CN104258055A

CN104258055A - Preparation method of heatstroke relieving agent used in outdoor power operations

Info

Publication number: CN104258055A
Application number: CN201410464520.8A
Authority: CN
Inventors: 解晓东; 孟庆阵; 王丽; 陈静; 陈光伟; 谷程程; 徐学伟
Original assignee: JUNAN POWER SUPPLY CO Ltd; State Grid Corp of China SGCC; Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
Current assignee: JUNAN POWER SUPPLY CO Ltd; State Grid Corp of China SGCC; Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
Priority date: 2014-09-13
Filing date: 2014-09-13
Publication date: 2015-01-07

Abstract

The invention relates to a preparation method of a heatstroke relieving agent used in outdoor power operations. The following raw materials are used in the method: 35 parts of salvia miltiorrhiza, 35 parts of asiatic cornelian cherry fruit, 35 parts of lotus leaves, 30 parts of spina date seed, 30 parts of dark plum, 25 parts of heartleaf houttuynia herb, 25 parts of prepared rehmannia root, 22 parts of dwarf lilyturf tuber, 22 parts of osmanthus fragrans, 22 parts of white paeony root, 22 parts of eupatorium fortunei, 22 parts of dandelion, 20 parts of Indian bread, 20 parts of dried tangerine peel, 20 parts of polygala tenuifolia, 20 parts of acorus calamus, 18 parts of trichosanthes kirilowii Maxim, 18 parts of mulberries, 18 parts of campsis grandiflora, 18 parts of palmleaf raspberry fruit, 15 parts of fragrant solomonseal rhizome, 15 parts of Chinese magnoliavine fruit, 15 parts of common anemarrhena rhizome, 10 parts of morinda root, 8 parts of plantain herb and 8 parts of liquorice. The preparation method has the beneficial effects that the medicines are jointly used and complement each other; the heatstroke relieving agent has obvious and stable heatstroke treatment effects and broad application prospects.

Description

Preparation method of summer-heat relieving agent for outdoor power operation

Technical Field

The invention belongs to the technical field of health care products, and particularly relates to a preparation method of a summer-heat relieving agent for outdoor power operation.

Background

In full summer, the summer heat is hard to endure, in order to ensure the normal power supply in the peak period of power utilization in summer, a power company needs to invest a large amount of manpower and material resources every year, test and adjustment of the load of a public transformer are performed, multiple times of inspection of circuits and equipment in a power supply area are organized, the hidden dangers, defects, illegal buildings and the like which can endanger the power supply safety are rectified and improved in time, about 2.5 million employees in a system of the power company in Shandong province work outdoors and outdoors at every year, the power company tries to work for keeping the power supply, an electric power worker who works outdoors cannot enter the grid when wearing three quarters, wears a safety helmet, wears long sleeves and trousers, wears leather gloves on the arms, buckles tight collars, often pushes away the summer heat, suffers from burning sun, works aloft outdoors for a long time, is common family meal of the people, and heatstroke medicines are common medicines for the people, the medicine is taken immediately after discomfort is found, and the patient is rested and then put on the table.

Heatstroke is a common emergency in summer and is a general term for the symptoms of body thermoregulation disturbance, water and electrolyte metabolism disorder and nervous system function damage under the long-term action of high temperature and heat radiation. When the heat production of a human body is greater than the heat dissipation, the heat accumulation in the human body causes the central control of the regulation of the body temperature, the cardiac function is reduced, the cardiac output is reduced, the central venous pressure is increased, the sweat gland function is exhausted, the heat in the human body is further accumulated, the body temperature rises suddenly in a short time, when the body temperature is higher than 41.5 ℃, the high heat causes damage to multiple organs, tissue cell membranes and internal structures of cells, the cell membranes have poor stability, the oxidative phosphorylation of mitochondria is obstructed, the oxygen-dependent metabolic pathway is damaged, the tissue is anoxic, the permeability of tissue capillaries is increased, edema, microcirculation obstruction, water electrolysis of alkali hyaluronate is disturbed, and the multiple organ dysfunction of the heart, the lung, the brain, the kidney, the liver and the like. The reasons for heatstroke are many, except for high temperature and burning sun, the common causes of overstrain, over-dense people, over-strong working strength, over-long time, insufficient sleep, over-fatigue and the like.

