CN204240707U - For the fluid bed of dripping pill drying - Google Patents
For the fluid bed of dripping pill drying Download PDFInfo
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- CN204240707U CN204240707U CN201420384491.XU CN201420384491U CN204240707U CN 204240707 U CN204240707 U CN 204240707U CN 201420384491 U CN201420384491 U CN 201420384491U CN 204240707 U CN204240707 U CN 204240707U
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- drying
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Landscapes
- Drying Of Solid Materials (AREA)
Abstract
A kind of fluid bed for dripping pill drying, comprise fluid bed body of heater, material feeding mouth is provided with below body of heater, in body of heater, the below of described charging aperture is provided with airflow-distribution board, the wind pipe of normal temperature low humidity supply air system is arranged on the bottom of described airflow-distribution board, low for normal temperature humid gas is sent in fluid bed body of heater through wind pipe by normal temperature low humidity supply air system, and gas carries out fluidized drying process through airflow-distribution board to the material being built in furnace interior.The utility model adds normal temperature low humidity supply air system on existing equipment basis, utilizes sublimation principle, carries out fluidized drying by solid-gas balance, saves the energy and operating efficiency is high; Coordinate moisture content on-Line Monitor Device simultaneously, the moisture degree of dripping pill in fluid bed furnace body is monitored, effectively control its water content; Be arranged on the nozzle of fluid bed body of heater bottom center, the mode of being sprayed the end of by, coating process stablized, effectively saves coating material simultaneously; Therefore, simple, the with low cost and efficient work of the utility model structure.
Description
Technical field
The utility model relates to a kind of fluid bed, particularly relates to a kind of fluid bed for dripping pill drying.
Background technology
Fluid unit is a kind of common equipment in drug production process, normally moist wood is inserted in fluid bed body of heater, and by high-temperature gas, drying process is carried out to moist wood, the temperature of existing high-temperature gas controls usually at 70 DEG C about-80 DEG C, and high-temperature gas remains temperature constant.Under the effect of high-temperature gas, through the moist wood of condensation of gas system cools, it has been liquid from solid-state thawing that its surface and inner ice crystal need first, then becomes gaseous state from liquid state, and then reaches dry effect.Treat moist wood under high-temperature gas effect and, after dry a period of time, carry out injection dressing by stove inner nozzle.Due to the mode of the constant drying of this high temperature adopted in prior art, and need through from solid-state to liquid state again to the process of gaseous state, likely cause degree of drying inside and outside moist wood to differ in this this process, overall water content is unbalanced.In addition, owing to being the degree of drying by determining moist wood drying time, can cause moist wood water content disunity when at every turn producing, the product water content between each production batch may have deviation.Further, the dressing nozzle in existing fluid bed is in the majority with the structure being arranged on body of heater top, can consume too much coating material like this, the while of wasting to a certain extent, coating process is stable not.
Utility model content
The utility model provides a kind of fluid unit for the deficiencies in the prior art, existing equipment basis adds normal temperature low humidity supply air system, utilize the principle of distillation, solid matter is made directly to be transformed into gaseous state without liquid state, what utilize solid-gas balance to carry out raw material and moisture content to dripping pill is separated drying, saves the energy and operating efficiency is high; Coordinate moisture content on-Line Monitor Device simultaneously, the moisture degree of dripping pill in fluid bed furnace body is monitored, effectively control its water content; Be arranged on the nozzle of fluid bed body of heater bottom center, the mode of being sprayed the end of by, coating process stablized, effectively saves coating material simultaneously; Therefore, simple, the with low cost and efficient work of the utility model structure.
The utility model provides a kind of fluid bed for dripping pill drying, comprise fluid bed body of heater, material feeding mouth is provided with below described body of heater, top is provided with discharging opening, in body of heater, the below of described charging aperture is provided with airflow-distribution board, it is characterized in that, the wind pipe of normal temperature low humidity supply air system is arranged on the bottom of described airflow-distribution board, low for normal temperature humid gas is sent in fluid bed body of heater through wind pipe by described normal temperature low humidity supply air system, and described gas carries out fluidized drying process through airflow-distribution board to the material being built in furnace interior.
Further, described normal temperature low humidity supply air system comprises housing and is arranged on the low humidity unit in housing, and housing is provided with intake stack and wind pipe, through the process of low humidity unit after air enters housing from intake stack, then inputs described body of heater through wind pipe; Described normal temperature low humidity supply air system also comprises the return air duct for air flow recovery, and its two ends are connected with housing with described body of heater respectively.
Further, described low humidity unit is in series by multiple treating apparatus, comprises dust arrester, dehydrating unit, air-supply arrangement, heater, filter and effective filter successively along gas from the inflow direction of described intake stack.
