CN102813767A - First-aid drug for treating heatstroke and preparation method thereof - Google Patents

First-aid drug for treating heatstroke and preparation method thereof Download PDF

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CN102813767A
CN102813767A CN2012102794675A CN201210279467A CN102813767A CN 102813767 A CN102813767 A CN 102813767A CN 2012102794675 A CN2012102794675 A CN 2012102794675A CN 201210279467 A CN201210279467 A CN 201210279467A CN 102813767 A CN102813767 A CN 102813767A
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rhizoma
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pericarpium citri
citri reticulatae
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董庆林
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董庆林
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Abstract

The invention discloses a first-aid drug for treating heatstroke and a preparation method thereof. The first-aid drug for treating heatstroke is prepared from 6 to 10 parts by weight of all grass of mosla chinensis maxim, 8 to 15 parts by weight of largetrifoliolious bugbane rhizome, 8 to 15 parts by weight of all grass of ordos wormwood, 6 to 10 parts by weight of rhizoma calami, 6 to 10 parts by weight of tangerine peel, 8 to 15 parts by weight of oriental waterplantain rhizome, 6 to 10 parts by weight of amur corktree bark, 8 to 15 parts by weight of immature tangerine peel and 3 to 6 parts by weight of irkutsk anemone rhizome. The preparation method comprises the following steps of 1, extracting volatile oil from all grass of mosla chinensis maxim, all grass of ordos wormwood, rhizoma calami, immature tangerine peel and irkutsk anemone rhizome by a distillation method and collecting dregs for next use, 2, mixing the dregs obtained by the step 1, largetrifoliolious bugbane rhizome, tangerine peel, oriental waterplantain rhizome and amur corktree bark, carrying out water decoction and alcohol precipitation to obtain extract, standing the extract at a temperature of 5 DEG C for 15 days, and filtering to obtain a filtrate, and 3, adding the filtrate obtained by the step 2 into the volatile oil obtained by the step 1, uniformly mixing, carrying out ultrafiltration by an ultrafiltration membrane, and then carrying out sterilization filling and sealing. A clinical test proves that the first-aid drug provided by the invention has good effects of treating heatstroke.

Description

A kind of first aid medicine of treating heatstroke and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of first aid medicine of treating heatstroke.
Background technology
Heatstroke is a common emergency case in a kind of summer, is meant under high temperature and thermal-radiating long duration of action body thermoregulation obstacle, the general name of the symptom of water, metabolic disturbance of electrolyte and nervous function infringement.When the body heat production greater than when heat radiation, heat storage in the body causes thermotaxic centre out of control, cardiac function goes down; Cardiac output reduces, and central venous pressure raises, and the sweat gland MSOF is further accumulated intimate heat; Body temperature rises sharply at short notice, and when body temperature was higher than 41.5 ℃, hyperpyrexia caused damage to many organs, cell membranes in tissue and cell interior structure, and cell membrane stability is poor; Obstacle takes place in mitochondrial oxidative phosphorylation, and the oxygen dependence metabolic pathway goes to pot, and causes histanoxia, makes to organize capillary permeability increase, edema; Microcirculation disturbance, the Water-Electrolyte soda acid is disorderly, causes multiple organs dysfunctions such as the heart, lung, brain, kidney, liver.The reason of heatstroke is very many, and except high temperature, burning sun tanned by the sun, spiritual hypertonicity, personnel were too intensive, working strength is excessive, overlong time, do not have enough sleep, overtired etc. be common inducement.Different according to pathogenesis with clinical manifestation, usually heatstroke is divided into heat cramp, heat exhaustion and heat (day) and penetrates disease.Above-mentioned three kinds of situation can develop in proper order, but also juxtaposition.Mild heat stroke, the patient shows as profuse sweating, thirsty, dizzy, tinnitus, feels sick, nervous, myasthenia of limbs, tired out, distraction, exercise not harmony, the flushed face that continues or pale, uncomfortable in chest, skin is scorching hot, and body temperature is more than 38.5 ℃.The patient of severe heatstroke then produces delirium, spasm, stupor, skin and does lossless, body temperature more than 40 ℃ or shock occurs.The treatment of emergency treatment at present mainly is to handle moisturizing fluid infusion, serious symptom intramuscular injection chlorpromazine to the secondary symptom.And the medication of Chinese traditional treatment heatstroke mainly is menthocamphorate, rheocamphoradin, and the effect of above-mentioned two kinds of medicines is to dispel the wind, and is little for the cooling effect of having one's ideas straightened out, and oral taste is difficult to accept.
