CN104491378A - Method for preparing medicine for treating bronchial asthma - Google Patents
Method for preparing medicine for treating bronchial asthma Download PDFInfo
- Publication number
- CN104491378A CN104491378A CN201410786933.8A CN201410786933A CN104491378A CN 104491378 A CN104491378 A CN 104491378A CN 201410786933 A CN201410786933 A CN 201410786933A CN 104491378 A CN104491378 A CN 104491378A
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- medicine
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- bronchial asthma
- asthma
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Abstract
The invention relates to a method for preparing a medicine for treating bronchial asthma. The medicine is prepared from the following raw materials: thunberg fritillary bulb, arisaema cum bile, common andrographis herb, dandelion, monkshood, smoked plums, cassia twig, houttuynia cordata, lily, folia perillae acutae, semen raphani, rhizoma corydalis, honeysuckle, white mulberry bark, Chinese yam, loquat leaves, cinnamon, liquorice, golden cypress, asparagus fern, poria cocos, cortex acanthopanacis, mulberry, elecampane and radix scrophulariae. The components are mutually matched, the effects are harmonized, the cost is low, and the clinical application shows that the medicine has a very good treatment effect on bronchial asthma.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a method for preparing a medicine for treating bronchial asthma.
Background
Bronchial asthma is a chronic airway inflammation involving a variety of cells, particularly mast cells, eosinophils and T lymphocytes, which in susceptible individuals can cause recurrent wheezing, shortness of breath, chest tightness and/or cough, which often occur during the night and/or early morning hours, and increased responsiveness of the airway to a variety of stimuli. But the symptoms can be relieved by themselves or by treatment. In the last one hundred years, the prevalence rate and the death rate of asthma in the countries such as the United states, the United kingdom, Australia, New Zealand and the like have an increasing trend, about one hundred million asthma patients exist all over the world, the asthma patients become a main chronic disease seriously threatening public health, the prevalence rate of the asthma in China is about 1 percent, children can reach 3 percent, and more than 1 million asthma patients exist in the country according to the calculation. Typical asthma, which is preceded by aura symptoms such as sneezing, watery nasal discharge, cough, chest distress and the like, can be treated untimely, asthma can appear due to the aggravation of bronchial obstruction, severe patients can be forced to take a sitting position or breathe in an end position, dry cough or spit a large amount of white foam phlegm, even cyanosis and the like, but the asthma can be relieved by oneself or by self-treatment or treatment with antiasthmatic medicines and the like, and some patients can attack again after relieving for hours, even cause the persistent state of the asthma.
The Chinese medical science considers that: "the lung governs qi and controls respiration". As used herein, "qi" refers to the respiratory qi, and the lung and other zang-fu organs function in respiration. The lung opens into the nose and throat, and is externally associated with fur. The theory of Su Wen cough: the combination of skin and hair, the skin and hair are affected by pathogenic qi first, and the pathogenic qi is combined from the skin and hair, so that the lung communicates with the outside through the nasopharynx and skin and hair orifices as a barrier to govern the defense function of the human body. In asthma attack, the pathogenic factors are abundant in the lung, but the root of the disease is related to the kidney and spleen, because the lung governs qi and controls respiration, but the essence of qi is in the kidney, and the kidney deficiency can not receive qi, so that the qi transmission between the upper and lower parts is abnormal, so the "type of syndrome and sanction" refers to that the lung is the main part of qi, the kidney is the root of qi, the lung mainly gives out qi, the kidney mainly gives up qi, the kidney mainly takes up qi, yin and yang are crossed, and respiration is balanced, so that asthma is caused if the ascending and descending of the upper and lower parts are abnormal. "explains the close relationship between the lung and kidney, which indicates that qi is derived from the lung and kidneys, and that the syndrome differentiation of asthma patients is also common in cases of deficiency of kidney qi. The lung is the 'phlegm storage device', the spleen is the 'source of phlegm generation', if the spleen fails to transport and transform, the fluid is gathered into phlegm, and the phlegm is blocked in the lung to cause asthma, and the < syndrome treatment > is cloud: the lung is the main part of qi, while the spleen is the mother of lung, and deficiency of spleen and lung leads to insufficient qi transformation and shortness of breath and dyspnea. The preponderance or decline of kidney qi in spleen and kidney plays a more important role in the progression and regression of asthma.