The degree of heatstroke can be divided into three stages: the premonitory heatstroke. In high temperature environment, excessive sweating, thirst, dizziness, tinnitus, chest distress, cardiopalmus, nausea, myasthenia of limbs, and inattention, with body temperature not more than 37.5 deg.C; ② mild heatstroke. Has the symptoms of premonitory heatstroke, simultaneously has the body temperature of over 38.5 ℃, and is accompanied with the phenomena of flushing, chest distress, burning skin and the like; or skin wetness and coldness, emesis, blood pressure decrease, and fine and rapid pulse; ③ severe heatstroke. In addition to the above symptoms, syncope or spasm occurs; or no sweating, and body temperature above 40 deg.C. A large amount of dust, which is very high in free silica, is inhaled into the lungs and often cannot be removed from the respiratory tract in a timely and complete manner. Sometimes, though the heatstroke symptom does not appear, the heatstroke appears after a plurality of years after the work is removed, and the heatstroke is often called as 'late heatstroke'; even if the patient in early heatstroke breaks away from dust work, the condition can continue to develop, if no complications exist, the patient can live for a long time, but the patient often loses the labor capacity.

At present, the treatment of the emergency treatment mainly aims at treating secondary symptoms, replenishing water and fluid, injecting chlorpromazine into severe muscles, and the traditional Chinese medicine has deep research on heatstroke and belongs to the categories of summer-heat and summer-heat syncope. Summer-heat refers to an acute febrile disease with rapid transmission in the course of disease, which is caused by pathogenic summer-heat, manifested as high fever, polydipsia, sweating, surging pulse and other syndromes of yang-qi system with extreme heat, and is liable to damage the body fluid and consume qi, and frequent obstruction of the orifices and stirring wind. The occurrence of summer-heat is caused by pathogenic summer-heat induced by attack from the exterior and by deficiency of the healthy qi of the body. Summer-heat is pathogenic fire, heart is fire, and summer-heat is usually absorbed by heart, so in summer-heat process, summer-heat tends to sink heart-ying. In addition, summer-heat can also suddenly block the pericardium, leading to sudden coma, "summer-heat faint", manifested as burning, restlessness, coma, sudden coma, unconsciousness, dyspnea, slight tense of the tooth joints, convulsion of the limbs, deep red tongue and thready and rapid pulse. The pathogenic factors of summer-heat are the exogenous factors causing heatstroke, while the deficiency of healthy qi is the endogenous factor causing the invasion of exogenous factors. Summer heat is moderate in summer, the temperature is high, the humidity is high, if the body consumes body fluid due to insufficient healthy qi or excessive fatigue, summer heat can invade the body to cause disease, the heatstroke is clinically treated, and the traditional Chinese medicine with the effects of tonifying qi and promoting the production of body fluid is applied to treat the disease and seek the foundation, so that the clinical effect is better.

Disclosure of Invention

The invention refers to the understanding of the pathogenesis of the summer-heat warm disease and the precious experience of treatment in traditional Chinese medicine, refers to the existing reasonable formula, treats based on syndrome differentiation, and is improved to some extent according to the Chinese pharmacopoeia and pharmacological compatibility. The inventor selects natural ingredients for tonifying qi, promoting the production of body fluid and inducing resuscitation and cooling from the Chinese medical treasury by researching the traditional Chinese medicine and combining dialectical argument and collecting the advantages of many people, seeks an optimal treatment scheme, extracts essence according to the formula of the traditional Chinese medicine theory, elaborately prepares the preparation for treating heatstroke, which is disclosed by the invention, by combining the traditional Chinese medicine technology, has an obvious effect compared with western medicines, and treats both principal and secondary aspects of diseases.

