CN102614335A - Method for preparing Huoxiang Zhengqi oral liquid - Google Patents
Method for preparing Huoxiang Zhengqi oral liquid Download PDFInfo
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Abstract
The invention relates to a method for preparing a Huoxiang Zhengqi oral liquid. The method comprises the following steps: 1, adding ethanol to cortex magnoliae officinalis, adjusting the pH value of the resulting liquid, and extracting; and 2, carrying out secondary extraction on herb residues obtained after distilling Atractylodes lancea, dried orange peel, and dahurian angelica root with ethanol. The method of the invention makes the loss of effective components in medicines be reduced, and makes the obtained oral liquid have strong pain easing, anti-inflammation and antibiosis effects.
Description
Technical field
The present invention relates to a kind of is the Chinese patent medicine method for preparing of main component with the Herba Pogostemonis, is specifically related to a kind of method for preparing HUOXIANGZHENGQI KOUFUYE.
Background technology
Said Herba Pogostemonis is named now and is " Herba Pogostemonis " in the classic of TCM, because of main product in Guangdong, Hainan gets.Herba Pogostemonis is a labiate, and stem and leaf contains volatile oil, and main component is a patchouli alcohol.The traditional Chinese medical science thinks that the reason that Herba Pogostemonis can be cured the disease is because its fragrant odour.According to record in " medicineization justice " and " the book on Chinese herbal medicine justice ", according to theory of Chinese medical science, sick epidemic disease is dyed the people with gas, sucks from mouth and nose, arrived first stomach, and fragrance can help clearing heat in QI system, remove bad odor, so the Herba Pogostemonis benefaction gastric qi of fragrant odour, be amusing, can control cholera and vomit.
The ageratum prescription is made up of Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, the Rhizoma Pinelliae, Radix Glycyrrhizae, Herba Pogostemonis and Folium Perillae ten flavor Chinese medicines; Have the removing dampness of inducing sweat, regulate the flow of vital energy with in effect, cure mainly affection of exogenous wind-cold; The all diseases of internal injury humidity hysteresis are expelling summer-heat medicines commonly used in summer.Its pharmacological action is mainly emesis, analgesia, spasmolytic, enhancing cellular immune function and antibacterial.
The initial preparation of ageratum is a huoxiang zhengqi powder, and loosing is powder, and HUOXIANG ZHENGQI PIAN promptly is the tablet that medication powder is pressed into, and powder, tablet are difficult for hiding for a long time, and the property of medicine is volatilized easily.At present, main dosage form has pill, tincture and water preparation.The characteristics of pill are lasting medicine, but absorption is slow and dosage is relatively large.Tincture is a HUOXIANG ZHENGQI SHUI, process through the ethanol percolation raw material, thereby product to contain alcohol amount higher, big to GI irritation, be inappropriate for old man, child, gastrointestinal ulceration patient and the personage that drives and take.HUOXIANGZHENGQI KOUFUYE belongs to water preparation, absorbs soon, good than the tincture mouthfeel, zest is little than pill and powder, but has the weakness that volatile effective component runs off in the pharmacy procedure, and same onset is slow relatively.
The prescription and the method for making of HUOXIANGZHENGQI KOUFUYE have been stipulated in the Pharmacopoeia of the People's Republic of China (hereinafter to be referred as " pharmacopeia "); Rhizoma Atractylodis, Pericarpium Citri Reticulatae and the Radix Angelicae Dahuricae are after distillation in this method; Medicinal residues promptly are dropped; Make that the content of this three flavors medicine reduces in the product, thereby its analgesia, antiinflammatory and antibacterial action can reduce thereupon also.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of HUOXIANGZHENGQI KOUFUYE; Overcome the deficiency of prior art, Cortex Magnoliae Officinalis adds ethanol, reflux, extract, behind the adjust pH; And Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Radix Angelicae Dahuricae distillation back medicinal residues secondary back extract, thereby make product have stronger analgesia, antiinflammatory and antibacterial action.
The method for preparing HUOXIANGZHENGQI KOUFUYE provided by the invention; With Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil and Folium perillae acutae oil is primary raw material, comprises the steps: 1) Cortex Magnoliae Officinalis adds and extracts after ethanol is transferred pH; 2) medicinal residues after Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae distillation carry out second extraction with ethanol.
Wherein, described step 1 is: it is 50～80% ethanol that Cortex Magnoliae Officinalis adds volume by volume concentration, and the repeated hydrogenation sodium oxide is regulated pH value, and it is remained on is 5～6, and reflux is 0.5～3 hour then, and it is subsequent use to get ethanol extract.