Preferably, the technological parameter of the low humid gas of described normal temperature comprises: humidity≤5g/kg, and expulsion pressure is 1-4bar, and temperature is 20 DEG C-100 DEG C, preferably 20 DEG C-60 DEG C.
Preferably, the bottom center of described body of heater is provided with hydrojet nozzle, carries out injection dressing when dry materials to 4%.
The baking temperature of described fluid bed is-20 DEG C-100 DEG C, and drying time is 1-4 hour;
Preferably, described fluid bed-20 DEG C-30 DEG C forms fluidisation state, 15 DEG C of-35 DEG C of dry 10-120 minute, 35 DEG C of-55 DEG C of dry 10-60 minute, 55 DEG C of-100 DEG C of dry 0-60 minute;
Optimum, described fluid bed 0 DEG C-20 DEG C forms fluidisation state, 25 DEG C of dryings 60 minutes, 45 DEG C of dryings 30 minutes, 55 DEG C of dry 0-30 minute.
Further, be also provided with online moisture content detection device in described fluid bed body of heater, this online moisture monitoring device is microwave remote sensor.
Further, the charging aperture of described fluid bed is all connected with vacuum negative pressure device with discharging opening, under described vacuum negative pressure device effect, the dripping pill element ball vacuum holding collected by dripping pill production line inserts described body of heater, and the dripping pill Vacuum discharge after fluidized coating is exported.
In sum, the utility model adds normal temperature low humidity supply air system on existing equipment basis, utilizes the principle of distillation, makes solid matter directly be transformed into gaseous state without liquid state, what utilize solid-gas balance to carry out raw material and moisture content to dripping pill is separated drying, saves the energy and operating efficiency is high; Coordinate moisture content on-Line Monitor Device simultaneously, the moisture degree of dripping pill in fluid bed furnace body is monitored, effectively control its water content; Be arranged on the nozzle of fluid bed body of heater bottom center, the mode of being sprayed the end of by, coating process stablized, effectively saves coating material simultaneously; Therefore, simple, the with low cost and efficient work of the utility model structure.
Below in conjunction with the drawings and specific embodiments, the technical solution of the utility model is described in detail.
Accompanying drawing explanation
Fig. 1 is the schematic side view of the utility model fluid bed;
Fig. 2 is the front elevational schematic of the utility model fluid bed;
Fig. 3 is the air cooling dripping pill production line overall structure schematic diagram with the utility model fluid bed;
Fig. 4 is the partial enlarged drawing of the refrigerating plant of Fig. 3.
Detailed description of the invention
Fig. 1 is the schematic side view of the utility model fluid bed; Fig. 2 is the front elevational schematic of the utility model fluid bed.As Fig. 1 and shown in composition graphs 2, fluid bed provided by the utility model is in fact on existing fluid unit basis, has set up normal temperature low humidity supply air system.Specifically, the utility model mainly provides a kind of fluid bed 710, fluid bed can be divided into fluid bed body of heater 711 and filter dome 712, chassis is fixed on chassis supports 713, whole chassis can be promoted with chassis supports 713 or be reduced, and also can screw out (as shown in Figure 2) below fluid bed body of heater simultaneously.Chassis is made up of multiple coaxial chassis annulus and a central screw cap type annulus, and multiple coaxial chassis descending pile row of annulus get up, and each chassis annulus exists the gap that supplied gas flows through.Chassis annulus is fixed by this central screw cap type annulus and dead bolt.Hydrojet nozzle is positioned in the middle of chassis, is arranged in nozzle support, protrudes from the central screw cap type annulus of chassis annulus.The lower sidewalls of fluid bed body of heater 711 is provided with charging aperture 714, described charging aperture 714 is connected with the end of described cooling pipe 600, the dripping pill element ball vacuum feeding of shaping through air cooling is inputted fluidized drying dressing in fluid bed, between charging aperture 714 and chassis, is also provided with airflow-distribution board.
When needs fluid bed works, first by charging aperture 714 vacuum feeding above fluid bed body of heater, then pass into process gas, goods fluid is dried to when humidity is 4% and carries out dressing.Then pass through device for discharging 715 discharging to charging basket 731, charging basket 731 is also provided with and vacuumizes interface 732 to produce negative pressure of vacuum the collecting dripping pill after liquefaction dressing.
