CN102078259A - Equipment and method for preparing uniform dripping pills - Google Patents
Equipment and method for preparing uniform dripping pills Download PDFInfo
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- CN102078259A CN102078259A CN2010106118441A CN201010611844A CN102078259A CN 102078259 A CN102078259 A CN 102078259A CN 2010106118441 A CN2010106118441 A CN 2010106118441A CN 201010611844 A CN201010611844 A CN 201010611844A CN 102078259 A CN102078259 A CN 102078259A
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Abstract
The invention discloses equipment and method for preparing uniform dripping pills. The equipment comprises a melting tank 2, a feeding pipeline 5, a flow sensor 7, a nozzle 15, a vibrator, a cooling column 16 and a dripping pill collector 18, wherein the melting tank 2 is sequentially connected with a valve 6, the flow sensor 7 and the nozzle 15 through the feeding pipeline 5; the vibrator comprises a signal generator 9, a power amplifier 10 and a vibration exciter 11; the signal generator 9 is sequentially connected electrically with the power amplifier 10 and the vibration exciter 11; the vibration exciter 11 is connected with the nozzle 15 through a connecting rod 14; the cooling column 16 is installed under the nozzle 15; cooling liquid 17 is filled in the cooling column 16; and the dripping pill collector 18 is arranged at the bottom in the cooling column 16. The dripping pill product produced by the equipment disclosed by the invention has good roundness and uniformity, the rejection rate can be reduced, the product quality can be improved, and the granularity and weight of the prepared product can be regulated in an on-line mode by changing vibration frequency, flow rate and other conditions.
Description
Technical field
The present invention relates to a kind of Apparatus and method for for preparing even drop pill.
Technical background
Drop pill is one of ripe dosage form of solid dispersion, compares with conventional formulation, at aspects such as preparation, drug releases incomparable advantage is arranged all, meets " three is little " of modern medicines preparation, the basic demand of " triple effect " and " five convenience ".The preparation of existing drop pill is with after solid or liquid medicine and the adjuvant heating melting that suits or being dissolved as solution, suspension or emulsion, splashes in the not miscible condensed fluid to obtain, and output is subjected to dripping the restriction of system speed.
Preparing at present the method that drop pill uses, mainly is nature dropping preparation method and pulse patterning method.Wherein natural dropping preparation method is not suitable for medicinal liquid feeding-up, that mistake is rare or surface tension is little, and ball is heavy mainly by the decision of water dropper internal diameter, and it is heavy to regulate ball by the mode of changing water dropper, and production efficiency is low.The pulse patterning method can drip the higher medicinal liquid of system viscosity, but its system product ball heavily differs greatly, the low manufacturing enterprise of always perplexing drop pill of qualification rate.
Summary of the invention
The objective of the invention is that the production capacity that exists at prior art is low, the different deficiency such as big of the ball method of double differences, provide a kind of utilization vibration that fusion medicinal liquid jet is disperseed to become symmetrical liquid drop, the Apparatus and method for for preparing even drop pill, can heavily accurately control ball, and can improve production capacity to a great extent.
Technical scheme of the present invention is summarized as follows:
A kind of equipment for preparing even drop pill, comprise melting pot 2, feeding pipe 5, flow transducer 7, shower nozzle 15, vibrating device, cooling column 16 and drop pill catcher 18, melting pot 2 by feeding pipe 5 successively with valve 6, flow transducer 7 is connected with shower nozzle 15, vibrating device comprises signal generator 9, power amplifier 10 and vibrator 11, signal generator 9 is electrically connected with power amplifier 10 and vibrator 11 successively, vibrator 11 is connected with shower nozzle 15 by connecting rod 14, cooling column 16 be installed in shower nozzle 15 under, be provided with liquid coolant 17 in the cooling column 16, the bottom in cooling column 16 is provided with drop pill catcher 18.
The equipment of the even drop pill of above-mentioned preparation can also comprise computer centralized displaying and control system 20 and be arranged on melting pot temperature sensor 3 on the melting pot 2, be arranged on the melting pot pressure transducer 4 of melting pot 2 internal upper parts, be arranged on the pipeline temperature sensor 8 on the feeding pipe 5, be arranged on the nozzle temperature pick off 12 on shower nozzle 15 surfaces, be arranged on the shower nozzle vibrating sensor 13 on shower nozzle 15 surfaces and be arranged on bottom in the cooling column 16, the cooling system temperature sensor 19 on middle part and top, the input of computer centralized displaying and control system 20 by holding wire respectively with the outfan of melting pot temperature sensor 3, the outfan of melting pot pressure transducer 4, the outfan of pipeline temperature sensor 8, the outfan of flow transducer 7, the outfan of nozzle temperature pick off 12, the outfan of the outfan of shower nozzle vibrating sensor 13 and cooling system temperature sensor 19 connects, and the outfan of computer centralized displaying and control system 20 is connected with the input of actuator on being arranged on valve 6 by holding wire.
