CN104274323A - Liquid cooling dropping pill production line - Google Patents
Liquid cooling dropping pill production line Download PDFInfo
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- CN104274323A CN104274323A CN201410330553.3A CN201410330553A CN104274323A CN 104274323 A CN104274323 A CN 104274323A CN 201410330553 A CN201410330553 A CN 201410330553A CN 104274323 A CN104274323 A CN 104274323A
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Abstract
The invention provides a liquid cooling dropping pill production line, which comprises a dropping pill system, a liquid cooling circulation system and a control system, wherein the dropping pill system comprises a material melting tank and a dropper connected with the material melting tank, a vibration device is arranged between the material melting tank and the dropper and drives the dropper to vertically vibrate, medicine liquid flowing out from the dropper is sheared into drips by the generated vibration shearing force, the drips fall into the liquid cooling circulation system, dropping pills are formed after the cooling, the dropper comprises a material storage tank and a dropping disc arranged at the bottom of the material storage tank, a plurality of dropping holes are formed in the dropping disc, and the periphery of the dropping holes is provided with concave annular grooves. The liquid cooling dropping pill production line has the advantages that the concave annular grooves are formed in the periphery of the dropping holes, the spray hole blockage or the dropping influence finally caused by residual medicine liquid accumulation around the spray holes during the high-speed spraying out of sticky and thick liquid can be prevented, the high-frequency cutting dropping is combined, the dropping pill quality is detected on line in real time, and is controlled and regulated, and the yield is improved.
Description
Technical field
The present invention relates to a kind of liquid cooling dripping pill production line, belong to dripping pill production line manufacturing technology field.
Background technology
Drop pill is the conventional dosage forms of Chinese medicine preparation, and its advantage is with short production cycle, no dust pollution; Bioavailability is high, onset is rapid and topical has long-acting; Can drug volatilization be reduced, increase medicine stability; Be easy to carry again and store.
The pill dripping machine produced on the market at present all adopts nature dripping substantially, or the pressurization dripping improved by natural dropping preparation method, by being arranged on the drip nozzle dripped on dish, utilizes natural gravity or pressure dripping, relies on medical liquid surface tension to become ball voluntarily with internal stress.Existing water dropper, when thick liquid sprays at a high speed, has remaining medicinal liquid and piles up around drip nozzle, finally cause drip nozzle block and affect dripping.In use likely the frequency of occurrences is unstable to be arranged on the vibrating device dripped on dish, causes into ball size heterogeneity, directly affects the end product quality of drop pill.
Summary of the invention
Technical problem to be solved by this invention is for the deficiencies in the prior art, provides a kind of liquid cooling dripping pill production line, and in conjunction with high frequency cutting dripping, on-line real-time measuremen regulating and controlling drop pill quality, improve productive rate, widen drop pill diameter range; Effective elimination springs up and pulse, makes pill dripping machine feeding steady; By the draw ratio of adjustment discharging pipeline, increase drop pill cool time, while ensuring the quality of products, reduce energy consumption; Periphery further by drip hole offers spill annular groove, and preventing, when thick liquid sprays at a high speed, has remaining medicinal liquid to pile up around spray orifice, finally causes spray orifice block or affect dripping.
Technical problem to be solved of the present invention is achieved by the following technical solution:
A kind of liquid cooling dripping pill production line, comprise drop pill system, liquid-cooling circulating system and control system, drop pill system comprises material tank and coupled water dropper, vibrating device is provided with between described material tank and water dropper, vibrating device drives water dropper up-down vibration, the nibbling shear shear force produced, the medicinal liquid flowed out in water dropper is cut into and drips, drop pill is formed after falling into liquid-cooling circulating system cooling, described water dropper comprises storage tank and is arranged on the dish bottom it, drip dish and be provided with multiple drip hole, the periphery of drip hole offers spill annular groove.
As required, the internal diameter=drip hole internal diameter+0.4 millimeter of described spill annular groove, external diameter >=1.5 millimeter, groove depth is 0.5-5 millimeter.
For the ease of Real-Time Monitoring in dripping process and control drop pill quality, described water dropper is provided with on-Line Monitor Device, this device comprises pulse signal trigger mechanism, its tranmitting frequency is identical with the frequency of vibration of described vibrating device, and control system is according to the monitoring result regulating and controlling dripping parameter of described on-Line Monitor Device.
For the ease of observing, described on-Line Monitor Device is arranged on the side below described water dropper; Described pulse signal trigger mechanism is stroboscopic lamp, and described stroboscopic lamp is identical with the frequency of vibration of vibrating device; Except can directly by except perusal, described on-Line Monitor Device also comprises the photographic head that arrange corresponding to stroboscopic lamp, and photographic head and stroboscopic lamp are in same level, and to irradiate route with stroboscopic lamp be 15 ° of-145 ° of angles.
As required, described dripping parameter mainly comprises: the frequency of vibration of described stroboscopic lamp and vibrating device: 2-2000HZ, preferred 90-200Hz, optimum 130-140HZ; Dripping speed: 10-40Kg/hr, preferred 12-30Kg/hr, optimum 15-25Kg/hr; Dripping acceleration: 1-20G, preferred 3-10G, optimum 3.5-4.5G; Dripping pressure: 0.5-4.0Bar, preferred 1.0-3.0Bar, optimum 1.8Bar; Water dropper temperature: 70-200 DEG C, preferred 70-100 DEG C, optimum 75-85 DEG C.