Process gas just accesses fluid bed furnace body 711 after being first processed into the low humid gas of normal temperature via normal temperature low humidity supply air system by fresh air, specifically, fresh air enters normal temperature low humidity supply air system from the intake stack 721 of normal temperature low humidity supply air system, through process gas outlet 722 enters fluid bed body of heater 711 after filtering the PROCESS FOR TREATMENT such as compression through dry heat.Wherein, described normal temperature low humidity supply air system comprises housing and is arranged on the low humidity unit in housing, housing is provided with intake stack 721 and the wind pipe 723 of normal temperature low humidity system, air from after the intake stack 721 of normal temperature low humidity system enters housing after the process of low humidity unit through wind pipe 723 inputs the airflow-distribution board of described body of heater, the bottom of described airflow-distribution board is connected with the wind pipe of normal temperature low humidity supply air system.Described normal temperature low humidity supply air system also comprises the return air duct for air flow recovery, and two ends are connected with housing with described body of heater respectively.Described low humidity unit is in series by multiple treating apparatus, comprises dust arrester, dehydrating unit, air-supply arrangement, heater, dedusting filter, effective filter successively along gas from the inflow direction of described intake stack.Wherein dust arrester carries out first dedusting; Dehydrating unit is divided into twice dehumidifying, shows cold dehumidifying and rotary wheel dehumidifying; Heater by gas-heated to 20-100 DEG C, preferred 20-60 DEG C; Gas after heating filters and forms clean air feeding fluid bed by dedusting filter and effective filter again.Gas humidity after processed is less than or equal to 5g/kg, and expulsion pressure is 1-4bar, and temperature is 20-60 DEG C.Process gas is under the wind pipe 723 entering normal temperature low humidity unit by process gas outlet 22 flows into the chassis of fluid bed body of heater 711 again, moved in the chassis annulus be piled up by chassis descending and direction to fluid bed furnace body wall, then product turns back to the central authorities of fluid bed body of heater along with flow regime moves upward along fluid bed furnace body wall, simultaneously in fluid bed body of heater central authorities, the nozzle being positioned at middle position carries out hydrojet dressing to product.
As required, under normal circumstances, the baking temperature of described fluid bed is-20 DEG C-100 DEG C, and drying time is 1-4 hour.In order to keep dripping pill to be in fluidized state, the problem solving dripping pill adhesion is enhanced productivity simultaneously, and described fluid bed preferably adopts gradient increased temperature seasoning,-20-30 DEG C forms fluidisation state, 15-35 DEG C dry 10-120 minute, 35-55 DEG C dry 10-60 minute, 55-100 DEG C of dry 0-60 minute; Most preferably 0-20 DEG C forms fluidisation state, 25 DEG C of dryings 60 minutes, 45 DEG C of dryings 30 minutes, 55 DEG C of dry 0-30 minute.
Be convenient to control to effectively detect dripping pill moisture, the on-line measuring device 716 for monitoring micropill water content and domain size distribution situation is also provided with in described fluid bed, be located at the microwave remote sensor 716 on limit, fluid bed furnace side specifically, can the humidity of Real-Time Monitoring material, once reach 4%, with regard to starting nozzle, hydrojet dressing is carried out to material.Fluid bed body of heater opposite side limit is also provided with sampler 717, can sample material in real time, and to analyze the state of material, such as whether dressing completes.Described sampler 717 comprise valve and with the sampling bottle that valve removably connects, open valve by material sample load sampling bottle.
Filter dome 712 is up entered by the process gas of fluid bed, filter is provided with in filter dome, after filter tentatively filters, enter by exhaust duct 724 deduster 725 dedusting of giving vent to anger, be then pumped to exhaust outlet 727 through scavenger fan 726 and enter air.
In addition, what the utility model fluid bed also provided online cleaning systems WIP, WIP system can carry out by programme controlled clean or equipment is preliminary clean.It is divided into 3 scavenger circuits: the region of setting out on a journey of equipment, and region, Road and lower area, cleaning agent may be combined in cold water, hot water, forms cleaning solution in distilled water.Fluid bed body of heater, air inlet, and outlet pipe, filter dome 712 can be cleaned in WIP pattern by WIP spray gun 716, and clean shower nozzle is positioned at chassis supports 713, admission line 723, exhaust piping 724, and in filter dome 712.Also be provided with the delivery pipe of online cleaning systems WIP below chassis, the sewage after having cleaned is got rid of fluid bed.
As dripping cooling and the all-in-one of fluidized drying dressing, the fluidized drying increased, solving dripping pill prepared by air cooling equipment is depositing in process, the problem that the adhesion that may occur and one-tenth analyze, also ensure that dripping pill moisture can reach stationary value, improve the uniformity of equipment medicine carrying and dressing.Spray hot melt liquid and carry out medicine carrying parcel, can further improve dripping pill drugloading rate; Also this equipment can be used to spray and to carry out dripping pill dressing, to meet different process requirement, as: sustained release coating, film coating, sugar coating etc.