Described step 2 is: Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae add the water distillation, collect distillate, filter the aqueous solution after distilling, filtrate for later use, and it is 70% (volume ratio) alcohol reflux 1.5 hours that medicinal residues add volume by volume concentration, it is subsequent use to get ethanol extract.
The method that the present invention prepares HUOXIANGZHENGQI KOUFUYE also comprises the steps:
3) decocting boils Pericarpium Arecae, Poria and Rhizoma Pinelliae and filters respectively;
4) combining step 2 and each water of 3 gained are carried filtrating, with Radix Glycyrrhizae extractum, add ethanol again and filter after concentrating;
5) step 4 gained filtrating merges 1 and 2 ethanol extract, reclaims ethanol;
6) add patchouli oil, Folium perillae acutae oil and step 2 gained distillate, add water, adjust pH leaves standstill, and filters fill, sterilization.
Wherein, in the said step 3, Pericarpium Arecae decocte with water secondary filters; Poria adds behind the water boil in 80 ℃ of warm macerating secondaries, filters; After Rhizoma Pinelliae extremely passed through the heart with blister, other added Rhizoma Zingiberis 13.5 weight portions, and the decocte with water secondary filters.
In the said step 4, combining step 2 and each water of 3 gained are carried filtrating, and relative density is 1.10～1.20 clear paste when being concentrated into 50 ℃, add Radix Glycyrrhizae extractum, and mixing adds 2 times of amount ethanol and makes deposition, filters.
Said step 5 is: step 4 gained filtrating merges with the ethanol extract of step 1 gained Cortex Magnoliae Officinalis and the ethanol extract of step 2 gained medicinal residues, reclaims ethanol, and is subsequent use.
Said step 6 is: patchouli oil, Folium perillae acutae oil are joined in the tween 80 and mix, join in the extractum of step 5 gained again, add the distillate that step 2 is collected, mixing; Add water, regulate pH value to 5.8～6.2, leave standstill, filter with sodium hydroxide solution; Fill, sterilization promptly gets.
The weight proportion of each primary raw material that provides in " pharmacopeia " is:
Rhizoma Atractylodis 160 weight portion Pericarpium Citri Reticulataes 160 weight portions
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) the 160 weight portion Radixs Angelicae Dahuricae 240 weight portions
Poria 240 weight portion Pericarpium Arecae 240 weight portions
Rhizoma Pinelliae 160 weight portion Radix Glycyrrhizae extractum 20 weight portions
Patchouli oil 1.6 parts by volume Folium perillae acutae oils 0.8 parts by volume
Particularly, the method for preparing of HUOXIANGZHENGQI KOUFUYE of the present invention comprises the steps:
1) Cortex Magnoliae Officinalis adds 60% (percent by volume) ethanol, and it is 5～6 that the repeated hydrogenation sodium oxide is regulated pH value, and reflux is 1 hour then, and it is subsequent use to get ethanol extract.
2) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae add the water distillation, collect distillate, filter the aqueous solution after distilling, filtrate for later use, and medicinal residues add 70% (percent by volume) alcohol reflux 1.5 hours, and it is subsequent use to get ethanol extract.
3) Pericarpium Arecae decocte with water secondary filters; Poria adds behind the water boil in 80 ℃ of warm macerating secondaries, filters; After Rhizoma Pinelliae extremely passed through the heart with blister, other added Rhizoma Zingiberis 13.5 weight portions, and the decocte with water secondary filters.
4) combining step 2 and each water of 3 gained are carried filtrating, and being concentrated into relative density is the clear paste of 1.10～1.20 (50 ℃ of surveys), add Radix Glycyrrhizae extractum, and mixing adds 2 times of amount ethanol and makes deposition, filters.
5) step 4 gained filtrating merges with the ethanol extract of step 1 gained Cortex Magnoliae Officinalis and the ethanol extract of step 2 gained medicinal residues, reclaims ethanol, and is subsequent use.
6) patchouli oil, Folium perillae acutae oil are joined in the tween 80 (being Tween-80) mix, join again in the extractum of step 5 gained, add the distillate that step 2 is collected; Mixing adds water and makes full dose become 2050 parts by volume, regulates pH value to 5.8～6.2 with sodium hydroxide solution; Leave standstill, filter fill; Sterilization promptly gets.
