CN206508254U - A kind of quick spherical makeup of liquid is put - Google Patents
A kind of quick spherical makeup of liquid is put Download PDFInfo
- Publication number
- CN206508254U CN206508254U CN201621203792.3U CN201621203792U CN206508254U CN 206508254 U CN206508254 U CN 206508254U CN 201621203792 U CN201621203792 U CN 201621203792U CN 206508254 U CN206508254 U CN 206508254U
- Authority
- CN
- China
- Prior art keywords
- tower body
- sets
- liquid
- cone
- spherical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 17
- 238000009413 insulation Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 18
- 238000007711 solidification Methods 0.000 abstract description 15
- 230000008023 solidification Effects 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000010924 continuous production Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 2
- 239000011344 liquid material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000011540 sensing material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A kind of quick spherical makeup of liquid is put, including tower body, cold wind pusher and liquid ejector, and the top of the tower body sets gas distributor, and cold wind pusher is connected with gas distributor through stretching into tower body at the top of tower body；The bottom of tower body sets the vertex of a cone towards having gap, i.e. material outlet between conical baffled in tower body, conical baffled cone bottom and the side wall of tower body, and the lower section of material outlet sets material collecting tank；The playpipe of the liquid ejector is stretched into tower body through the conical baffled vertex of a cone, and the tail end of playpipe sets nozzle.During using the present apparatus, the drug quality of preparation is high, and bioavilability is high；Sprayed the bottom of using simultaneously by the way of, the movement locus of drop is in first up and then down parabolic track, there is enough hardening times；Spherical, one step of solidification is completed, and production efficiency is high, simple production process, and continuous production, the manufacturing cost reduction of medicine, more conducively marketing can be achieved.
Description
Technical field
The utility model belongs to pharmaceutical field, more particularly, to a kind of quick spherical solidification equipment of liquid.
Background technology
The veterinary medicine field of pharmaceutical field, particularly jumpbogroup administration, it usually needs by the medicine being much in a liquid state at room temperature
Product solid state, but need to increase water miscible category by solid dispersion technology and realize solid state, so meet jumpbogroup spice to
The requirement of medicine or drinking water administration.Need to use thermally sensitive carrier material, such as Macrogol 4000 or 6000 in technology,
It is solid-state when these materials are below 55 DEG C, but just melts during more than more than 65 DEG C as liquid, dissolubility to medicine and scattered
Property is good, uses safety.But generally, when this material prepares solid dispersion, the temperature finally controlled is lower, and water-soluble effect is just
It is better, rapid drawdown speed drop it is faster, how not only water-soluble effect is also better, so fast but also low control system temperature, directly
Connect the quality and the market competitiveness for being related to product.
When traditional method is applied, although ambient temperature control ratio is relatively low, but because dispersion is less than certain temperature
After be changed into solid-state, temperature starts to cool by the thermaltransmission mode of system outer surface, and heat transfer heat transfer efficiency is very low, although most table
Face sudden temperature drop, but internal temperature is also high, causes product quality uneven.Some technique wearing or featuring stage armour systems are poured on flat board, stand
It is very thin one layer, then ice bath method prepare, due to dividing after decoction it is very thin, can be with fast cooling, the medicinal substances of preparation
Measure, but preparation efficiency is substantially reduced, and the medicine of solidification onboard is not readily separated, drug loss is big, and frozen water demand is big, more can not
Continuous production is realized, medicine cost is ultimately caused very expensive.
Utility model content
The purpose of this utility model is to provide a kind of liquid quick spherical solidification equipment.
Based on object above, the utility model takes following technical scheme：
The technical solution of the utility model is：A kind of quick spherical solidification equipment of liquid, including tower body, cold wind pusher and
Liquid ejector, the top of the tower body sets gas distributor, and cold wind pusher passes through and stretches into tower body and gas at the top of tower body
Body distributor is connected；The bottom of tower body sets the vertex of a cone towards conical baffled in tower body, conical baffled cone bottom and the side of tower body
There are gap, i.e. material outlet between wall, the lower section of material outlet sets material collecting tank；The playpipe of the liquid ejector is worn
Cross the conical baffled vertex of a cone to stretch into tower body, the tail end of playpipe sets nozzle.
The side wall of the tower body sets heat-insulation layer.
The side wall of the tower body sets gradually upper and lower two temperature controllers.
The side wall of the tower body also sets up observation window.Observation window can be further selected as glass observation window, can play from outer
The effect dynamically produced in boundary's monitoring tower, and it is easy to cleaning；The side wall of tower body sets upper and lower two temperature controllers respectively, and it is made
With being monitoring solidification temperature, technological parameter is conveniently adjusted.