Preferably: shower nozzle 15 is arranged on the bottom of connecting rod 14 or is arranged on the sidewall of connecting rod 14.
The aperture of spray orifice is 0.1mm～1.5mm on the shower nozzle 15.Preferred 0.3mm～1.5mm.
A kind of method for preparing even drop pill comprises the steps:
Prepare a kind of equipment for preparing even drop pill, this equipment comprises melting pot 2, feeding pipe 5, flow transducer 7, shower nozzle 15, vibrating device, cooling column 16 and drop pill catcher 18, melting pot 2 by feeding pipe 5 successively with valve 6, flow transducer 7 is connected with shower nozzle 15, vibrating device comprises signal generator 9, power amplifier 10 and vibrator 11, signal generator 9 is electrically connected with power amplifier 10 and vibrator 11 successively, vibrator 11 is connected with shower nozzle 15 by connecting rod 14, cooling column 16 be installed in shower nozzle 15 under, be provided with liquid coolant 17 in the cooling column 16, the bottom in cooling column 16 is provided with drop pill catcher 18;
The medicine and the adjuvant of preparation drop pill are put in the melting pot 2 according to mass ratio, heating makes material melting and is warmed up to setting value, stirring makes the material uniform mixing become the fusion medicinal liquid, heating feed pipe 5 and shower nozzle 15 are to design temperature, start signal generator 9, power amplifier 10 and vibrator 11, regulate vibrator 11 and produce vibration, by the connecting rod 14 between vibrator 11 and the shower nozzle 15, give shower nozzle with transfer of vibration, open the heating and the refrigerating plant of cooling column 16, make cooling column 16 interior liquid coolants 17 reach the thermograde of setting, use compressed air as motive force, the fusion medicinal liquid is delivered to shower nozzle 15 by feed pipe 5 in melting pot 2, use valve 6 and flow transducer 7 (on-the-spotly indicating on the flow transducer 7) that the flow of fusion medicinal liquid is controlled and measured, under the effect of shower nozzle vibration, be broken into the fusion medicinal liquid drop of uniform grading with the fusion medicinal liquid of effusive form ejection from the spray orifice of shower nozzle 15, drop drips in the liquid coolant 17 that enters in the cooling column 16, be solidified as the uniform drop pill granule of particle diameter and fall into drop pill catcher 18, collect by drop pill catcher 18.
A kind of method for preparing even drop pill, the equipment for preparing even drop pill can also comprise computer centralized displaying and control system 20 and be arranged on melting pot temperature sensor 3 on the melting pot 2, be arranged on the melting pot pressure transducer 4 of melting pot 2 internal upper parts, be arranged on the pipeline temperature sensor 8 on the feeding pipe 5, be arranged on the nozzle temperature pick off 12 on shower nozzle 15 surfaces, be arranged on the shower nozzle vibrating sensor 13 on shower nozzle 15 surfaces and be arranged on bottom in the cooling column 16, the cooling system temperature sensor 19 on middle part and top, the input of computer centralized displaying and control system 20 by holding wire respectively with the outfan of melting pot temperature sensor 3, the outfan of melting pot pressure transducer 4, the outfan of pipeline temperature sensor 8, the outfan of flow transducer 7, the outfan of nozzle temperature pick off 12, the outfan of the outfan of shower nozzle vibrating sensor 13 and cooling system temperature sensor 19 connects, and the outfan of computer centralized displaying and control system 20 is connected with the input of actuator on being arranged on described valve 6.
The fusion medicinal liquid during by described spray nozzle flow velocity be 0.3m～3m.
Preferably: the frequency of vibration of vibrator is 20Hz～2000Hz, preferably 150Hz～1000Hz; Oscillation Amplitude is 0.01mm～1mm, preferably 0.05mm～0.2mm.