Beneficial effect of the present invention is:
The method for preparing of HUOXIANGZHENGQI KOUFUYE of the present invention has improved the utilization rate of pharmaceutical raw material, makes product obtain enhancing in the drug effect of analgesia, antiinflammatory and antibiosis.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Radix Glycyrrhizae extractum is available from Baoji Jin Sen pharmaceutical Co. Ltd;
Patchouli oil is available from the extra large natural perfume material oil of: Jishui County gold Science and Technology Ltd.;
Folium perillae acutae oil is available from the extra large natural perfume material oil of: Jishui County gold Science and Technology Ltd..Embodiment 1
Rhizoma Atractylodis 160 weight portion Pericarpium Citri Reticulataes 160 weight portions
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) the 160 weight portion Radixs Angelicae Dahuricae 240 weight portions
Poria 240 weight portion Pericarpium Arecae 240 weight portions
Rhizoma Pinelliae 160 weight portion Radix Glycyrrhizae extractum 20 weight portions
Patchouli oil 1.6 parts by volume Folium perillae acutae oils 0.8 parts by volume
Method for preparing:
1) Cortex Magnoliae Officinalis adds 60% (percent by volume) ethanol, and it is 5 that the repeated hydrogenation sodium oxide is regulated pH value, and reflux is 1 hour then, and it is subsequent use to get ethanol extract;
2) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae add the water distillation, collect distillate, filter the aqueous solution after distilling, filtrate for later use, and medicinal residues add 70% (percent by volume) alcohol reflux 1.5 hours, and it is subsequent use to get ethanol liquid;
3) Pericarpium Arecae decocte with water secondary filters; Poria adds behind the water boil in 80 ℃ of warm macerating secondaries, filters; After Rhizoma Pinelliae extremely passed through the heart with blister, other added Rhizoma Zingiberis 13.5 weight portions, and the decocte with water secondary filters;
4) combining step 2 and each water of 3 gained are carried filtrating, and being concentrated into relative density is the clear paste of 1.15 (50 ℃ of surveys), add Radix Glycyrrhizae extractum, and mixing adds 2 times of amount ethanol and makes deposition, filters;
5) step 4 gained filtrating merges with the ethanol extract of step 1 gained Cortex Magnoliae Officinalis and the ethanol extract of step 2 gained medicinal residues, reclaims ethanol, and is subsequent use;
6) patchouli oil, Folium perillae acutae oil are joined in the tween 80 (being Tween-80) mix, join in the extractum of step 5 gained, add the distillate that step 2 is collected; Mixing adds water and makes full dose become 2050 parts by volume, regulates pH value to 6.0 with sodium hydroxide solution; Leave standstill, filter fill; Sterilization promptly gets embodiment 1 medicament.
Reference examples 1
Prescription is with embodiment 1, and Cortex Magnoliae Officinalis adds 60% alcohol heating reflux 1 hour, and it is subsequent use to get ethanol liquid; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae add the water distillation, collect distillate, and the aqueous solution after the distillation filters, and is subsequent use; Pericarpium Arecae decocte with water secondary filters; Poria adds behind the water boil in 80 ℃ of warm macerating secondaries, filters; After Rhizoma Pinelliae extremely passed through the heart with blister, other added Rhizoma Zingiberis 13.5 weight portions, and the decocte with water secondary filters; Merge above-mentioned each filtrating, being concentrated into relative density is 1.10-1.20 (50 ℃ of surveys), adds Radix Glycyrrhizae extractum, and mixing adds 2 times of amount ethanol and makes deposition; Filter, filtrating merges with the Cortex Magnoliae Officinalis ethanol extract, reclaims ethanol, and patchouli oil, Folium perillae acutae oil are joined above-mentioned distillate; Mixing adds water and makes full dose become 2050 parts by volume, regulates pH value to 5.8～6.2 with sodium hydroxide solution, leaves standstill; Filter, fill, sterilization promptly gets reference examples 1 medicament.
Experimental example 1 analgesic activity
Get 45 of white mice, be divided into 3 groups at random, 15 every group.Three groups of normal saline, embodiment 1 medicament and reference examples 1 medicaments that give same dose respectively.30 minutes lumbar injection 0.3% acetic acid after the administration, 0.2ml/ are only observed each treated animal in 30 minutes and are turned round the body number by what acetic acid brought out, referring to table 1.Experiment shows, causes more persistent pain stimulation behind the mouse peritoneal injection acetic acid.After the administration, in 1 group of embodiment and 1 group of the reference examples, the pain reaction of mice has in various degree and reduces, and the animal among 1 group of the embodiment is turned round the body number and obviously is less than 1 group of reference examples, and therefore analgesic activity of the present invention is remarkable.
