CN103446414B - Xiangmahanchuantie (XMHCT) and preparation technology - Google Patents
Xiangmahanchuantie (XMHCT) and preparation technology Download PDFInfo
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Abstract
The invention belongs to the field of medical technology, and discloses xiangmahanchuantie (XMHCT). The XMHACT is prepared from flos caryophyllata, ephedra herb, radix bupleuri, burdock root, radix puerariae, safflower, radix platycodonis, rhizoma pinelliae, radix pseudostellariae, mulberry leaf, liquorice, bulbus fritillariae cirrhosae, pepper, radix sophorae tonkinensis, periostracum cicadae, earthworm and the like. The invention further discloses a preparation method of the XMHACT. The XMHACT prepared is capable of treating both manifestation and root causes of diseases, has no side effects, can be separately used and has good treatment effect on pediatric asthma.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of patch for the treatment of infantile asthma, relate in particular to a kind of fragrant numb dyspnea due to cold and paste and preparation technology.
Background technology
Bronchial asthma is one of modal chronic respiratory tract disease of child, and different regions and ethnic prevalence have very large difference, and developed country is usually above developing country, and city is higher than rural area.Infantile asthma prevalence is not from 0-30% etc.The prevalence of asthma is in rising trend in the world, according to the investigation in 1998 of international childhood asthma and allergy basic research (ISAAC) group, Britain's school age population asthma prevalence by 1989 10.2% rise to 1996 20.9%.The following childhood asthma prevalence of U.S. 17 years old increased to 4.3%, 1997 year and reaches 5.7% by original 3.2% in the eighties in 20th century.Investigation in 2000 shows, China city 0-14 year childhood asthma, average prevalence is 0.5%-3.33%, nineteen ninety is 0.11-2.03%, in 10 years, childhood asthma prevalence has on average risen 64.8%.Asthma is because of complexity, and risk factor is a lot, causes morbidity by the combined effect of h and E factor.Primary disease mostly is polygenic inheritance disease, and approximately 20% patient has family history.Most of patients have infantile eczema, allergic rhinitis or and food (medicine) allergies; Part infant is with slight immunodeficiency, as low inferior in IgG Subclass Deficiency, complement activity.Morbidity is often relevant with environmental factors (anaphylactogen suction, infection, environmental pollution, medicated cigarette exposure etc.).
For many years, be mainly western medicine for the approach of infantile asthma treatment, except using spasmolytic suppressing panting calming medicine, conventional medicine also has glucocorticoid.By the way of relievining asthma and antiallergic inflammation medicine is worked along both lines, to reach rapid and lasting curative effect, but the asthmatic patient of prolonged application glucocorticoid can bring comparatively serious toxic and side effects, at present known side effect comprises and easily occurs that ecchymosis (because subcutaneous tissue attenuation), adrenal cortex function suppress, Decrease of Bone Mineral Density, and increases and suffer from cataract and glaucoma risk.The deficiency of bringing based on above-mentioned Western medicine, at present, study more Chinese herbal medicine technology, for example, Chinese herbal medicine is prepared into patch or oral powder etc., wherein, CN200910227111 has prepared a kind of patch that is used for the treatment of infantile asthma, obtained certain therapeutic effect, but this patch is only for patients with mild, and need to coordinate Western medicine to treat together, caused the burden of taking medicine to infant, range of application is subject to larger limitation.Prior art needs the patch of a kind of independent use, curative effect is good and toxic and side effects is little treatment infantile asthma.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, can be used alone and the patch of eutherapeutic treatment infantile asthma (fragrant numb dyspnea due to cold pastes) and preparation method thereof.
Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, for the pathogeny of infantile asthma, the present invention adopts the Chinese crude drug of different properties, carry out science compatibility, obtained the numb dyspnea due to cold of perfume (or spice) of the present invention and paste.