In order to keep dripping temperature constant, described water dropper outside is provided with incubation cavity, the skin of described incubation cavity is provided with heat-barrier material, internal layer is provided with steam heater or infrared heating device, the below of incubation cavity is provided with opening, the position of opening is corresponding with the exit position of water dropper to be arranged, and the size of opening is corresponding with the width of water dropper to be arranged.
In addition, described liquid-cooling circulating system mainly comprises cooling tank, discharging pipeline, filter ball device and coolant circulation unit, and described cooling tank is arranged on immediately below water dropper, and the end of cooling tank connects discharging pipeline, and the exit of discharging pipeline is provided with filter ball device; Coolant circulation unit mainly comprises liquid coolant collecting tank and heat exchanger, flow out from cooling tank and flow into liquid coolant collecting tank by the liquid coolant that filter ball device is separated with drop pill, enter heat exchanger by pipeline and carry out heat exchange, liquid coolant after heat exchange re-enters cooling tank by pipeline, forms liquid circulation; Described pipeline is provided with cooling tank Liquid level circulating pump.In order to effectively reduce the drop impulsive force that cooling-liquid level causes it when entering cooling tank, cooling tank tank skin offers multiple tangential inlet.Under normal circumstances, the magnitude setting of tangential inlet is 2-30, and preferred 2-10, optimum is 6.
For the ease of collecting and discharging, described cooling tank is cylindrical or inverted cone staving, and bottom is provided with conical discharge port, and staving outside is provided with rubber and plastic heat-insulation layer.
In order to effectively extend the cool time of drop pill, the length of described cooling tank is 0.5-10 rice; The length of described discharging pipeline is 1-50 rice.
In sum, the invention solves existing equipment and prepare drop pill limited size, energy utilization rate is low, equipment dead angle is difficult to the problems such as cleaning more; In conjunction with high frequency cutting dripping, arrange stroboscopic lamp, make the pulse signal frequency of stroboscopic lamp identical with dither frequencies, on-line real-time measuremen regulating and controlling drop pill quality near water dropper, raising productive rate, widens drop pill diameter range; By the setting of surge tank, eliminate and spring up and pulse, make pill dripping machine feeding steady; In addition, by the draw ratio of adjustment discharging pipeline, increase drop pill cool time, reduce energy consumption while ensuring the quality of products, be with a wide range of applications; Periphery further by drip hole offers spill annular groove, and preventing, when thick liquid sprays at a high speed, has remaining medicinal liquid to pile up around spray orifice, finally causes spray orifice block or affect dripping.
Below in conjunction with the drawings and specific embodiments, technical scheme of the present invention is described in detail.
Accompanying drawing explanation
Fig. 1 is overall structure schematic diagram of the present invention;
Fig. 2 checks and regulates body structure schematic diagram for dripping;
Fig. 3 is for dripping dish sectional view;
Fig. 4 is the part A partial enlarged drawing of Fig. 3.
Detailed description of the invention
Fig. 1 is overall structure schematic diagram of the present invention.As shown in Figure 1, the invention provides a kind of liquid cooling dripping pill production line, comprise drop pill system, liquid-cooling circulating system and control system, drop pill system comprises material tank 100 and coupled water dropper 200, vibrating device 300 is provided with between described material tank 100 and water dropper 200, as required, described vibrating device 300 can be arranged on top or the side of water dropper 200.In the embodiment shown in fig. 1, vibrating device 300 is arranged on above water dropper 200.Vibrating device 300 drives water dropper 200 up-down vibration, the nibbling shear shear force of generation, is cut into by the medicinal liquid flowed out and drip in water dropper 200, forms drop pill after falling into liquid-cooling circulating system cooling.Described water dropper 200 is provided with on-Line Monitor Device 400, and this device comprises pulse signal trigger mechanism and the corresponding testing agency for on-line real-time measuremen drop pill shape arranged.The tranmitting frequency of described pulse signal trigger mechanism is identical with the frequency of vibration of described vibrating device, testing agency's output detections signal to control system, and according to described detection signal regulating and controlling dripping parameter.Generally speaking, by needing the described dripping parameter of adjustment in time mainly to comprise after on-line monitoring: dripping speed, dripping acceleration and dripping pressure etc.Under normal conditions, the scope of above-mentioned parameters is: frequency of vibration is 2-2000Hz, dripping acceleration 1-15G, and dripping pressure is 0.5-4.0Bar, water dropper temperature 70-200 DEG C, and dripping speed and material speed match.As shown in Figure 1, for the ease of monitoring, described on-Line Monitor Device 400 can be arranged on the side below described water dropper 200.In actual applications, the pulse signal trigger mechanism in described on-Line Monitor Device 400 is stroboscopic lamp, correspondingly with it arranges a photographic head, and photographic head and stroboscopic lamp are in same level, and to irradiate route with stroboscopic lamp be 15 ° of-145 ° of angles.
