CN109364221B - Traditional Chinese medicine preparation for treating renal edema - Google Patents
Traditional Chinese medicine preparation for treating renal edema Download PDFInfo
- Publication number
- CN109364221B CN109364221B CN201811602600.XA CN201811602600A CN109364221B CN 109364221 B CN109364221 B CN 109364221B CN 201811602600 A CN201811602600 A CN 201811602600A CN 109364221 B CN109364221 B CN 109364221B
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- prepared
- chinese medicine
- medicine preparation
- edema
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010030113 Oedema Diseases 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 210000000582 semen Anatomy 0.000 claims abstract description 23
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 15
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 15
- 241000132012 Atractylodes Species 0.000 claims abstract description 14
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 14
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 14
- 229910052623 talc Inorganic materials 0.000 claims abstract description 14
- 235000012222 talc Nutrition 0.000 claims abstract description 14
- 239000000454 talc Substances 0.000 claims abstract description 14
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 13
- 241000037740 Coptis chinensis Species 0.000 claims abstract description 13
- 235000004347 Perilla Nutrition 0.000 claims abstract description 13
- 244000197580 Poria cocos Species 0.000 claims abstract description 13
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 13
- 240000001417 Vigna umbellata Species 0.000 claims abstract description 13
- 235000011453 Vigna umbellata Nutrition 0.000 claims abstract description 13
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 13
- 235000011477 liquorice Nutrition 0.000 claims abstract description 13
- 235000012874 Phaseolus calcaratus Nutrition 0.000 claims abstract description 12
- 235000006533 astragalus Nutrition 0.000 claims abstract description 12
- 244000061520 Angelica archangelica Species 0.000 claims abstract description 11
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 11
- 244000171085 Polyporus umbellatus Species 0.000 claims abstract description 11
- 235000004837 Polyporus umbellatus Nutrition 0.000 claims abstract description 11
- 241001061264 Astragalus Species 0.000 claims abstract description 10
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 10
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 10
- 244000124853 Perilla frutescens Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 210000004233 talus Anatomy 0.000 claims abstract description 10
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 9
- 241001598107 Imperata Species 0.000 claims abstract description 9
- 241000227129 Aconitum Species 0.000 claims description 12
- 240000007890 Leonurus cardiaca Species 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 20
- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 206010000060 Abdominal distension Diseases 0.000 abstract description 5
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 3
- 241000173529 Aconitum napellus Species 0.000 abstract description 2
- 241000675108 Citrus tangerina Species 0.000 abstract description 2
- 244000164480 Curcuma aromatica Species 0.000 abstract description 2
- 235000003398 Curcuma aromatica Nutrition 0.000 abstract description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 24
- 230000007812 deficiency Effects 0.000 description 18
- 210000004072 lung Anatomy 0.000 description 17
- 208000004880 Polyuria Diseases 0.000 description 13
- 230000035619 diuresis Effects 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 241000207925 Leonurus Species 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 210000003734 kidney Anatomy 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000010926 purge Methods 0.000 description 8
- 230000027939 micturition Effects 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 6
- 241000222684 Grifola Species 0.000 description 5
- 206010042674 Swelling Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 239000002398 materia medica Substances 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 241000382455 Angelica sinensis Species 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 244000077995 Coix lacryma jobi Species 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 240000000249 Morus alba Species 0.000 description 3
- 235000008708 Morus alba Nutrition 0.000 description 3
- 241000229722 Perilla <angiosperm> Species 0.000 description 3
- 235000014676 Phragmites communis Nutrition 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000008506 pathogenesis Effects 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 241000045403 Astragalus propinquus Species 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 208000006083 Hypokinesia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 235000003805 Musa ABB Group Nutrition 0.000 description 2
- 240000008790 Musa x paradisiaca Species 0.000 description 2
- 235000015266 Plantago major Nutrition 0.000 description 2
- 235000003407 Sigesbeckia orientalis Nutrition 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 240000001519 Verbena officinalis Species 0.000 description 2
- 235000018718 Verbena officinalis Nutrition 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229940107666 astragalus root Drugs 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 241000555682 Forsythia x intermedia Species 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010021036 Hyponatraemia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 235000001188 Peltandra virginica Nutrition 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 229940023019 aconite Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000010015 huanglian Substances 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 235000015598 salt intake Nutrition 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000021023 sodium intake Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine preparation for treating renal edema, which is prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-decocted), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of lalang grass rhizome. 15 g of curcuma aromatica and 10 g of green tangerine peel are added for treating the two types of abdominal distension; for abdominal distension, 10 g of dried orange peel is added. The traditional Chinese medicine preparation is prepared from pure traditional Chinese medicines, treats both principal and secondary aspects of diseases and has obvious curative effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating renal edema.
