论，选用清热利湿，利胆退黄的药物进行配伍，并采用简便易行的制备方法得到一种稳定的中药颗粒剂。将本发明所制得的产品用于临床试验，对水貂钩端螺旋体病的治愈率达到95％以上，其疗效明显优于抗生素治疗方案，值得推广。
(2)本发明各中药原料的药理是：
茵陈：清利湿热，利胆退黄。
栀子：泻火除烦，清热利湿，凉血解毒。
大黄：泻下攻积，清热泻火，凉血解毒。
甘草：补脾益气，祛痰止咳，清热解毒，调和诸药。
桃仁：活血祛瘀，润肠通便，止咳平喘。
芒硝：泻下攻积，润燥软坚，清热消肿。
猪苓：利水渗湿。
茯苓：利水渗湿，健脾，宁心。
滑石：利尿通淋，清热解暑，收湿敛疮。
泽泻：利水渗湿。
依据中医观点，钩端螺旋体病，即传染性黄疸病属湿热黄疸。配方之中，茵陈苦泄下降，性寒清热，善清利脾胃肝胆湿热，使之从小便而出，为治黄疸之要药。栀子亦有清利下焦湿热之功效，可用治肝胆湿热郁结之黄疸。大黄能泻下通便，导湿热外出，故可治湿热蕴结之症。钩端螺旋体病的另一症状为喝水增加但却尿少、无尿。茯苓、猪苓、泽泻同为利水渗湿之药，茯苓味甘而淡，甘则能补，淡则能渗，药性平和，即可祛邪，又可扶正，利水而不伤正气，猪苓、泽泻甘淡渗泄，利水作用较强，滑石利尿通淋，四者合用，治疗水热互结，小便不利。桃仁富含油脂，能润燥滑肠，治疗肠燥便秘证。芒硝能泻下攻积，且性寒能清热，味咸润燥软坚，对湿热积滞，大便燥结者尤为适宜。芒硝与大黄相须为用，可增强泻下通便作用。甘草调和诸药，可解毒，亦可缓解大黄对肠胃的刺激，还可矫正方中药物滋味。诸药合用，既可清热利湿，利胆退黄，又可利水渗湿，润燥通便。
具体实施方式
下面通过具体实施例对本发明作进一步详述，以下实施例只是描述性的，不是限定性的，不能以此限定本发明的保护范围。
实施例1
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈15份、栀子15份、大黄10份、甘草5份、桃仁10份、芒硝5份、猪苓15份、茯苓10份、滑石10份、泽泻5份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
实施例2
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈20份、栀子10份、大黄5份、甘草10份、桃仁10份、芒硝5份、猪苓10份、茯苓15份、滑石5份、泽泻10份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
实施例3
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈10份、栀子20份、大黄15份、甘草5份、桃仁15份、芒硝5份、猪苓8份、茯苓7份、滑石8份、泽泻7份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
实施例4
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈20份、栀子10份、大黄5份、甘草10份、桃仁15份、芒硝15份、猪苓5份、茯苓10份、滑石5份、泽泻5份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
实施例5
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈15份、栀子10份、大黄10份、甘草5份、桃仁5份、芒硝5份、猪苓20份、茯苓10份、滑石10份、泽泻10份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
实施例6
一种治疗水貂钩端螺旋体病的中药颗粒剂，各原料的重量份数如下：茵陈10份、栀子10份、大黄13份、甘草8份、桃仁7份、芒硝7份、猪苓15份、茯苓15份、滑石7份、泽泻8份。其制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
临床试验
实验1：
山东省某水貂养殖场10月龄左右的水貂陆续发病，出现粪便黄稀下痢,重者如煤焦油样,粘膜贫血、饮水迅猛,食欲减退、精神沉郁、眼部疾患、后肢瘫痪，脉搏增快。初步怀疑为钩端螺旋体病。经实验室病原检查确定为钩端螺旋体引起。遂将已发病的病貂隔离，并分组进行治疗。其中一组30头给予实施例1所制得的产品，每5g产品兑水1L，给病貂自由饮用，连续用药5d后，与治疗前相比，病貂精神恢复，烦渴多饮症状缓解，粪便成形颜色正常，基本康复，治愈率达到96.3％。另一组28头肌肉注射青霉素，每日2次，连续注射5天，大群治愈，治愈率88.2％。还有一组28头肌肉注射链霉素，每日2次，连续注射5天，大群治愈，治愈率86.4％。其他试验结果见表1。
实验2：
重庆某水貂养殖场从外地购入45日龄左右的水貂50只。饲养至第3日部分水貂发病，至第5日全群均有不同程度感染。病貂最初精神不振,不喜活动,体温升高,食欲不振,但尚有饮欲,排尿呈黄红色；严重者神志低落,目滞耳耸,食欲降低甚至废绝,粪便时有溏稀,眼结膜潮红,耳部皮肤渐有褐色痂块。对3只急性死亡病例进行剖检，均见皮肤、眼结膜等呈不同程度的黄染,下颌、头部轻度水肿,胸腹腔内有少量淡黄色积液,肝脏肿大呈黄褐色,肾脏稍肿,肾盂肾盏结构模糊不清,胃壁和肠系膜有小点出血,其中2只膀胱内积有少量尿液,色较黄。经临床和剖检诊断为钩端螺旋体病。遂给予全群实施例1所制得产品。每5g颗粒剂兑水1L，让病貂自由饮用，连续饮用7天，病情基本得到控制，各项指征恢复正常。
表1不同药物对水貂钩端螺旋体病的治疗效果比较
| 组别 | 样本数量(只) | 治疗时间 | 治愈率 | 死亡率 |
| 实施例1产品 | 30 | 5d | 96.3％ | 无 |
| 青霉素 | 28 | 5d | 88.2％ | 3.6％ |
| 链霉素 | 28 | 5d | 86.4％ | 7.1％ |
实验证明实施例1所制得产品疗效显著，明显优于抗生素药物，且具有统计学差异，P＞0.05。
以上所述，仅为本发明的较佳实例，是说明性的而不是限定性的，可按照所限定的范围列举出若干个实施例，因此在不脱离本发明总体构思下的变化和修改，应属本发明的保护范围之内。
Claims (4)
1.一种治疗水貂钩端螺旋体病的中药组合物，其特征在于：由如下质量份数的原料制备而成：茵陈10～20份、栀子10～20份、大黄5～15份、甘草5～10份、桃仁5～15份、芒硝5～15份、猪苓5～20份、茯苓5～15份、滑石5～10份、泽泻5～10份。
