CN102813767B - First-aid drug for treating heatstroke and preparation method thereof - Google Patents
First-aid drug for treating heatstroke and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a first-aid drug for treating heatstroke and a preparation method thereof. The first-aid drug for treating heatstroke is prepared from 6 to 10 parts by weight of all grass of mosla chinensis maxim, 8 to 15 parts by weight of largetrifoliolious bugbane rhizome, 8 to 15 parts by weight of all grass of ordos wormwood, 6 to 10 parts by weight of rhizoma calami, 6 to 10 parts by weight of tangerine peel, 8 to 15 parts by weight of oriental waterplantain rhizome, 6 to 10 parts by weight of amur corktree bark, 8 to 15 parts by weight of immature tangerine peel and 3 to 6 parts by weight of irkutsk anemone rhizome. The preparation method comprises the following steps of 1, extracting volatile oil from all grass of mosla chinensis maxim, all grass of ordos wormwood, rhizoma calami, immature tangerine peel and irkutsk anemone rhizome by a distillation method and collecting dregs for next use, 2, mixing the dregs obtained by the step 1, largetrifoliolious bugbane rhizome, tangerine peel, oriental waterplantain rhizome and amur corktree bark, carrying out water decoction and alcohol precipitation to obtain extract, standing the extract at a temperature of 5 DEG C for 15 days, and filtering to obtain a filtrate, and 3, adding the filtrate obtained by the step 2 into the volatile oil obtained by the step 1, uniformly mixing, carrying out ultrafiltration by an ultrafiltration membrane, and then carrying out sterilization filling and sealing. A clinical test proves that the first-aid drug provided by the invention has good effects of treating heatstroke.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of first aid medicine for the treatment of heatstroke.
Background technology
Heatstroke is common emergency case in a kind of summer, refers under high temperature and thermal-radiating long duration of action body thermoregulation obstacle, the general name of the symptom of water, metabolic disturbance of electrolyte and nervous function infringement.When body heat production is greater than heat radiation, heat storage in body, cause thermotaxic centre out of control, Heart function fails, cardiac output reduces, central venous pressure raises, sweat gland nonfunction, intimate heat is further accumulated, body temperature rises sharply at short notice, when body temperature is during higher than 41.5 ℃, high heat is to many organs, cell membranes in tissue and cell interior structure cause damage, cell membrane stability is poor, mitochondrial oxidative phosphorylation generation obstacle, oxygen dependence metabolic pathway goes to pot, cause histanoxia, make to organize capillary permeability to increase, edema, microcirculation disturbance, Water-Electrolyte soda acid is disorderly, cause the heart, lung, brain, kidney, the multiple organs dysfunctions such as liver.The reason of heatstroke is very many, and except high temperature, burning sun tan by the sun, spiritual hypertonicity, personnel are too intensive, working strength is excessive, overlong time, do not have enough sleep, overtired etc. be common inducement.Different with clinical manifestation according to pathogenesis, conventionally heatstroke is divided into heat cramp, heat exhaustion and heat (day) and penetrates disease.Above-mentioned three kinds of situations can sequentially develop, also can juxtaposition.Mild heat stroke, patient shows as profuse sweating, thirsty, dizzy, tinnitus, feels sick, nervous, myasthenia of limbs, tired out, distraction, exercise not harmony, and then flushed face or pale, uncomfortable in chest, and skin is scorching hot, and body temperature is more than 38.5 ℃.The patient of severe heatstroke produces dry lossless, the body temperature of delirium, spasm, stupor, skin more than 40 ℃ or occur suffering a shock.The treatment of emergency treatment is at present mainly to process for secondary symptom, moisturizing fluid infusion, serious symptom intramuscular injection chlorpromazine.And the medication of Chinese traditional treatment heatstroke is mainly menthocamphorate, rheocamphoradin, the effect of above-mentioned two kinds of medicines is to dispel the wind, little for the cooling effect of having one's ideas straightened out, and oral taste is difficult to accept.