Background
Renal edema is one of the more common diseases, and is a syndrome of water-salt metabolism disorder. Renal edema can be accompanied by a series of clinical symptoms such as swelling of the head, face, eyelids, limbs and abdomen. The treatment method is divided into medication and sodium salt intake restriction. The medicine treatment mainly comprises taking honeysuckle flower inflammation-secreting tablets and antibiotics, but the long-term taking is needed, and the side effect is large. Long term restriction of sodium intake can lead to hyponatremia. The medicament is prepared from a plurality of traditional Chinese medicine components, the traditional Chinese medicine focuses on regulating the body, has small side effect and small effect, has the effect of treating both principal and secondary aspect of disease, and has particularly obvious effect on patients who are not cured for a long time and have recurrent attacks.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for treating renal edema, which has quick effect on treating the renal edema and small side effect.
The technical scheme of the invention is as follows: the traditional Chinese medicine preparation for treating renal edema is prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-decocted), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of lalang grass rhizome. 15 g of curcuma aromatica and 10 g of green tangerine peel are added for treating the two types of abdominal distension; for abdominal distension, 10 g of dried orange peel is added.
The preparation method comprises the following steps: putting the raw materials into a decocting vessel, adding 1500ml of water, soaking for 20 minutes, decocting with slow fire for 30 minutes, filtering to obtain liquid medicine, adding 500ml of boiled water into the decocting vessel, decocting with slow fire for 20 minutes, and filtering to obtain liquid medicine. Mixing the two liquid medicines, averagely dividing into two parts, and taking twice in the morning and evening. A treatment course lasts for 10 days. For people with three highs of hyperglycemia, hyperlipemia and hypertension, the effect of assisting in treating the three highs can be better when the traditional Chinese medicine is taken.
The traditional Chinese medicine theory considers that the renal edema is a water-salt metabolism disorder syndrome. Edema is associated with dysfunction of the lung, spleen and kidney. The lung governs qi of the whole body, and lung qi is dispersing and unblocking, so spleen qi ascends, kidney qi transforms into fluid and water four distribute and its swelling is self-eliminated. The principal deficiency and excess syndrome is the main pathogenesis of kidney disease, the kidney edema mainly refers to qi deficiency and spleen deficiency, and the liver qi stagnation and spleen-kidney deficiency are the etiology and pathogenesis of kidney edema. According to the invisible relationship between the lung and the kidney, the mother-organ is tonified in case of deficiency, and the lung-qi is tonified in case of deficiency to strengthen the kidney-water; the lung is the upper source of water, and the invention can complement each other to strengthen the diuresis function by using the lung-ventilating product on the basis of replenishing qi to invigorate the spleen, so that the invention has the condition of lifting a kettle and uncovering the cover. The formula has effects of strengthening body resistance, eliminating pathogenic factors, and tonifying and eliminating, and can be used for treating various edemas caused by deficiency of lung qi, spleen qi, and water-dampness stagnation. Adopts the traditional Chinese medicine treatment to expand the blocked part, drain the accumulated water and relieve the compression so as to achieve the healing effect.
In the formula of the invention, the astragalus, the codonopsis pilosula, the liquorice and the angelica tonify the middle-jiao and qi; coix seed, red tuckahoe, bighead atractylodes rhizome, prepared monkshood and cassia twig have the effects of tonifying spleen, removing dampness, tonifying fire and supporting yang. Perilla leaf, mulberry bark and fresh reed rhizome for ventilating the lung and expressing the exterior; rhizoma alismatis, grifola, semen plantaginis, talcum, herba leonuri and rhizoma imperatae are capable of inducing diuresis and excreting dampness and promoting diuresis; fructus forsythiae and rhizoma Coptidis are used as adjuvant materials for clearing heat and purging fire, and relieving inflammation and removing toxic substance. The medicines are combined to tonify middle-jiao and Qi, invigorate spleen and remove dampness, ventilate lung qi, promote urination and remove dampness. Treat the pathogenesis of the renal edema and treat both principal and secondary aspects of diseases.