Fig. 3 is the air cooling dripping pill production line overall structure schematic diagram with the utility model fluid bed.As shown in Figure 3, fluid bed provided by the utility model can be connected with air cooling dripping pill production line, the charging aperture of fluid bed is connected with vacuum negative pressure device, and under described vacuum negative pressure device effect, the dripping pill element ball collected by dripping pill production line is loaded in body of heater by the mode of vacuum feeding.
Specifically, this dripping pill production line comprises dripping pill system, the air cooling circulatory system and control system, dripping pill system comprises material tank 100 and coupled water dropper 200, vibrating device 300 is provided with between described material tank 100 and water dropper 200, vibrating device drives water dropper up-down vibration, the nibbling shear shear force produced, the liquid flowed out in water dropper is cut into and drips, dripping pill is formed after falling into the cooling of the air cooling circulatory system, side below described water dropper is provided with stroboscopic lamp 201, its strobing frequency is identical with the vibration frequency of described vibrating device, for the dripping situation of monitoring dripping pill, by observing the face shaping of dripping pill, judge the domain size distribution situation of dripping pill, control system is according to the monitoring result of on-Line Monitor Device, control and regulation dripping parameter.Described dripping parameter comprises: the vibration frequency of described stroboscopic lamp and vibrating device: 50-300HZ, preferred 90-200Hz, optimum 130-140HZ; Dripping speed: 10-40Kg/hr, preferred 12-30Kg/hr, optimum; 15-25Kg/hr; Dripping acceleration: 1-20G, preferred 3-10G, optimum 3.5-4.5G; Dripping pressure: 0.5-4.0Bar, preferred 1.0-3.0Bar, optimum 1.8Bar; Water dropper temperature: 70-200 DEG C, preferred 70-100 DEG C, optimum 75-85 DEG C.This stroboscopic real-time inspection and monitoring technology on-line, make dripping pill product become rate to bring up to more than 95% by traditional 70%.
Shown in composition graphs 3, the air cooling circulatory system of dripping pill production line comprises: cooling pipe 600, and is connected with described cooling pipe 600 and the refrigerating plant freezed to cooling pipe.Described cooling pipe 600 is arranged on immediately below the water dropper 200 of dripping pill device, and described cooling pipe 600 can be straight barrel type or spiral type pipe, and as required, the length of described cooling pipe 600 is 5m-10m, and preferred length is 6m.Be provided with interlayer 610 outside described cooling pipe 600, described interlayer 610 bottom is communicated with cooling pipe 600 inside by connected entrance 601.
As shown in Figure 4, described refrigerating plant comprises: cold wind refrigerating plant 4, described cold wind refrigerating plant comprises freezer 41, the air outlet of described freezer 41 is connected with the cold air inlet of cooling pipe 600, cold wind is circulated rising in cooling pipe 600 inner chamber, and the cold air inlet of described cooling pipe 600 and horizontal plane angle a are 0 °-90 °.In order to realize quick cooling further, described refrigerating plant also comprises cold-trap refrigerating plant 5, described cold-trap refrigerating plant 5 comprises: the coolant storage tank 51 that refrigerant is housed, and the refrigeration machine 52 that the refrigerant in coolant storage tank 51 freezed and heat exchanger 53, the refrigerant exit of described coolant storage tank 51 is connected with the refrigerant inlet that described interlayer 610 top is arranged by pump 54, refrigerant, by refrigerant inlet input interlayer 610, transfers to interlayer 610 bottom from interlayer 610 top and is transferred to cooling pipe 600 inner chamber; Described refrigerant circulates with cold wind simultaneously rises in the inner chamber of cooling pipe 600, and discharges or reclaim refrigerant and cold wind with the gas concentration unit 6 be connected by cooling pipe 600 top.Refrigerant adopts usually: nitrogen, argon gas or carbon dioxide etc.
Shown in composition graphs 1, Fig. 2 and Fig. 3, specifically, the course of work with the air cooling dripping pill production line of the utility model fluid bed is such: utilize surge tank 500 to push liquid, the liquid melted is transported in the water dropper 200 with incubation cavity, described water dropper has the outlet with incubation cavity 210 bottom opening equidirectional, guarantees that liquid can ooze bottom water dropper.Utilize pressure, admixing medical solutions is flowed out from the outlet at bottom of water dropper 200.According to the size of required dripping pill, regulate pressure or vibration parameters that is pneumatic or electric vibrating water dropper, the medicine making the powder column flowed out from water dropper be cut into required diameter drips.Wherein vibration acceleration 0-110g (sine), Oscillation Amplitude (0-25.4mm).