Summary of the invention
Technical assignment of the present invention is for the deficiencies in the prior art, and first aid medicine of the sure treatment heatstroke of a kind of curative effect and preparation method thereof is provided.
The technical scheme that the present invention solves its technical problem is: a kind of first aid medicine for the treatment of heatstroke, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are 6 ~ 10 parts of: Herba Moslae Chinensis, 8 ~ 15 parts of Rhizoma Cimicifugaes, 8 ~ 15 parts of Radix Artemisia ordosicae, 6 ~ 10 parts of Rhizoma Acori Calami, 6 ~ 10 parts of Pericarpium Citri Reticulataes, 8 ~ 15 parts of Rhizoma Alismatis, 6 ~ 10 parts of Cortex Phellodendris, 8 ~ 15 parts, Pericarpium Citri Reticulatae Viride, 3 ~ 6 parts of Rhizoma Anemones Altaicaes.
Its optimum weight proportioning is 8 parts of: Herba Moslae Chinensis, 10 parts of Rhizoma Cimicifugaes, 10 parts of Radix Artemisia ordosicae, 8 parts of Rhizoma Acori Calami, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 8 parts of Cortex Phellodendris, 10 parts, Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Anemones Altaicaes.
Treat a preparation method for the first aid medicine of heatstroke, its raw material comprises: Herba Moslae Chinensis, Rhizoma Cimicifugae, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae; It is characterized in that, preparation method is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt respectively the way of distillation to extract volatile oil, volatile oil mix mixed volatilization oil is standby, medicinal residues are standby;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and obtains extracting solution, after 5 ℃ of following standing 15d of extracting solution, filter to get filtrate;
(3), get step 2 gained filtrate and add step 1 gained mixed volatilization oil, mix homogeneously, utilizes ultrafilter membrane to carry out ultrafiltration, sterilizing embedding after ultrafiltration.
The aperture of above-mentioned ultrafilter membrane is 200nm.
Wherein said: Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are arduous, temperature.Merit can be driven away summer heat, and invigorates blood circulation, regulate the flow of vital energy, and removing dampness.
Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Radix Artemisia ordosicae, Compositae Radix Artemisia ordosicae Artemisia dubia Wall. var. longeracemulosa Pamp., with all herbal medicine.Nature and flavor are bitter, cold.Merit can heat-clearing and toxic substances removing, expelling summer-heat, hemostasis.
Rhizoma Acori Calami is the rhizome of aroid Rhizoma Acori Graminei Acorus calamus L..Nature and flavor acrid in the mouth; Bitter; Warm in nature.GUIXIN; Liver; Stomach warp.Merit can waking up the patient from unconsciousness by dissipating phlegm; Dehumidifying stomach invigorating; Killing parasites for relieving itching.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.Merit can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Alismatis is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet, cold.Return kidney, urinary bladder channel.Merit can diuresis, clearing away damp-heat.
Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor are bitter, cold.Return kidney, urinary bladder channel.Merit can heat clearing and damp drying, and pathogenic fire purging is except steaming, detoxification sore treatment.
Pericarpium Citri Reticulatae Viride is the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit.Nature and flavor are bitter, pungent, temperature.Return liver, gallbladder, stomach warp.Merit can soothing the liver dispelling the stagnated QI, and removing food stagnancyization is stagnant.
Rhizoma Anemones Altaicae, for Ranunculaceae thimbleweed anemone altaica Anemone altaica Mey., is used as medicine with root stock.Nature and flavor are pungent, temperature.Merit can causing resuscitation with aromatic drugs, reduces phlegm, and calms the nerves.