Compared with prior art, the utility model has following technical advantage：
1）The characteristics of the utility model is according to liquid curing technology, the effect of liquidating is sprayed by high-temp liquid and cold wind, can
Realize the instantaneous solidification of Thermo-sensitive material.Specifically, when being sprayed using the present apparatus, because the droplet size ejected is small, weightlessness
Spherical in shape afterwards, very bigger than surface, temperature can realize quick transmission so as to moment rapid drawdown, and the drug quality of preparation is high, biological
Availability is high；Sprayed the bottom of using simultaneously by the way of, the movement locus of drop is in first up and then down parabolic track, when having enough solidifications
Between；
2）Compared with traditional ice-water bath, during using the present apparatus, spherical, one step of solidification is completed, and production efficiency is high, production technology
Simply, continuous production, the manufacturing cost reduction of medicine, more conducively marketing can be achieved；
3）The medicaments uniformity obtained by the present apparatus, quality is good, efficiency high, can farthest play liquid curing technology
Advantage；Secondly, by the control to technical parameter, being precisely controlled for spherical particle diameter can be achieved, pill, micropill is can be made into
And microballoon, increase drug absorption, improve bioavilability.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is use state schematic diagram of the present utility model（In Fig. 2：Open circles represent the drop sprayed, filled black circle
Represent the spherical of solidification）.
Embodiment
A kind of quick spherical solidification equipment of liquid as illustrated in fig. 1 and 2, including tower body 1, cold wind pusher and liquid injection
Device, the side wall of tower body 1 sets heat-insulation layer 3, effectively prevents ambient temperature from producing influence to temperature in tower.The side wall of the tower body 1
Set gradually upper and lower two temperature controllers 5.The side wall of the tower body 1 also sets up observation window 2.The top of the tower body 1 sets gas
Distributor, the top of cold wind pusher through tower body 1 is stretched into tower body 1 and is connected with gas distributor 6；The bottom of tower body 1 sets cone
There are gap, i.e. material outlet 9 in top towards conical baffled 8 in tower body 1 between conical baffled 8 cone bottom and the side wall of tower body 1,
The lower section of material outlet sets material collecting tank 7, is easy to the drug microparticles after solidification to be pooled to material collection under gravity
Groove 7；The playpipe 4 of the liquid ejector is stretched into tower body 1 through conical baffled 8 vertex of a cone, and the tail end of playpipe 4 sets spray
Mouth.During injection, by adjusting jet velocity and injection bore, the particle size distribution of medicine after solidification can be controlled；
When being produced using the present apparatus, high-temp liquid material is first prepared, then high-temp liquid material is sprayed by injector 4
Enter tower body 1 and be internally formed medicine drop, while cold wind is pushed to gas distributor 6 by cold wind pusher, cold wind drips with medicine to be formed pair
Punching, medicine drop temperature moment rapid drawdown, temperature sensing material solidification forms spherical, and be pooled under gravity in material collection groove 7
It is collected.Whole solidification process can carry out dynamic monitoring by observation window 2 and temperature controller 5, and according to the actual feelings of production
Condition adjusting process, the operation of specific adjusting process includes to the jet velocity of injector and the adjustment of injection bore and cold wind is pushed away
Intake velocity and the EAT adjustment of device are sent, wherein liquid ejector of the prior art and cold wind pusher can be met pair
The adjustment of above-mentioned technique.
It should be noted that：Tower body 1 in the present apparatus can be cylinder can also be multiaspect hollow cylinder, such as four sides
Body, pentagonal prism shape etc., such approximate transform is all fallen within protection domain of the present utility model.
Claims (4)
1. a kind of quick spherical makeup of liquid is put, it is characterised in that including tower body, cold wind pusher and liquid ejector are described
The top of tower body sets gas distributor, and cold wind pusher is connected with gas distributor through stretching into tower body at the top of tower body；Tower
The bottom of body sets the vertex of a cone to have gap towards between conical baffled in tower body, conical baffled cone bottom and the side wall of tower body, i.e.,
Material outlet, the lower section of material outlet sets material collecting tank；The playpipe of the liquid ejector passes through conical baffled cone
Top is stretched into tower body, and the tail end of playpipe sets nozzle.
2. the quick spherical makeup of liquid as claimed in claim 1 is put, it is characterised in that the side wall of the tower body sets insulation
Layer.
3. the quick spherical makeup of liquid as claimed in claim 2 is put, it is characterised in that the side wall of the tower body is set gradually
Upper and lower two temperature controllers.
4. the quick spherical makeup of liquid as claimed in claim 3 is put, it is characterised in that the side wall of the tower body also sets up observation
Window.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621203792.3U CN206508254U (en) | 2016-11-08 | 2016-11-08 | A kind of quick spherical makeup of liquid is put |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621203792.3U CN206508254U (en) | 2016-11-08 | 2016-11-08 | A kind of quick spherical makeup of liquid is put |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206508254U true CN206508254U (en) | 2017-09-22 |
Family
ID=59861582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621203792.3U Expired - Fee Related CN206508254U (en) | 2016-11-08 | 2016-11-08 | A kind of quick spherical makeup of liquid is put |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206508254U (en) |
-
2016
- 2016-11-08 CN CN201621203792.3U patent/CN206508254U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170922 |