The pharmacological effects of the raw materials of the traditional Chinese medicine are as follows:
astragalus root: tonify qi, consolidate the constitution, astringe sweating, promote granulation, and eliminate edema. Edema due to chronic nephritis, deficiency of spleen and kidney: it is often combined with Dang Shen, Bai Zhu and Fu Ling.
Radix codonopsitis; tonify middle-jiao and Qi, strengthen spleen and nourish lung, calm and allay fever, and tonify lung qi. Compendium supplement: for lung deficiency, it can tonify lung qi.
White atractylodes rhizome: dry dampness and invigorate spleen, strengthen superficies to check sweating, induce diuresis and alleviate edema. The book Ben Cao Hui Yan (treatise on materia Medica): bai Zhu is also the key herb for strengthening spleen and stomach, dissipating dampness and removing arthralgia, promoting digestion and relieving stuffiness. Spleen deficiency failing to strengthen the body can tonify the body, stomach deficiency failing to accommodate the body, and operation can help.
Licorice root, radix Glycyrrhizae Praeparata has effects of invigorating qi and strengthening the middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonize the drugs. The book Ben Cao Hui Yan (treatise on materia Medica): licorice root, radix Glycyrrhizae is also indicated for regulating the middle warmer, tonifying qi, tonifying deficiency and removing toxicity. Invigorating spleen and stomach, consolidating deficiency of qi, coordinating yin and yang, and regulating ying and wei. For internal injury due to strain, spleen qi deficiency, yang deficiency, lung qi deficiency, it is combined with Shen and Qin to reinforce its actions with mild action.
Angelica sinensis for enriching blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The book materia Medica is as follows: dang Gui is sweet and heavy in flavor, so it can tonify blood, and its qi is light and pungent, so it can also move blood, tonify middle energizer and move middle energizer, and is good at qi in blood and holy herb in blood. It is usually used as an assistant to tonify the body, so it can nourish yin and blood, tonify qi and produce essence, calm the five internal organs, strengthen the body and benefit the spirit, and is not suitable for diseases with physical deficiency.
Coix seed: induce diuresis to alleviate edema, invigorate spleen to remove dampness, relax muscles and tendons and remove arthralgia. The book Danjing Shu (the single Jing Shu): "Yi ren" is sweet in flavor and can enter spleen and tonify spleen due to dry nature, and also can seep and purge when it is bland, so it can not flex and stretch in the main tendons and spasm, and rheumatism, remove pathogenic factors of muscles and bones, promote the intestines and stomach, eliminate edema, and make people eat.
Talc: induce diuresis to treat stranguria, clear away summer-heat.
Red poria: move water, remove dampness and heat, benefit heart qi. In the recipe of the medicine, Fu Ling, a holy medicine with the actions of inducing resuscitation, supporting yang and removing dampness, is also known. Sweet and neutral in flavor, tonifying yang, invigorating spleen, expelling water, promoting the production of body fluid and guiding qi.
And (3) polyporus umbellatus: induce diuresis and excrete dampness. Difficulty in urination; edema and fullness; the book of medical science: polyporus umbellatus is light in flavor, and light in flavor mainly permeates and circulates in the channels of the human spleen, so that the Polyporus umbellatus is the most rapid in treatment of water retention, dampness and diarrhea, stranguria treatment, dampness removal, edema elimination and jaundice treatment, and therefore, Yun and Succinum have the same effect.
Motherwort: promoting blood circulation to regulate menstruation; promoting urination and relieving swelling; clearing away heat and toxic material. The herbal Zhenzhen: motherwort herb, herba Leonuri, as a essential agent for antenatal and postnatal fetus, has the effects of removing water and promoting blood circulation, removing lochiostasis and promoting tissue regeneration, regulating menstruation and removing toxicity.
Rhizoma alismatis: induce diuresis, drain dampness and purge heat. The book of materia Medica: alisma orientale, best seeps into the water channel and is special for passing urine.
Semen plantaginis for clearing away heat and promoting urination; eliminating dampness and relieving diarrhea; improving eyesight; dispel phlegm. The book Jing: mainly treat dysuria, alleviate pain, induce diuresis, remove damp arthralgia.