Composition principle: heatstroke belongs to " fever disease in summer ", " syncope caused by summer-heat pathogen " category in motherland's medical science.Fever disease in summer refers to experiences summer-heat pathogenic factor in summer, from the beginning of take the excessive heat in the QI system of YANG MING syndromes such as high fever, excessive thirst, sweating, full and large pulse, be main manifestations, in the course of disease change of disease rapid, easily impairment of body fluid consumption gas, closes a kind of acute calenture of the change of key wind symptom more.The generation exopathogenic factor of fever disease in summer disease is experienced the summer-heat pathogenic factor in season, endogenous cause of ill human righteousness's virtual loss.Summer-heat is pathogenic fire, and the heart is that fire is dirty, " summer heat leads in the heart ", therefore in summer-heat process, the summer-heat the heart-nutriment that often easily caves in.In addition, the heresy of summer-heat also can sudden middle the heart-nutriment and in close pericardium, cause " syncope caused by summer-heat pathogen " of suddenly fainting, reveal any symptoms is scorching hot, agitation, coma, suddenly faint, syncope, rough as breathe heavily, mandibular joint is micro-tight, tic of the limbs, deep red tongue, thready and rapid pulse.Orientation treatment is generally the heat clearing away of driving away summer heat at present, but in fact, summer-heat is often held under the arm wet and entered damp and hot raw expectorant, mental confusion due to phlegm.Therefore we take to drive away summer heat, removing dampness, the method for activating yang, having one's ideas straightened out, get Herba Moslae Chinensis and drive away summer heat side, regulate the flow of vital energy, and removing dampness; Rhizoma Cimicifugae elevate a turnable ladder yang-energy, Pericarpium Citri Reticulatae Viride is soothing the liver dispelling the stagnated QI; Radix Artemisia ordosicae clearing away summer-heat; Rhizoma Acori Calami waking up the patient from unconsciousness by dissipating phlegm; Pericarpium Citri Reticulatae drying dampness to eliminate phlegm; Rhizoma Alismatis clearing away damp-heat; Cortex Phellodendri heat clearing and damp drying; Rhizoma Anemones Altaicae causing resuscitation with aromatic drugs, reduces phlegm, and calms the nerves.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Moslae Chinensis 60g, Rhizoma Cimicifugae 80g, Radix Artemisia ordosicae 80g, Rhizoma Acori Calami 60g, Pericarpium Citri Reticulatae 60g, Rhizoma Alismatis 80g, Cortex Phellodendri 60g, Pericarpium Citri Reticulatae Viride 80g, Rhizoma Anemones Altaicae 30g.Preparation method is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt respectively the way of distillation to extract volatile oil, volatile oil mix mixed volatilization oil is standby, medicinal residues are standby;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and obtains extracting solution, after 5 ℃ of following standing 15d of extracting solution, filter to get filtrate;
(3), get step 2 gained filtrate and add step 1 gained mixed volatilization oil, mix homogeneously, utilizes the ultrafilter membrane that aperture is 250nm to carry out ultrafiltration, sterilizing embedding after ultrafiltration.
Embodiment 2, crude drug weight proportion: Herba Moslae Chinensis 10g, Rhizoma Cimicifugae 15g, Radix Artemisia ordosicae 15g, Rhizoma Acori Calami 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Alismatis 15g, Cortex Phellodendri 10g, Pericarpium Citri Reticulatae Viride 15g, Rhizoma Anemones Altaicae 6g.Preparation method is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt respectively the way of distillation to extract volatile oil, volatile oil mix mixed volatilization oil is standby, medicinal residues are standby;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and obtains extracting solution, after 5 ℃ of following standing 15d of extracting solution, filter to get filtrate;
(3), get step 2 gained filtrate and add step 1 gained mixed volatilization oil, mix homogeneously, utilizes the ultrafilter membrane that aperture is 150nm to carry out ultrafiltration, sterilizing embedding after ultrafiltration.
Embodiment 3, crude drug weight proportion: Herba Moslae Chinensis 8g, Rhizoma Cimicifugae 10g, Radix Artemisia ordosicae 10g, Rhizoma Acori Calami 8g, Pericarpium Citri Reticulatae 8g, Rhizoma Alismatis 10g, Cortex Phellodendri 8g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Anemones Altaicae 5g.Preparation method is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt respectively the way of distillation to extract volatile oil, volatile oil mix mixed volatilization oil is standby, medicinal residues are standby;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and obtains extracting solution, after 5 ℃ of following standing 15d of extracting solution, filter to get filtrate;
(3), get step 2 gained filtrate and add step 1 gained mixed volatilization oil, mix homogeneously, utilizes the ultrafilter membrane that aperture is 200nm to carry out ultrafiltration, sterilizing embedding after ultrafiltration.