Summary of the invention
Technical assignment of the present invention is the deficiency to prior art, and first aid medicine of the sure treatment heatstroke of a kind of curative effect and preparation method thereof is provided.
The technical scheme that the present invention solves its technical problem is: a kind of first aid medicine of treating heatstroke, it is characterized in that processing by plurality of Chinese, and its composition of raw materials and weight proportion are 6 ~ 10 parts of: Herba Moslae Chinensis; 8 ~ 15 parts of Rhizoma Cimicifugaes, 8 ~ 15 parts of Radix Artemisia ordosicae, 6 ~ 10 parts of Rhizoma Acori Calami; 6 ~ 10 parts of Pericarpium Citri Reticulataes, 8 ~ 15 parts of Rhizoma Alismatis, 6 ~ 10 parts of Cortex Phellodendris; 8 ~ 15 parts on Pericarpium Citri Reticulatae Viride, 3 ~ 6 parts of Rhizoma Anemones Altaicaes.
Its optimum weight proportioning is 8 parts of: Herba Moslae Chinensis, 10 parts of Rhizoma Cimicifugaes, 10 parts of Radix Artemisia ordosicae, 8 parts of Rhizoma Acori Calami, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 8 parts of Cortex Phellodendris, 10 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Anemones Altaicaes.
A kind of method for preparing of treating the first aid medicine of heatstroke, its raw material comprises: Herba Moslae Chinensis, Rhizoma Cimicifugae, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae; It is characterized in that method for preparing is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt the way of distillation to extract volatile oil respectively, volatile oil is blended that mixed volatilization oil is subsequent use, medicinal residues are subsequent use;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and gets extracting solution, extracting solution leaves standstill the 15d after-filtration below 5 ℃ must filtrate;
(3), get step 2 gained filtrating and add step 1 gained mixed volatilization oil, mix homogeneously utilizes ultrafilter membrane to carry out ultrafiltration, the embedding of sterilizing after the ultrafiltration.
The aperture of above-mentioned ultrafilter membrane is 200nm.
Wherein said: Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are arduous, temperature.Merit can be driven away summer heat, and invigorates blood circulation, and regulates the flow of vital energy removing dampness.
Rhizoma Cimicifugae is the big SANYE Rhizoma Cimicifugae of ranunculaceae plant Cimicifuga heracleifolia Kom., the Rhizoma Cimicifugae Cimicifuga dahurica of Xingan (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are hot, little sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Radix Artemisia ordosicae, Compositae Radix Artemisia ordosicae Artemisia dubia Wall. var. longeracemulosa Pamp. is with all herbal medicine.Nature and flavor are bitter, and are cold.But the merit heat-clearing and toxic substances removing, expelling summer-heat, hemostasis.
Rhizoma Acori Calami is aroid Rhizoma Acori Graminei Acorus calamus L. rhizome.The nature and flavor acrid in the mouth; Bitter; Warm in nature.GUIXIN; Liver; The stomach warp.But merit waking up the patient from unconsciousness by dissipating phlegm; Dehumidifying is good for the stomach; Killing parasites for relieving itching.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Alismatis is the dry tuber of Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet, and are cold.Return kidney, urinary bladder channel.But the merit diuresis, clearing away damp-heat.
Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor are bitter, and are cold.Return kidney, urinary bladder channel.But merit heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.
Pericarpium Citri Reticulatae Viride is the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit.Nature and flavor are bitter, hot, temperature.Return liver, gallbladder, stomach warp.Merit can soothing the liver dispelling the stagnated QI, and removing food stagnancyization stagnates.