Traditional Chinese medicine accumulates abundant experience in the aspect of treating bronchial asthma. Although there are intrinsic and extrinsic asthma clinically, the inventor believes that two factors cannot be separated from the traditional Chinese medicine theory and the modern medical knowledge: the first is the deficiency of constitution (including healthy state, mood, allergic constitution); the second is the initiation of exogenous factors (sensitization sources including dust, wind, cold and hot, humidity, peculiar smell, pollen and the like). The regulation of constitution can be carried out by nutrition, exercise and applying traditional Chinese medicine prescriptions such as ' Guilu Bushen Wan ', ' Shenqi Wan ', ' Yupingfeng san ', ' Buzhong Yiqi Tang ' and the like, which are necessary for the treatment of the disease with syndrome differentiation, in recent years, a plurality of traditional Chinese medicine prescriptions for treating bronchial asthma have been applied for invention patents, such as 200510114645 ' a traditional Chinese medicine compound preparation for treating asthma and a preparation method thereof ', 201010221755 ' a traditional Chinese medicine composition for treating bronchial asthma ', 2011103723028 ' a traditional Chinese medicine for treating bronchial asthma and the like. The formulations of the above patent applications are different, and the therapeutic effects are different. In medical practice, generally speaking, the traditional Chinese medicine has good curative effect and basically has no side effect. Therefore, the method continues to excavate Chinese medicinal material resources, searches effective and safe medicaments from natural medicaments, and is an important direction for clinically treating the bronchial asthma.
Disclosure of Invention
The invention aims to provide a method for preparing a medicament for treating bronchial asthma. The treatment based on syndrome differentiation is always the core theory of the traditional Chinese medicine for treating diseases, and how to take medicine aiming at main pathogenesis and secondary pathogenesis into consideration and take common and individual treatment into consideration, thereby reflecting the connotation and extension of the traditional Chinese medicine for treating diseases to the greatest extent and being a practical problem of the compatibility of Chinese patent medicines. The applicant aims at the main pathogenesis characteristics of bronchial asthma, combines a large number of secret recipes according to years of medical practice, researches on traditional Chinese medicines, combines dialectical argumentation, collects the advantages of many people, seeks an optimal treatment scheme, selects proper Chinese medicinal components from a large number of natural prescriptions, requires no stimulation, and plays a role in calming and calming asthma.
In order to realize the purpose of the invention, the technical scheme adopted by the invention is as follows:
the method for preparing the medicine for treating bronchial asthma comprises the following steps:
thunberg fritillary bulb, arisaema cum bile, common andrographis herb, dandelion, monkshood, dark plum fruit, cassia twig, houttuynia cordata, lily, perilla leaf, radish seed, rhizoma corydalis, honeysuckle, white mulberry root-bark, Chinese yam, loquat leaf, cinnamon, liquorice, golden cypress, asparagus cochinchinensis, poria cocos, cortex acanthopanacis, mulberry, costustoot and figwort root.
Preferably, the medicine is prepared from the following raw materials in parts by weight:
35 parts of thunberg fritillary bulb, 35 parts of arisaema cum bile, 35 parts of common andrographis herb, 30 parts of dandelion, 30 parts of monkshood,
28 parts of dark plum fruit, 28 parts of cassia twig, 25 parts of heartleaf houttuynia herb, 25 parts of lily, 25 parts of perilla leaf,
20 parts of radish seed, 20 parts of corydalis tuber, 20 parts of honeysuckle flower, 20 parts of white mulberry root-bark, 15 parts of Chinese yam,
15 parts of loquat leaf, 15 parts of cinnamon, 15 parts of liquorice, 12 parts of phellodendron, 12 parts of asparagus, 12 parts of ginseng, etc,
10 parts of tuckahoe, 10 parts of cortex acanthopanacis, 10 parts of mulberry, 5 parts of platycodon grandiflorum and 5 parts of radix scrophulariae.
The preparation method is preferably as follows:
1) weighing the raw materials for later use;
2) mixing herba Andrographitis, herba Taraxaci, radix Aconiti lateralis Preparata, mume fructus, ramulus Cinnamomi, herba Houttuyniae, Bulbus Lilii, rhizoma Dioscoreae, folium Eriobotryae, cortex Cinnamomi, Glycyrrhrizae radix, cortex Phellodendri, and radix Platycodi according to the above proportion, decocting with 5 times of water twice (2 hr for the first time and 1 hr for the second time), mixing the decoctions, drying under reduced pressure to obtain extract with density of 1.2g/ml, and oven drying at 80 deg.C to obtain compound A;
(3) extracting the rest components with 75% ethanol 3 times the weight of the mixture under reflux for 1 hr for 2 times, mixing extractive solutions, concentrating to obtain fluid extract with density of 1.2g/ml, oven drying at 80 deg.C, and pulverizing to obtain compound B;
(4) and mixing and stirring the compound A and the compound B uniformly to obtain the composite material.