In order to realize the purpose of the invention, the technical scheme adopted by the invention is as follows:

a preparation method of a summer-heat relieving agent for outdoor power operation is characterized by being prepared from the following raw materials in parts by weight:

30-35 parts of salvia miltiorrhiza, 30-35 parts of dogwood, 30-35 parts of lotus leaf, 25-30 parts of spina date seed, 25-30 parts of dark plum fruit,

22-25 parts of houttuynia cordata, 22-25 parts of prepared rehmannia root, 20-22 parts of radix ophiopogonis, 20-22 parts of sweet osmanthus, 20-22 parts of white paeony root,

20-22 parts of eupatorium, 20-22 parts of dandelion, 18-20 parts of poria cocos, 18-20 parts of dried orange peel, 18-20 parts of polygala tenuifolia,

18-20 parts of acorus calamus, 15-18 parts of snakegourd fruit, 15-18 parts of mulberry, 15-18 parts of campsis grandiflora, 15-18 parts of raspberry,

10-15 parts of radix polygonati officinalis, 10-15 parts of schisandra chinensis, 10-15 parts of rhizoma anemarrhenae, 8-10 parts of morinda officinalis, 5-8 parts of plantain herb, and,

5-8 parts of liquorice.

The preparation method of the heatstroke relieving agent comprises the following steps: the raw material medicines (such as the proportioning unit: g) in parts by weight are taken to prepare the capsule, and the specific operation is as follows:

1) weighing the raw materials for later use;

2) adding 5 times of water into Saviae Miltiorrhizae radix, folium Nelumbinis, semen Ziziphi Spinosae, mume fructus, herba Houttuyniae, radix rehmanniae Preparata, radix Ophiopogonis, Rubi fructus, rhizoma Polygonati Odorati, fructus Schisandrae chinensis, rhizoma anemarrhenae and radix Morindae officinalis, boiling with strong fire, decocting with slow fire for 1 hr, filtering, and collecting filtrate and residue; adding water into the filter residue, boiling with strong fire until the residue is not filtered, decocting with slow fire for 30 minutes, filtering, and collecting the filtrate; mixing the above two filtrates, cooling, and concentrating to obtain extract with density of 1.2 g/ml; drying at 80 ℃, and crushing into powder to obtain a compound A;

3) taking the rest components: soaking Corni fructus, flos Osmanthi Fragrantis, radix Paeoniae alba, herba Eupatorii, herba Taraxaci, Poria, pericarpium Citri Tangerinae, cortex et radix Polygalae, rhizoma Acori Calami, fructus Trichosanthis, Mori fructus, flos Campsis, herba plantaginis, and Glycyrrhrizae radix in 70% ethanol for 1.5 hr, extracting twice (each for 1-2 hr), mixing extractive solutions, filtering, concentrating into extract with density of 1.2g/ml, drying, and pulverizing to obtain compound B;

4) mixing compound A and compound B, stirring, sterilizing, and making into capsule, 0.5g for oral administration, twice a day.

The components of the heatstroke relieving agent are all natural traditional Chinese medicine raw materials, the preparation is simple and convenient, the medicine source is wide, the cost is low, the traditional Chinese medicine prescription and the medicine principle are followed, the medicines are combined, the best is obtained, the effects of the medicines are exerted by monarch, minister, assistant and guide, the purpose of treating heatstroke can be effectively achieved, and the clinical application verifies that the heatstroke relieving agent has obvious and reliable curative effect, flat medicine property and wide application prospect.

Detailed Description

Example 1

A preparation method of a summer-heat relieving agent for treating outdoor power operation is disclosed, wherein the summer-heat relieving agent is prepared from the following raw materials in parts by weight:

30 parts of salvia miltiorrhiza, 30 parts of dogwood, 30 parts of lotus leaf, 25 parts of spina date seed, 25 parts of dark plum fruit,

22 parts of heartleaf houttuynia herb, 22 parts of prepared rehmannia root, 20 parts of dwarf lilyturf tuber, 20 parts of sweet osmanthus flower, 20 parts of white paeony root,

20 parts of eupatorium, 20 parts of dandelion, 18 parts of poria cocos, 18 parts of dried orange peel, 18 parts of polygala tenuifolia,

18 parts of acorus calamus, 15 parts of snakegourd fruit, 15 parts of mulberry, 15 parts of campsis grandiflora, 15 parts of raspberry,

10 parts of polygonatum, 10 parts of schisandra, 10 parts of rhizoma anemarrhenae, 8 parts of morinda officinalis, 5 parts of plantain herb, and,

And 5 parts of liquorice.