In the embodiment shown in fig. 1, vibrating device 300 is connected with water dropper 200 through the top of incubation cavity, vibration is produced for making water dropper 200, vibration parameters sets by control system, and revise by the collection of vibrational waveform, simultaneously can also by the face shaping of the cooperation on-line monitoring drop pill of stroboscopic lamp and photographic head.In addition, in whole dripping pill production line, being general standard rustless steel SUS316L or 316Ti for transmitting the pipeline medium of material, using electric heater unit or water-bath to be incubated.Use dither cutting dripping, rely on the effect of acceleration great oscillatory shear power that drop pill is shaped, can by the aperture of drip hole on regulating dropping head 200, shake the various ways such as frequency, acceleration and feed pressure, realizes the control to drop pill diameter.Adopt the drop pill of dripping pill production line institute of the present invention dripping, its diameter is adjustable within the scope of 0.2-3.0mm, and dripping frequency can reach 2-2000Hz, unit water dropper output increased more than 50 times.
Specifically, by the melting medicinal liquid pressurized delivered in material tank 100 to water dropper 200, utilize the vibration principle of magnetic force/electronic or pneumatic, make water dropper 200 with the frequency of setting, waveform and acceleration up-down vibration, oscillatory shear masterpiece is used for fluid column, make it form drop, vibration frequency range is large, can be arranged between 2Hz-10kHz.Usual meeting selects mode of vibration according to the viscosity of material, and more specifically, the mode of magnetic force/electric vibrating, has frequency of vibration high, the feature that amplitude is little, is applicable to the high speed drop pill mode of low-viscosity material.And the mode of pneumatic vibration, frequency of vibration, amplitude is large.When material viscosity is more than 800cp (centipoise), material cannot effectively cut by electronic mode, easily cause the blocking of water dropper 200, affect drop pill preparation, now, then can adopt pneumatic vibration mode.Simultaneously in dripping process, utilize vibrational waveform as the monitoring index of PAT (on-line analysis technology), the particle size distribution situation of drop pill can be measured, and monitor in real time by the fluidized state of strobe apparatus to drop pill.The stroboscopic real-time inspection that the present invention adopts and monitoring technology on-line, make drop pill product yield bring up to more than 95% by traditional 70%.
As shown in Figure 1, in order to effectively cushion pulse and spring up, ensure that feeding is steady, between described material tank 100 and water dropper 200, be also provided with surge tank 500.Surge tank 500 is provided with compressed air inlet, is connected with air pump by pressure pipeline, and pressure pipeline is provided with pressure-regulating valve, makes surge tank 500 inner liquid medicine keep supplied with constant voltage.Liquidometer is provided with, for controlling charging rate in described surge tank 500.In order to ensure medicinal liquid constant temperature, described surge tank 500 is also provided with heat-insulation layer, adopts water-bath, oil bath and electric tracing thermal insulation.The stirring paddle (not shown) of scalable mixing speed is also provided with, mixing speed scalable in surge tank 500.
In order to keep fluid temperature constant, described water dropper 200 outside is provided with incubation cavity 210, the skin of described incubation cavity 210 is provided with heat-barrier material, internal layer is provided with steam heater or infrared heating device, the below of incubation cavity 210 is provided with opening, the position of opening is corresponding with the exit position of water dropper 200 to be arranged, and the size of opening is corresponding with the width of water dropper 200 to be arranged.In addition, incubation cavity 210 internal production is fillet, makes its more easy cleaning.Under the insulation effect of incubation cavity 210, the dripping temperature of water dropper 200 controls within the scope of 70 DEG C-100 DEG C.
As shown in Figure 1, described liquid-cooling circulating system mainly comprises cooling tank 600, discharging pipeline 610, filter ball device 620 and coolant circulation unit 630.Described cooling tank 600 is arranged on immediately below water dropper 200, and the end of cooling tank 600 connects discharging pipeline 610, and the exit of discharging pipeline 610 is provided with filter ball device 620.Coolant circulation unit 630 mainly comprises liquid coolant collecting tank and heat exchanger, flow out from cooling tank 600 and flow into liquid coolant collecting tank by the liquid coolant that filter ball device 620 is separated with drop pill, enter heat exchanger by pipeline and carry out heat exchange, liquid coolant after heat exchange re-enters cooling tank 600 by pipeline, forms liquid circulation.Described pipeline is provided with cooling tank Liquid level circulating pump.That is, filter ball device 620 is leached by simple screen cloth to solidify drop pill, and the paraffin oil as liquid coolant enters heat-exchange device and carries out the use of refrigeration Posterior circle.The circulation rate of paraffin oil is realized by cooling tank 600 Liquid level circulating pump, and therefore, the liquid level of cooling tank 600 and these two factors of the duty of circulating pump are used for controlling the speed of discharging.Based on the exploitativeness of equipment and the reasonability of size, the diameter range of discharging pipeline 610 can between 0.8-80 centimetre; Can by reducing the area of section of discharging pipeline 8, the mode simultaneously suitably increasing discharging pipeline 8 length suitably extends cool time, guarantees drop pill quality.Under normal circumstances, about the length of described discharging pipeline 610 can be arranged on 1-50 rice, about being preferably 1-25 rice.Can select according to the place size of place apparatus and actual needs.In order to ensure cooling effect, the diameter of described cooling tank 600 can be 0.5-6 rice, is highly 0.5-10 rice.In addition, for the ease of collecting, the shape of described cooling tank 600 is cylindrical or inverted cone staving, and bottom is provided with conical discharge port, is also provided with rubber and plastic heat-insulation layer in the outside of staving simultaneously.The first half of cooling tank 600, with heater, heats the liquid coolant upper strata in tank, and make liquid coolant form a thermograde from top to bottom, the scope of this thermograde is at 5 DEG C about-110 DEG C.The fluid temperature that chuck heating-up temperature sets according to water dropper sets, within the superiors' heating-up temperature is generally not less than 0 DEG C-30 DEG C of fluid temperature, can according to technique and material characteristic setting heating-up temperature, thus prevent medicinal liquid from entering suddenly the liquid coolant of excessive temperature differentials, there is quenching phenomenon, and cause drop pill to be out of shape.
