CN104258056A

CN104258056A - Heatstroke relieving agent used in outdoor power operations

Info

Publication number: CN104258056A
Application number: CN201410464774.XA
Authority: CN
Inventors: 解晓东; 彭博; 蒋世燕; 孙羽中; 刘龙晶; 李静鹏
Original assignee: JUNAN POWER SUPPLY CO Ltd; State Grid Corp of China SGCC; Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
Current assignee: JUNAN POWER SUPPLY CO Ltd; State Grid Corp of China SGCC; Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
Priority date: 2014-09-13
Filing date: 2014-09-13
Publication date: 2015-01-07

Abstract

The invention relates to a heatstroke relieving agent used in outdoor power operations. The heatstroke relieving agent is prepared from the following raw materials: 35 parts of salvia miltiorrhiza, 35 parts of asiatic cornelian cherry fruit, 35 parts of lotus leaves, 30 parts of spina date seed, 30 parts of dark plum, 25 parts of heartleaf houttuynia herb, 25 parts of prepared rehmannia root, 22 parts of dwarf lilyturf tuber, 22 parts of osmanthus fragrans, 22 parts of white paeony root, 22 parts of eupatorium fortunei, 22 parts of dandelion, 20 parts of Indian bread, 20 parts of dried tangerine peel, 20 parts of polygala tenuifolia, 20 parts of acorus calamus, 18 parts of trichosanthes kirilowii Maxim, 18 parts of mulberries, 18 parts of campsis grandiflora, 18 parts of palmleaf raspberry fruit, 15 parts of fragrant solomonseal rhizome, 15 parts of Chinese magnoliavine fruit, 15 parts of common anemarrhena rhizome, 10 parts of morinda root, 8 parts of plantain herb and 8 parts of liquorice. The heatstroke relieving agent has the beneficial effects that the medicines are jointly used and complement each other; the heatstroke relieving agent has obvious and stable heatstroke treatment effects and broad application prospects.

Description

A kind of agent of relieving summer heat for outdoor electric operating

Technical field

The invention belongs to health product technology field, concrete, relate to a kind of agent of relieving summer heat for outdoor electric operating.

Background technology

Time in midsummer, heat is hard to bear, for guaranteeing the normal power supply of peak times of power consumption in summer, Utilities Electric Co. will drop into a large amount of manpower and materials every year, to the testing and debugging of common transformer load, tissue is to the circuit in service area, equipment is repeatedly maked an inspection tour, to the hidden danger found, defect, the hidden danger of the entail dangers to power supply safeties such as architecture against regulations thing is rectified and improved in time, annual about 2.5 ten thousand employees of Utilities Electric Co. of Shandong Province system are under high temperature and heating summer, out of doors, field work, work hard for saving electric power saving supply from damage, the power worker of open work and the dress in dog days incompatible with, wear safety helmet, wear long sleeves and trousers work clothes, arm has on leather glove, collar buckle obtain tight, often head on heat, stand burning sun to scorch, long-time work high above the ground out of doors, heatstroke is their homely food, heatstroke medicine is also their standing medicine, find that uncomfortable just horse back is taken medicine, have a rest again on top.

Heatstroke is common emergency case in a kind of summer, refers under high temperature and thermal-radiating long duration of action, body thermoregulatory dysfunctions, the general name of the symptom of the disorderly and nervous function infringement of water and electrolyte metabolism.When body heat production is greater than heat radiation, heat storage in body, cause thermotaxic centre out of control, Heart function fails, cardiac output reduces, central venous pressure raises, sweat gland nonfunction, intimate heat is accumulated further, body temperature rises sharply at short notice, when body temperature is higher than 41.5 DEG C, high heat is to multiple organ, cell membranes in tissue and cell interior structure cause damage, cell membrane stability is poor, mitochondrial oxidative phosphorylation generation obstacle, oxygen dependence metabolic pathway goes to pot, cause histanoxia, make to organize capillary permeability to increase, edema, microcirculation disturbance, Water-Electrolyte acid-base disturbance, cause the heart, lung, brain, kidney, the multiple organs dysfunctions such as liver.The reason of heatstroke is very many, and except high temperature, burning sun tan by the sun, spiritual hypertonicity, personnel are too intensive, working strength is excessive, overlong time, do not have enough sleep, overtired etc. be common inducement.

