CN204170104U - Drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device - Google Patents
Drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device Download PDFInfo
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- CN204170104U CN204170104U CN201420384171.4U CN201420384171U CN204170104U CN 204170104 U CN204170104 U CN 204170104U CN 201420384171 U CN201420384171 U CN 201420384171U CN 204170104 U CN204170104 U CN 204170104U
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- cooling pipe
- dripping
- air cooling
- coolant
- cooling
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- 238000001816 cooling Methods 0.000 title claims abstract description 160
- 239000006187 pill Substances 0.000 title claims abstract description 93
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 27
- 239000002826 coolant Substances 0.000 claims abstract description 66
- 239000011229 interlayer Substances 0.000 claims abstract description 28
- 238000003860 storage Methods 0.000 claims abstract description 17
- 239000003507 refrigerant Substances 0.000 claims abstract description 14
- 238000011084 recovery Methods 0.000 claims abstract description 9
- 230000000630 rising effect Effects 0.000 claims abstract description 7
- 238000005057 refrigeration Methods 0.000 claims abstract description 4
- 239000007789 gas Substances 0.000 claims description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 60
- 239000000463 material Substances 0.000 claims description 42
- 238000000576 coating method Methods 0.000 claims description 41
- 238000001035 drying Methods 0.000 claims description 40
- 239000011248 coating agent Substances 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 16
- 230000001133 acceleration Effects 0.000 claims description 15
- 238000004064 recycling Methods 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 230000001276 controlling effect Effects 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 4
- 229910052786 argon Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 description 19
- 206010013786 Dry skin Diseases 0.000 description 15
- 241000196324 Embryophyta Species 0.000 description 14
- 239000003814 drug Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 238000005243 fluidization Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 239000009277 Panax notoginseng extract Substances 0.000 description 4
- 241000304195 Salvia miltiorrhiza Species 0.000 description 4
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000008118 PEG 6000 Substances 0.000 description 3
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 3
- 235000011194 food seasoning agent Nutrition 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 2
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 2
- 229950009789 cetomacrogol 1000 Drugs 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
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- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 240000003870 Ageratum houstonianum Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 230000008023 solidification Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
This utility model provides a kind of drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device, its air cooling circulating device comprises: cooling pipe, and be connected and the refrigerating plant that cooling pipe is freezed with cooling pipe, be provided with interlayer outside cooling pipe, interlayer bottom is communicated with cooling pipe inside by connected entrance; Refrigerating plant comprises: cold wind refrigerating plant, and the outlet of the cold wind of cold wind refrigerating plant is connected with the cold air inlet bottom cooling pipe, and cold wind is circulated rising in cooling pipe inner chamber; Cold-trap refrigerating plant comprises: the coolant storage tank that coolant is housed, and the refrigeration machine that the coolant in coolant storage tank freezed and heat exchanger, the refrigerant inlet that refrigerant exit and the interlayer top of coolant storage tank are arranged is connected, coolant, by refrigerant inlet input interlayer, transfers to interlayer bottom from interlayer top and is transferred to cooling pipe inner chamber; Coolant circulates with cold wind simultaneously rises in the inner chamber of cooling pipe, and by cooling pipe top discharge or recovery.
Description
Technical field
This utility model relates to a kind of drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device, particularly relates to a kind of cooling pipe band drop pill air cooling with dissection circulating device and the dripping pill production line with this air cooling circulating device.
Background technology
Pill dripping machine is the special equipment used in a kind of pharmaceutical industry, is generally used for dripping Chinese medicinal pill.Air-cooling apparatus drips from dripping medicine head dripping liquid medicine out the chiller that cooling becomes solid-state powder, coolant is just circulated in cooling pipe and liquid medicine is dripped become solid-state powder by current existing air-cooling apparatus, but the cooling pipe of prior art can make temperature in whole cooling pipe rise under the impact of room temperature affects condensation effect, and the temperature in the prior art in order to maintain cooling pipe can increase a large amount of coolant in condensation drum, not only waste coolant in large quantities and along with the increase of cold matchmaker, the concentration of coolant also increases thereupon, the purity of powder certainly will be have impact on.
If harmful coolant is discharged in air after being used to complete in addition, will certainly contaminated environment.
Utility model content
Technical problem to be solved in the utility model is, a kind of drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device is provided for the deficiencies in the prior art, the waste not only decreasing cooling medium also reduces the dustiness to powder, and reduces environmental pollution.
