CN105687450A - Medicament capable of treating lung cancer by virtue of combined treatment of traditional Chinese medicine and western medicine - Google Patents
Medicament capable of treating lung cancer by virtue of combined treatment of traditional Chinese medicine and western medicine Download PDFInfo
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- CN105687450A CN105687450A CN201610170933.4A CN201610170933A CN105687450A CN 105687450 A CN105687450 A CN 105687450A CN 201610170933 A CN201610170933 A CN 201610170933A CN 105687450 A CN105687450 A CN 105687450A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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Abstract
The invention discloses a medicament capable of treating lung cancer by virtue of combined treatment of traditional Chinese medicine and western medicine. The medicament is prepared from the following raw materials in parts by weight: 55-80 parts of butterflybush flower, 41-59 parts of erycibe obtusifolia benth, 31-49 parts of Indian adenosma herb, 22-43 parts of cluster mallow fruit, 20-34 parts of medulla stachyuri, 15-28 parts of stenoloma chusana, 10-18 parts of ardisia crenata, 5-12 parts of hypericum perforatum, 3-12 parts of cynomorium songaricum, 0.2-1 part of mitomycin and 0.3-1.5 parts of pemetrexed. Compared with treatment based on single traditional Chinese medicine or western medicine, the medicament capable of treating lung cancer by virtue of combined treatment of traditional Chinese medicine and western medicine has a better curative effect, and is capable f improving the efficacies of Chinese herbal medicinal ingredients and western medicine to the greatest extent, giving play to complementation and promotion effects and improving the medical effect.
Description
Technical field
The present invention relates to the medicine of a kind of Lung Cancer with Integrated Traditonal Chinese Westren Medicine。
Background technology
Pulmonary carcinoma is that M & M increases the soonest, one of malignant tumor maximum to population health and life threat。The many countries of immediate and mid-term all report that the M & M of pulmonary carcinoma all substantially increases, and male lung cancer M & M all accounts for first of all malignant tumor。So far still not exclusively clearly, great mass of data shows the cause of disease of pulmonary carcinoma, and long-term a large amount of smokings have very close relationship with pulmonary carcinoma。Existing research proves: the probability that long-term a large amount of smokers suffer from pulmonary carcinoma is 10~20 times of non-smoker, and the age starting smoking is more little, and the probability suffering from pulmonary carcinoma is more high。Additionally, smoking not only directly affects my healthy, also the health of surrounding population is produced harmful effect, cause that involuntary smoker's pulmonary carcinoma prevalence substantially increases。The sickness rate of urbanite's pulmonary carcinoma is higher than rural area, and this is likely to relevant containing carcinogen with urban atmospheric pollution and flue dust。
The therapeutic modality of current pulmonary carcinoma has excision or chemicotherapy etc.。Aforesaid way is relatively big to the physical impairment of patient, sometimes even can accelerate the death of patient。Simultaneously for Patients with Advanced Lung Cancer, above-mentioned therapeutic modality is unsuitable for。
Summary of the invention
The technical problem to be solved is: provide the pharmaceutical preparation of the Lung Cancer with Integrated Traditonal Chinese Westren Medicine that a kind of cure rate is high。
For solving above-mentioned technical problem, the technical solution used in the present invention is:
The medicine of Lung Cancer with Integrated Traditonal Chinese Westren Medicine provided by the invention, it is characterised in that be made up of the raw material of following weight portion: Flos Buddlejae 55-80 part, Caulis Erycibes 41-59 part, Herba Adenosmae 31-49 part, Fructus Malvae 22-43 part, Medulla Stachyuri (Medulla Helwingiae) 20-34 part, Stenoloma chusana 15-28 part, Radix Ardisiae Crenatae 10-18 part, Herba Hyperici Monogyni 5-12 part, Herba Cynomorii 3-12 part, mitomycin 0.2-1 part, pemetrexed 0.3-1.5 part。
