CN105267915A - Patch for eliminating phlegm and stopping cough and process for preparing patch - Google Patents
Patch for eliminating phlegm and stopping cough and process for preparing patch Download PDFInfo
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- CN105267915A CN105267915A CN201510675968.9A CN201510675968A CN105267915A CN 105267915 A CN105267915 A CN 105267915A CN 201510675968 A CN201510675968 A CN 201510675968A CN 105267915 A CN105267915 A CN 105267915A
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Abstract
The invention relates to a patch for eliminating phlegm and stopping cough. The patch comprises 200 g of herba ephedrae, 200 g of mustard, 33 g of clove, 100 g of asarum sieboldii, 333 g of herba ardisiae japonicae and 200 g of ginger. The patch has the advantages that various components of the patch are compatible with one another and are synergistic in effectiveness, the patch is low in cost, and excellent treatment effects can be realized for infantile asthma as clinically verified.
Description
Technical field
The invention belongs to Chinese medicine technical field, concrete, relate to a kind of patch and the preparation technology thereof that can be used for preventing phlegm from forming and stopping coughing.
Background technology
Infantile asthma, bronchitis are Pediatric Clinic common frdquently encountered diseases, not only endanger child health, and cause huge financial burden to family and society.According to data report, Chinese children asthma prevalence is 0.5% ~ 2%, and indivedual local up to 5%, about there are 2 ~ 4,000 ten thousand infants in the whole nation.Modern medicine thinks that bronchial asthma is a kind of respiratory tract high response disease caused by allergy.Emphasize according to state of an illness needs at drug treatment, except use spasmolytic suppressing panting calming medicine (symptomatic treatment), also should be combined the medicine (etiological treatment) of anti-airways allergic inflammation, glucocorticoid (GCS) is the most active drug for the treatment of asthma at present, mainly adopts spray larynx or Neulized inhalation.By the way of relievining asthma and anti-allergic inflammation medicine is worked along both lines, to reach rapid and lasting curative effect, but the side effect that GCS sucks is general, particularly to asthmatic children, even Nicolaizik research thinks that asthmatic children short-term sucks low dose of GCS and adrenal gland also can be caused to suppress, long-term taking GCS can make asthmatic children bone density reduce, and growth rate is reduced, and GCS receives larger restriction for the clinical treatment of infantile asthma thus.
For many years, for the approach mainly western medicine of infantile asthma treatment, except use spasmolytic suppressing panting calming medicine, conventional medicine also has glucocorticoid.By the way of relievining asthma and anti-allergic inflammation medicine is worked along both lines, to reach rapid and lasting curative effect, but the asthmatic patient of prolonged application glucocorticoid can bring comparatively serious toxic and side effects, side effect known at present comprises and easily occurs ecchymosis (because subcutaneous tissue is thinning), adrenal cortex function suppresses, bone density reduces, and increases trouble cataract and glaucoma risk.
Motherland's medical science adopts " treating winter disease in summer ", and plastering therapy control infantile asthma, carries out throughout the country widely.The composition of prescription, according to the situation of locality, have nothing in common with each other in various places, method and the acupuncture point of pasting medicine are selected, have in then different with, be mostly that prescription medical material is crushed into powder, reconcile into pasty state with Rhizoma Zingiberis Recens juice, make medicine cake, apply ointment or plaster at hundred labor, region below the heart, Feiyu acupuncture point, apply ointment or plaster the dog days of sweltering heat.Have one to be foaming of applying ointment or plaster, medicine makes and changes Rhizoma Zingiberis Recens juice into honey mediation patent medicine cake, is placed on fire and warms, first wipe point skin with Rhizoma Zingiberis Recens and make it heating, till patient tingles, then medicine cake will be warmed stick, can there is blister in skin, local feels that hot twinge represents effective.This method, easily cause a skin inflammation infection, and in addition, the skin that blister occurs, to the absorption of medicine, will be affected.Asthma external treatment also has a lot of method, and as acupoint embedment therapy, bury acupuncture point with gutstring, this method curative effect is also imprecise.Acupuncture and moxibustion treatment treatment asthma, children's not easily accepts, and is difficult to coordinate.Someone controls infantile asthma with choosing Fpir Crevices cave, painful unbearable, is difficult to be accepted.