The degree of heatstroke can be divided into three grades: 1. premonitory heatstroke.In hot environment, a large amount of to perspire, thirsty, dizzy, tinnitus, uncomfortable in chest, cardiopalmus, nauseating, myasthenia of limbs, absent minded, body temperature is no more than 37.5 DEG C; 2. mild heat stroke.Have the symptom of premonitory heatstroke, simultaneously body temperature is more than 38.5 DEG C, and with phenomenons such as flushed face, uncomfortable in chest, skin burns; Or skin is clammy, vomiting, blood pressure drops, situation that pulse is thin and fast; 3. severe heat stroke.Except above symptom, occur to faint or spasm; Or do not perspire, body temperature is more than 40 DEG C.A large amount of dust very high containing free silicon dioxide sucks in lung, often cannot be removed in time and completely by respiratory tract.Though sometimes there is not heatstroke sign, after disengaging work, there is heatstroke again through the several years, be often called " late-onset heatstroke "; Even if early stage heatstroke patient departs from dust work, the state of an illness also can continue development, and as without complication, patient can be survived the long period, but normal disability.

The treatment of current emergency treatment mainly processes for secondary symptom, moisturizing fluid infusion, serious symptom intramuscular injection chlorpromazine, and motherland's medical science has also had deep research to heatstroke, and it belongs to " fever disease in summer ", " syncope caused by summer-heat pathogen " category.Fever disease in summer refers to experiences summer-heat pathogenic factor in summer, from the beginning of with excessive heat in the QI system of YANG MING syndromes such as high fever, excessive thirst, sweating, full and large pulse for main manifestations, in the course of disease, the change of disease is rapid, and easy injury-gas consumption, closes a kind of acute calenture of the change of key wind symptom more.The generation exopathogenic factor of fever disease in summer disease experiences the summer-heat pathogenic factor in season, endogenous cause of ill human righteousness virtual loss.Summer-heat is pathogenic fire, and the heart is that fire is dirty, " summer heat leads in the heart ", therefore in summer-heat process, and summer-heat often easily caves in the heart-nutriment.In addition, the heresy of summer-heat also can sudden middle the heart-nutriment and in close pericardium, cause " syncope caused by summer-heat pathogen " of suddenly fainting, reveal any symptoms is scorching hot, agitation, coma, suddenly faint, syncope, rough as breathed heavily, mandibular joint is tightly micro-, tic of the limbs, deep red tongue, thready and rapid pulse.Experiencing summer-heat pathogenic factor summer is the exopathogenic factor causing heatstroke, and positive QI-insufficiency is then cause exopathogen to be attacked and the endogenous cause of ill of morbidity.Summer summer heat in season, temperature is high, high humidity, if the positive QI-insufficiency of human body or consumption impairment of body fluid gas of overworking, the gas of summer-heat just can invade human body and fall ill, clinical treatment heatstroke, and the Chinese medicine of application supplementing QI for promoting the production of body fluid effect is with treatment must aim at the pathogenesis of disease, and clinical effectiveness is better.

Summary of the invention

The present invention is with reference to the motherland medical science invaluable experience to the sick pathogenetic understanding of fever disease in summer and treatment, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to Chinese Pharmacopoeia and pharmacology compatibility, push away Chen Zhixin gain to some extent, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.Inventor is by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out supplementing QI for promoting the production of body fluid, have one's ideas straightened out cooling natural component, by theory of Chinese medical science prescription, skim the cream off milk, the preparation for heatstroke of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, relative to Western medicine, successful, treating both the principal and secondary aspects of a disease.

For realizing the object of the invention, the technical solution used in the present invention is as follows:

For an agent of relieving summer heat for outdoor electric operating, it is characterized in that being prepared by the raw material of following weight proportioning and obtaining:

Radix Salviae Miltiorrhizae 30-35 part, Fructus Corni 30-35 part, Folium Nelumbinis 30-35 part, Semen Ziziphi Spinosae 25-30 part, Fructus Mume 25-30 part,

Herba Houttuyniae 22-25 part, Radix Rehmanniae Preparata 22-25 part, Radix Ophiopogonis 20-22 part, Flos Osmanthi Fragrantis 20-22 part, Radix Paeoniae Alba 20-22 part,

Herba Eupatorii 20-22 part, Herba Taraxaci 20-22 part, Poria 18-20 part, Pericarpium Citri Reticulatae 18-20 part, Radix Polygalae 18-20 part,

Rhizoma Acori Calami 18-20 part, Fructus Trichosanthis 15-18 part, Fructus Mori 15-18 part, Flos Campsis 15-18 part, Fructus Rubi 15-18 part,

Rhizoma Polygonati Odorati 10-15 part, Fructus Schisandrae Chinensis 10-15 part, Rhizoma Anemarrhenae 10-15 part, Radix Morindae Officinalis 8-10 part, Herba Plantaginis 5-8 part,

Radix Glycyrrhizae 5-8 part.