Effective combination of said medicine, coordinates mutually, can effectively reach the object for the treatment of heatstroke, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is crude drug weight proportion and preparation method in embodiment 3.
1 object and method.
1.1 objects: choose severe heat stroke patient's 50 examples of realization of Emergent Diagnosis And Treatment between year July in June, 2011 to 2012, all patients all meet the 5th edition severe heat stroke typing standard of < < internal medicine > >.
1.2 method.
1.2.1 grouping: patient is divided into treatment group and matched group at random, treatment group 25 examples wherein, male 14 examples, female's 11 examples, age 34-62 year, average (50.21 ± 2.42) year; Light coma 15 examples, middle severe coma 10 examples; Thermoplegia 9 examples, heat exhaustion 12 examples, heat cramp 4 examples; Fall ill to consultation time 0.6 ~ 24h, average (12.23 ± 2.48) h; Complicated hypertension 8 examples, heart disease 4 examples, chronic obstructive pulmonary disease 2 examples, chronic hepatopathy 1 example.Matched group 25 examples, male 15 examples, female's 10 examples, age 32-65 year, average (50.34 ± 2.45) year; Light coma 14 examples, middle severe coma 11 examples; Thermoplegia 10 examples, heat exhaustion 10 examples, heat cramp 5 examples; Fall ill to consultation time 0.5 ~ 22h, average (12.28 ± 2.40) h; Complicated hypertension 7 examples, heart disease 4 examples, chronic obstructive pulmonary disease 3 examples.Two groups of patients, at aspect comparing difference not statistically significants (P>0.05) such as age, sex, the state of an illness, have comparability.
1.2.2 Therapeutic Method: give emergency aid and treatment after two groups of patients are admitted to hospital, comprise Physical temperature-lowering, maintain respiratory and circulatory function, correct Electrolyte imbalance and acid base imbalance, control multiple organ dysfunction syndrome, fast venous transfusion, shock and hydration treatment; Give that mannitol adds furosemide dehydration, alkalized urine, prevention infection, wakens simultaneously, stabilizing cell membrane, antioxidant give vitamin C, protection gastric mucosa, promote the complex treatment measures such as digestive tract power, nutritional support.Treatment group therapeutic scheme for adding the oral or nasal feeding of the embodiment of the present invention 3 gained oral liquids, every day 2 times on the basis of above-mentioned Comprehensive Treatment again.
1.2.3 observation index: observe patient's mind recovery time, temperature recovery time and hospital stays, evaluate two groups of patient clinical therapeutic effect, and record adverse effect.
1.2.4 curative effect determinate standard: effective: patient is Consciousness in 4h, blood pressure, pulse, breathing, body temperature all recover normally, and every test rating is all normal.Effective: patient after 4h, Consciousness in 8h, blood pressure, pulse, breathing, temperature recovery are normal, it is normal that every laboratory indexes is tending towards.Invalid: patient has slight disturbance of consciousness after 8h, body temperature is higher and have complication to occur, as hepatic and renal function damage, aspiration pneumonitis etc.
1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, and P< 0.05 indicates significant.
2 results.
2.1 liang of group patient fever times, symptom and signs improve time comparison: treatment group fever time, symptom and sign improve the time obviously faster than matched group (P< 0.05 or P< 0.01), especially bring down a fever, the improving of the recovery of disturbance of consciousness and headache and dizzy (P< 0.01).See the following form.
| ? | Continue high heat | Persistent fever | Disturbance of consciousness | Dizziness headache | Tachycardia |
| Matched group | 1.37±0.44 | 5.09±1.66 | 1.18±0.34 | 3.22±0.80 | 2.39±0.81 |
| Treatment group | 0.43±0.14 | 3.05±0.61 | 0.31±0.10 | 0.64±0.18 | 1.91±0.60 |
The curative effect comparison of 2.2 liang of group cases: see the following form, obvious effective rate and total effective rate treatment group are obviously better than matched group (P<0.05).