Technical problem to be solved in the utility model is achieved by the following technical solution:
Drop pill air cooling circulating device, comprising: cooling pipe, and is connected with described cooling pipe and the refrigerating plant freezed to cooling pipe, is provided with interlayer outside described cooling pipe, and described interlayer bottom is communicated with cooling pipe inside by connected entrance; Described refrigerating plant comprises: cold wind refrigerating plant, and the outlet of the cold wind of described cold wind refrigerating plant is connected with the cold air inlet bottom described cooling pipe, and cold wind is circulated rising in cooling pipe inner chamber; Cold-trap refrigerating plant, described cold-trap refrigerating plant comprises: the coolant storage tank that coolant is housed, and the refrigeration machine that the coolant in coolant storage tank freezed and heat exchanger, the refrigerant inlet that refrigerant exit and the described interlayer top of described coolant storage tank are arranged is connected, coolant, by refrigerant inlet input interlayer, transfers to interlayer bottom from interlayer top and is transferred to cooling pipe inner chamber; Described coolant circulates with cold wind simultaneously rises in the inner chamber of cooling pipe, and by cooling pipe top discharge or recovery.
Better, described cold wind refrigerating plant comprises: freezer, and the air outlet of described freezer is connected with the cold air inlet of cooling pipe; The cold air inlet of described cooling pipe is 0 °-90 ° with satisfying plane included angle a.
Better, described drop pill air cooling circulating device also comprises: gas concentration unit, and it comprises: the first valve, the second valve, gas recycling machine and seperator, and pipeline one end of described first Valve controlling is communicated with cooling pipe, and the other end is communicated with air; Pipeline one end of second Valve controlling is communicated with cooling pipe, and the other end is connected with seperator by gas recycling machine;
Described gas recycling machine comprises: gas discharge pipe, vortex fan, gas recovery pipe, gas collection box, when described second valve open, described vortex fan work extracts the gas in cooling pipe by described gas discharge pipe, and is drained in described gas collection box by described gas recovery pipe by the gas collecting collection.
Better, when coolant is innocuous gas, open described first valve and close described second valve simultaneously, make the coolant in the inner chamber of cooling pipe and cold wind circulate the top of cooling pipe of rising the discharge of pipes be communicated with by the first valve in air simultaneously; When coolant is harmful gas, described second valve is opened while closing described first valve, top coolant in cooling pipe inner chamber and cold wind being circulated simultaneously rise to cooling pipe also receives in gas recycling machine by the back of pipeline that the second valve is communicated with, be separated by seperator, and be transported in described freezer by the cold wind after separation respectively, coolant is transported in described coolant storage tank; Described coolant is: nitrogen, argon or carbon dioxide.
Better, described cooling pipe is straight barrel type or spiral type pipe, long 5m-10m.
Preferably, described cooling pipe is long is 6m.
This utility model also provides a kind of air cooling dripping pill production line, comprise above-mentioned drop pill air cooling circulating device, drop pill system and fluidized drying coated systems, drop pill system comprises material tank and coupled water dropper, vibrating device is provided with between described material tank and water dropper, vibrating device drives water dropper up-down vibration, the nibbling shear shear force produced, the medicinal liquid flowed out in water dropper is cut into and drips, form drop pill after falling into the cooling of described drop pill air cooling circulating device, drop pill is delivered to fluidized drying coated systems and carry out drying and coating.
Better, described air cooling dripping pill production line also comprises: control system and on-Line Monitor Device, described on-Line Monitor Device is arranged on the side below described water dropper, this dress on-line monitoring is put and is comprised stroboscopic lamp, the tranmitting frequency of described stroboscopic lamp is identical with the frequency of vibration of described vibrating device, on-Line Monitor Device outputs signal to control system, and according to this signal regulating and controlling dripping parameter.
Better, the frequency of vibration of described stroboscopic lamp and vibrating device is 50-300HZ, and preferred frequency of vibration is 90-200Hz, and optimum frequency of vibration is 130-140HZ.
Better, described dripping parameter comprises: dripping speed 10-40Kg/hr, dripping acceleration 1-15G, dripping pressure 0.5-4.0Bar and water dropper temperature 70-200 DEG C; The preferred 12-30Kg/hr of described dripping speed, optimum; 15-25Kg/hr; The preferred 3-10G of described dripping acceleration, optimum 3.5-4.5G; The preferred 1.0-3.0Bar of described dripping pressure, optimum 1.8Bar; The preferred 70-100 DEG C of described water dropper temperature, optimum 75-85 DEG C.