Start gas refrigeration, the medicine utilizing low temperature to make to ooze drops in cooled and solidified in cooling pipe 600 and becomes solid granulates, and collects in cooling pipe lower end simultaneously.The upper port of cooling pipe 600 seals with the opening of the incubation cavity lower end of water dropper 200 and is communicated with, and the lower end of cooling pipe 600 is the hatch frame corresponding with dripping pill collecting vessel.
The inner chamber circulation that produced cold wind enters into cooling pipe 600 by cold air inlet is risen by freezer 41, refrigerant is input in interlayer 610 by refrigerant inlet by coolant storage tank 51 simultaneously, now in interlayer 610, the flow direction of refrigerant is from top to bottom, and the connected entrance 601 be communicated with cooling pipe 600 by this interlayer 610 enters into the inner chamber of cooling pipe 600, mix with the cold wind in cooling pipe 600 inner chamber and circulate and rise, when the mist of refrigerant and cold wind rises to cooling pipe top, by gas concentration unit 6 respectively by cold wind and refrigerant recovering in freezer 41 or coolant storage tank 51, or by gas concentration unit 6, this mist is disposed in air.
Owing to being directly blown at an angle between cooling-air and cooling pipe 600, cold wind and refrigerant form laminar flow in cooling pipe 600, make the medicine oozed continuously drip the purging of the gas obtaining a small amount of lower temperature, maintain a certain distance, avoid dripping pill to be adhered in this region, affect follow-up shaping.
Subsequently, cooling pipe 600 end is connected to fluidized drying coated systems 700 by pipeline, regulate air intake and air draft air quantity, and control temperature scope, dried piller is by negative pressure of vacuum discharging, rejoin fluid bed after sieving, regulate air intake and air draft air quantity, carry out medicine carrying or film coating by technological requirement; Thermograde intensification seasoning is adopted to make humidity of materials carry out dressing lower than during certain value.Coating process is stablized, and simultaneously effectively saves coating material, simple, the with low cost and efficient work of structure.After dressing, equipment also can connect capsule filling machine and pours into, and capsule check-weighing machine carries out by grain check weighing.Therefore, according to practical application needs, on basis integrally-built shown in Fig. 3, air cooling dripping pill production line provided by the utility model can also configure capsule filling machine and capsule check weighing device.Said apparatus is prior art, does not repeat them here.
Below by way of best exemplifying embodiment, equipment of the present utility model is described in detail further.This example only for illustration of the utility model, and does not limit the utility model.In fluidized drying process, process parameters range through the low humid gas of normal temperature of low humidity unit process comprises: humidity≤5g/kg, expulsion pressure is 1-4bar, temperature is 20 DEG C-100 DEG C, preferably 20 DEG C-60 DEG C, according to different dry requirements, select the parameter adapted with it, finally to reach fluidized drying requirement.
Embodiment one prepares compound danshen dripping pills
(1) material step: get Salvia miltiorrhiza and Panax notoginseng extract 600g, borneol 5g, and Macrogol 6000 (PEG-6000) auxiliary material 2000g.First PEG-6000 is added in material tank, be heated to 90 DEG C, in advance melting, add 5000rpm homogeneous mixing in Salvia miltiorrhiza and Panax notoginseng extract to homogenizer again, time 200min, then 10000rpm homogeneous material, time 100min, temperature 100 DEG C, must be mixed into liquid.
(2) dripping step: the vibration frequency regulating pneumatic vibration water dropper is 300Hz, moist closet adopts steam jacket insulation, and temperature controls 200 DEG C, and dripping speed and step (1) material speeds match, dripping pressure is 2Bar.
(3) condensing steps: supplied gas in material tank by pipeline by air pump, make the aforesaid liquid melted flow into water dropper and ooze in cooling pipe bottom water dropper, cooling pipe is perpendicular to the ground; Start cold air, chilling temperature is made to reach-120 DEG C, the angle of cooling air inlet and horizontal plane is 30 °, and make cold air at cooling pipe internal circulation flow, make to drop in cooled and solidified in cooling pipe from the liquid oozed and become solid-state dripping pill, Fluidized Bed Partial can be connected to from the pipeline of cooling pipe lower end and carry out fluidized drying and medicine carrying dressing.
(4) drying steps: then dripping pill is carried out fluidized drying and medicine carrying dressing, until material after forming good fluidised form in bed body, 50 DEG C of dryings drying in 2 hours 120 minutes, plain ball moisture controls 5.0%, obtains middle voxel ball.
(5) coating steps: calculate coating powder consumption according to dressing inventory and prescription, the concentration of coating solution is 10%, preparation coating solution, stirs 45 minutes.Setting EAT be 40 DEG C qualified dripping pill is dropped into fluid bed after, improve setting EAT to 48 DEG C, after temperature of charge reaches 38 DEG C, start dressing.In coating process, temperature of charge controls at 35-45 DEG C, is cooled to 30 DEG C with bottom discharge after dressing completes, and sieve ball, particle diameter is 2.0mm dripping pill.