Preferably, medicine provided by the invention is made up of the raw material of Chinese medicine of following weight portion: Flos Buddlejae 63 parts, Caulis Erycibes 52 parts, Herba Adenosmae 40 parts, Fructus Malvae 32 parts, Medulla Stachyuri (Medulla Helwingiae) 26 parts, Stenoloma chusana 20 parts, Radix Ardisiae Crenatae 14 parts, Herba Hyperici Monogyni 8 parts, Herba Cynomorii 6 parts, mitomycin 0.5 part, pemetrexed 0.8 part。
The present invention also provides for a kind of method preparing medicine, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby;Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
Preferably, the nt wt net weight of the medicine that every capsules is built-in is 1 gram, and the using method of medicine is: oral, twice on the one, one time one。
Beneficial effects of the present invention:
The present invention provides the Drug therapy pulmonary carcinoma of the combination of Chinese and Western medicine than the general simple traditional Chinese medical science and western medical treatment effect more preferably, it is possible to improves effect of Chinese medicine ingredients and Western medicine, performance complementation and castering action to greatest extent, improves medicinal effects。
Chinese medicine and its effect of Western medicine component all act on lung, the heart, have detumescence, lung moistening, reduce phlegm, cough-relieving effect, and cancerous cell has very strong inhibitory action。While anticancer, also promoting body constitution, invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, to improve patient's resistance, reaches the effect for the treatment of both the principal and secondary aspects of a disease。
Chinese medicine used by the present invention, collocation rationally, can alleviate the clinical symptoms of patients with lung cancer, alleviates the toxicity of Radiotherapy chemotherapy, improves treatment rate, extends life span。
Detailed description of the invention
Embodiment 1
The medicine of the Lung Cancer with Integrated Traditonal Chinese Westren Medicine that the present embodiment provides, it is made up of the raw material of following weight: Flos Buddlejae 63 parts, Caulis Erycibes 52 parts, Herba Adenosmae 40 parts, Fructus Malvae 32 parts, Medulla Stachyuri (Medulla Helwingiae) 26 parts, Stenoloma chusana 20 parts, Radix Ardisiae Crenatae 14 parts, Herba Hyperici Monogyni 8 parts, Herba Cynomorii 6 parts, mitomycin 0.5 part, pemetrexed 0.8 part。
The method of medicine in preparation, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby;Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
Embodiment 2
The medicine of the Lung Cancer with Integrated Traditonal Chinese Westren Medicine that the present embodiment provides, it is made up of the raw material of following weight: Flos Buddlejae 80 parts, Caulis Erycibes 59 parts, Herba Adenosmae 49 parts, Fructus Malvae 43 parts, Medulla Stachyuri (Medulla Helwingiae) 34 parts, Stenoloma chusana 28 parts, Radix Ardisiae Crenatae 18 parts, Herba Hyperici Monogyni 12 parts, Herba Cynomorii 12 parts, mitomycin 1 part, pemetrexed 1.5 parts。
The method of medicine in preparation, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby;Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
Embodiment 3
The medicine of the Lung Cancer with Integrated Traditonal Chinese Westren Medicine that the present embodiment provides, it is made up of the raw material of following weight: Flos Buddlejae 55 parts, Caulis Erycibes 41 parts, Herba Adenosmae 31 parts, Fructus Malvae 22 parts, Medulla Stachyuri (Medulla Helwingiae) 20 parts, Stenoloma chusana 15 parts, Radix Ardisiae Crenatae 10 parts, Herba Hyperici Monogyni 5 parts, Herba Cynomorii 3 parts, mitomycin 0.2 part, pemetrexed 0.3 part。
The method of medicine in preparation, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby;Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
Clinical data:
1, physical data
Patients with Non-small-cell Lung 200 example is carried out clinical observation, and the age of patient is 35-76 year, 55 years old mean age。Wherein patients with terminal 92 example, early stage patient 108 example。
2, diagnostic criteria
Western medicine diagnose standard: Diagnosis of Non-Small Cell Lung standard adopts specified standard in " the China's common cancer diagnosis and treatment specification " that Department of Medical Administration of Ministry of Health of the People's Republic of China writes。
3, Therapeutic Method