2.根据权利要求1所述的治疗水貂钩端螺旋体病的中药组合物，其特征在于：最佳原料的质量份数如下：
茵陈15份、栀子15份、大黄10份、甘草5份、桃仁10份、芒硝5份、猪苓15份、茯苓10份、滑石10份、泽泻5份。
3.根据权利要求1所述的治疗水貂钩端螺旋体病的中药组合物，其特征在于：所述制剂可以是颗粒剂。
4.一种制备如权利要求3所述的治疗水貂钩端螺旋体病的中药组合物的方法，其特征在于，制备方法是：(1)将中药粉碎至60目，按配方量称取，三维混合得中药粉；(2)加水煮2次，每次煮30min，过滤，合并两次滤液。将滤液浓缩至原体积的10％～20％，得浓缩浸膏；(3)称取元明粉30份，白砂糖20份，淀粉40份，混合三粉；(4)将浓缩浸膏10份分3次均匀加入混合粉中。一边搅拌一边加入，搅拌时间为10-15min；(5)压粒，60-80℃烘干即得成品。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410563724.7A CN104288376A (zh) | 2014-10-22 | 2014-10-22 | 一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410563724.7A CN104288376A (zh) | 2014-10-22 | 2014-10-22 | 一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104288376A true CN104288376A (zh) | 2015-01-21 |
Family
ID=52308487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410563724.7A Pending CN104288376A (zh) | 2014-10-22 | 2014-10-22 | 一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288376A (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706442A (zh) * | 2005-05-30 | 2005-12-14 | 许建文 | 治疗黄疸性疾病的药物和含有该药物的口服液的制备方法 |
| CN103083454A (zh) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | 一种用于治疗犬钩端螺旋体病的中药组合物及其制备方法 |
-
2014
- 2014-10-22 CN CN201410563724.7A patent/CN104288376A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706442A (zh) * | 2005-05-30 | 2005-12-14 | 许建文 | 治疗黄疸性疾病的药物和含有该药物的口服液的制备方法 |
| CN103083454A (zh) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | 一种用于治疗犬钩端螺旋体病的中药组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 卫有才，等。: ""中药治疗钩端螺旋体病六例报告"", 《云南医学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102000301A (zh) | 治疗乳腺炎及乳腺小叶增生的中药组合物及其制备方法 | |
| CN102688420B (zh) | 一种治疗牛皮癣的中药汤剂 | |
| CN105106588A (zh) | 一种有效治疗便秘的中药组合物 | |
| CN102327512B (zh) | 一种治疗前列腺炎的中药 | |
| CN104027666A (zh) | 一种用于治疗大肠癌的中药及其制备方法 | |
| CN102973827B (zh) | 治疗仔猪黄白痢的纯中药组合物及其制备方法 | |
| CN102499970B (zh) | 一种治疗牛瘤胃积食的纯中药组合物及其制备方法 | |
| CN102178866B (zh) | 用于气郁、血瘀体质人袪湿活血、软坚散结的中药制剂及其制备方法和应用 | |
| CN105168799A (zh) | 一种治疗鸡白痢的药物及其制备方法 | |
| CN104922538A (zh) | 一种用于IgA肾病中药制剂及其制备方法 | |
| CN104288376A (zh) | 一种治疗水貂钩端螺旋体病的中药组合物及其制备方法 | |
| CN102100826A (zh) | 一种治疗犬细小病毒性肠炎的中药复方制剂及其制备方法 | |
| CN104189845A (zh) | 一种治疗仔猪腹泻的中药组合物及其制备方法 | |
| CN105194499A (zh) | 一种用于治疗仔猪下痢病的中药组合物及其应用 | |
| CN104324235A (zh) | 一种治疗婴儿湿疹的中药洗剂及其制备方法 | |
| CN104771585A (zh) | 一种治疗急性肾炎的中药组合物及制备方法 | |
| CN104623612A (zh) | 一种治疗乳痈的活血化瘀药及制备方法 | |
| CN103816486A (zh) | 一种治疗急慢性肝炎的中药制剂 | |
| CN103566241A (zh) | 一种治疗腹泻的中药组合物 | |
| CN102961732B (zh) | 治疗家兔肠炎的组合物及其制备方法 | |
| CN101628088B (zh) | 一种治疗皮肤病的中药组合物 | |
| CN111588818A (zh) | 痛风口服液 | |
| CN105920503A (zh) | 一种治疗泄泻的中药制剂、胶囊及其制备方法 | |
| CN103566351B (zh) | 一种治疗小儿腹泻的中药制剂 | |
| CN104524443A (zh) | 一种用于月经过少的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150121 |
|
| WD01 | Invention patent application deemed withdrawn after publication |