Drop pill air cooling circulating device of the present utility model and the dripping pill production line with this air cooling circulating device, coolant is injected by the interlayer to cooling pipe, keep the temperature of cooling pipe, decrease the waste of coolant, decrease the dustiness to powder and minimizing environmental pollution simultaneously.
In addition, because air cooling circulating device adopts Cryogenic air and coolant to cool, avoid the follow-up residual solvent process formality of the condenses modes such as traditional employing liquid paraffin and silicone oil, as follow-up deoiling treatment step, simplify operation sequence, complete organic solvent-free remains, and reduces cost prepared by drop pill.
Below in conjunction with the drawings and specific embodiments, the technical solution of the utility model is described in detail.
Accompanying drawing explanation
Fig. 1 is this utility model air cooling circulating device structural representation;
Fig. 2 is this utility model gas recycling machine structural representation;
Fig. 3 is this utility model dripping pill production line structural representation.
Detailed description of the invention
Fig. 1 is this utility model air cooling circulating device structural representation, and as shown in Figure 1, air cooling circulating device of the present utility model utilizes cryotrap or drips quick cooling to whereabouts medicine, makes the part of its solidification forming.Refrigerating gas temperature range is less than 0 DEG C.It comprises: cooling pipe 1, and is connected with described cooling pipe 1 and the refrigerating plant freezed to cooling pipe; Described cooling pipe 1 is arranged on immediately below the water dropper 2 of drop pill device, described cooling pipe 1 is straight barrel type or spiral type pipe, as required, the length 5m-10m of described cooling pipe 1, preferred length is 6m, be provided with interlayer 3 outside described cooling pipe 1, described interlayer 3 bottom is communicated with cooling pipe 1 inside by connected entrance 11.
Described cold wind refrigerating plant comprises: cold wind refrigerating plant 4, described cold wind refrigerating plant comprises freezer 41, the air outlet of described freezer 41 is connected with the cold air inlet of cooling pipe 1, cold wind is circulated rising in cooling pipe 1 inner chamber, and the cold air inlet of described cooling pipe 1 and plane included angle a are then 0 °-90 °.
In order to realize quick cooling further, described refrigerating plant also comprises cold-trap refrigerating plant 5, described cold-trap refrigerating plant 5 comprises: the coolant storage tank 51 that coolant is housed, and the refrigeration machine 52 that the coolant in coolant storage tank 51 freezed and heat exchanger 53, the refrigerant exit of described coolant storage tank 51 is connected with the refrigerant inlet that described interlayer 3 top is arranged by pump 54, coolant, by refrigerant inlet input interlayer 3, transfers to interlayer 3 bottom from interlayer 3 top and is transferred to cooling pipe 1 inner chamber; Described coolant circulates with cold wind simultaneously rises in the inner chamber of cooling pipe 1, and discharges or reclaim coolant and cold wind with the gas concentration unit 6 be connected by cooling pipe 1 top.Coolant adopts usually: nitrogen, argon or carbon dioxide etc.
Specifically, gas concentration unit 6 comprises: gas recycling machine 61, first valve 62, second valve 63 and seperator 64, and pipeline one end that described first valve 62 controls is communicated with cooling pipe 1, and the other end is communicated with air; Pipeline one end that second valve 63 controls is communicated with cooling pipe 1, the other end is connected with seperator 64 by gas recycling machine 61, as shown in Figure 2, described gas recycling machine 61 comprises: gas discharge pipe 611, vortex fan 612, gas recovery pipe 613, gas collection box 614, when described second valve 63 is opened, described vortex fan 612 is worked the gas extracted by described gas discharge pipe 611 in cooling pipe 1, and is drained in described gas collection box 614 by the gas collecting collection by described gas recovery pipe 613; Described seperator 64 is connected with described gas collection box 614.
When coolant is innocuous gas, opens the first valve 62 and close the second valve 63 simultaneously, make the coolant in the inner chamber of cooling pipe 1 and cold wind circulate the top of cooling pipe 1 of rising the discharge of pipes be communicated with by the first valve 62 in air simultaneously; When coolant is harmful gas, the second valve 63 is opened while closing the first valve 62, top coolant in cooling pipe 1 inner chamber and cold wind being circulated simultaneously rise to cooling pipe 1 also receives in gas recycling machine 61 by the back of pipeline that the second valve 63 is communicated with, be separated by seperator 64, and be transported in freezer 41 by the cold wind after separation respectively, coolant is transported in coolant storage tank 51.