Adopt medicine of the present invention, oral, twice on the one, one time one。
4, efficacy assessment standard:
Complete incidence graph (CR): all visible focuses are wholly absent, and at least maintain more than 4 weeks;
Partial rcsponse (PR): the product in longest diameter of tumor and maximum perpendicular footpath reduces more than 50%, is in progress without other focuses, occurs without any new focus;
Stable disease unchanged (SD): the product in longest diameter of tumor and maximum perpendicular footpath reduces less than 50%, or increase less than 25%, occur without any new focus;
Progress (PD): the product in longest diameter of tumor and maximum perpendicular footpath increases more than 25%;CR+PR is total effective rate。
5, therapeutic effect: complete incidence graph: 156 examples, partial rcsponse: 32 examples, stable disease is unchanged: 12 examples, PD:0 example。Total effective rate is 100%。
Model case
Case 1: poplar, man, 59 years old。Patient's dry cough, becoming thin, be diagnosed as pulmonary carcinoma in local hospital through CT examination, adopt the medicine of the present invention to treat, after 3 courses for the treatment of, patients symptomatic substantially alleviates。Continuing to take 3 courses for the treatment of, patient's focal symptom is wholly absent, and follows up a case by regular visits to 1 year without recurrence。
Case 2: Lee, man, 65 years old。Patient has vicennial smoking history。Cough, sputum mixed with blood, the symptom such as chest pain occur in this year, checks and be diagnosed as pulmonary carcinoma。Through taking medicine of the present invention, after 4 courses for the treatment of, patients symptomatic substantially alleviates, and continues to take 3 courses for the treatment of, and patient's focal symptom is wholly absent, and follows up a case by regular visits to 1 year without recurrence。
Case 3: Wang, female, 53 years old, chronic cough, hemoptysis, become thin, be lung bronchogenic carcinoma through hospital diagnosis, after taking 2 courses for the treatment of of medicine of the present invention, cough hemoptysis stops, and feed is normal, and the tired sense of health alleviates, and complexion recovers ruddy。
Claims (3)
1. the medicine of Lung Cancer with Integrated Traditonal Chinese Westren Medicine, it is characterised in that be made up of the raw material of following weight portion: Flos Buddlejae 55-80 part, Caulis Erycibes 41-59 part, Herba Adenosmae 31-49 part, Fructus Malvae 22-43 part, Medulla Stachyuri (Medulla Helwingiae) 20-34 part, Stenoloma chusana 15-28 part, Radix Ardisiae Crenatae 10-18 part, Herba Hyperici Monogyni 5-12 part, Herba Cynomorii 3-12 part, mitomycin 0.2-1 part, pemetrexed 0.3-1.5 part。
2. medicine according to claim 1, it is characterised in that be made up of the raw material of Chinese medicine of following weight portion: Flos Buddlejae 63 parts, Caulis Erycibes 52 parts, Herba Adenosmae 40 parts, Fructus Malvae 32 parts, Medulla Stachyuri (Medulla Helwingiae) 26 parts, Stenoloma chusana 20 parts, Radix Ardisiae Crenatae 14 parts, Herba Hyperici Monogyni 8 parts, Herba Cynomorii 6 parts, mitomycin 0.5 part, pemetrexed 0.8 part。
3. the method preparing medicine described in any of the above-described claim, it is characterised in that comprise the following steps: that Chinese medicine is after sterilizing and cleaning, putting into pulverizer, to be crushed to 300 orders standby;Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
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CN201610170933.4A CN105687450A (en) | 2016-03-24 | 2016-03-24 | Medicament capable of treating lung cancer by virtue of combined treatment of traditional Chinese medicine and western medicine |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107998304A (en) * | 2018-01-26 | 2018-05-08 | 杜成秀 | A kind of medicine and preparation method for treating lung cancer |
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2016
- 2016-03-24 CN CN201610170933.4A patent/CN105687450A/en active Pending
Non-Patent Citations (2)
Title |
---|
周德生: "《名医推荐家庭必备名方》", 30 September 2015, 湖南科学技术出版社 * |
江滨等: "《抗肿瘤药物临床应用指南》", 31 May 2005, 中国协和医科大学出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107998304A (en) * | 2018-01-26 | 2018-05-08 | 杜成秀 | A kind of medicine and preparation method for treating lung cancer |
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