Embodiment two prepares Danshen Root dropping ball
(1) material step: get Salvia root P.E 600g, add water 60g, add Macrogol 6000 auxiliary material 1500g, put into material tank and be heated to 90 DEG C, adopt low speed homogeneous (3200rpm) mixed material, after having mixed, improve homogeneous speed and carry out material to 5000rpm, 6 minutes time.Make it melt completely and be mixed into liquid.
(2) dripping step: the vibration frequency regulating pneumatic vibration water dropper is 50Hz, moist closet adopts infrared heating insulation, and temperature controls 80 DEG C.
(3) condensing steps: supplied gas in material tank by pipeline by air pump, make to melt uniform aforesaid liquid flow into water dropper and ooze in cooling pipe bottom water dropper, dripping pressure 0.18MPa, cold air is started while aforesaid liquid oozes, chilling temperature is made to reach-10 DEG C, and make cold air at cooling pipe internal circulation flow, the angle of cooling air inlet and horizontal plane is 45 °, make the liquid oozed from water dropper drop in cooled and solidified in cooling pipe and become solid-state dripping pill, and be connected to Fluidized Bed Partial from the pipeline of cooling pipe lower end.
(4) fluidisation: then dripping pill is carried out fluidized drying and medicine carrying dressing, until material after forming good fluidised form in bed body, be warming up to 25 DEG C of dryings 60 minutes, then be warming up to 45 DEG C of dryings 30 minutes, continue to be warming up to 55 DEG C of dryings 30 minutes, be then cooled to 30 DEG C with bottom discharge.Element ball moisture controls at 3.0-7.0%, obtains middle voxel ball.
(5) coating steps: calculate coating powder consumption according to dressing inventory and prescription, the concentration of coating solution is 18%, preparation coating solution, stirs 45 minutes.Setting EAT be 25 DEG C qualified dripping pill is dropped into fluid bed after, improve setting EAT to 48 DEG C, after temperature of charge reaches 38 DEG C, start dressing.In coating process, temperature of charge controls at 35-45 DEG C, is cooled to 30 DEG C with bottom discharge after dressing completes, and sieve ball, particle diameter is 1.0-2.0mm dripping pill.
Embodiment three prepares compound danshen dripping pills
(1) material step: get Salvia miltiorrhiza and Panax notoginseng extract 600g, borneol 5g, and Macrogol 6000 auxiliary material 2000g.First polyethylene glycol is added in material tank, be heated to 80 DEG C, in advance melting, then add Salvia miltiorrhiza and Panax notoginseng extract, put into 2500rpm homogeneous mixing in homogenizer, time 100min, then 6000rpm homogeneous material, time 20min, temperature 100 DEG C, is mixed into liquid.
(2) dripping step: the vibration frequency regulating pneumatic vibration water dropper is 100HZ, acceleration 1G, dripping speed 10Kg/hr, dripping pressure 1.0Bar.Moist closet adopts steam jacket insulation, and temperature controls 70 DEG C,
(3) condensing steps: supplied gas in material tank by pipeline by air pump, make the aforesaid liquid melted flow into water dropper and ooze in cooling pipe bottom water dropper, cooling pipe is perpendicular to the ground; Start cold air, chilling temperature is made to reach-100 DEG C, the angle of cooling air inlet and horizontal plane is 90 °, and make cold air at cooling pipe internal circulation flow, make to drop in cooled and solidified in cooling pipe from the liquid oozed and become solid-state dripping pill, Fluidized Bed Partial can be connected to from the pipeline of cooling pipe lower end and carry out fluidized drying and medicine carrying dressing.Specifically, 20 DEG C form fluidisation states, 25 DEG C of dryings 60 minutes, 45 DEG C of dryings 30 minutes, 55 DEG C of dryings 30 minutes.
Embodiment four prepares compound danshen dripping pills
(1) material step: the mixture of compound Salviae Miltiorrhizae extract and Arabic gum and lactose=1:1 is put into 5000rpm homogeneous in homogenizer and mixes, time 200min, then 10000rpm homogeneous material, time 100min, temperature 100 DEG C, obtains intermediate feed liquid;
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, vibration frequency is 300Hz, and dripping pressure is 4.0Bar, water dropper temperature 200 DEG C, dripping speed and step (1) material speeds match;
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 4.0mm dripping pill element ball, described refrigerating gas temperature is-300 DEG C.
Fluidized Bed Partial can be connected to from the pipeline of cooling pipe lower end and carry out fluidized drying and medicine carrying dressing.Specifically, 0 DEG C forms fluidisation state, 25 DEG C of dryings 60 minutes, 45 DEG C of dryings 30 minutes, 55 DEG C of dryings 30 minutes.