Operation principle:
Please refer to shown in Fig. 1, the inner chamber circulation that produced cold wind enters into cooling pipe 1 by cold air inlet is risen by freezer 41, coolant is input in interlayer 3 by refrigerant inlet by coolant storage tank 51 simultaneously, now in interlayer 3, the flow direction of coolant is from top to bottom, and the connected entrance 11 be communicated with cooling pipe 1 by this interlayer 3 enters into the inner chamber of cooling pipe 1, mix with the cold wind in cooling pipe 1 inner chamber and circulate and rise, when the mist of coolant and cold wind rises to cooling pipe top, by gas concentration unit 6 respectively by cold wind and refrigerant recovering in freezer 41 or coolant storage tank 51, or by gas concentration unit 6, this mist is disposed in air, concrete discharge process refers to foregoing.
Fig. 3 is this utility model dripping pill production line structural representation, as shown in Figure 3, this utility model also provides a kind of air cooling dripping pill production line, comprise above-mentioned drop pill air cooling circulating device, drop pill system, control system, on-Line Monitor Device and fluidized drying coated systems 9, drop pill system comprises material tank 7 and coupled water dropper 2, vibrating device 8 is provided with between described material tank 7 and water dropper 2, vibrating device 8 drives water dropper 2 up-down vibration, the nibbling shear shear force produced, the medicinal liquid flowed out in water dropper 2 is cut into and drips, drop pill is formed after falling into the cooling of described drop pill air cooling circulating device, drop pill is delivered to fluidized drying coated systems 9 and carry out drying and coating, described on-Line Monitor Device is arranged on the side below described water dropper 2, this on-line monitoring is put and is comprised stroboscopic lamp 10, the tranmitting frequency of described stroboscopic lamp 10 is identical with the frequency of vibration of described vibrating device 8, on-Line Monitor Device outputs signal to control system (not shown), and according to this signal regulating and controlling dripping parameter.
The frequency of vibration of described stroboscopic lamp 10 and vibrating device 8 is 50-300HZ, and preferred frequency of vibration is 90-200Hz, and optimum frequency of vibration is 130-140HZ.Described dripping parameter comprises: dripping speed 10-40Kg/hr, dripping acceleration 1-15G, dripping pressure 0.5-4.0Bar and water dropper temperature 70-200 DEG C;
The preferred 12-30Kg/hr of described dripping speed, optimum; 15-25Kg/hr;
The preferred 3-10G of described dripping acceleration, optimum 3.5-4.5G;
The preferred 1.0-3.0Bar of described dripping pressure, optimum 1.8Bar;
The preferred 70-100 DEG C of described water dropper temperature, optimum 75-85 DEG C.
Below by way of best exemplifying embodiment, equipment of the present utility model is described in detail further.This example only for illustration of this utility model, and does not limit this utility model.
Embodiment one
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and PEG-6000 (PEG-4000) adjuvant 2000g.First PEG-6000 is added in material tank 7, be heated to 90 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, be mixed into liquid.The frequency of vibration regulating pneumatic vibration water dropper 2 is 50Hz, dripping speed 10Kg/hr, dripping acceleration 4.5G and dripping pressure 1.8Bar, and incubation cavity adopts electric heating jacket heat-preservation, and water dropper temperature controls 85 DEG C.By stroboscopic lamp 10 perusal drop pill profile, single drop pill size, shape are moderate, each other without adhesion between upper and lower drop pill, continue to keep normal dripping.The upper strata chuck heating-up temperature of cooling tank is set in 80 DEG C, and orlop coolant temperature is to 3 DEG C.Supplied gas in surge tank by pipeline by air pump, make the aforesaid liquid melted flow into water dropper 2 and ooze in cooling tank bottom water dropper 2.Start heat-exchange device, make paraffin oil temperature reach 3 DEG C, liquid circulation pressure is set to 1 Kilogram Force Per Square Centimeter, makes the medicinal liquid oozed from water dropper 2 drop in cooled and solidified in cooling tank and becomes solid-state drop pill, and from discharging pipeline, collect after filter ball device carries out solid-liquor separation.
Embodiment two
Get Radix Salviae Miltiorrhizae extract 600g, water 60g, polyethylene glycol 6000 adjuvant 1500g, be prepared into Radix Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
(1 :) material step: get Radix Salviae Miltiorrhizae extract 600g, add water 60g, add polyethylene glycol 6000 adjuvant 1500g, put into material tank and be heated to 90 DEG C, adopt low speed homogenizing (3200rpm) mixed material, after having mixed, improve homogenizing speed and carry out material to 5000rpm, 6 minutes time.Make it melt completely and be mixed into liquid.