Cassia twig: dispelling cold and relieving exterior syndrome; warming and dredging channels and collaterals; activate yang and transform qi. Caocaoda: cold-dampness congeals in the muscles and yang-qi is not in the exterior, so Zhong Zhi stands up the Gui Zhi Tang Fang to strengthen spleen yang and to achieve the depression of nutrient system. The essence of Gui Zhi is that it covers the skin and lines of skin, so it is cold in the skin, but it is not enough to get yang qi through, and the remainder of ying fen is not steamed to become sweat.
Fructus forsythiae: clearing away heat and toxic materials; dispersing swelling and dissipating stagnation and treating wind-heat type common cold. Treatise on herb Property: mainly relieve stranguria, promote urination, and remove heart heat.
Coptis chinensis: clearing heat and purging fire; drying dampness; and (5) detoxifying. The book of materia Medica: huang Lian is bitter and cold in nature, bitter and dry in nature, cold prevailing in heat, and can purge and descend all the remaining damp fire, but heat of heart, spleen, liver and kidney, fire of gallbladder, stomach and large and small intestines, it is not treated. The upper part of the body is to clear wind-fire, the middle part is to calm vomiting of liver and stomach, and the lower part is to relieve pain and stagnation of abdomen, so it can dry dampness and clear heat.
Preparing monkshood; reviving yang to rescue adverse qi, tonifying fire to strengthen yang, and expelling pathogenic wind, cold and dampness. The Fu Zi uses Bai Zhu as adjuvant and is the holy herb for eliminating cold-dampness, and the channel guiding is added for the damp herb. When benefiting fire, the yin nebula can be eliminated, so it is also indicated for constipation.
Perilla leaf: the material Zheng Yi (Perilla) causes the new and old Xuan Ji and the mild Xuan Ji. Therefore, the qi descending can be promoted and the qi ascending can be promoted and controlled. Leaves are dispersing, stems are dispersing, while children are mild in nature.
White mulberry root-bark: purge lung and relieve dyspnea, induce diuresis to alleviate edema, clear heat and purge lung.
Red bean; induce diuresis to remove dampness, resolve swelling and remove toxicity.
Fresh reed rhizome; clearing heat, promoting fluid production, relieving restlessness, moistening lung and regulating stomach.
Rhizoma Imperatae; cool blood, stop bleeding, induce diuresis, clear heat and remove toxicity.
The traditional Chinese medicine preparation is prepared from pure traditional Chinese medicines, treats both principal and secondary aspects of diseases and has obvious curative effect.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1: the traditional Chinese medicine preparation for treating renal edema is prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-decocted), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of lalang grass rhizome.
Example 2: the traditional Chinese medicine preparation for treating renal edema is prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-decocted), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis, 15 g of lalang grass rhizome, 15 g of radix curcumae and 10 g of pericarpium citri.
Example 3: the traditional Chinese medicine preparation for treating renal edema is prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of leonurus, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-decocted), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis, 15 g of lalang grass rhizome and 10 g of dried orange peel.
Clinical data
48 patients with renal edema are collected in a hospital from 2017, 1 month to 2018, 10 months, and randomly drawn into two groups, wherein the observation group comprises 24 patients, the age is 3-68 years, and the average age is 48.6 years; the control group had 24 cases aged 2-70 years, with a mean age of 46.2 years. The general clinical data of the two groups of patients are not statistically significant (P > 0.05). Both groups of patients had obvious edema symptoms of both lower limbs, had proteinuria of different degrees in the test, and had some symptoms accompanied by hypertension and hyperglycemia.
The treatment method comprises the following steps: 1. and (4) a control group. Based on basic treatment such as blood pressure reduction, blood fat reduction, blood sugar reduction and the like, the prednisone western medicine is also used for treatment.
2. And (5) observing the groups. On the basis of basic treatment such as blood pressure reduction, blood fat reduction, blood sugar reduction and the like, the basic recipe or the recipe of the embodiment 2 or the embodiment 3 of the traditional Chinese medicine preparation (20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talc, 20 g of poria cocos, 10 g of grifola, 15 g of leonurus, 12 g of rhizoma alismatis, 15 g of plantain seed (bag-fried), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of rhizoma imperatae). One dose is taken every day in the morning and at night, and the dose is taken half an hour after meals.
And (3) observation of curative effect: after 30 days of treatment, statistical analysis and treatment are carried out by observing each index of edema degree, symptom integral, laboratory examination and the like of the patients before and after two groups of treatment.