China's Chinese medicine is thought: " lung governing qi, department breathes "." gas " mentioned here, refers to the gas of breathing on the one hand, refers to that lung and other internal organs show the function of breathing aspect on the one hand." lung opening at nose and throat, outer conjunction fur "." Plain Questions. cough opinion " say: " fur person, also, fur is first by pathogen, and pathogen is to close also from it in the conjunction of lung ", what say is that lung is communicated with the external world by nasopharynx part and skin hair key, just as one barrier, and the defensive enginery of supervisor's human body.Asthma attack seasonal pathogen is contained in lung, but the root of disease is then relevant with kidney and spleen, this is because lung governing qi and take charge of breathing, but the basis of gas is at kidney, suffering from a deficiency of the kidney then can not improving inspiration by invigorating kidney-QI, causes purgation gas to join not normal, << Lei Zheng Zhi Cai >> alleged " the lung being the dominator of QI; the kidney being the root of QI, lung master give vent to anger, kidney governing inspiration; negative and positive intersect; breathing be and, if cashier's abnormal ascending-descending of QI, here this breathes heavily work." describe " and lung governing qi, kidney improving inspiration by invigorating kidney-QI, gas for lung root in kidney " lung kidney between substantial connection, also can common deficiency of kidney-QI person to the dialectical of asthmatic patient.Lung is " device of storage expectorant ", and spleen is " the source of producing phlegm ", if dysfunction of the spleen in transportation, then poly-liquid becomes expectorant, on hinder and cause asthma in lung, << card controls gains in depth of comprehension >> cloud: " the lung being the dominator of QI, spleen then lung mother also; spleen lung has the deficiency that thanks to then gasifies, and deficiency is then very brief and breathe heavily." especially there is prior effect with the prosperity and decline of kidney qi in the advance and retreat of asthma in spleen kidney.
Motherland's medical science have accumulated rich experience in treatment bronchial asthma.In medical practice, in general, the traditional Chinese medical science cure the disease effective, substantially have no side effect.Therefore continue to excavate Chinese material medicine resource, from natural drug, find effective, safe drugs, be the important directions of clinical treatment infantile asthma.
Summary of the invention
The object of the present invention is to provide a kind of patch and the preparation technology thereof that can be used for preventing phlegm from forming and stopping coughing.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.Applicant is for asthma main pathogenesis characteristics, in conjunction with a large amount of secret recipe according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, appropriate Chinese medicine ingredients is chosen from a large amount of natural prescription kind, require neither should cause stimulation, peace and quiet can be played again, calm down the effect of asthma, by continual and steady breathing for medicine, form one steadily, constant temperature, the good breathing environment of constant humidity, asthmatic patient symptom is made to be alleviated rapidly and to calm down, by the test of repeatedly a large amount of prescriptions and optimization, by theory of Chinese medical science prescription, skim the cream off milk, meticulously be mixed with the numb dyspnea due to cold of perfume (or spice) of the present invention in conjunction with Traditional Chinese Medicine technology to paste, relative to Western medicine, Chinese medicine of the present invention is rapid-action, effect is strong, short treating period, safety is high, without obvious toxic-side effects.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
For a patch for preventing phlegm from forming and stopping coughing, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 333g, Rhizoma Zingiberis Recens 200g.
The preparation method of described patch is as follows:
(1) mentioned component decocts with water twice, and first time adds 8 times of weight water, decocts 2 hours, and second time adds 6 times of weight water and decocts 1 hour, is concentrated into the extractum (80 DEG C) that density is 1.2g/ml;
(2) get raw rubber 100g, be pressed into reticular film with glue pressing machine, immerse 24h in gasoline, make it fully swelling, move into ingredients pot again and stir 3 hours, add Colophonium 80g successively, zinc oxide 80g, lanoline 15g, vaseline 15g, liquid paraffin 10g, mixing, adds extractum prepared by step (1), stirs, be coated with cream, cutting, lid lining, stripping and slicing, makes 1000 subsides, to obtain final product.
Preferably, a kind of patch for preventing phlegm from forming and stopping coughing of the present invention, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 100g,
Rhizoma Zingiberis Recens 50g, Cortex Moutan 50g, Pericarpium Citri Reticulatae 30g, Fructus Trichosanthis 30g, Cortex Mori 20g,
Cortex Cinnamomi 20g, Fructus Ligustri Lucidi 20g, Fructus Lycii 20g, Rhizoma Dioscoreae 20g, Cortex Phellodendri 20g,
Flos Lonicerae 20g, Herba Artemisiae Scopariae 15g, Radix Salviae Miltiorrhizae 15g, Fructus Aurantii 15g, Folium Ginkgo 15g,
Herba Cistanches 10g, Radix Ophiopogonis 10g, Bulbus Lilii 10g, Semen Coicis 10g, Fructus Arctii 10g.