Rhizoma Anemones Altaicae for Ranunculaceae thimbleweed anemone altaica Anemone altaica Mey., is used as medicine with root stock.Nature and flavor are hot, temperature.But the merit causing resuscitation with aromatic drugs reduces phlegm, and calms the nerves.
Composition principle: heatstroke belongs to " fever disease in summer ", " syncope caused by summer-heat pathogen " category in motherland's medical science.Fever disease in summer is meant experiences the summer-heat pathogenic factor in summer, from the beginning of serving as main performance with excessive heat in the QI system of YANG MING syndromes such as high fever, excessive thirst, sweating, full and large pulse, in the course of disease change of disease rapid, be prone to impairment of body fluid consumption gas, close a kind of acute calenture of the change of key wind symptom more.The sick generation exopathogenic factor of fever disease in summer is experienced the summer-heat pathogenic factor in season, and endogenous cause of ill human righteousness loses empty.Summer-heat is pathogenic fire, and the heart is that fire is dirty, and " summer heat leads in the heart " is so in the summer-heat process, summer-heat whenever is prone to the heart-nutriment that caves in.In addition, the heresy of summer-heat also can be sudden in the heart-nutriment and in close pericardium, cause " syncope caused by summer-heat pathogen " of suddenly fainting, reveal any symptoms is scorching hot, agitation, coma, suddenly faint, syncope, rough as breathe heavily, mandibular joint is little tightly, tic of the limbs, deep red tongue, thready and rapid pulse.Orientation treatment is generally the heat clearing away of driving away summer heat at present, but in fact, summer-heat is often held under the arm wet and gone into damp and hot living expectorant, mental confusion due to phlegm.So we take to drive away summer heat, removing dampness, the method for activating yang, having one's ideas straightened out, get Herba Moslae Chinensis and drive away summer heat the side, regulates the flow of vital energy removing dampness; Rhizoma Cimicifugae elevate a turnable ladder yang-energy, the soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride; The Radix Artemisia ordosicae clearing away summer-heat; The Rhizoma Acori Calami waking up the patient from unconsciousness by dissipating phlegm; The Pericarpium Citri Reticulatae drying dampness to eliminate phlegm; The Rhizoma Alismatis clearing away damp-heat; The Cortex Phellodendri heat clearing and damp drying; The Rhizoma Anemones Altaicae causing resuscitation with aromatic drugs reduces phlegm, and calms the nerves.
The specific embodiment
Below in conjunction with practical situation, specific embodiments of the invention elaborates.
Embodiment 1, crude drug weight proportion: Herba Moslae Chinensis 60g, Rhizoma Cimicifugae 80g, Radix Artemisia ordosicae 80g, Rhizoma Acori Calami 60g, Pericarpium Citri Reticulatae 60g, Rhizoma Alismatis 80g, Cortex Phellodendri 60g, Pericarpium Citri Reticulatae Viride 80g, Rhizoma Anemones Altaicae 30g.Method for preparing is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt the way of distillation to extract volatile oil respectively, volatile oil is blended that mixed volatilization oil is subsequent use, medicinal residues are subsequent use;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and gets extracting solution, extracting solution leaves standstill the 15d after-filtration below 5 ℃ must filtrate;
(3), get step 2 gained filtrating and add step 1 gained mixed volatilization oil, mix homogeneously utilizes the aperture to carry out ultrafiltration, the embedding of sterilizing after the ultrafiltration for the ultrafilter membrane of 250nm.
Embodiment 2, crude drug weight proportion: Herba Moslae Chinensis 10g, Rhizoma Cimicifugae 15g, Radix Artemisia ordosicae 15g, Rhizoma Acori Calami 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Alismatis 15g, Cortex Phellodendri 10g, Pericarpium Citri Reticulatae Viride 15g, Rhizoma Anemones Altaicae 6g.Method for preparing is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt the way of distillation to extract volatile oil respectively, volatile oil is blended that mixed volatilization oil is subsequent use, medicinal residues are subsequent use;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and gets extracting solution, extracting solution leaves standstill the 15d after-filtration below 5 ℃ must filtrate;
(3), get step 2 gained filtrating and add step 1 gained mixed volatilization oil, mix homogeneously utilizes the aperture to carry out ultrafiltration, the embedding of sterilizing after the ultrafiltration for the ultrafilter membrane of 150nm.