Table 1 analgesic activity experimental result of the present invention
Compare with the normal saline group:
*P＜0.05,
*Compare with matched group: #p＜0.05 p＜0.01
Experimental example 2 antiinflammatory actions
Get 45 of 180～220g male rats, be divided into 3 groups at random, every group 15.Three groups of normal saline, embodiment 1 medicament and reference examples 1 medicaments that give same dose respectively; And be successive administration 2 days; After the fasting 10 hours, survey earlier before the last administration and do not cause the right sufficient sole of the foot volume of scorching each rat, administration then; And only give 1% carrageenin 0.2ml/, foot sole of the foot fascia injected in a left side.Surveyed the right sufficient sole of the foot volume of each rat in 1,2,4,6 hour respectively at causing scorching back then; Obtain different time and respectively organize the rat paw change in volume; Each organizes the swelling degree referring to table 2; A statistical is organized in t check, here swelling degree=(cause scorching back volume-cause scorching front volume)/cause scorching front volume * 100%, like table 2.Experimental result shows that the rat paw edema that the medicament on Carrageenan of the present invention's preparation causes has the obvious suppression effect, and its antiinflammatory action is superior to 1 group of reference examples.
Table 2 the present invention is to the influence
of rat paw edema
Compare with the normal saline matched group:
*P＜0.05,
*P＜0.01
Experimental example 3 vivo bacteria corrosion actions
At first carry out the trial test of infection dosage.Get body weight and be 100 of the NIH kind mices of 12～14g, male and female half and half are divided into 5 groups at random, and 20 every group, each organizes body weight does not have significant difference (p＜0.O5).Each group is respectively at staphylococcus aureus (purchasing in Nat'l Pharmaceutical & Biological Products Control Institute strain chamber) liquid 0.4ml/ of lumbar injection variable concentrations gradient, and each is organized infection dosage and is respectively 2 * 10
8/ only, 4 * 10
8/ only, 6 * 10
8/ only, 8 * 10
8/ only, 10 * 10
8/ only.Observe the death condition of animal in 15 days, the result is referring to table 3.Table 4 explanation infection dosage is 6 * 10
8/ mouse death rate is only confirmed with 6 * 10 more than 80% at last
8/ only use infection dosage for test.
Table 3 mouse infection bacterium amount trial test result
Carry out the endogenous protective effect test of infecting mouse then.
Get 60 of NIH kind mices, body weight is 12.8 ± O.96g, and male and female half and half are divided into 3 groups at random, 20 every group, is respectively and infects 1 group of matched group, 1 group of embodiment and reference examples.Except that infecting matched group, each group gives the 40.Og crude drug respectively, and each organizes weight ratio than there was no significant difference (p＜0.05), before the infection, and 1 group of 1 group of embodiment and reference examples, gastric infusion is 1 day respectively, 2 times on the one, infects matched group and irritates distilled water; Second day, each only organized the lumbar injection gold bacterium liquid 0.4ml/ of Portugal, and infection dosage is 6 * 10
8/ only, 1 group of 1 group of embodiment and reference examples continue gastric infusion respectively, and 2 times on the one, successive administration 2 days; Observe general behavior, death toll and the death time of animal then, observed X continuously 15 days
2(2 * 2) method test experiment result, result are referring to table 4, and the result shows that the animal dis motility rate that embodiment is 1 group is significantly higher than 1 group of reference examples, explains that antibacterial action of the present invention has obtained reinforcement.
Antibacterial tests result in table 4 body
With general explanation and specific embodiments the present invention has been done detailed description in the preceding text; But on basis of the present invention, can do some modifications or improvement to it, this will be apparent to those skilled in the art; Therefore; On the basis of not departing from spirit of the present invention, these modifications or the improvement made all belong to the scope that requirement of the present invention is protected.
Claims (8)
1. method for preparing HUOXIANGZHENGQI KOUFUYE; With Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil and Folium perillae acutae oil is primary raw material; It is characterized in that, comprise the steps: 1) Cortex Magnoliae Officinalis adds and extracts after ethanol is transferred pH; 2) medicinal residues after Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae distillation carry out second extraction with ethanol.
2. method for preparing according to claim 1; It is characterized in that described step 1 is: it is 50～80% ethanol that Cortex Magnoliae Officinalis adds volume by volume concentration, and the repeated hydrogenation sodium oxide is regulated pH value, and it is remained on is 5～6; Reflux is 0.5～3 hour then, and it is subsequent use to get ethanol extract.