The components of the medicine are all natural traditional Chinese medicine raw materials, the preparation is simple and convenient, the medicine source is wide, the cost is low, the medicine conforms to the prescription medication principle of the traditional Chinese medicine, the medicines are combined and complement each other, and the clinical application verifies that the medicine has obvious and reliable curative effect, mild medicine property, no toxic or side effect and wide application prospect.
Detailed Description
Example 1
The method for preparing the medicine for treating bronchial asthma comprises the following steps of:
35 parts of thunberg fritillary bulb, 35 parts of arisaema cum bile, 35 parts of common andrographis herb, 30 parts of dandelion, 30 parts of monkshood,
28 parts of dark plum fruit, 28 parts of cassia twig, 25 parts of heartleaf houttuynia herb, 25 parts of lily, 25 parts of perilla leaf,
20 parts of radish seed, 20 parts of corydalis tuber, 20 parts of honeysuckle flower, 20 parts of white mulberry root-bark, 15 parts of Chinese yam,
15 parts of loquat leaf, 15 parts of cinnamon, 15 parts of liquorice, 12 parts of phellodendron, 12 parts of asparagus, 12 parts of ginseng, etc,
10 parts of tuckahoe, 10 parts of cortex acanthopanacis, 10 parts of mulberry, 5 parts of platycodon grandiflorum and 5 parts of radix scrophulariae.
The preparation method comprises the following steps:
1) weighing the raw materials for later use;
2) mixing herba Andrographitis, herba Taraxaci, radix Aconiti lateralis Preparata, mume fructus, ramulus Cinnamomi, herba Houttuyniae, Bulbus Lilii, rhizoma Dioscoreae, folium Eriobotryae, cortex Cinnamomi, Glycyrrhrizae radix, cortex Phellodendri, and radix Platycodi according to the above proportion, decocting with 5 times of water twice (2 hr for the first time and 1 hr for the second time), mixing the decoctions, drying under reduced pressure to obtain extract with density of 1.2g/ml, and oven drying at 80 deg.C to obtain compound A;
(3) extracting the rest components with 75% ethanol 3 times the weight of the mixture under reflux for 1 hr for 2 times, mixing extractive solutions, concentrating to obtain fluid extract with density of 1.2g/ml, oven drying at 80 deg.C, and pulverizing to obtain compound B;
(4) and mixing and stirring the compound A and the compound B uniformly to obtain the composite material.
The preparation is administered orally at a dose of 0.3g twice a day for 30 days as a treatment course.
Toxicity experiments show that 20 healthy SD rats are selected, the medicine prepared in the example 1 is orally taken (the maximum concentration is 30 times of the optimal concentration of pharmacodynamics), the medicine is continuously taken for 30 days, and the growth state, the activity diet, the hematology, the blood biochemistry, the organ tissue structure, the urine convention and the like of animals are not obviously influenced in the administration period of the rats and within 1 week after the medicine is stopped, so that the clinical medication is safe and reliable.
Example 2
Clinical data
The outpatient service of the group of patients was 120 patients, 18 patients aged 25 years, 48 patients aged 26-55 years and 54 patients aged 56 years. 120 patients were randomized into 60 treatment groups (example 1 drug) and 60 control groups (ketotifen), both groups having no statistical significance in gender, age, course and disease distribution (P > 0.05).
Diagnostic criteria
Typical symptoms of asthma are cough, air-lock, expectoration, shortness of breath, wheezing of phlegm in the throat, and vocal sounds such as a saw.
Asthma patients have different degrees of occurrence, cough, qi obstruction and expectoration sometimes cause blood in phlegm, serious tracheitis and pulmonary duct rupture, even long-time walking cannot be realized, stair climbing is difficult, and serious patients have peaceful daily life.
Method of treatment
The drug prepared in example 1 was administered orally at a dose of 0.3g twice a day for 30 days as a treatment course.
The control was given ketotifen at 1 mg/tablet twice daily for 30 days as a treatment period.