It should be noted that in addition, Fig. 1 is only the overall structure schematic diagram of liquid cooling dripping pill production line of the present invention, according to the requirement of the size of output, no matter be material tank, surge tank, or the water dropper of band incubation cavity, vibrating device and cooling tank, multiple stage or many covers can be joined to one another, coordinate the integrated control of control system, realize industrialized great production.
For materials'use involved in the present invention, feed liquid transport portion and refrigerating plant etc., be the current technology that oneself has, do not repeat them here.
Fig. 2 checks and regulates body structure schematic diagram for dripping; Fig. 3 is for dripping dish sectional view; Fig. 4 is the part A partial enlarged drawing of Fig. 3.Shown in composition graphs 2 to Fig. 4, water dropper 200 of the present invention mainly includes and drips dish 210, drips dish 210 and is provided with multiple drip hole 220, and drip hole 220 is dripping circumferentially being equidistantly spaced of dish 210.As shown in Figure 4, drip hole 220 is made up of cylindrical cavity 221, conical cavity 222 and straight tube chamber 223, and drop drips from the end in straight tube chamber 223.At described dish 210 towards on the side of cooling tank 600, the periphery exported in straight tube chamber 223 offers spill annular groove 230.The aperture D0 exported due to straight tube chamber 223 is generally 0.1-5mm, the internal diameter D1=D0+0.4mm of described spill annular groove 230, outer diameter D 2 >=1.5 millimeters, and groove depth h is 0.5-5mm.In addition, the diameter d of cylindrical cavity 221 is 0.1-5mm, and the tapering of conical cavity 222 is 20 °-170 °, and the gross thickness A dripping dish 210 is 6mm, height H=(0.5-6) D0 in straight tube chamber 223.By offering spill annular groove 230 in the periphery of drip hole 220, can prevent when thick liquid sprays at a high speed, the surrounding of drip hole 220 has remaining medicinal liquid to pile up, and finally causes the blocking of drip hole 220 or affects dripping.
For materials'use involved in the present invention, feed liquid transport portion and refrigerating plant etc., be the current technology that oneself has, the present invention does not repeat them here.
On the whole, the production stage of above-mentioned liquid cooling dripping pill production line is such:
Will to melt in material tank 100 and in the medicinal liquid of mix homogeneously input surge tank 500, holding temperature 40-120 DEG C, uses gravity and compressed air pressure to be water dropper constant speed feed.Utilize buffering pressurized canister to push medicinal liquid, be transported to by the medicinal liquid melted in the water dropper 200 with lagging casing, described water dropper 200 has the outlet with incubation cavity 210 bottom opening equidirectional, guarantees that medicinal liquid can ooze bottom water dropper 200.Utilize pressure, admixing medical solutions is flowed out from the outlet at bottom of water dropper 200.
Medicinal liquid is in water dropper 200, and the shearing force brought by vibrating device 300 carries out dripping, and in the process, the diameter of drop pill is by controlling the aperture of water dropper 200, and shake frequency, amplitude, acceleration and feed pressure adjust.According to the size of required drop pill, regulate pressure or vibration parameters that is pneumatic or electric vibrating water dropper 200, the medicine making the powder column flowed out from water dropper 200 be cut into required diameter drips.Wherein acceleration of vibration is 0-110g (sine), Oscillation Amplitude 0-25.4mm.By stroboscopic lamp, observe drop pill profile, because the flash rate of stroboscopic lamp is identical with the frequency of vibration of vibrating device 300, therefore, under normal circumstances, viewed drop pill profile is state drop by drop separated from one another in the process of whereabouts; Once to observe its state be linearity or stick together each other between one and one, at once need discharge pressure, frequency of vibration and Oscillation Amplitude adjust.Except adopting perusal, photographic head can also be coordinated by stroboscopic lamp, the dripping state of drop pill is filmed and observe.Vibrational waveform is undertaken gathering and automatic calibration by waveform acquisition device.Specifically, by the speed regulating discharge pressure to increase or reduce medicinal liquid spouting velocity, pressure is larger, and spouting velocity is faster, and drop spacing is closeer, easier adhesion; By the size and the separation degree that regulate frequency of vibration and acceleration of vibration to regulate drop, frequency is larger, and cutting liquid drop volume is less, and acceleration is larger, and droplet shearing power is larger, and what finally ensure to observe under stroboscopic lamp is the state that drop is separated completely.In whole dripping process, feed flow pipeline and water dropper 200 are in heating and thermal insulation state always, and to ensure liquid medicine flow, typical temperature controls at about 40-120 DEG C.
Liquid drop pill directly falls, fall within the cooling tank 600 of the liquid-cooling circulating system arranged immediately below water dropper 200, filled with cooling medium-paraffin oil in this cooling tank 600, liquid drop pill enters in paraffin oil and solidifies, and the temperature of paraffin oil controls the scope at about 4-7 DEG C usually.Move along discharging pipeline 610 in the lump with paraffin oil immediately, include drop pill whole cool time in cooling tank 600 and discharging pipeline 610 two parts.Solidify drop pill discharging together with part paraffin oil under gravity, by the filtration of filter ball device 620, drop pill is sifted out collection, the high temperature paraffin oil that another part is separated, temperature greatly about about 13-17 DEG C, enter heat-exchange device freeze after recycle.