Embodiment 3, crude drug weight proportion: Herba Moslae Chinensis 8g, Rhizoma Cimicifugae 10g, Radix Artemisia ordosicae 10g, Rhizoma Acori Calami 8g, Pericarpium Citri Reticulatae 8g, Rhizoma Alismatis 10g, Cortex Phellodendri 8g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Anemones Altaicae 5g.Method for preparing is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt the way of distillation to extract volatile oil respectively, volatile oil is blended that mixed volatilization oil is subsequent use, medicinal residues are subsequent use;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and gets extracting solution, extracting solution leaves standstill the 15d after-filtration below 5 ℃ must filtrate;
(3), get step 2 gained filtrating and add step 1 gained mixed volatilization oil, mix homogeneously utilizes the aperture to carry out ultrafiltration, the embedding of sterilizing after the ultrafiltration for the ultrafilter membrane of 200nm.
Effective combination of said medicine is coordinated mutually, can effectively reach the purpose of treatment heatstroke, and side effect is less.The above results is that clinical data proves that fully interrelated data is following, wherein studies drug use and is crude drug weight proportion and method for preparing among the embodiment 3.
1 object and method.
1.1 object: choose severe heat stroke patient's 50 examples of emergency treatment diagnosis and treatment between year July in June, 2011 to 2012, all patients all meet " internal medicine " the 5th edition severe heat stroke typing standard.
1.2 method.
1.2.1 divide into groups: the patient is divided into treatment group and matched group at random, and wherein 25 examples are organized in treatment, male 14 examples, women 11 examples, age 34-62 year, average (50.21 ± 2.42) year; Light coma 15 examples, middle severe coma 10 examples; Thermoplegia 9 examples, heat exhaustion 12 examples, heat cramp 4 examples; Fall ill to consultation time 0.6 ~ 24h average (12.23 ± 2.48) h; Complicated hypertension 8 examples, heart disease 4 examples, chronic obstructive pulmonary disease 2 examples, chronic hepatopathy 1 example.Matched group 25 examples, male 15 examples, women 10 examples, age 32-65 year, average (50.34 ± 2.45) year; Light coma 14 examples, middle severe coma 11 examples; Thermoplegia 10 examples, heat exhaustion 10 examples, heat cramp 5 examples; Fall ill to consultation time 0.5 ~ 22h average (12.28 ± 2.40) h; Complicated hypertension 7 examples, heart disease 4 examples, chronic obstructive pulmonary disease 3 examples.Two groups of patients have comparability at aspect comparing difference not statistically significants such as age, sex, the state of an illness (P>0.05).
1.2.2 Therapeutic Method: give emergency aid and treatment after two groups of patients are admitted to hospital, comprise Physical temperature-lowering, keep and breathe and circulatory function, correct Water-Electrolyte disorder and acid base imbalance, control multiple organ dysfunction syndrome, venous transfusion, shock and hydration treatment fast; Give simultaneously that mannitol adds furosemide dehydration, alkalized urine, prevention infection, wakens, stabilizing cell membrane, antioxidant give vitamin C, protection gastric mucosa, promote complex treatment measures such as digestive tract power, nutritional support.Treatment group therapeutic scheme is for add the oral or nasal feeding of the embodiment of the invention 3 gained oral liquids, every day 2 times again on the basis of above-mentioned Comprehensive Treatment.
1.2.3 observation index: observe patient's mind recovery time, temperature recovery time and hospital stays, evaluate two groups of patient's clinical therapeutic efficacies, and the record adverse effect.