Observation group: 24 patients, 16 patients are cured clinically, 4 patients are effective, 2 patients are ineffective, and the total effective rate is 91.7%; the average symptom integral of the observation group before treatment was 15.42 + -5.22 points, and the average symptom integral after treatment was 7.00 + -3.44 points.
Control group: 24 patients cured 4 cases clinically, 4 cases with obvious effect, 8 cases with effect and 8 cases with no effect, and the total effective rate is 66.7%. Mean symptom score after treatment was 10.06 ± 4.44 points.
And (4) conclusion: the traditional Chinese medicine preparation disclosed by the invention has a remarkable curative effect on treating renal edema and improving the comprehensive symptoms of patients, and is good in safety.
Typical cases
Case 1: tian Yi, male, 26 years old, 1 month in 2018 and 15 days of first diagnosis. The main complaints are: the patient has no obvious cause of edema of the lower limb 2 months ago, and the urine volume is reduced by 300-500 ml/d. The symptoms of edema have a tendency of aggravation, accompanied by abdominal distension and diarrhea, hypodynamia and anorexia, urinary protein (++++), which is diagnosed as nephrotic syndrome, and renal edema is diagnosed in the traditional Chinese medicine, the traditional Chinese medicine preparation (20 g of astragalus root, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of coix seed, 15 g of talcum, 20 g of poria cocos, 10 g of grifola, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of plantain seed (bag-fried), 9 g of cassia twig, 10 g of forsythia, 10 g of coptis chinensis, 12 g of prepared aconite, 10 g of perilla leaf, 10 g of white mulberry root-bark, 12 g of phaseolus calcaratus, 15 g of fresh reed rhizome, 15 g of lalang grass rhizome and 10 g of dried orange. One dose is taken every day in the morning and at night, and the dose is taken half an hour after meals. The disease can be cured in 30 days.
Case 2: a certain Wang is a male with age of 36 years and a first diagnosis in 12 months and 2 days in 2017. The patient complains about edema of both lower limbs for half a year, frequent micturition, urgent micturition, dizziness and hypodynamia. The tongue is dark red, yellow and thick, and the pulse is deep and thready. Urine examination; urine protein (+++), white blood cell (++). The syndrome differentiation of traditional Chinese medicine belongs to spleen and kidney deficiency type edema. The formula of the traditional Chinese medicine preparation (20 g of astragalus membranaceus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica sinensis, 15 g of semen coicis, 15 g of talc, 20 g of poria cocos, 10 g of grifola, 15 g of leonurus, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-fried), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of folium perillae, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of rhizoma imperatae) in the invention is. One dose is taken every day in the morning and at night, and the dose is taken half an hour after meals. Hospitalization is carried out for 10 days, then the patient is returned to home for medication treatment, and the patient is healed in 30 days.
Case 3: one certain male, 56 years old, first diagnosis in 2017, 10 and 5 months. A main complaint; edema in both lower limbs is aggravated in the near future, half a year. The medical history of hypertension and diabetes is more than 20 years. Physical examination: mild edema of the eyelid face, 168/90mmHg blood pressure, heart rate: 81 times/min, sunken edema (+++), red tongue with thin and white coating and deep and thready pulse. Traditional Chinese medicine diagnosis: edema is due to deficiency of both the spleen and kidney. For treatment, it can invigorate spleen, replenish qi, warm yang and induce diuresis. The formula of the traditional Chinese medicine preparation (20 g of astragalus membranaceus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica sinensis, 15 g of semen coicis, 15 g of talc, 20 g of poria cocos, 10 g of grifola, 15 g of leonurus, 12 g of rhizoma alismatis, 15 g of semen plantaginis (bag-fried), 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of folium perillae, 10 g of cortex mori, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of rhizoma imperatae) in the invention is. One dose is taken every day in the morning and at night, and the dose is taken half an hour after meals. After the medicine is taken at home for treatment, the disease is cured in 30 days.
Claims (3)
1. The traditional Chinese medicine preparation for treating renal edema is characterized by being prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis, 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori radicis, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis and 15 g of lalang grass rhizome.
2. The traditional Chinese medicine preparation for treating renal edema is characterized by being prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis, 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori radicis, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis, 15 g of lalang grass rhizome, 15 g of radix curcumae and 10 g of.