For realizing above-mentioned purpose of the present invention, the technical solution used in the present invention is as follows:
A kind of fragrant numb dyspnea due to cold pastes, and its crude drug by following weight parts is prepared from:
100 parts of Flos Caryophyllis, 95 parts, Herba Ephedrae, 85 parts of Radix Bupleuri, 80 parts of Radix Arctiis, 70 parts of Radix Puerariaes, 65 parts, Flos Carthami, 60 parts of Radix Platycodoniss, 55 parts of the Rhizoma Pinelliaes, 50 parts of Radix Pseudostellariaes, 45 parts, Folium Mori, 40 parts, Radix Glycyrrhizae, 35 parts of Bulbus Fritillariae Cirrhosaes, 30 parts, Fructus Piperis, 20 parts of Radix Sophorae Tonkinensiss, 10 parts of Periostracum Cicadaes, 10 parts of Pheretimas.
The preparation method that the invention also discloses said medicine, comprises the steps:
1) take Flos Caryophylli according to above-mentioned weight portion, Herba Ephedrae, Radix Bupleuri, Flos Carthami, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae and Fructus Piperis, mix homogeneously, the decocting that adds 5 times of weight boils 1 hour, filters and collects filtrate, then filtrate is condensed into the extractum that density is 1.1g/ml;
2) take Radix Puerariae according to above-mentioned weight portion, the Rhizoma Pinelliae, Radix Pseudostellariae and Folium Mori, put in pulverizer and pulverize, and takes out medicated powder and be laid into thickness 1cm, irradiates 6 minutes under ultraviolet, and uitraviolet intensity is 2000uW/cm
2; Then use deionized water as solvent, 60 DEG C are hydrolyzed 12 hours, filter and collect filtrate; Filtrate is placed in vacuum decker, is concentrated in vacuo to 1/10th of filtrate volume, obtain concentrated solution;
3) take Radix Arctii according to above-mentioned weight portion, Radix Platycodonis and Radix Sophorae Tonkinensis, put into volume fraction and be 85% ethanol and soak 20 minutes, and rotary evaporation is removed ethanol; Be placed under ultraviolet and irradiate 10 minutes, uitraviolet intensity is 3000uW/cm
2, then in 70 DEG C of drying bakers, being dried 1 hour, it is powders A more than 300 orders that final powder breakdown mill becomes particle diameter;
4) take Periostracum Cicadae and Pheretima according to above-mentioned weight portion, the water intense fire that adds 10 times of weight boils, and then slow fire boiling 1 hour is filtered and collected filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1g/ml; After 80 DEG C of oven dry, being ground into particle diameter is powder B more than 300 orders,
5) by step 1) extractum, the step 2 prepared) concentrated solution, the step 3 prepared) powders A and the step 4 prepared) the powder B for preparing is mixed to get composite medicine, stirs, and is spread out in patch, and be cut into small pieces and get final product; Every subsides are that in the patch of 5 × 5cm, there is 3g composite medicine at stand.
Method of application: in Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point docile, paste in every cave one, the next day, is changed once, within 6 days, is a course for the treatment of.
Beneficial effect: the component of medicine of the present invention all adopts natural raw material of Chinese medicine, its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, patch treating both the principal and secondary aspects of a disease of the present invention, have no side effect, can be used alone and good effect; And adopt different processing modes for the difference of herbal raw material, drug effect is discharged to greatest extent, through clinical practice checking, it is evident in efficacy reliable, and the property of medicine is gentle, does not occur toxic and side effects, has a extensive future.
Detailed description of the invention
Below employing specific embodiment is made to further explanation to the present invention, but it is not as the restriction to initiative spirit of the present invention.
Embodiment 1
A kind of patch (fragrant numb dyspnea due to cold pastes) for the treatment of infantile asthma, it is prepared from by following raw material medicaments: Flos Caryophylli 100g, Herba Ephedrae 95g, Radix Bupleuri 85g, Radix Arctii 80g, Radix Puerariae 70g, Flos Carthami 65g, Radix Platycodonis 60g, Rhizoma Pinelliae 55g, Radix Pseudostellariae 50g, Folium Mori 45g, Radix Glycyrrhizae 40g, Bulbus Fritillariae Cirrhosae 35g, Fructus Piperis 30g, Radix Sophorae Tonkinensis 20g, Periostracum Cicadae 10g, Pheretima 10g.