1.2.4 curative effect determinate standard: produce effects: the patient is Consciousness in 4h, and blood pressure, pulse, breathing, body temperature all recover normally, and each item test rating is all normal.Effectively: the patient behind 4h, Consciousness in the 8h, blood pressure, pulse, breathing, temperature recovery are normal, it is normal that each item laboratory indexes is tending towards.Invalid: the patient has slight disturbance of consciousness behind 8h, body temperature is higher and have complication to occur, like hepatic and renal function damage, aspiration pneumonitis etc.
1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, < 0.05 expression has the significance meaning to P.
2 results.
2.1 two groups of patient's fever times, symptom and signs improve time ratio: treatment group fever time, symptom and sign improve the time obviously faster than matched group (P 0.05 or P 0.01), especially bring down a fever, the improving of the recovery of disturbance of consciousness and headache and dizzy (P < 0.01).See the following form.
? Continue hyperpyrexia Persistent fever Disturbance of consciousness Dizziness headache Tachycardia
Matched group 1.37±0.44 5.09±1.66 1.18±0.34 3.22±0.80 2.39±0.81
The treatment group 0.43±0.14 3.05±0.61 0.31±0.10 0.64±0.18 1.91±0.60
2.2 the curative effect of two groups of cases relatively: see the following form, obvious effective rate and total effective rate treatment group obviously are superior to matched group (P < 0.05).
2.3 untoward reaction situation: two groups of patients all do not see tangible Drug therapy untoward reaction.
3. conclusion: discover that originally the present invention treats severe heat stroke, bring down a fever during than conventional therapy, waken, multiple organs dysfunction recovers faster; Cure rate is higher; And do not see untoward reaction, thus the treatment severe heat stroke, the present invention's good, safe selection of a kind of curative effect of can yet be regarded as.

Claims (4)

1. a first aid medicine of treating heatstroke is characterized in that being processed by plurality of Chinese, and its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Moslae Chinensis; 8 ~ 15 parts of Rhizoma Cimicifugaes, 8 ~ 15 parts of Radix Artemisia ordosicae, 6 ~ 10 parts of Rhizoma Acori Calami; 6 ~ 10 parts of Pericarpium Citri Reticulataes, 8 ~ 15 parts of Rhizoma Alismatis, 6 ~ 10 parts of Cortex Phellodendris; 8 ~ 15 parts on Pericarpium Citri Reticulatae Viride, 3 ~ 6 parts of Rhizoma Anemones Altaicaes.
2. a kind of first aid medicine of treating heatstroke according to claim 1 is characterized in that its weight proportion is 8 parts of: Herba Moslae Chinensis, 10 parts of Rhizoma Cimicifugaes, 10 parts of Radix Artemisia ordosicae, 8 parts of Rhizoma Acori Calami, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 8 parts of Cortex Phellodendris, 10 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Anemones Altaicaes.
3. method for preparing of treating the first aid medicine of heatstroke, its raw material comprises: Herba Moslae Chinensis, Rhizoma Cimicifugae, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae; It is characterized in that method for preparing is:
(1), get Herba Moslae Chinensis, Radix Artemisia ordosicae, Rhizoma Acori Calami, Pericarpium Citri Reticulatae Viride, Rhizoma Anemones Altaicae, adopt the way of distillation to extract volatile oil respectively, volatile oil is blended that mixed volatilization oil is subsequent use, medicinal residues are subsequent use;
(2), get step 1 gained medicinal residues and Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Phellodendri mixes decoction alcohol precipitation method and gets extracting solution, extracting solution leaves standstill the 15d after-filtration below 5 ℃ must filtrate;
(3), get step 2 gained filtrating and add step 1 gained mixed volatilization oil, mix homogeneously utilizes ultrafilter membrane to carry out ultrafiltration, the embedding of sterilizing after the ultrafiltration.
4. a kind of method for preparing of treating the first aid medicine of heatstroke according to claim 3 is characterized in that: the aperture of described ultrafilter membrane is 200nm.
CN201210279467.5A 2012-08-08 2012-08-08 First-aid drug for treating heatstroke and preparation method thereof Expired - Fee Related CN102813767B (en)

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