Embodiment five prepares compound danshen dripping pills
Get compound Salviae Miltiorrhizae extract 75g, borneol 7.5g, lactitol 165g, be prepared into compound Danshen Root droplet ball, preparation method is as follows:
(1) material step: compound Salviae Miltiorrhizae extract and lactitol are put into 2500rpm homogeneous in homogenizer and mix, time 100min, then 6000rpm homogeneous material, time 50min, temperature 80 DEG C, obtains intermediate feed liquid;
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, vibration frequency is 150Hz, and dripping pressure is 2Bar, water dropper temperature 150 DEG C, dripping speed and step (1) material speeds match;
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 1mm dripping pill element ball, described refrigerating gas temperature is-100 DEG C.
(4) drying steps: adopt fluidization drying apparatus dry ,-20 DEG C of dryings 4 hours, obtain dry dripping pill element ball.
(5) coating steps: described drying element ball dressing in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of dressings obtain coated drop pill.
Embodiment six prepares compound danshen dripping pills
Get compound Salviae Miltiorrhizae extract 75g, borneol 7.5g, PEG 8000 165g, be prepared into compound Danshen Root droplet ball, preparation method is as follows:
After compound Salviae Miltiorrhizae extract powder is added water, stir more than 10 minutes in 60 DEG C, obtain pharmaceutical premixed material.
(1) material step:
Compound Salviae Miltiorrhizae extract and PEG 8000 are put into 2500rpm homogeneous in homogenizer to mix, time 100min, then 6000rpm homogeneous material, time 50min, temperature 80 DEG C, obtains intermediate feed liquid;
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, vibration frequency is 150Hz, and dripping pressure is 2Bar, water dropper temperature 150 DEG C, dripping speed and step (1) material speeds match;
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 2mm dripping pill element ball, described refrigerating gas temperature is-100 DEG C.
(4) drying steps: adopt fluidization drying apparatus dry, 100 DEG C of dryings 1 hour, obtain dry dripping pill element ball.
(5) coating steps: described drying element ball dressing in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of dressings obtain coated drop pill.
Embodiment seven prepares compound danshen dripping pills
Get compound Salviae Miltiorrhizae extract 90g, borneol 2g, cetomacrogol 1000 270g, be prepared into compound Danshen Root droplet ball, preparation method is as follows:
After compound Danshen Root powdered active ingredient is added water, stir more than 10 minutes in 30 DEG C, obtain pharmaceutical premixed material.
(1) material step: compound Salviae Miltiorrhizae extract and cetomacrogol 1000 are put into 2500rpm homogeneous in homogenizer and mix, time 100min, then 6000rpm homogeneous material, time 20min, temperature 100 DEG C, obtains intermediate feed liquid;
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, vibration frequency 100HZ, acceleration 1G, dripping speed 10Kg/hr, dripping pressure 1.0Bar, water dropper temperature 70 C.
Dripping speed and step (1) material speeds match;
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 1.5mm dripping pill element ball, described refrigerating gas temperature is-80 DEG C.
(4) drying steps: dry adopt gradient increased temperature seasoning ,-20 DEG C form fluidisation states, 15 DEG C of dryings 10 minutes, 35 DEG C of dryings 10 minutes, and 55 DEG C of dryings 0 minute, obtain dry dripping pill element ball.
(5) coating steps: described drying element ball dressing in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of dressings obtain coated drop pill.
Embodiment eight prepares compound danshen dripping pills
Get compound Salviae Miltiorrhizae extract 100g, borneol 5g, the combination 35g of Macrogol 4000 and Macrogol 6000=1:1, be prepared into compound Danshen Root droplet ball, preparation method is as follows:
After compound Salviae Miltiorrhizae extract powder is added water, stir more than 10 minutes in 80 DEG C, obtain pharmaceutical premixed material.
(1) material step: the combinatorial introduction of compound Salviae Miltiorrhizae extract with Macrogol 4000 and Macrogol 6000=1:1 is mixed to 2500rpm homogeneous in homogenizer, time 100min, then 6000rpm homogeneous material, time 80min, temperature 80 DEG C, obtains intermediate feed liquid;
(2) dripping step: intermediate feed liquid vibrates dripping through water dropper, vibration frequency 200HZ, acceleration 20G, dripping speed 40Kg/hr, dripping pressure 3.0Bar, water dropper temperature 100 DEG C.
Dripping speed and step (1) material speeds match;
(3) condensing steps: the medicine oozed drop in quick cooled and solidified in refrigerating gas become diameter be 0.5mm dripping pill element ball, described refrigerating gas temperature is 120 DEG C.