1) weighing the raw materials for later use;

3) taking the rest components: soaking Corni fructus, flos Osmanthi Fragrantis, radix Paeoniae alba, herba Eupatorii, herba Taraxaci, Poria, pericarpium Citri Tangerinae, cortex et radix Polygalae, rhizoma Acori Calami, fructus Trichosanthis, Mori fructus, flos Campsis, herba plantaginis, and Glycyrrhrizae radix in 70% ethanol for 1.5 hr, extracting twice (each for 1-2 hr), mixing extractive solutions, filtering, concentrating into extract with relative density of 1.2, drying, and pulverizing to obtain compound B;

Example 2

A preparation method of a summer-heat relieving agent for outdoor power operation is disclosed, wherein the summer-heat relieving agent is prepared from the following raw materials in parts by weight:

35 parts of salvia miltiorrhiza, 35 parts of dogwood, 35 parts of lotus leaf, 30 parts of spina date seed, 30 parts of dark plum fruit,

25 parts of heartleaf houttuynia herb, 25 parts of prepared rehmannia root, 22 parts of dwarf lilyturf tuber, 22 parts of sweet osmanthus flower, 22 parts of white paeony root,

22 parts of eupatorium, 22 parts of dandelion, 20 parts of poria cocos, 20 parts of dried orange peel, 20 parts of polygala tenuifolia,

20 parts of acorus calamus, 18 parts of snakegourd fruit, 18 parts of mulberry, 18 parts of campsis grandiflora, 18 parts of raspberry,

15 parts of polygonatum, 15 parts of schisandra, 15 parts of rhizoma anemarrhenae, 10 parts of morinda officinalis, 8 parts of plantain herb, and,

8 parts of liquorice.

1) weighing the raw materials for later use;

Example 3

Toxicity test

In the experiment, healthy SD rats are respectively orally administered with the heatstroke relieving agent prepared in the embodiment 1 and the embodiment 2 for 30 days, and the growth state, active diet, hematology, blood biochemistry, organ tissue structure, urine convention and the like of animals have no obvious influence during the administration period of the rats and within 1 week after the administration is stopped, so that the clinical medication is safe and reliable.

Example 4

Clinical data

90 diagnosed heatstroke patients were randomly divided into 45 cases each of the treatment group and the control group. The age, sex and severity of illness of the two groups of patients have no obvious difference and are comparable.

The inclusion criteria of cases were: meets the national sanitary standard of the people's republic of China (GB 11508-; the traditional Chinese medicine composition has a history of high-temperature environment contact, the body temperature is more than or equal to 40 ℃, the body temperature rise caused by other reasons is eliminated, various clinical symptoms of heatstroke are achieved, and severe heatstroke symptoms do not appear in the above cases.

Method of treatment

The control group orally takes herba Agastaches decoction for treatment of hypertension, 2 times per day; the treatment group orally administered 0.5g of the heatstroke relieving agent prepared in example 1 twice a day.

The therapeutic effect judgment standard is as follows: is formulated according to the standard of curative effect of diagnosis of internal medical diseases of traditional Chinese medicine formulated by the State administration of traditional Chinese medicine.

And (3) curing: the symptoms and signs disappear, and the spirit recovers. Improvement: the symptoms and signs are basically disappeared, and the physical strength is not completely recovered. The disease is not cured: no improvement or worsening of symptoms was evident:

statistical treatment:

using SPSS13.0 statistical software to process data, expressing the measured data by mean +/-standard deviation, using t test, and using x as counting data²And (6) checking.