Below in conjunction with specific embodiment, technical scheme of the present invention is described in detail.
Embodiment one prepares FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 (PEG-4000) adjuvant 2000g.First PEG-6000 is added in material tank 100, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, be mixed into liquid.The frequency of vibration regulating pneumatic vibration water dropper 200 is 50Hz, dripping speed 10Kg/hr, and dripping acceleration 4.5G and dripping pressure 1.8Bar, incubation cavity 210 adopts electric heating jacket heat-preservation, and water dropper temperature controls 85 DEG C.By stroboscopic lamp perusal drop pill profile, single drop pill size, shape are moderate, each other without adhesion between upper and lower drop pill, continue to keep normal dripping.The upper strata chuck heating-up temperature of cooling tank 600 is set in 80 DEG C, and orlop coolant temperature is to 3 DEG C.Supplied gas in surge tank 500 by pipeline by air pump, make the aforesaid liquid melted flow into water dropper 200 and ooze in cooling tank 600 bottom water dropper 200.Start heat-exchange device, make paraffin oil temperature reach 3 DEG C, liquid circulation pressure is set to 1 Kilogram Force Per Square Centimeter, makes the medicinal liquid oozed from water dropper 200 drop in cooled and solidified in cooling tank 600 and becomes solid-state drop pill, and from discharging pipeline 610, collect after filter ball device 620 carries out solid-liquor separation.
Embodiment two prepares Radix Salviae Miltiorrhizae drop pill
Get Radix Salviae Miltiorrhizae extract 600g, add water 60g, adds PEG-6000 adjuvant 1500g, puts into material tank and be heated to 90 DEG C, makes it melt completely and be mixed into liquid.Medicinal liquid pressurized delivered is to water dropper, and dripping frequency of vibration is 90Hz, dripping speed 40Kg/hr, dripping acceleration 20G and dripping pressure 4Bar, and adopt Infrared Heating insulation, dripping temperature controls at 100 DEG C.Drop pill profile is observed by stroboscopic lamp and photographic head, the photo taken by photographic head compares with the standard drop pill profile preset, and finds hypotelorism between upper and lower drop pill and has adhesion, reduces dripping pressure to 3Bar, frequency of vibration 140Hz, dripping speed 12Kg/hr, and continue to observe, drop pill spacing is excessive, increase dripping pressure to 3.5Bar, frequency of vibration 130Hz, dripping speed 25Kg/hr, observation drop pill spacing is normal.Supplied gas in surge tank 1 by pipeline by air pump, the aforesaid liquid melted is flowed into water dropper 3, and oozes in cooling tank 5 bottom water dropper 3; Start heat-exchange device, paraffin oil temperature is made to reach 3 DEG C, liquid circulation pressure is set to 3 Kilogram Force Per Square Centimeters, makes the medicinal liquid oozed from water dropper 3 drop in cooled and solidified in cooling tank 5 and becomes solid-state drop pill, and collects after filter ball device 6 carries out solid-liquor separation from discharging pipeline 8.And by sieve ball and granulate, be finally packaged into final products.
Embodiment three prepares ageratum drop pill
Get ageratum extractum 200g, patchouli oil 1ml, Folium perillae acutae oil 2ml, Macrogol 600 g, add in material tank simultaneously, be heated to 65-85 DEG C, melting, be mixed into liquid.Medicinal liquid imports surge tank into, by sending into water dropper again to surge tank pressuring method, and oozes in cooling tank bottom water dropper.The frequency of vibration regulating electric vibrating water dropper is 200Hz, dripping speed 30Kg/hr, dripping acceleration 10G and dripping pressure 0.5Bar, and moist closet adopts electrical heating jacket heat-preservation, and temperature controls 70 DEG C.By stroboscopic lamp perusal drop pill profile, find that cutting liquid drop volume is bigger than normal, regulate and strengthen frequency of vibration to 300Hz, cutting liquid drop volume is reduced; Regulating and strengthening acceleration of vibration is 10G, and droplet shearing power is strengthened, dripping speed 15Kg/hr, temperature controls 75 DEG C, dripping pressure 1Bar, and what finally ensure to observe under stroboscopic lamp is the state that drop is separated completely.Employing paraffin oil cools, and chilling temperature gradient is from 80 to 10 DEG C.
Embodiment four prepares Radix Salviae Miltiorrhizae drop pill
Radix Salviae Miltiorrhizae extract 600g, add PEG-6000 adjuvant 3000g and drop in homogenizer, 1000rpm intimate mixing, time 1min, then 3000rpm homogenizing material, time 1min, temperature 60 C, obtains intermediate feed liquid.Intermediate feed liquid vibrates dripping through water dropper 200, and frequency of vibration is 50Hz, and dripping pressure is 0.5Bar, water dropper temperature 70 C, dripping speed and material speeds match.The medicine oozed drop in quick cooled and solidified in condensed fluid become diameter be 0.2mm drop pill element ball, described condensed fluid is selected from liquid paraffin, methyl-silicone oil, kerosene or their mixture.The temperature of described condensed fluid is-30 DEG C, is no less than 30 seconds cool time.Then carry out fluidized drying and medicine carrying coating, and by sieve ball and granulate, be finally packaged into final products.