3. The traditional Chinese medicine preparation for treating renal edema is characterized by being prepared from the following raw materials: 20 g of astragalus, 20 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 9 g of liquorice, 15 g of angelica, 15 g of semen coicis, 15 g of talcum, 20 g of poria cocos, 10 g of polyporus umbellatus, 15 g of motherwort, 12 g of rhizoma alismatis, 15 g of semen plantaginis, 9 g of cassia twig, 10 g of fructus forsythiae, 10 g of coptis chinensis, 12 g of prepared monkshood, 10 g of perilla leaf, 10 g of cortex mori radicis, 12 g of phaseolus calcaratus, 15 g of fresh rhizoma phragmitis, 15 g of lalang grass rhizome and 10 g of dried orange peel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811602600.XA CN109364221B (en) | 2018-12-26 | 2018-12-26 | Traditional Chinese medicine preparation for treating renal edema |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811602600.XA CN109364221B (en) | 2018-12-26 | 2018-12-26 | Traditional Chinese medicine preparation for treating renal edema |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109364221A CN109364221A (en) | 2019-02-22 |
| CN109364221B true CN109364221B (en) | 2021-06-08 |
Family
ID=65371528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811602600.XA Expired - Fee Related CN109364221B (en) | 2018-12-26 | 2018-12-26 | Traditional Chinese medicine preparation for treating renal edema |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109364221B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606574A (en) * | 2013-11-04 | 2015-05-13 | 陈洪波 | Medicament for treating nephrosis syndrome of edema due to spleen deficiency symptom |
| CN104258320B (en) * | 2014-09-11 | 2016-01-20 | 湖北省中医院 | A kind ofly treat Chinese medicine preparation of hypertensive renal damage edema and preparation method thereof |
-
2018
- 2018-12-26 CN CN201811602600.XA patent/CN109364221B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN109364221A (en) | 2019-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104338062A (en) | Chinese medicinal preparation for treating stomachache and diarrhea | |
| CN105056124A (en) | Medicine for treating hypertension and diabetes | |
| CN104288412B (en) | A kind of Chinese medicine composition for treating metabolic syndrome | |
| CN108578563B (en) | Traditional Chinese medicine for treating diabetic nephropathy | |
| CN104399023A (en) | Traditional Chinese medicine composition for treating dysmenorrheal caused by cold-damp stagnation | |
| CN104069466A (en) | Traditional Chinese medicament for treating uremia | |
| CN104208545A (en) | Traditional Chinese medicine preparation for treating pruritus vulvae and preparation method of traditional Chinese medicine preparation | |
| CN111658735A (en) | Intelligent system plaster for conditioning physique and preventing and treating various gastrointestinal diseases and preparation method | |
| CN109364221B (en) | Traditional Chinese medicine preparation for treating renal edema | |
| CN104758606A (en) | Traditional Chinese medicine composition for treating qi-deficiency and sputum-stasis type hepatic hemangioma | |
| CN103893457A (en) | Traditional Chinese medicine for treating ulcerative colitis | |
| CN105944059A (en) | Traditional Chinese medicine composition for treating gastropathy | |
| CN110559276A (en) | intelligent system plaster for conditioning physique and preventing and treating various types of diarrhea and preparation method | |
| CN104645144A (en) | Traditional Chinese medicine preparation for treating nephritis and preparation method of traditional Chinese medicine preparation | |
| CN107961355A (en) | A kind of navel ball for treating liver ascites and preparation method thereof | |
| CN102335407A (en) | Chinese medicinal composition for treating acute gastric dilatation of horses | |
| CN106620506A (en) | Pill medicine for treating spleen dampness transporting dysfunction type mouth tinea and preparation method | |
| CN104758889A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN105079661A (en) | Traditional Chinese medicine composition for treating hemafecia | |
| CN104800688A (en) | Traditional Chinese medicine composition for treating chronic nephritis and application | |
| CN104784649A (en) | Traditional Chinese medicine decoction for treating scapulohumeral periarthritis | |
| CN105770832A (en) | Traditional Chinese medicine composition for treating abdominal distension | |
| CN105125903A (en) | Traditional Chinese medicinal composition for treating diabetes | |
| CN105106922A (en) | Decoction medicine for treating stomach cancer postoperative fever and preparation method of decoction medicine | |
| CN105641594A (en) | Medicine for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210608 |