Product efficiency height with device fabrication of the present invention, drop pill product rounding property and good uniformity, the rate of can reducing the number of rejects and seconds simultaneously, improve the quality of products, and the granularity of preparing product and weight can be by changing the online adjustings of condition such as frequency of vibration, flow velocity, and output also can in very large range be adjusted by changing modes such as spray nozzle quantity.Therefore, equipment of the present invention both had been applicable to small-scale test, also can be applicable in large-scale the production, and its beneficial effect is fairly obvious.
Description of drawings:
Fig. 1 forms sketch map for present device.
The specific embodiment
The present invention is further illustrated below in conjunction with accompanying drawing.
A kind of equipment (see figure 1) for preparing even drop pill, comprise melting pot 2, feeding pipe 5, flow transducer 7, shower nozzle 15, vibrating device, cooling column 16 and drop pill catcher 18, melting pot 2 by feeding pipe 5 successively with valve 6, flow transducer 7 is connected with shower nozzle 15, vibrating device comprises signal generator 9, power amplifier 10 and vibrator 11, signal generator 9 is electrically connected with power amplifier 10 and vibrator 11 successively, vibrator 11 is connected with shower nozzle 15 by connecting rod 14, cooling column 16 be installed in shower nozzle 15 under, be provided with liquid coolant 17 in the cooling column 16, the bottom in cooling column 16 is provided with drop pill catcher 18.
The equipment of the even drop pill of above-mentioned preparation can also comprise computer centralized displaying and control system 20 and be arranged on melting pot temperature sensor 3 on the melting pot 2, be arranged on the melting pot pressure transducer 4 of melting pot 2 internal upper parts, be arranged on the pipeline temperature sensor 8 on the feeding pipe 5, be arranged on the nozzle temperature pick off 12 on shower nozzle 15 surfaces, be arranged on the shower nozzle vibrating sensor 13 on shower nozzle 15 surfaces and be arranged on bottom in the cooling column 16, the cooling system temperature sensor 19 on middle part and top, the input of computer centralized displaying and control system 20 by holding wire respectively with the outfan of melting pot temperature sensor 3, the outfan of melting pot pressure transducer 4, the outfan of pipeline temperature sensor 8, the outfan of flow transducer 7, the outfan of nozzle temperature pick off 12, the outfan of the outfan of shower nozzle vibrating sensor 13 and cooling system temperature sensor 19 connects, and the outfan of computer centralized displaying and control system 20 is connected with the input of actuator on being arranged on valve 6 by holding wire.
Preferably: shower nozzle 15 is arranged on the bottom of connecting rod 14 or is arranged on the sidewall of connecting rod 14.
The aperture of spray orifice is 0.1mm～1.5mm on the shower nozzle 15.Preferred 0.3mm～1.5mm.
A kind of method for preparing even drop pill comprises the steps:
Prepare a kind of equipment for preparing even drop pill, this equipment comprises melting pot 2, feeding pipe 5, flow transducer 7, shower nozzle 15, vibrating device, cooling column 16 and drop pill catcher 18, melting pot 2 by feeding pipe 5 successively with valve 6, flow transducer 7 is connected with shower nozzle 15, vibrating device comprises signal generator 9, power amplifier 10 and vibrator 11, signal generator 9 is electrically connected with power amplifier 10 and vibrator 11 successively, vibrator 11 is connected with shower nozzle 15 by connecting rod 14, cooling column 16 be installed in shower nozzle 15 under, be provided with liquid coolant 17 in the cooling column 16, the bottom in cooling column 16 is provided with drop pill catcher 18;
The medicine and the adjuvant of preparation drop pill are put in the melting pot 2 according to mass ratio, heating makes material melting and is warmed up to setting value, stirring makes the material uniform mixing become fusion medicinal liquid 1, heating feed pipe 5 and shower nozzle 15 are to design temperature, start signal generator 9, power amplifier 10 and vibrator 11, regulate vibrator 11 and produce vibration, by the connecting rod 14 between vibrator 11 and the shower nozzle 15, give shower nozzle with transfer of vibration, open the heating and the refrigerating plant of cooling column 16, make cooling column 16 interior liquid coolants 17 (liquid paraffin or dimethicone) reach the thermograde of setting, use compressed air as motive force, the fusion medicinal liquid is delivered to shower nozzle 15 by feed pipe 5 in melting pot 2, use valve 6 and flow transducer 7 (on-the-spotly indicating on the flow transducer 7) that the flow of fusion medicinal liquid is controlled and measured, under the effect of shower nozzle vibration, be broken into the fusion medicinal liquid drop of uniform grading with the fusion medicinal liquid of effusive form ejection from the spray orifice of shower nozzle 15, drop drips in the liquid coolant 17 that enters in the cooling column 16, be solidified as the uniform drop pill granule of particle diameter and fall into drop pill catcher 18, collect by drop pill catcher 18.As the need continued operation, can before melting pot, increase continuous charging and premelt jar, medicinal liquid enters melting pot and is delivered to shower nozzle again after the fusion; Can add the continuous drawing mechanism of drop pill in the cooling column bottom simultaneously,, enhance productivity to realize continued operation.