Embodiment five prepares ageratum drop pill
Get ageratum extractum 200g.Patchouli oil 1ml, Folium perillae acutae oil 2ml, Polyethylene Glycol 40g, drop in homogenizer, 5000rpm intimate mixing, time 200min, then 10000rpm homogenizing material, time 100min, temperature 100 DEG C, obtains intermediate feed liquid.Intermediate feed liquid vibrates dripping through water dropper 200, and frequency of vibration is 300Hz, and dripping pressure is 4.0Bar, and water dropper 200 temperature is 200 DEG C, dripping speed and material speeds match.The medicine oozed drop in quick cooled and solidified in condensed fluid become diameter be 4.0mm drop pill element ball, described condensed fluid is selected from liquid paraffin, methyl-silicone oil, kerosene or their mixture, and described condensate temperature is 10 DEG C, and cool time is for being no less than 30 seconds.Then carry out fluidized drying and medicine carrying coating, and by sieve ball and granulate, be finally packaged into final products.
Embodiment six prepares QISHEN YIQI DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extractum 100g, Radix Astragali extractum 200g, volatile oil of Lignum Dalbergiae Odoriferae 10g, and PEG-6000 adjuvant 900g, drop in homogenizer, 3000rpm intimate mixing, time 20min, then 6000rpm homogenizing material, time 20min, temperature 80 DEG C, obtains intermediate feed liquid.Intermediate feed liquid vibrates dripping through water dropper 200, and frequency of vibration is 100Hz, acceleration 1G, dripping speed 10Kg/hr, dripping pressure 1.0Bar, water dropper temperature 70 C.The medicine oozed drop in quick cooled and solidified in condensed fluid become diameter be 2.0mm drop pill element ball, described condensed fluid methyl-silicone oil, described condensate temperature is 0 DEG C, and cool time is for being no less than 30 seconds.Then carry out fluidized drying and medicine carrying coating, and by sieve ball and granulate, be finally packaged into final products.
Embodiment seven prepares dripping pills of andrographolide
Get andrographolide 400g and PEG-6000 adjuvant 800g, PEG-4000 adjuvant 800g.First PEG-6000, PEG-4000 are added in material tank 100, be heated to 100 DEG C, in advance melting: add andrographolide again, mix 80 minutes, evenly become liquid to form intermediate feed liquid.Intermediate feed liquid vibrates dripping through water dropper 200, frequency of vibration 200HZ, acceleration 20G, dripping speed 40Kg/hr, dripping pressure 3.0Bar, water dropper temperature 100 DEG C.The medicine oozed drop in quick cooled and solidified in condensed fluid become diameter be 2.0mm drop pill element ball, described condensed fluid is selected from liquid paraffin, and described condensate temperature is 0 DEG C, and cool time is for being no less than 30 seconds.Then carry out fluidized drying and medicine carrying coating, and by sieve ball and granulate, be finally packaged into final products.
Embodiment eight prepares ageratum drop pill
Get ageratum extractum 200g, patchouli oil 1ml, Folium perillae acutae oil 2ml, Macrogol 600 g, low speed homogenizing 5000rpm, time 60min, mixed material, then high speed homogenization 9000rpm, time 30min, carries out material, and temperature remains on 90 DEG C.Intermediate feed liquid vibrates dripping through water dropper 200, and frequency of vibration is 150Hz, and dripping pressure is 2.0Bar, water dropper temperature 150 DEG C, dripping speed and material speeds match.The medicine oozed drop in quick cooled and solidified in condensed fluid become diameter be 2.0mm drop pill element ball, described condensed fluid is selected from the mixture of methyl-silicone oil, kerosene, and described condensate temperature is 0 DEG C, and cool time is for being no less than 30 seconds.
Embodiment nine FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 adjuvant 2000g.First PEG-6000 is added in material tank 100, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum, be mixed into liquid.High speed homogenization 4000rpm carries out material, 6 minutes time, and temperature is 75 DEG C.The frequency of vibration regulating pneumatic vibration water dropper 200 is 50Hz, and water dropper adopts steam jacket insulation, and temperature controls 80 DEG C.Medicinal liquid flows into water dropper by pressuring method, and oozes in drainer 600 bottom water dropper.Adopt liquid paraffin, chilling temperature-10 DEG C, cool time is not less than 30s, to ensure that drop pill fully cools the medicinal liquid making to ooze and is cooled to solid-state drop pill.Be that 1.0-2.0mm drop pill carries out capsule filling by the particle diameter made, and complete 100% online check weighing by capsule check-weighing machine, be then packaged into final products.
Embodiment ten FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 adjuvant 2000g.First PEG-6000 is added in material tank 100, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum, be mixed into liquid.High speed homogenization 6000rpm carries out material, 30 minutes time, and temperature is 85 DEG C.The frequency of vibration regulating pneumatic vibration water dropper 200 is 50Hz, and water dropper adopts steam jacket insulation, and temperature controls 80 DEG C.Medicinal liquid flows into water dropper 200 by pressuring method, and oozes in drainer 600 bottom water dropper.Condensed fluid adopts liquid paraffin, and chilling temperature-10 DEG C, cool time is not less than 30s, to ensure that drop pill fully cools the medicinal liquid making to ooze and is cooled to solid-state drop pill.Be that 1.0-2.0mm drop pill carries out capsule filling by the particle diameter made, and complete 100% online check weighing by capsule check-weighing machine, be then packaged into final products.