3. method for preparing according to claim 1; It is characterized in that described step 2 is: Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae add the water distillation, collect distillate; Filter the aqueous solution after distilling; It is 70% alcohol reflux 1.5 hours that filtrate for later use, medicinal residues add volume by volume concentration, and it is subsequent use to get ethanol extract.
4. according to each described method for preparing of claim 1～3, it is characterized in that, also comprise the steps:
3) decocting boils Pericarpium Arecae, Poria and Rhizoma Pinelliae and filters respectively;
4) combining step 2 and each water of 3 gained are carried filtrating, with Radix Glycyrrhizae extractum, add ethanol again and filter after concentrating;
5) step 4 gained filtrating merges 1 and 2 ethanol extract, reclaims ethanol;
6) add patchouli oil, Folium perillae acutae oil and step 2 gained distillate, add water, adjust pH leaves standstill, and filters fill, sterilization.
5. method for preparing according to claim 4 is characterized in that, in the said step 3, Pericarpium Arecae decocte with water secondary filters; Poria adds behind the water boil in 80 ℃ of warm macerating secondaries, filters; After Rhizoma Pinelliae extremely passed through the heart with blister, other added Rhizoma Zingiberis 13.5 weight portions, and the decocte with water secondary filters.
6. method for preparing according to claim 4 is characterized in that, in the said step 4; Combining step 2 and each water of 3 gained are carried filtrating, and relative density is 1.10～1.20 clear paste when being concentrated into 50 ℃, add Radix Glycyrrhizae extractum; Mixing adds 2 times of amount ethanol and makes deposition, filters.
7. method for preparing according to claim 4 is characterized in that, said step 5 is: step 4 gained filtrating merges with the ethanol extract of step 1 gained Cortex Magnoliae Officinalis and the ethanol extract of step 2 gained medicinal residues, reclaims ethanol, and is subsequent use.
8. method for preparing according to claim 4 is characterized in that, said step 6 is: patchouli oil, Folium perillae acutae oil are joined in the tween 80 and mix, join in the extractum of step 5 gained again; Add the distillate that step 2 is collected, mixing adds water; Regulate pH value to 5.8～6.2 with sodium hydroxide solution, leave standstill, filter; Fill, sterilization promptly gets.
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| CN103071142A (en) * | 2013-02-26 | 2013-05-01 | 栗明峰 | Quick-acting external patch for tracheitis |
| CN103768299A (en) * | 2012-08-08 | 2014-05-07 | 董庆林 | Method for preparing emergency medicine for treating sunstroke |
| CN105079362A (en) * | 2015-09-16 | 2015-11-25 | 韩志强 | Huoxiang Zhengqi tablet |
| CN108392556A (en) * | 2018-05-21 | 2018-08-14 | 高伟玲 | The Chinese medicine of antipruritic anti-inflammatory, topical agent and preparation method thereof |
| CN109453280A (en) * | 2019-01-07 | 2019-03-12 | 重庆太极实业（集团）股份有限公司 | A kind of Chinese medicine composition is for treating the application in mucosa injury associated diseases |
| CN117257883A (en) * | 2023-11-23 | 2023-12-22 | 北京亚东生物制药有限公司 | Method for preparing Huoxiang Zhengqi oral liquid |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768299A (en) * | 2012-08-08 | 2014-05-07 | 董庆林 | Method for preparing emergency medicine for treating sunstroke |
| CN103768299B (en) * | 2012-08-08 | 2016-06-22 | 杜棉 | A kind of first aid medicine preparation method treating heatstroke |
| CN103071142A (en) * | 2013-02-26 | 2013-05-01 | 栗明峰 | Quick-acting external patch for tracheitis |
| CN105079362A (en) * | 2015-09-16 | 2015-11-25 | 韩志强 | Huoxiang Zhengqi tablet |
| CN108392556A (en) * | 2018-05-21 | 2018-08-14 | 高伟玲 | The Chinese medicine of antipruritic anti-inflammatory, topical agent and preparation method thereof |
| CN109453280A (en) * | 2019-01-07 | 2019-03-12 | 重庆太极实业（集团）股份有限公司 | A kind of Chinese medicine composition is for treating the application in mucosa injury associated diseases |
| CN117257883A (en) * | 2023-11-23 | 2023-12-22 | 北京亚东生物制药有限公司 | Method for preparing Huoxiang Zhengqi oral liquid |
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Application publication date: 20120801 |