Its preparation method, comprises the steps:
1) take Flos Caryophylli 100g, Herba Ephedrae 95g, Radix Bupleuri 85g, Flos Carthami 65g, Radix Glycyrrhizae 40g, Bulbus Fritillariae Cirrhosae 35g and Fructus Piperis 30g, mix homogeneously, the decocting that adds 5 times of weight boils 1 hour, filters and collects filtrate, then filtrate is condensed into the extractum that density is 1.1g/m1;
2) take Radix Puerariae 70g, Rhizoma Pinelliae 55g, Radix Pseudostellariae 50g and Folium Mori 45g, put in pulverizer and pulverize, and takes out medicated powder and be laid into thickness 1cm, irradiates 6 minutes under ultraviolet, and uitraviolet intensity is 2000uW/cm
2; Then use the deionized water of 2L as solvent, 60 DEG C are hydrolyzed 12 hours, filter and collect filtrate; Filtrate is placed in vacuum decker, is concentrated in vacuo to 1/10th of filtrate volume, obtain concentrated solution;
3) take Radix Arctii 80g, Radix Platycodonis 60g and Radix Sophorae Tonkinensis 20g, put into 1L volume fraction and be 85% ethanol and soak 20 minutes, and rotary evaporation is removed ethanol; Be placed under ultraviolet and irradiate 10 minutes, uitraviolet intensity is 3000uW/cm
2, then in 70 DEG C of drying bakers, being dried 1 hour, it is powders A more than 300 orders that final powder breakdown mill becomes particle diameter;
4) take Periostracum Cicadae 10g and Pheretima 10g, the water intense fire that adds 10 times of weight boils, and then slow fire boiling 1 hour is filtered and collected filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1g/ml; After 80 DEG C of oven dry, being ground into particle diameter is powder B more than 300 orders,
5) by step 1) extractum, the step 2 prepared) concentrated solution, the step 3 prepared) powders A and the step 4 prepared) the powder B for preparing is mixed to get composite medicine, stirs, and is spread out in patch, and be cut into small pieces and get final product; Every subsides are that in the patch of 5 × 5cm, there is 3g composite medicine at stand.
Method of application: in Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point docile, paste in every cave one, the next day, is changed once, within 6 days, is a course for the treatment of.
Embodiment 2
One, animal safety test:
With 1 times, 5 times and 10 times of amounts of subsides amount, be affixed on respectively de-plucked rabbit back, paste 24 hours at every turn, paste continuous 10 days every day 1 time.Its hemogram, lung, liver, renal function are observed, found no toxic action; Do not find the toxic infringements of organ such as the heart, liver, spleen, lung, kidney through pathological section.Visible, patch of the present invention is safe and reliable to have no side effect.
Two, clinical trial:
One) Diagnosing Asthma standard:
1, repeatedly outbreak pant, out of breath, uncomfortable in chest or cough, many with to contact allergen, cold air, physics, chemical irritation and viral upper respiratory tract infection, motion etc. relevant; 2, taking expiratory phase as main wheezing sound, expiratory phase extends at two lung audibles and be dispersed in or diffusivity when outbreak; 3, above-mentioned symptom and sign can be alleviated or spontaneous remission through treatment; 4, except other diseases causedly pant, out of breath, uncomfortable in chest and cough; 5, its atypical clinical manifestations person's (as without obviously panting or sign), should at least possess following 1 the pulmonary function test positive (1) brinchial provocation test or the motion activated test positive; (2) the positive FEV1 of Bronchodilation Test increases >=12%, and FEV1 increases absolute value >=200m1; (3) peak expiratory flow (PEF) day interior (or 2 weeks) aberration rate >=20%.Meet 1～4 or 4,5 persons, can be diagnosed as asthma.