Embodiment 11 FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 adjuvant 2000g.First PEG-6000 is added in material tank 100, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum, be mixed into liquid.The frequency of vibration regulating pneumatic vibration water dropper 200 is 130Hz, and water dropper adopts steam jacket insulation, and temperature controls 80 DEG C.Medicinal liquid flows into water dropper by pressuring method, and oozes in drainer 600 bottom water dropper.Condensed fluid adopts kerosene, and chilling temperature-10 DEG C, cool time is not less than 30s, to ensure that drop pill fully cools the medicinal liquid making to ooze and is cooled to solid-state drop pill.Be that 1.0-2.0mm drop pill carries out capsule filling by the particle diameter made, and complete 100% online check weighing by capsule check-weighing machine, be then packaged into final products.
Embodiment 12 prepares ageratum drop pill
Get ageratum extractum 200g, patchouli oil 1ml, Folium perillae acutae oil 2ml, Polyethylene Glycol 40g, drop in homogenizer, 1000rpm intimate mixing, time 150min, then 9000rpm homogenizing material, time 10min, temperature 100 DEG C, obtains intermediate feed liquid.Intermediate feed liquid vibrates dripping through water dropper 200, and frequency of vibration is 300Hz, and dripping pressure is 4.0Bar, water dropper temperature 150 DEG C, dripping speed and material speeds match.The medicine oozed drop in quick cooled and solidified in drainer 600 become diameter be 4.0mm drop pill element ball, described condensed fluid is selected from the mixture of methyl-silicone oil, kerosene, and described condensate temperature is 10 DEG C, and cool time is for being no less than 30 seconds.Then carry out fluidized drying and medicine carrying coating, and by sieve ball and granulate, be finally packaged into final products.
Embodiment 13 FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 adjuvant 2000g.First PEG-6000 is added in material tank 100, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum, 3000rpm homogenizing, time 20min, is mixed into liquid, then, high speed homogenization 6000rpm carries out material, 6 minutes time, and temperature is 75 DEG C.The frequency of vibration regulating pneumatic vibration water dropper 200 is 50Hz, and water dropper adopts steam jacket insulation, and temperature controls 80 DEG C.Medicinal liquid flows into water dropper by pressuring method, and oozes in drainer 600 bottom water dropper.Condensed fluid adopts liquid paraffin, and chilling temperature-10 DEG C, cool time is not less than 30s, to ensure that drop pill fully cools the medicinal liquid making to ooze and is cooled to solid-state drop pill.Be that 3.0-4.0mm drop pill carries out capsule filling by the particle diameter made, and complete 100% online check weighing by capsule check-weighing machine, be then packaged into final products.
Embodiment 14 FUFANG DANSHEN DIWAN
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 adjuvant 2000g.First added in material tank 100 by PEG-6000, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum, 3000rpm homogenizing, time 20min, is mixed into and evenly becomes liquid.Then, high speed homogenization 6000rpm carries out material, 30 minutes time, and temperature is 85 DEG C.The frequency of vibration regulating pneumatic vibration water dropper 200 is 100Hz, and water dropper adopts steam jacket insulation, and temperature controls 80 DEG C.Medicinal liquid flows into water dropper by pressuring method, and oozes in drainer 600 bottom water dropper.Condensed fluid adopts liquid paraffin, and chilling temperature-10 DEG C, cool time is not less than 30s, to ensure that drop pill fully cools the medicinal liquid making to ooze and is cooled to solid-state drop pill.Be that 2.0-3.0mm drop pill carries out capsule filling by the particle diameter made, and complete 100% online check weighing by capsule check-weighing machine, be then packaged into final products.
In sum, the invention solves existing equipment and prepare drop pill limited size, energy utilization rate is low, equipment dead angle is difficult to the problems such as cleaning more; In conjunction with high frequency cutting dripping, arrange stroboscopic lamp, make the pulse signal frequency of stroboscopic lamp identical with dither frequencies, on-line real-time measuremen regulating and controlling drop pill quality near water dropper, raising productive rate, widens drop pill diameter range; By the setting of surge tank, eliminate and spring up and pulse, make pill dripping machine feeding steady; In addition, by the draw ratio of adjustment discharging pipeline, increase drop pill cool time, reduce energy consumption while ensuring the quality of products, be with a wide range of applications; Periphery further by drip hole offers spill annular groove, and preventing, when thick liquid sprays at a high speed, has remaining medicinal liquid to pile up around spray orifice, finally causes spray orifice block or affect dripping.
Claims (10)
1. a liquid cooling dripping pill production line, comprise drop pill system, liquid-cooling circulating system and control system, drop pill system comprises material tank and coupled water dropper, vibrating device is provided with between described material tank and water dropper, vibrating device drives water dropper up-down vibration, the nibbling shear shear force produced, the medicinal liquid flowed out in water dropper is cut into and drips, drop pill is formed after falling into liquid-cooling circulating system cooling, it is characterized in that, described water dropper comprises storage tank and is arranged on the dish bottom it, and drip dish and be provided with multiple drip hole, the periphery of drip hole offers spill annular groove.