The equipment for preparing even drop pill can also comprise computer centralized displaying and control system 20 and be arranged on melting pot temperature sensor 3 on the melting pot 2, be arranged on the melting pot pressure transducer 4 of melting pot 2 internal upper parts, be arranged on the pipeline temperature sensor 8 on the feeding pipe 5, be arranged on the nozzle temperature pick off 12 on shower nozzle 15 surfaces, be arranged on the shower nozzle vibrating sensor 13 on shower nozzle 15 surfaces and be arranged on bottom in the cooling column 16, the cooling system temperature sensor 19 on middle part and top, the input of computer centralized displaying and control system 20 by holding wire respectively with the outfan of melting pot temperature sensor 3, the outfan of melting pot pressure transducer 4, the outfan of pipeline temperature sensor 8, the outfan of flow transducer 7, the outfan of nozzle temperature pick off 12, the outfan of the outfan of shower nozzle vibrating sensor 13 and cooling system temperature sensor 19 connects, and the outfan of computer centralized displaying and control system 20 is connected with the input of actuator on being arranged on described valve 6.
The fusion medicinal liquid during by spray nozzle flow velocity be 0.3m～3m.
The frequency of vibration of vibrator can select 20Hz, 40Hz, 150Hz, 500Hz, 1000Hz, 1500Hz, 1800Hz or 2000Hz, and Oscillation Amplitude can select 0.01mm, 0.02mm, 0.05mm, 0.1mm, 0.2mm, 0.5mm or 1mm.
Computer centralized displaying used in the present invention and control system can be that production needs according to the present invention design voluntarily, also can buy, and belong to known technology.(say again here, show that these parts are prior aries)
Use the temperature of temperature, shower nozzle 15 of temperature in the described melting pots 2 of 20 pairs of described computer centralized displaying and control system, pressure, feed pipe 5 and Oscillation Amplitude, the flow of flow transducer 7, the temperature of the liquid coolant 17 in the cooling column 16 to measure and centralized displaying, the centralized displaying that uses a computer and control system 20 are set the flow in the feed pipes 5 and the aperture of valve 6 are carried out chain control to realize the stable of flow.
The present invention is further illustrated below by specific embodiment.
Medicine is a nifedipine, and adjuvant is Polyethylene Glycol (PEG) 4000 and (PEG) 6000, and both ratios are 5: 1, and the ratio of adjuvant and medicine is 5: 1.Cooling column height 2m uses dimethicone as liquid coolant, and it is 120 ℃ that cooling column top is provided with temperature, and the middle part is a room temperature, and the bottom is 5 ℃.When the shower nozzle aperture is 0.3mm, 3 of numbers, when arranging for equilateral triangle, the fusion medicinal liquid is pressurised into 0.05MPa, shower nozzle place jet velocity is about 1.6m/s, and design temperature is 135 ℃, and frequency of vibration is set at 200Hz, amplitude is 0.15mm, and preparing the drop pill diameter is that drop pill accounts for 98% of gross mass in 1.5mm ± 0.05mm scope; When the shower nozzle aperture is 0.2mm, 7 of numbers, when star was equidistantly arranged, the fusion medicinal liquid was pressurised into 0.06MPa, and shower nozzle place spray orifice jet velocity is about 1.8m/s.Design temperature is 140 ℃, and frequency of vibration is set at 300Hz, and amplitude is 0.12mm, and preparing the drop pill diameter is that drop pill accounts for 96.8% of gross mass in 0.70mm ± 0.05mm scope.
Claims (10)
1. equipment for preparing even drop pill, comprise melting pot (2), feeding pipe (5), flow transducer (7), shower nozzle (15), vibrating device, cooling column (16) and drop pill catcher (18), described melting pot (2) by feeding pipe (5) successively with valve (6), flow transducer (7) is connected with shower nozzle (15), described vibrating device comprises signal generator (9), power amplifier (10) and vibrator (11), described signal generator (9) is electrically connected with described power amplifier (10) and vibrator (11) successively, described vibrator (11) is connected with described shower nozzle (15) by connecting rod (14), cooling column (16) be installed in described shower nozzle (15) under, be provided with liquid coolant (17) in the described cooling column (16), the bottom in described cooling column (16) is provided with described drop pill catcher (18).