Agent preparation method of relieving summer heat of the present invention is: the crude drug (such as proportioning unit: gram) getting above-mentioned parts by weight prepares capsule, and concrete operations are:

1) each crude drug is taken, for subsequent use;

2) get Radix Salviae Miltiorrhizae, water intense fire that Folium Nelumbinis, Semen Ziziphi Spinosae, Fructus Mume, Herba Houttuyniae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Rubi, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, Radix Morindae Officinalis add 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 30 minutes, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;

3) residual components is got namely: Fructus Corni, Flos Osmanthi Fragrantis, the Radix Paeoniae Alba, Herba Eupatorii, Herba Taraxaci, Poria, Pericarpium Citri Reticulatae, Radix Polygalae, Rhizoma Acori Calami, Fructus Trichosanthis, Fructus Mori, Flos Campsis, Herba Plantaginis, Radix Glycyrrhizae add 70% soak with ethanol 1.5 hours, extract twice, each 1-2 hour, merge extractive liquid, filter, be condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtain complex B;

4) by complex A, complex B mixing and stirring, sterilization obtains capsule product, oral each 0.5g, twice on the one.

The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, and bring out the best in each other, monarch respectively executes its effect, effectively can reach the object for the treatment of heatstroke, through clinical practice checking, it is reliably evident in efficacy, mild in medicine property, has a extensive future.

Detailed description of the invention

Embodiment 1

For the agent of relieving summer heat that outdoor electric operating is treated, it is characterized in that being prepared by the raw material of following weight proportioning and obtaining:

Radix Salviae Miltiorrhizae 30 parts, Fructus Corni 30 parts, 30 parts, Folium Nelumbinis, Semen Ziziphi Spinosae 25 parts, Fructus Mume 25 parts,

Herba Houttuyniae 22 parts, Radix Rehmanniae Preparata 22 parts, Radix Ophiopogonis 20 parts, Flos Osmanthi Fragrantis 20 parts, the Radix Paeoniae Alba 20 parts,

Herba Eupatorii 20 parts, Herba Taraxaci 20 parts, 18 parts, Poria, Pericarpium Citri Reticulatae 18 parts, Radix Polygalae 18 parts,

Rhizoma Acori Calami 18 parts, Fructus Trichosanthis 15 parts, 15 parts, Fructus Mori, Flos Campsis 15 parts, Fructus Rubi 15 parts,

Rhizoma Polygonati Odorati 10 parts, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Morindae Officinalis 8 parts, Herba Plantaginis 5 parts,

5 parts, Radix Glycyrrhizae.

Pharmaceutical composition its preparation method of the present invention is: the crude drug (such as proportioning unit: gram) getting above-mentioned parts by weight prepares capsule, and concrete operations are:

1) each crude drug is taken, for subsequent use;

3) residual components is got namely: Fructus Corni, Flos Osmanthi Fragrantis, the Radix Paeoniae Alba, Herba Eupatorii, Herba Taraxaci, Poria, Pericarpium Citri Reticulatae, Radix Polygalae, Rhizoma Acori Calami, Fructus Trichosanthis, Fructus Mori, Flos Campsis, Herba Plantaginis, Radix Glycyrrhizae add 70% soak with ethanol 1.5 hours, extract twice, each 1-2 hour, merge extractive liquid, filter, be condensed into the extractum that relative density is 1.2, crushed after being dried, obtain complex B;

Embodiment 2

Radix Salviae Miltiorrhizae 35 parts, Fructus Corni 35 parts, 35 parts, Folium Nelumbinis, Semen Ziziphi Spinosae 30 parts, Fructus Mume 30 parts,

Herba Houttuyniae 25 parts, Radix Rehmanniae Preparata 25 parts, Radix Ophiopogonis 22 parts, Flos Osmanthi Fragrantis 22 parts, the Radix Paeoniae Alba 22 parts,

Herba Eupatorii 22 parts, Herba Taraxaci 22 parts, 20 parts, Poria, Pericarpium Citri Reticulatae 20 parts, Radix Polygalae 20 parts,

Rhizoma Acori Calami 20 parts, Fructus Trichosanthis 18 parts, 18 parts, Fructus Mori, Flos Campsis 18 parts, Fructus Rubi 18 parts,

Rhizoma Polygonati Odorati 15 parts, Fructus Schisandrae Chinensis 15 parts, the Rhizoma Anemarrhenae 15 parts, Radix Morindae Officinalis 10 parts, Herba Plantaginis 8 parts,

8 parts, Radix Glycyrrhizae.

1) each crude drug is taken, for subsequent use;

Embodiment 3

Toxicity test

This experiment adopts healthy SD rat, the pharmaceutical preparation of oral administration embodiment 1, embodiment 2 preparation respectively, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.

Embodiment 4

Clinical data

Meet diagnosis 90 routine heatstroke patients are divided at random treatment group and each 45 examples of matched group.The aspects such as two groups of patient ages, sex, state of an illness weights, relatively all without significant difference, have comparability.