(4) drying steps: dry adopt gradient increased temperature seasoning, 30 DEG C form fluidisation states, 35 DEG C of dryings 120 minutes, 55 DEG C of dryings 60 minutes, and 100 DEG C of dryings 60 minutes, obtain dry dripping pill element ball.
(5) coating steps: described drying element ball dressing in fluid bed, coating material and plain ball weight ratio are 1:25, and coating solution concentration is 10%, and namely temperature 40 DEG C of dressings obtain coated drop pill.
In sum, the utility model adds normal temperature low humidity supply air system on existing fluid unit basis, utilizes the principle of distillation, makes solid matter directly be transformed into gaseous state without liquid state, what utilize solid-gas balance to carry out raw material and moisture content to dripping pill is separated drying, saves the energy and operating efficiency is high; Coordinate moisture content on-Line Monitor Device simultaneously, the moisture degree of dripping pill in fluid bed furnace body is monitored, effectively control its water content; Be arranged on the nozzle of fluid bed body of heater bottom center, the mode of being sprayed the end of by, coating process stablized, effectively saves coating material simultaneously; Therefore, simple, the with low cost and efficient work of the utility model structure.
Claims (11)
1. the fluid bed for dripping pill drying, comprise fluid bed body of heater, material feeding mouth is provided with below described body of heater, top is provided with discharging opening, in body of heater, the below of described charging aperture is provided with airflow-distribution board, it is characterized in that, the wind pipe of normal temperature low humidity supply air system is arranged on the bottom of described airflow-distribution board, low for normal temperature humid gas is sent in fluid bed body of heater through wind pipe by described normal temperature low humidity supply air system, and described gas carries out fluidized drying process through airflow-distribution board to the material being built in furnace interior.
2. as claimed in claim 1 for the fluid bed of dripping pill drying, it is characterized in that, described normal temperature low humidity supply air system comprises housing and is arranged on the low humidity unit in housing, housing is provided with intake stack and wind pipe, through the process of low humidity unit after air enters housing from intake stack, then input described body of heater through wind pipe;
Described normal temperature low humidity supply air system also comprises the return air duct for air flow recovery, and its two ends are connected with housing with described body of heater respectively.
3. as claimed in claim 2 for the fluid bed of dripping pill drying, it is characterized in that, described low humidity unit is in series by multiple treating apparatus, comprises dust arrester, dehydrating unit, air-supply arrangement, heater, filter and effective filter successively along gas from the inflow direction of described intake stack.
4., as claimed in claim 3 for the fluid bed of dripping pill drying, it is characterized in that, the technological parameter of the low humid gas of described normal temperature comprises: humidity≤5g/kg, and expulsion pressure is 1-4bar, and temperature is 20 DEG C-100 DEG C.
5., as claimed in claim 4 for the fluid bed of dripping pill drying, it is characterized in that, described temperature is 20 DEG C-60 DEG C.
6., as claimed in claim 2 for the fluid bed of dripping pill drying, it is characterized in that, the bottom center of described body of heater is provided with hydrojet nozzle, carries out injection dressing when dry materials to 4%.
7., as claimed in claim 3 for the fluid bed of dripping pill drying, it is characterized in that, the baking temperature of described fluid bed is-20 DEG C-100 DEG C, and drying time is 1-4 hour.
8. as claimed in claim 7 for the fluid bed of dripping pill drying, it is characterized in that, described fluid bed-20 DEG C-30 DEG C forms fluidisation state, 15 DEG C of-35 DEG C of dry 10-120 minute, 35 DEG C of-55 DEG C of dry 10-60 minute, 55 DEG C of-100 DEG C of dry 0-60 minute.
9. as claimed in claim 8 for the fluid bed of dripping pill drying, it is characterized in that, described fluid bed 0 DEG C-20 DEG C forms fluidisation state, 25 DEG C of dryings 60 minutes, 45 DEG C of dryings 30 minutes, 55 DEG C of dry 0-30 minute.
10., as claimed in claim 6 for the fluid bed of dripping pill drying, it is characterized in that, be also provided with online moisture content detection device in described fluid bed body of heater, this online moisture monitoring device is microwave remote sensor.
11. as claimed in claim 1 for the fluid bed of dripping pill drying, it is characterized in that, the charging aperture of described fluid bed is all connected with vacuum negative pressure device with discharging opening, under described vacuum negative pressure device effect, the dripping pill element ball vacuum holding collected by dripping pill production line inserts described body of heater, and the dripping pill Vacuum discharge after fluidized coating is exported.
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| CN104279840A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Fluidized bed for drop pill drying |
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| CN104279840A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Fluidized bed for drop pill drying |
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Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 (city of the modern Chinese Medicine) Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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