2. according to the described a kind of equipment for preparing even drop pill of claim 1, it is characterized in that also comprising computer centralized displaying and control system (20) and be arranged on melting pot temperature sensor (3) on the described melting pot (2), be arranged on the melting pot pressure transducer (4) of described melting pot (2) internal upper part, be arranged on the pipeline temperature sensor (8) on the described feeding pipe (5), be arranged on the nozzle temperature pick off (12) on described shower nozzle (15) surface, be arranged on the shower nozzle vibrating sensor (13) on described shower nozzle (15) surface and be arranged on the interior bottom of described cooling column (16), the cooling system temperature sensor (19) on middle part and top, the input of described computer centralized displaying and control system (20) by holding wire respectively with the outfan of described melting pot temperature sensor (3), the outfan of melting pot pressure transducer (4), the outfan of pipeline temperature sensor (8), the outfan of flow transducer (7), the outfan of nozzle temperature pick off (12), the outfan of the outfan of shower nozzle vibrating sensor (13) and cooling system temperature sensor (19) connects, and the outfan of described computer centralized displaying and control system (20) is connected with the input of actuator on being arranged on described valve (6) by holding wire.
3. according to the described a kind of equipment for preparing even drop pill of claim 1, it is characterized in that described shower nozzle (15) is arranged on the bottom of described connecting rod (14) or is arranged on the sidewall of described connecting rod (14).
4. according to claim 1 or 3 described a kind of equipment that prepare even drop pill, it is characterized in that it is 0.1mm～1.5mm that described shower nozzle (15) is gone up the aperture of spray orifice.
5. according to the described a kind of equipment for preparing even drop pill of claim 4, the aperture that it is characterized in that described spray orifice is 0.3mm～1.0mm.
6. method for preparing even drop pill, its feature comprises the steps:
Prepare a kind of equipment for preparing even drop pill, this equipment comprises melting pot (2), feeding pipe (5), flow transducer (7), shower nozzle (15), vibrating device, cooling column (16) and drop pill catcher (18), described melting pot (2) by feeding pipe (5) successively with valve (6), flow transducer (7) is connected with shower nozzle (15), described vibrating device comprises signal generator (9), power amplifier (10) and vibrator (11), described signal generator (9) is connected with vibrator (11) with described power amplifier (10) successively by circuit, described vibrator (11) is connected with described shower nozzle (15) by connecting rod (14), cooling column (16) be installed in described shower nozzle (15) under, be provided with liquid coolant (17) in the described cooling column (16), the bottom in described cooling column (16) is provided with described drop pill catcher (18);
The medicine and the adjuvant of preparation drop pill are put in the described melting pot (2) according to mass ratio, heating makes material melting and is warmed up to setting value, stirring makes the material uniform mixing become the fusion medicinal liquid, heat described feed pipe (5) and described shower nozzle (15) to design temperature, open described signal generator (9), power amplifier (10) and vibrator (11), regulate described vibrator (11) and produce vibration, give shower nozzle by the connecting rod (14) between described vibrator (11) and the described shower nozzle (15) with transfer of vibration, the heating and the refrigeration of opening described cooling column (16) make the interior described liquid coolant (17) of described cooling column (16) reach the thermograde of setting, use compressed air as motive force, the fusion medicinal liquid is delivered to described shower nozzle (15) by described feed pipe (5) in described melting pot (2), use described valve (6) and flow transducer (7) that the flow of fusion medicinal liquid is controlled and measured, under the effect of shower nozzle vibration, be broken into the fusion medicinal liquid drop of uniform grading with the fusion medicinal liquid of effusive form ejection from the spray orifice of described shower nozzle (15), the drop drippage enters in the interior liquid coolant (17) of described cooling column (16), be solidified as the uniform drop pill granule of particle diameter and fall into described drop pill catcher (18), collect by described drop pill catcher (18).