Results

Clinical efficacy comparisons, statistical data processing was performed using SPSS13.0 statistical software, and the data are shown in table 1:

TABLE 1

Example 5

The invention is used for clinical data of severe heatstroke

51 severe heatstroke patients for emergency treatment are selected, and all patients meet the severe heatstroke typing standard of 5 th edition of internal science. Patients are randomly divided into a treatment group and a control group, wherein the treatment group comprises 26 patients and the control group comprises 25 patients, and the comparison difference of the patients in the two groups in terms of age, sex, disease conditions and the like has no statistical significance (P > 0.05) and is comparable.

The two groups of patients are treated in an emergency after hospitalization, including physical cooling, respiratory and circulation maintaining, water electrolyte disorder and acid-base balance disorder correcting, multi-organ failure preventing and treating, rapid venous transfusion, antishock and hydration treatment; simultaneously, mannitol is given to accelerate urine dehydration, alkalize urine, prevent infection, wake up, stabilize cell membrane, and give vitamin C as antioxidant, protect gastric mucosa, promote gastrointestinal motility, support nutrition, etc. The treatment scheme of the treatment group is to add the medicinal preparation obtained in the example 2 of the invention on the basis of the comprehensive treatment.

The mental recovery time, the body temperature recovery time and the hospitalization time of the patients are observed, the clinical treatment effect of the two groups of patients is evaluated, and the adverse drug reactions are recorded.

The therapeutic effect judgment standard is as follows: the effect is shown: the patient is conscious within 4h, and the blood pressure, pulse, respiration and body temperature are all recovered to be normal, and all the inspection indexes are all normal.

The method has the following advantages: after 4 hours, the patient is conscious within 8 hours, the blood pressure, the pulse, the respiration and the body temperature are recovered to be normal, and various test indexes tend to be normal.

And (4) invalidation: after 8 hours, the patient has mild disturbance of consciousness, high body temperature and complications such as liver and kidney function damage, aspiration pneumonia and the like.

Statistical analysis was performed with SPSS13.0, P < 0.05 indicating significance. The results are shown in Table 2

TABLE 2

Group of	Number of examples	Show effect	Is effective	Invalidation	Total effective rate
						EXAMPLE 2 group	26	19	6	1	96%
Control group	25	13	4	8	68％

The fever time and symptom sign improvement time of the treatment group are obviously faster than those of the control group, especially the fever abatement, the recovery of the disturbance of consciousness and the improvement of headache and dizziness.

Compared with the conventional treatment, the preparation of the invention has the advantages of fast recovery of fever abatement, awakening, multi-organ dysfunction, higher cure rate and no adverse reaction, so the preparation of the invention is a good and safe choice for treating severe heatstroke.

The foregoing list is only illustrative of the preferred embodiments of the present invention. It is obvious that the invention is not limited to the above embodiments, but that many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.

Claims

1. A preparation method of a summer-heat relieving agent for outdoor power operation is characterized by comprising the following steps:

1) weighing the raw material medicines according to the parts by weight for later use; wherein,

8 parts of liquorice;

2) adding 5 times of water into salvia miltiorrhiza, lotus leaves, spina date seeds, dark plums, houttuynia cordata, prepared rehmannia roots, radix ophiopogonis, raspberries, polygonatum odoratum, schisandra chinensis, rhizoma anemarrhenae and morinda officinalis, boiling with strong fire, decocting with slow fire for 1 hour, filtering, and collecting filtrate and filter residues; adding water into the filter residue, boiling with strong fire until the residue is not filtered, decocting with slow fire for 30 minutes, filtering, and collecting the filtrate; mixing the above two filtrates, cooling, and concentrating to obtain extract with density of 1.2 g/ml; drying at 80 ℃, and crushing into powder to obtain a compound A;

3) soaking the rest raw materials in 70% ethanol for 1.5 hr, extracting for two times (each for 1-2 hr), mixing extractive solutions, filtering, concentrating to obtain extract with density of 1.2g/ml, drying, and pulverizing to obtain compound B;

4) mixing the compound A and the compound B, stirring uniformly, and sterilizing.

2. Use of the sunstroke-relieving agent prepared by the method of claim 1 for heatstroke.