(2) dripping step: the frequency of vibration regulating pneumatic vibration water dropper is 50Hz, moist closet adopts Infrared Heating insulation, temperature controls 80 DEG C, supplied gas in material tank by pipeline by air pump, make to melt uniform aforesaid liquid flow into water dropper and ooze in cooling pipe bottom water dropper, dripping pressure 0.18Bar, dripping speed 12Kg/hr, dripping acceleration 12G.
(3) condensing steps: start cold wind while aforesaid liquid oozes, chilling temperature is made to reach-10 DEG C, and make cold wind at cooling pipe internal circulation flow, the angle of cooling air inlet and horizontal plane is 45 °, make the medicinal liquid oozed from water dropper drop in cooled and solidified in cooling pipe and become solid-state drop pill, and be connected to Fluidized Bed Partial from the pipeline of cooling pipe lower end.
(4) drying steps: until material after forming good fluidised form in bed body, is warming up to 25 DEG C of dryings 60 minutes, then is warming up to 45 DEG C of dryings 30 minutes, continues to be warming up to 55 DEG C of dryings 30 minutes, is then cooled to 30 DEG C with bottom discharge.Element ball moisture Control, at 3.0-7.0%, obtains middle voxel ball.
(5) coating steps: calculate coating powder consumption according to coating inventory and prescription, the concentration of coating solution is 18%, preparation coating solution, stirs 45 minutes.Setting inlet temperature be 25 DEG C qualified drop pill is dropped into fluid bed after, improve setting inlet temperature to 48 DEG C, after temperature of charge reaches 38 DEG C, start coating.In coating process, temperature of charge controls at 35 ~ 45 DEG C, is cooled to 30 DEG C with bottom discharge after coating completes, and sieve ball, particle diameter is 1.0 ~ 2.0mm drop pill.
Embodiment three
Get Salvia miltiorrhiza and Panax notoginseng extract 600g, Borneolum Syntheticum 5g, and polyethylene glycol 6000 adjuvant 2000g, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
(1) material step: first Polyethylene Glycol is added in material tank, be heated to 80 DEG C, melting in advance, add Salvia miltiorrhiza and Panax notoginseng extract again, put into 2500rpm intimate mixing in homogenizer, time 100min, then 6000rpm homogenizing material, time 20min, temperature 100 DEG C, is mixed into liquid.
(2) dripping step: the frequency of vibration regulating pneumatic vibration water dropper is 100HZ, acceleration 1G, dripping speed 10Kg/hr, dripping pressure 1.0Bar.Moist closet adopts steam jacket insulation, and temperature controls 70 DEG C.
(3) condensing steps: supplied gas in material tank by pipeline by air pump, make the aforesaid liquid melted flow into water dropper and ooze in cooling pipe bottom water dropper, cooling pipe is perpendicular to the ground; Start cold wind, make chilling temperature reach-100 DEG C, the angle of cooling air inlet and horizontal plane is 90 °, and makes cold wind at cooling pipe internal circulation flow, makes to drop in cooled and solidified in cooling pipe from the medicinal liquid oozed and becomes solid-state drop pill.
(4) drying steps: dry adopt gradient increased temperature seasoning ,-20 DEG C form fluidisation states, 15 DEG C of dryings 10 minutes, 35 DEG C of dryings 10 minutes, and 55 DEG C of dryings 0 minute, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment four
Get compound Salviae Miltiorrhizae extract 75g, Borneolum Syntheticum 7.5g, arabic gum and lactose 165g, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
(1) material step: the mixture of compound Salviae Miltiorrhizae extract and arabic gum and lactose=1:1 is put into 5000rpm intimate mixing in homogenizer, time 200min, then 10000rpm homogenizing material, time 100min, temperature 100 DEG C, obtains intermediate feed liquid.
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, frequency of vibration is 300Hz, and dripping pressure is 4.0Bar, water dropper temperature 200 DEG C, dripping speed and step (1) material speeds match, dripping acceleration 3G.
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 4.0mm drop pill element ball, described refrigerating gas temperature is-300 DEG C.