Two), therapeutic scheme
Patient's data: patient is totally 180 examples, wherein male 97 examples, female's 83 examples, between age 3-12 year, 7.5 years old mean age; Be equally divided at random two groups, i.e. experimental group and matched group; Experimental group: at the patch of Tiantu, Zhongfu, big vertebra, fei shu, the Dingchuan acupuncture point docile embodiment of the present invention 1, paste in every cave one, the next day, is changed once, within 6 days, is a course for the treatment of, treats 3 courses for the treatment of.Patch prepared by matched group: CN200910227111, pastes respectively Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point, pastes every day 1 time, and each 6 hours 4 days is a course for the treatment of, totally 3 courses for the treatment of.
Three) efficacy assessment standard:
Cure: the symptom that diagnostic criteria provides, its symptom disappears completely, physical recovery health; Effective: the symptom that diagnostic criteria provides, symptom has clear improvement or improves, and asthma all has and obviously alleviates or alleviate, and needs continual cure;
Invalid: the symptom that diagnostic criteria provides, symptom is without improvement.
Concrete treatment situation is referring to table 1:
Table 1
| Group | Cure | Effectively | Invalid | Effective percentage |
| Matched group | 24 | 26 | 40 | 55.6％ |
| Experimental group | 39 | 48 | 3 | 96.7％ |
Conclusion: the therapeutic effect of patch prepared by the present invention is significantly better than matched group, and effective percentage and cure rate improve greatly.
Model case
Virgin so-and-so, 6 years old, man, within 1 years old half, after edible fresh milk, there is cough with asthma in patient, show effect two to three later annual autumn.Asthma out of breath at night when outbreak, crow sound in larynx, breathe mutually extend, rise morning in larynx and have sticky expectorant, sneeze many, rhinocnesmus, nasal obstruction.Have a medical check-up and find that tonsil has no enlargement, two lungs are heard and a little wheezing sound, rabat no abnormality seen.Patient repeatedly adopts various Drug therapys by father and mother, at that time can be controlled, but easily outbreak is repeatedly cured the symptoms, not the disease.Starting the patch of the docile embodiment of the present invention 1 in October, 2012,6 days is a course for the treatment of, treats after 3 courses for the treatment of, and symptom all disappears, and follows up a case by regular visits to and does not recur half a year.
Liu, 8 years old half, female, asthma is more than 3 years, and sense wind and cold sent out, and adopts various Western medicine to treat while outbreak in the past, at that time can mitigate the disease, but normal easily recurrence.Asthma attack while examining, disease sees that the empty body of shape is thin, the grey ash of complexion, cough wheezing, expectorant sound does not stop, and expectoration difficulty is coughed up, and diet reduces, mental weariness, dysphoria, oliguria with reddish urine, defecates stiff, red tongue with yellow fur, rapid pulse is strong.The patch of the docile embodiment of the present invention 1,6 days is a course for the treatment of, treats after 3 courses for the treatment of, and symptom part disappears, and then adds with 2 courses for the treatment of of patch, and symptom all disappears, and follows up a case by regular visits to not recurrence in three months.
Although, above use general explanation, detailed description of the invention and clinical trial, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, modifications or improvements on the basis of not departing from initiative spirit of the present invention, all belong to the scope of protection of present invention.