Case inclusion criteria: meet People's Republic of China's state health standards (GB 11508-1989) " heatstroke diagnostic criteria and treatment principle "; Have hot environment contact history, body temperature >=40 DEG C are also got rid of the body temperature that other reasons causes and are raised, and have every clinical symptoms of heatstroke, above case does not all occur severe heat stroke symptom.

Therapeutic Method

The oral HUOXIANG ZHENGQI SHUI of matched group, every day 2 times; Medicine prepared by the oral embodiment 1 for the treatment of group, oral each 0.5g, twice on the one.

Curative effect determinate standard: formulate according to the tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect that State Administration of Traditional Chinese Medicine formulates.

Cure: symptom and sign disappear, mental restoration.Take a turn for the better: symptom and sign disappear substantially, and muscle power fails to recover completely.Do not heal: symptom is without improvement or worsen effective:

Statistical procedures adopts SPSS13.0 statistical software to carry out date processing, and measurement data represents with mean ± standard deviation, and adopt t inspection, enumeration data adopts x ²inspection.

Result

Clinical efficacy comparison, adopt SPSS13.0 statistical software to carry out statistical data process, data are in table 1:

Table 1

Embodiment 5

The present invention is used for the clinical data of severe heat stroke

Choose severe heat stroke patient 51 example of realization of Emergent Diagnosis And Treatment, all patients all meet " internal medicine " the 5th edition severe heat stroke typing standard.Patient is divided into treatment group and matched group at random, wherein treatment group 26 example, matched group 25 example, two groups of patients comparing difference not statistically significant (P>0.05) in age, sex, the state of an illness etc., has comparability.

Give emergency aid and treatment after two groups of patient admits, comprise Physical temperature-lowering, Hold up voltage and circulatory function, correct Electrolyte imbalance and acid base imbalance, control multiple organ dysfunction syndrome, rapid intravenous transfusion, shock and hydration treatment; Give that mannitol adds furosemide dehydration, alkalized urine, prevention infection, wakens, stabilizing cell membrane, antioxidant give vitamin C simultaneously, protection gastric mucosa, promote the complex treatment measure such as digestive tract power, nutritional support.Treatment group therapeutic scheme is on the basis of above-mentioned Comprehensive Treatment, add the pharmaceutical preparation of the embodiment of the present invention 2 gained again.

Observe patient mind recovery time, temperature recovery time and hospital stays, evaluate two groups of patient clinical therapeutic effect, and record adverse effect.

Curative effect determinate standard: effective: patient is Consciousness in 4h, blood pressure, pulse, breathing, body temperature all recover normal, and every test rating is all normal.

Effective: patient is after 4h, and Consciousness in 8h, normally, every laboratory indexes is tending towards normal for blood pressure, pulse, breathing, temperature recovery.

Invalid: patient has slight disturbance of consciousness, body temperature higher and has complication to occur after 8h, as hepatic and renal function damage, aspiration pneumonitis etc.

Carry out statistical analysis with SPSS 13.0, P< 0.05 indicates significant.Result is as shown in table 2

Table 2

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Embodiment 2 groups	26	19	6	1	96%
Matched group	25	13	4	8	68％

Embodiment 2 groups of (treatment group) fever times, symptom and sign improve the time obviously faster than matched group, especially bring down a fever, the recovery of disturbance of consciousness and the improvement of headache and dizzy.

Invention formulation treatment severe heat stroke, comparatively bring down a fever during conventional therapy, waken, multiple organs dysfunction recovers faster, cure rate is higher, and has no untoward reaction, therefore treatment severe heat stroke, and invention formulation be can yet be regarded as good, the safe selection of a kind of curative effect.

What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.

Claims

1. for an agent of relieving summer heat for outdoor electric operating, it is characterized in that, the described raw material by agent following weight parts of relieving summer heat is prepared and obtains:

8 parts, Radix Glycyrrhizae.

2. agent of relieving summer heat according to claim 1, is characterized in that, described in the relieve summer heat preparation method of agent comprise the steps:

1) each raw material is taken according to weight portion, for subsequent use;

2) get Radix Salviae Miltiorrhizae, Folium Nelumbinis, Semen Ziziphi Spinosae, Fructus Mume, Herba Houttuyniae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Fructus Rubi, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, Radix Morindae Officinalis, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 30 minutes, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;

3) get surplus stock, add 70% soak with ethanol 1.5 hours, extract twice, each 1-2 hour, merge extractive liquid, filter, be condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtain complex B;

4) by complex A, complex B mixing and stirring, sterilization and get final product.

3. preparation described in claim 1-2 is used for the purposes of heatstroke.