(4) drying steps: adopt fluidization drying apparatus dry, 50 DEG C of dryings 2 hours, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment five
Get compound Salviae Miltiorrhizae extract 75g, Borneolum Syntheticum 7.5g, lactose 165g, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
(1) material step: compound Salviae Miltiorrhizae extract and lactose are put into 2500rpm intimate mixing in homogenizer, time 100min, then 6000rpm homogenizing material, time 50min, temperature 80 DEG C, obtains intermediate feed liquid.
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, frequency of vibration is 150Hz, and dripping pressure is 2Bar, water dropper temperature 150 DEG C, dripping speed and step (1) material speeds match.
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 1mm drop pill element ball, described refrigerating gas temperature is-100 DEG C.
(4) drying steps: adopt fluidization drying apparatus dry, 50 DEG C of dryings 2 hours, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment six
Get compound Salviae Miltiorrhizae extract 75g, Borneolum Syntheticum 7.5g, PEG 8000 165g, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
After compound Salviae Miltiorrhizae extract powder is added water, stir more than 10 minutes in 60 DEG C, obtain pharmaceutical premixed material.
(1) material step: compound Salviae Miltiorrhizae extract and PEG 8000 are put into 2500rpm intimate mixing in homogenizer, time 100min, then 6000rpm homogenizing material, time 50min, temperature 80 DEG C, obtains intermediate feed liquid.
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, frequency of vibration is 150Hz, and dripping pressure is 2Bar, water dropper temperature 150 DEG C, dripping speed and step (1) material speeds match.
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 2mm drop pill element ball, described refrigerating gas temperature is-100 DEG C.
(4) drying steps: adopt fluidization drying apparatus dry, 50 DEG C of dryings 2 hours, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment seven
Get compound Salviae Miltiorrhizae extract 90g, Borneolum Syntheticum 2g, cetomacrogol 1000 270g, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
After compound Salviae Miltiorrhizae powdered active ingredient is added water, stir more than 10 minutes in 30 DEG C, obtain pharmaceutical premixed material.
(1) material step: compound Salviae Miltiorrhizae extract and cetomacrogol 1000 are put into 2500rpm intimate mixing in homogenizer, time 100min, then 6000rpm homogenizing material, time 20min, temperature 100 DEG C, obtains intermediate feed liquid.
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, frequency of vibration 100HZ, acceleration 1G, dripping speed 10Kg/hr, dripping pressure 1.0Bar, water dropper temperature 70 C.Dripping speed and step (1) material speeds match.
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 1.5mm drop pill element ball, described refrigerating gas temperature is-80 DEG C.
(4) drying steps: dry adopt gradient increased temperature seasoning ,-20 DEG C form fluidisation states, 15 DEG C of dryings 10 minutes, 35 DEG C of dryings 10 minutes, and 55 DEG C of dryings 0 minute, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment eight
Get compound Salviae Miltiorrhizae extract 100g, Borneolum Syntheticum 5g, the combination 35g of Macrogol 4000 and polyethylene glycol 6000=1:1, be prepared into compound Salviae Miltiorrhizae microdroplet ball, preparation method is as follows:
After compound Salviae Miltiorrhizae extract powder is added water, stir more than 10 minutes in 80 DEG C, obtain pharmaceutical premixed material.
(1) material step: by the combinatorial introduction of compound Salviae Miltiorrhizae extract and Macrogol 4000 and polyethylene glycol 6000=1:1 to 2500rpm intimate mixing in homogenizer, time 100min, then 6000rpm homogenizing material, time 80min, temperature 80 DEG C, obtains intermediate feed liquid.
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, frequency of vibration 130HZ, acceleration 2G, dripping speed 40Kg/hr, dripping pressure 3.0Bar, water dropper temperature 100 DEG C.Dripping speed and step (1) material speeds match.
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 0.5mm drop pill element ball, described refrigerating gas temperature is 120 DEG C.
(4) drying steps: dry adopt gradient increased temperature seasoning, 30 DEG C form fluidisation states, 35 DEG C of dryings 120 minutes, 55 DEG C of dryings 60 minutes, and 100 DEG C of dryings 60 minutes, obtain dry drop pill element ball.
(5) coating steps: described drying element ball coating in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of coatings obtain coated drop pill.