Criteria for efficacy assessment
The effect is shown: the asthma symptom is healed and returns to normal;
improvement: the asthma symptom is relieved, and the disease condition is gradually improved;
and (4) invalidation: the improvement standard can not be achieved.
The results of the treatment, see table 1 below:
TABLE 1
Group of | Number of examples | Show effect | Improvement of life | Invalidation | Total effective rate |
Experimental group | 60 | 29 | 25 | 6 | 90% |
Control group | 60 | 13 | 28 | 19 | 68% |
Compared with a control group, the experimental group has obvious difference, and the drug group of the invention is obviously superior to the ketotifen group.
Example 3
Typical cases
Zhou some, male 53 years old. The early diagnosis symptoms comprise aggravated cough and asthma for 2 days, dyspnea with reversed flow of qi, wheezy phlegm in the throat, fullness and stuffiness of the chest and diaphragm like a plug, white expectoration, rareness and foam, aversion to cold, headache without sweating, aching whole body, thin and white tongue fur, dark and red tongue with petechia, and superficial and tense pulse. The patients with dyspnea due to expiration, inability to lie flat, cyanotic lips, and wheezing sounds in both lungs. X-ray examination prompt: the double lung has thickened texture. And (3) diagnosis: bronchial asthma, which is in acute attack. After the medicine prepared in the embodiment 1 of the invention is orally taken for 7 days, the cough and asthma are relieved, the chilliness and headache are relieved, and the chest is still stuffy and uncomfortable, and the expectoration is not comfortable. After taking the medicine for 1 course of treatment, the chest distress is removed, the phlegm is clear and smooth, and the cough and asthma, clinical symptoms and physical signs basically disappear, and the disease is cured.
The foregoing list is only illustrative of the preferred embodiments of the present invention. It is obvious that the invention is not limited to the above embodiments, but that many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.
Claims (2)
1. A method for preparing a medicament for treating bronchial asthma, the method comprising the steps of:
step 1) weighing all raw materials for later use; wherein Bulbus Fritillariae Thunbergii, rhizoma arisaematis cum bile, herba Andrographitis, herba Taraxaci, radix Aconiti lateralis Preparata, mume fructus, ramulus Cinnamomi, herba Houttuyniae, Bulbus Lilii, folium Perillae, Raphani semen, rhizoma corydalis, flos Lonicerae, cortex Mori, rhizoma Dioscoreae, folium Eriobotryae, cortex Cinnamomi, Glycyrrhrizae radix, cortex Phellodendri, radix asparagi, Poria, cortex Acanthopanacis, Mori fructus, radix aucklandiae, and radix scrophulariae;
step 2) taking common andrographis herb, dandelion, monkshood, dark plum fruit, cassia twig, houttuynia cordata, lily, Chinese yam, loquat leaf, cinnamon, liquorice, phellodendron and platycodon grandiflorum, mixing, adding 5 times of water by weight, decocting twice, decocting for 2 hours for the first time and 1 hour for the second time, combining decoction liquids of the two times, drying the decoction liquids under reduced pressure to obtain an extract with the density of 1.2g/ml, and drying at 80 ℃ to obtain a compound A;
step 3) mixing the rest raw materials, adding 75% ethanol which is 3 times of the mixture in weight, reflux-extracting for 2 times, each time for 1 hour, mixing the extracting solutions, concentrating to obtain a clear paste with the density of 1.2g/ml, drying at 80 ℃, and crushing to prepare a compound B;
and 4) mixing and stirring the compound A and the compound B uniformly to obtain the composite material.
2. The method according to claim 1, wherein in the step 1), the raw material medicines are weighed according to parts by weight for later use; wherein,
35 parts of thunberg fritillary bulb, 35 parts of arisaema cum bile, 35 parts of common andrographis herb, 30 parts of dandelion, 30 parts of monkshood,
28 parts of dark plum fruit, 28 parts of cassia twig, 25 parts of heartleaf houttuynia herb, 25 parts of lily, 25 parts of perilla leaf,
20 parts of radish seed, 20 parts of corydalis tuber, 20 parts of honeysuckle flower, 20 parts of white mulberry root-bark, 15 parts of Chinese yam,
15 parts of loquat leaf, 15 parts of cinnamon, 15 parts of liquorice, 12 parts of phellodendron, 12 parts of asparagus, 12 parts of ginseng, etc,
10 parts of tuckahoe, 10 parts of cortex acanthopanacis, 10 parts of mulberry, 5 parts of platycodon grandiflorum and 5 parts of radix scrophulariae.
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