7. according to the described a kind of method for preparing even drop pill of claim 6, it is characterized in that described a kind of equipment for preparing even drop pill also comprises computer centralized displaying and control system (20) and is arranged on melting pot temperature sensor (3) on the described melting pot (2), be arranged on the melting pot pressure transducer (4) of described melting pot (2) internal upper part, be arranged on the pipeline temperature sensor (8) on the described feeding pipe (5), be arranged on the nozzle temperature pick off (12) on described shower nozzle (15) surface, be arranged on the shower nozzle vibrating sensor (13) on described shower nozzle (15) surface and be arranged on the interior bottom of described cooling column (16), the cooling system temperature sensor (19) on middle part and top, the input of described computer centralized displaying and control system (20) by holding wire respectively with the outfan of described melting pot temperature sensor (3), the outfan of melting pot pressure transducer (4), the outfan of pipeline temperature sensor (8), the outfan of flow transducer (7), the outfan of nozzle temperature pick off (12), the outfan of the outfan of shower nozzle vibrating sensor (13) and cooling system temperature sensor (19) connects, and the outfan of described computer centralized displaying and control system (20) is connected with the input of actuator on being arranged on described valve (6).
8. according to claim 6 or 7 described a kind of methods that prepare even drop pill, flow velocity is 0.3m～3m when it is characterized in that the fusion medicinal liquid by described spray nozzle.
9. according to claim 6 or 7 described a kind of methods that prepare even drop pill, the frequency of vibration that it is characterized in that described vibrator is 20Hz～2000Hz, and Oscillation Amplitude is 0.01mm～1mm.
10. according to claim 6 or 7 described a kind of methods that prepare even drop pill, the frequency of vibration that it is characterized in that described shower nozzle is 150Hz～1000Hz, and Oscillation Amplitude is 0.05mm～0.2mm.
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| CN2010106118441A CN102078259A (en) | 2010-12-29 | 2010-12-29 | Equipment and method for preparing uniform dripping pills |
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| CN2010106118441A CN102078259A (en) | 2010-12-29 | 2010-12-29 | Equipment and method for preparing uniform dripping pills |
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| CN102578443A (en) * | 2011-12-28 | 2012-07-18 | 上海统益生物科技有限公司 | Equipment for preparing curdlan circular gel particles |
| CN104211851A (en) * | 2014-09-24 | 2014-12-17 | 天津大学 | Preparation method of monodisperse macromolecule composite magnetic microspheres |
| CN104274326A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Air-cooled dropping pill production line |
| CN104274327A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Liquid cooling dropping pill production line |
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| CN102578443A (en) * | 2011-12-28 | 2012-07-18 | 上海统益生物科技有限公司 | Equipment for preparing curdlan circular gel particles |
| USRE49035E1 (en) | 2013-07-11 | 2022-04-19 | Tasly Pharmaceutical Group Co., Ltd. | Traditional Chinese medicine composition, and preparation and application thereof |
| CN104274326A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Air-cooled dropping pill production line |
| CN104274327A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Liquid cooling dropping pill production line |
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| US11013694B2 (en) | 2013-07-11 | 2021-05-25 | Tasly Pharmaceutical Group Co., Ltd. | Formulation of a micro drop pill and the preparation method thereof |
| CN104274323B (en) * | 2013-07-11 | 2019-05-17 | 天士力医药集团股份有限公司 | Liquid cooling dripping pill production line |
| CN104274326B (en) * | 2013-07-11 | 2018-11-30 | 天士力医药集团股份有限公司 | Be gas-cooled dripping pill production line |
| USRE49050E1 (en) | 2013-07-11 | 2022-04-26 | Tasly Pharmaceutical Group Co., Ltd. | Traditional Chinese medicine composition, and preparation and application thereof |
| CN104211851A (en) * | 2014-09-24 | 2014-12-17 | 天津大学 | Preparation method of monodisperse macromolecule composite magnetic microspheres |
| CN104211851B (en) * | 2014-09-24 | 2016-08-24 | 天津大学 | A kind of preparation method of mono-disperse polymer composite magnetic microballoon |
| CN105624650A (en) * | 2016-01-04 | 2016-06-01 | 京东方科技集团股份有限公司 | Device and use method of device |
| CN105624650B (en) * | 2016-01-04 | 2018-11-23 | 京东方科技集团股份有限公司 | A kind of application method of device and the device |
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| CN109875119A (en) * | 2017-12-06 | 2019-06-14 | 贵州中烟工业有限责任公司 | A kind of quick-fried pearl two phase flow molding equipment of cigarette and the quick-fried pearl process equipment of cigarette |
| CN109701801A (en) * | 2018-12-28 | 2019-05-03 | 天津中新药业集团股份有限公司第六中药厂 | It eliminates liquid and passes through the method in jet pipe drip process with drop |
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Application publication date: 20110601 |