Embodiment nine
Get ageratum extractum 200g, patchouli oil 1ml, Folium perillae acutae oil 2ml, Macrogol 600 g, add in material tank 7 simultaneously, be heated to 65-85 DEG C, melting, be mixed into liquid.Medicinal liquid imports surge tank into, by sending into water dropper 2 again to surge tank pressuring method, and oozes in cooling tank bottom water dropper 2.The frequency of vibration regulating electric vibrating water dropper 2 is 200Hz, dripping speed 30Kg/hr, dripping acceleration 10G and dripping pressure 0.5Bar, and moist closet adopts electrical heating jacket heat-preservation, and temperature controls 70 DEG C.By stroboscopic lamp 10 perusal drop pill profile, find that cutting liquid drop volume is bigger than normal, regulate and strengthen frequency of vibration to 300Hz, cutting liquid drop volume is reduced; Regulating and strengthening dripping acceleration is 13G, and droplet shearing power is strengthened, dripping speed 15Kg/hr, temperature controls 75 DEG C, dripping pressure 1Bar, and what finally ensure to observe for 10 times at stroboscopic lamp is the state that drop is separated completely.Employing paraffin oil cools, and chilling temperature gradient is from 80 to 10 DEG C.
In sum, this utility model drop pill air cooling circulating device adopts Cryogenic air and coolant to cool, avoid the follow-up residual solvent process formality of the condenses modes such as traditional employing liquid paraffin and silicone oil, as follow-up deoiling treatment step, simplify operation sequence, complete organic solvent-free remains, and reduces cost prepared by drop pill.
Claims (20)
1. drop pill air cooling circulating device, comprising: cooling pipe, and is connected with described cooling pipe and the refrigerating plant freezed to cooling pipe, it is characterized in that, is provided with interlayer outside described cooling pipe, and described interlayer bottom is communicated with cooling pipe inside by connected entrance;
Described refrigerating plant comprises: cold wind refrigerating plant, and the outlet of the cold wind of described cold wind refrigerating plant is connected with the cold air inlet bottom described cooling pipe, and cold wind is circulated rising in cooling pipe inner chamber;
Cold-trap refrigerating plant, described cold-trap refrigerating plant comprises: the coolant storage tank that coolant is housed, and the refrigeration machine that the coolant in coolant storage tank freezed and heat exchanger, the refrigerant inlet that refrigerant exit and the described interlayer top of described coolant storage tank are arranged is connected, coolant, by refrigerant inlet input interlayer, transfers to interlayer bottom from interlayer top and is transferred to cooling pipe inner chamber; Described coolant circulates with cold wind simultaneously rises in the inner chamber of cooling pipe, and by cooling pipe top discharge or recovery.
2. drop pill air cooling circulating device as claimed in claim 1, it is characterized in that, described cold wind refrigerating plant comprises: freezer, and the air outlet of described freezer is connected with the cold air inlet of cooling pipe, and the cold air inlet of described cooling pipe is 0 °-90 ° with satisfying plane included angle a.
3. drop pill air cooling circulating device as claimed in claim 1, it is characterized in that, described drop pill air cooling circulating device also comprises: gas concentration unit, it comprises: the first valve, the second valve, gas recycling machine and seperator, pipeline one end of described first Valve controlling is communicated with cooling pipe, and the other end is communicated with air; Pipeline one end of second Valve controlling is communicated with cooling pipe, and the other end is connected with seperator by gas recycling machine; Described gas recycling machine comprises: gas discharge pipe, vortex fan, gas recovery pipe, gas collection box, when described second valve open, described vortex fan work extracts the gas in cooling pipe by described gas discharge pipe, and is drained in described gas collection box by described gas recovery pipe by the gas collecting collection.
4. drop pill air cooling circulating device as claimed in claim 3, it is characterized in that, when coolant is innocuous gas, open described first valve and close described second valve simultaneously, make the coolant in the inner chamber of cooling pipe and cold wind circulate the top of cooling pipe of rising the discharge of pipes be communicated with by the first valve in air simultaneously;
When coolant is harmful gas, described second valve is opened while closing described first valve, top coolant in cooling pipe inner chamber and cold wind being circulated simultaneously rise to cooling pipe also receives in gas recycling machine by the back of pipeline that the second valve is communicated with, be separated by seperator, and respectively the cold wind after separation is transported in described freezer, coolant is transported in described coolant storage tank, and described coolant is: nitrogen, argon or carbon dioxide.
5. the drop pill air cooling circulating device as described in any one of claim 1-4, is characterized in that, described cooling pipe is straight barrel type or spiral type pipe, long 5m-10m.
6. drop pill air cooling circulating device as claimed in claim 5, is characterized in that, described cooling pipe is long is 6m.