2. liquid cooling dripping pill production line as claimed in claim 1, it is characterized in that, the internal diameter=drip hole internal diameter+0.4 millimeter of described spill annular groove, external diameter >=1.5 millimeter, groove depth is 0.5-5 millimeter.
3. liquid cooling dripping pill production line as claimed in claim 2, it is characterized in that, described water dropper is provided with on-Line Monitor Device, this device comprises pulse signal trigger mechanism, its tranmitting frequency is identical with the frequency of vibration of described vibrating device, and control system is according to the monitoring result regulating and controlling dripping parameter of described on-Line Monitor Device.
4. liquid cooling dripping pill production line as claimed in claim 3, it is characterized in that, described on-Line Monitor Device is arranged on the side below described water dropper;
Described pulse signal trigger mechanism is stroboscopic lamp, and described stroboscopic lamp is identical with the frequency of vibration of vibrating device;
Described on-Line Monitor Device also comprises the photographic head that arrange corresponding to stroboscopic lamp, and photographic head and stroboscopic lamp are in same level, and to irradiate route with stroboscopic lamp be 15 ° of-145 ° of angles.
5. liquid cooling dripping pill production line as claimed in claim 4, it is characterized in that, described dripping parameter mainly comprises:
The frequency of vibration of described stroboscopic lamp and vibrating device: 2-2000HZ, preferred 90-200Hz, optimum 130-140HZ;
Dripping speed: 10-40Kg/hr, preferred 12-30Kg/hr, optimum 15-25Kg/hr;
Dripping acceleration: 1-20G, preferred 3-10G, optimum 3.5-4.5G;
Dripping pressure: 0.5-4.0Bar, preferred 1.0-3.0Bar, optimum 1.8Bar;
Water dropper temperature: 70-200 DEG C, preferred 70-100 DEG C, optimum 75-85 DEG C.
6. liquid cooling dripping pill production line as claimed in claim 1, it is characterized in that, described water dropper outside is provided with incubation cavity, the skin of described incubation cavity is provided with heat-barrier material, internal layer is provided with steam heater or infrared heating device, the below of incubation cavity is provided with opening, and the position of opening is corresponding with the exit position of water dropper to be arranged, and the size of opening is corresponding with the width of water dropper to be arranged.
7. liquid cooling dripping pill production line as claimed in claim 6, it is characterized in that, described liquid-cooling circulating system mainly comprises cooling tank, discharging pipeline, filter ball device and coolant circulation unit, described cooling tank is arranged on immediately below water dropper, the end of cooling tank connects discharging pipeline, and the exit of discharging pipeline is provided with filter ball device;
Coolant circulation unit mainly comprises liquid coolant collecting tank and heat exchanger, flow out from cooling tank and flow into liquid coolant collecting tank by the liquid coolant that filter ball device is separated with drop pill, enter heat exchanger by pipeline and carry out heat exchange, liquid coolant after heat exchange re-enters cooling tank by pipeline, forms liquid circulation; Described pipeline is provided with cooling tank Liquid level circulating pump;
Liquid coolant is along the multiple tangential inlet input cooling tanks be arranged on cooling tank tank skin.
8. liquid cooling dripping pill production line as claimed in claim 7, is characterized in that, the magnitude setting of described tangential inlet is 2-30, and preferred 2-10, optimum is 6.
9. liquid cooling dripping pill production line as claimed in claim 7, it is characterized in that, described cooling tank is cylindrical or inverted cone staving, and bottom is provided with conical discharge port, and staving outside is provided with rubber and plastic heat-insulation layer.
10. liquid cooling dripping pill production line as claimed in claim 9, it is characterized in that, the length of described cooling tank is 0.5-10 rice; The length of described discharging pipeline is 1-50 rice.
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| CN201410330553.3A CN104274323B (en) | 2013-07-11 | 2014-07-11 | Liquid cooling dripping pill production line |
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| CN201410330553.3A CN104274323B (en) | 2013-07-11 | 2014-07-11 | Liquid cooling dripping pill production line |
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| CN201410330552.9A Pending CN104274322A (en) | 2013-07-11 | 2014-07-11 | Method for preparing drop pill by high-speed vibration in dropping way |
| CN201410330553.3A Active CN104274323B (en) | 2013-07-11 | 2014-07-11 | Liquid cooling dripping pill production line |
| CN201420383998.3U Expired - Lifetime CN204033786U (en) | 2013-07-11 | 2014-07-11 | Liquid cooling dripping pill production line |
| CN201410333565.1A Pending CN104274327A (en) | 2013-07-11 | 2014-07-11 | Liquid cooling dropping pill production line |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017045610A1 (en) * | 2015-09-18 | 2017-03-23 | 天士力制药集团股份有限公司 | Intelligent dripping pill machine for continuous liquid solidification |
| CN114572436A (en) * | 2020-12-01 | 2022-06-03 | 上海烟草集团有限责任公司 | High-speed forming device for blasting beads |
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| CN104274322A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Method for preparing drop pill by high-speed vibration in dropping way |
| CN106539690B (en) * | 2015-09-18 | 2020-08-04 | 天士力医药集团股份有限公司 | Continuous intelligent preparation method of liquid cooling dropping pills |
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| CN104274322A (en) | 2015-01-14 |
| CN104274327A (en) | 2015-01-14 |
| CN104274323B (en) | 2019-05-17 |
| CN204033786U (en) | 2014-12-24 |
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