Claims (1)
1. the numb dyspnea due to cold of perfume (or spice) pastes, and its crude drug by following weight parts is prepared from:
100 parts of Flos Caryophyllis, 95 parts, Herba Ephedrae, 85 parts of Radix Bupleuri, 80 parts of Radix Arctiis, 70 parts of Radix Puerariaes, 65 parts, Flos Carthami, 60 parts of Radix Platycodoniss, 55 parts of the Rhizoma Pinelliaes, 50 parts of Radix Pseudostellariaes, 45 parts, Folium Mori, 40 parts, Radix Glycyrrhizae, 35 parts of Bulbus Fritillariae Cirrhosaes, 30 parts, Fructus Piperis, 20 parts of Radix Sophorae Tonkinensiss, 10 parts of Periostracum Cicadaes, 10 parts of Pheretimas;
The preparation method that the numb dyspnea due to cold of described perfume (or spice) pastes comprises the steps:
1) take Flos Caryophylli according to above-mentioned weight portion, Herba Ephedrae, Radix Bupleuri, Flos Carthami, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae and Fructus Piperis, mix homogeneously, the decocting that adds 5 times of weight boils 1 hour, filters and collects filtrate, then filtrate is condensed into the extractum that density is 1.1g/ml;
2) take Radix Puerariae according to above-mentioned weight portion, the Rhizoma Pinelliae, Radix Pseudostellariae and Folium Mori, put in pulverizer and pulverize, and takes out medicated powder and be laid into thickness 1cm, irradiates 6 minutes under ultraviolet, and uitraviolet intensity is 2000uW/cm
2; Then use deionized water as solvent, 60 DEG C are hydrolyzed 12 hours, filter and collect filtrate; Filtrate is placed in vacuum decker, is concentrated in vacuo to 1/10th of filtrate volume, obtain concentrated solution;
3) take Radix Arctii according to above-mentioned weight portion, Radix Platycodonis and Radix Sophorae Tonkinensis, put into volume fraction and be 85% ethanol and soak 20 minutes, and rotary evaporation is removed ethanol; Be placed under ultraviolet and irradiate 10 minutes, uitraviolet intensity is 3000uW/cm
2, then in 70 DEG C of drying bakers, being dried 1 hour, it is powders A more than 300 orders that final powder breakdown mill becomes particle diameter;
4) take Periostracum Cicadae and Pheretima according to above-mentioned weight portion, the water intense fire that adds 10 times of weight boils, and then slow fire boiling 1 hour is filtered and collected filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boils, and then slow fire boiling 30 minutes is filtered and collected filtrate; Merge above-mentioned twice filtrate, cooling after, be condensed into the extractum that density is 1.1g/ml; After 80 DEG C of oven dry, being ground into particle diameter is powder B more than 300 orders,
5) by step 1) extractum, the step 2 prepared) concentrated solution, the step 3 prepared) powders A and the step 4 prepared) the powder B for preparing is mixed to get composite medicine, stirs, and is spread out in patch, and be cut into small pieces and get final product.
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| CN201310391469.8A CN103446414B (en) | 2013-08-30 | 2013-08-30 | Xiangmahanchuantie (XMHCT) and preparation technology |
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| CN201310391469.8A CN103446414B (en) | 2013-08-30 | 2013-08-30 | Xiangmahanchuantie (XMHCT) and preparation technology |
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| CN103446414B true CN103446414B (en) | 2014-10-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104740581B (en) * | 2015-04-13 | 2018-04-06 | 翔宇药业股份有限公司 | A kind of application of cold asthma patch of fragrant fiber crops and its detection method |
| CN107670005A (en) * | 2017-10-13 | 2018-02-09 | 翔宇药业股份有限公司 | The preparation technology and its detection method of the fragrant cold asthma patch of fiber crops |
| CN107670004A (en) * | 2017-10-13 | 2018-02-09 | 翔宇药业股份有限公司 | A kind of pharmaceutical preparation for being used for asthma, bronchitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100393342C (en) * | 2006-03-01 | 2008-06-11 | 唐大兵 | Chinese medicine preparation for releasing lung and detoxification |
| CN101926871A (en) * | 2009-06-25 | 2010-12-29 | 赵保云 | Method for preparing medicament for treating cold asthma |
| CN102085337B (en) * | 2009-12-07 | 2012-10-24 | 罗谦 | Patch for treating bronchial asthma of children |
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