7. an air cooling dripping pill production line, it is characterized in that, comprise drop pill air cooling circulating device, drop pill system and the fluidized drying coated systems described in any one of claim 1-6, drop pill system comprises material tank and coupled water dropper, vibrating device is provided with between described material tank and water dropper, vibrating device drives water dropper up-down vibration, the nibbling shear shear force produced, the medicinal liquid flowed out in water dropper is cut into and drips, form drop pill after falling into the cooling of described drop pill air cooling circulating device, drop pill is delivered to fluidized drying coated systems and carry out drying and coating.
8. air cooling dripping pill production line as claimed in claim 7, it is characterized in that, described air cooling dripping pill production line also comprises: control system and on-Line Monitor Device, described on-Line Monitor Device is arranged on the side below described water dropper, this on-line monitoring is put and is comprised stroboscopic lamp, the tranmitting frequency of described stroboscopic lamp is identical with the frequency of vibration of described vibrating device, and on-Line Monitor Device outputs signal to control system, and according to this signal regulating and controlling dripping parameter.
9. air cooling dripping pill production line as claimed in claim 8, it is characterized in that, the frequency of vibration of described stroboscopic lamp and vibrating device is 50-300HZ.
10. air cooling dripping pill production line as claimed in claim 9, it is characterized in that, the frequency of vibration of described stroboscopic lamp and vibrating device is 90-200Hz.
11. air cooling dripping pill production lines as claimed in claim 10, it is characterized in that, the frequency of vibration of described stroboscopic lamp and vibrating device is 130-140HZ.
12. air cooling dripping pill production lines as claimed in claim 8, it is characterized in that, the dripping speed of described water dropper is 10-40Kg/hr, and dripping acceleration is 1-15G, dripping pressure is 0.5-4.0Bar and water dropper temperature is 70-200 DEG C.
13. air cooling dripping pill production lines as claimed in claim 12, is characterized in that, the dripping speed of described water dropper is 12-30Kg/hr.
14. air cooling dripping pill production lines as claimed in claim 13, is characterized in that, the dripping speed of described water dropper is 15-25Kg/hr.
15. air cooling dripping pill production lines as claimed in claim 12, is characterized in that, the dripping acceleration of described water dropper is 3-10G.
16. air cooling dripping pill production lines as claimed in claim 15, is characterized in that, the dripping acceleration of described water dropper is 3.5-4.5G.
17. air cooling dripping pill production lines as claimed in claim 12, is characterized in that, the dripping pressure of described water dropper is 1.0-3.0Bar.
18. air cooling dripping pill production lines as claimed in claim 17, is characterized in that, the dripping pressure of described water dropper is 1.8Bar.
19. air cooling dripping pill production lines as claimed in claim 12, it is characterized in that, described water dropper temperature is 70-100 DEG C.
20. air cooling dripping pill production lines as claimed in claim 19, it is characterized in that, described water dropper temperature is 75-85 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420384171.4U CN204170104U (en) | 2014-07-11 | 2014-07-11 | Drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420384171.4U CN204170104U (en) | 2014-07-11 | 2014-07-11 | Drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204170104U true CN204170104U (en) | 2015-02-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420384171.4U Withdrawn - After Issue CN204170104U (en) | 2014-07-11 | 2014-07-11 | Drop pill air cooling circulating device and the dripping pill production line with this air cooling circulating device |
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| Country | Link |
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| CN (1) | CN204170104U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274320A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Dropping pill air cooling circulation device and dropping pill production line with air cooling circulation device |
| WO2017045610A1 (en) * | 2015-09-18 | 2017-03-23 | 天士力制药集团股份有限公司 | Intelligent dripping pill machine for continuous liquid solidification |
-
2014
- 2014-07-11 CN CN201420384171.4U patent/CN204170104U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274320A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Dropping pill air cooling circulation device and dropping pill production line with air cooling circulation device |
| CN104274320B (en) * | 2013-07-11 | 2018-10-30 | 天士力医药集团股份有限公司 | Dripping pill air cooling circulator and the dripping pill production line with the air cooling circulator |
| WO2017045610A1 (en) * | 2015-09-18 | 2017-03-23 | 天士力制药集团股份有限公司 | Intelligent dripping pill machine for continuous liquid solidification |
| US10918575B2 (en) | 2015-09-18 | 2021-02-16 | Tasly Pharmaceutical Group Co., Ltd. | Intelligent dripping pill machine for continuous liquid solidification |
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Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 (city of the modern Chinese Medicine) Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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Granted publication date: 20150225 Effective date of abandoning: 20181030 |