2.3 untoward reaction situations: two groups of patients are showed no obvious Drug therapy untoward reaction.
3. conclusion: this research finds, the present invention treats severe heat stroke, brings down a fever, wakens, multiple organs dysfunction recovers faster during compared with conventional therapy, cure rate is higher, and have no untoward reaction, thus treatment severe heat stroke, the present invention's good, safe selection of a kind of curative effect of can yet be regarded as.
Claims (2)
1. a first aid medicine for the treatment of heatstroke, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are 6 ~ 10 parts of: Herba Moslae Chinensis, 8 ~ 15 parts of Rhizoma Cimicifugaes, 8 ~ 15 parts of Radix Artemisia ordosicae, 6 ~ 10 parts of Rhizoma Acori Calami, 6 ~ 10 parts of Pericarpium Citri Reticulataes, 8 ~ 15 parts of Rhizoma Alismatis, 6 ~ 10 parts of Cortex Phellodendris, 8 ~ 15 parts, Pericarpium Citri Reticulatae Viride, 3 ~ 6 parts of Rhizoma Anemones Altaicaes.
2. a kind of first aid medicine for the treatment of heatstroke according to claim 1, is characterized in that its weight proportion is 8 parts of: Herba Moslae Chinensis, 10 parts of Rhizoma Cimicifugaes, 10 parts of Radix Artemisia ordosicae, 8 parts of Rhizoma Acori Calami, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 8 parts of Cortex Phellodendris, 10 parts, Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Anemones Altaicaes.
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| CN201210279467.5A CN102813767B (en) | 2012-08-08 | 2012-08-08 | First-aid drug for treating heatstroke and preparation method thereof |
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| CN101143205A (en) * | 2007-08-25 | 2008-03-19 | 尹克华 | Traditional Chinese medicine for treating qi deficiency fever |
| CN101601491A (en) * | 2009-07-07 | 2009-12-16 | 林秀连 | A kind of drive away summer heat wet, the Chinese medicine drink that relieving restlessness is quenched the thirst |
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| JP4824836B1 (en) * | 2011-04-04 | 2011-11-30 | 株式会社 伊藤園 | Containerized barley tea beverage |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101143205A (en) * | 2007-08-25 | 2008-03-19 | 尹克华 | Traditional Chinese medicine for treating qi deficiency fever |
| CN101601491A (en) * | 2009-07-07 | 2009-12-16 | 林秀连 | A kind of drive away summer heat wet, the Chinese medicine drink that relieving restlessness is quenched the thirst |
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| CN102813767A (en) | 2012-12-12 |
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Inventor after: Hu Lichun Inventor before: Dong Qinglin |
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Effective date of registration: 20150120 Address after: 510640 Guangdong city of Guangzhou province Tianhe District gold Yinglu No. 1 was 1106 room two Patentee after: Guangdong Huabo Enterprise Management Consulting Co., Ltd. Address before: 276826 Rizhao People's Hospital, 126 Tai'an Road, Shandong, Rizhao City, China Patentee before: Dong Qinglin |
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Effective date of registration: 20160217 Address after: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee after: Guangdong Gaohang Intellectual Property Operation Co., Ltd. Address before: 510640 Guangdong city of Guangzhou province Tianhe District gold Yinglu No. 1 was 1106 room two Patentee before: Guangdong Huabo Enterprise Management Consulting Co., Ltd. |
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Effective date of registration: 20161027 Address after: 532800 the Guangxi Zhuang Autonomous Region Chongzuo Tianfu Tiandeng County township road six road No. 038 days Patentee after: Liang Dezheng Address before: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee before: Guangdong Gaohang Intellectual Property Operation Co., Ltd. |
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