The preparation method of described patch is as follows:
(1) get Herba Ephedrae, Semen Sinapis, Flos Caryophylli, Herba Asari, Herba Ardisiae Japonicae, Rhizoma Zingiberis Recens decoct with water twice, first time adds 8 times of weight water, decocts 2 hours, and adding 6 times of weight water decocts 1 hour for the second time, is concentrated into the extractum A (80 DEG C) that density is 1.2g/ml;
(2) get the ethanol that all the other material compositions add 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum B(80 DEG C that density is 1.2g/ml);
(3) get raw rubber 100g, be pressed into reticular film with glue pressing machine, immerse 24h in gasoline, make it fully swelling, move into ingredients pot again and stir 3 hours, add Colophonium 80g successively, zinc oxide 80g, lanoline 15g, vaseline 15g, liquid paraffin 10g, mixing, adds extractum prepared by step (1) and step (2), stirs, be coated with cream, cutting, lid lining, stripping and slicing, makes 1000 subsides, to obtain final product.
Application process: in Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point docile, every cave one is pasted, the next day, is changed once, within 3 days, is a course for the treatment of.
Beneficial effect: the component of medicine of the present invention all adopts natural raw material of Chinese medicine, its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, patch treating both the principal and secondary aspects of a disease of the present invention, have no side effect, can be used alone and good effect; And the difference for herbal raw material adopts different processing modes, drug effect is discharged to greatest extent, through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.
Detailed description of the invention
Embodiment 1
For a patch for preventing phlegm from forming and stopping coughing, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 333g, Rhizoma Zingiberis Recens 200g.
The preparation method of described patch is as follows:
(1) mentioned component decocts with water twice, and first time adds 8 times of weight water, decocts 2 hours, and second time adds 6 times of weight water and decocts 1 hour, is concentrated into the extractum (80 DEG C) that density is 1.2g/ml;
(2) get raw rubber 100g, be pressed into reticular film with glue pressing machine, immerse 24h in gasoline, make it fully swelling, move into ingredients pot again and stir 3 hours, add Colophonium 80g successively, zinc oxide 80g, lanoline 15g, vaseline 15g, liquid paraffin 10g, mixing, adds extractum prepared by step (1), stirs, be coated with cream, cutting, lid lining, stripping and slicing, makes 1000 subsides, to obtain final product.
Application process: in Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point docile, every cave one is pasted, the next day, is changed once, within 4 days, is a course for the treatment of.
Embodiment 2
For a patch for preventing phlegm from forming and stopping coughing, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 100g,
Rhizoma Zingiberis Recens 50g, Cortex Moutan 50g, Pericarpium Citri Reticulatae 30g, Fructus Trichosanthis 30g, Cortex Mori 20g,
Cortex Cinnamomi 20g, Fructus Ligustri Lucidi 20g, Fructus Lycii 20g, Rhizoma Dioscoreae 20g, Cortex Phellodendri 20g,
Flos Lonicerae 20g, Herba Artemisiae Scopariae 15g, Radix Salviae Miltiorrhizae 15g, Fructus Aurantii 15g, Folium Ginkgo 15g,
Herba Cistanches 10g, Radix Ophiopogonis 10g, Bulbus Lilii 10g, Semen Coicis 10g, Fructus Arctii 10g.
The preparation method of described patch is as follows:
(1) get Herba Ephedrae, Semen Sinapis, Flos Caryophylli, Herba Asari, Herba Ardisiae Japonicae, Rhizoma Zingiberis Recens decoct with water twice, first time adds 8 times of weight water, decocts 2 hours, and adding 6 times of weight water decocts 1 hour for the second time, is concentrated into the extractum A (80 DEG C) that density is 1.2g/ml;
(2) get all the other Chinese medicine ingredients, mixing, add the ethanol of 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum B(80 DEG C that density is 1.2g/ml);
(3) get raw rubber 100g, be pressed into reticular film with glue pressing machine, immerse 24h in gasoline, make it fully swelling, move into ingredients pot again and stir 3 hours, add Colophonium 80g successively, zinc oxide 80g, lanoline 15g, vaseline 15g, liquid paraffin 10g, mixing, adds extractum prepared by step (1) and step (2), stirs, be coated with cream, cutting, lid lining, stripping and slicing, makes 1000 subsides, to obtain final product.
Application process: in Tiantu, Zhongfu, big vertebra, fei shu, Dingchuan acupuncture point docile, every cave one is pasted, the next day, is changed once, within 3 days, is a course for the treatment of.
Zoopery 3
Acute toxicity test: patch embodiment 1 and embodiment 2 prepared respectively is and damaged skin complete with 6 times amount subsides rabbit of children's's external application amount at every turn, and multiple dosing is all non-stimulated, to guinea pig skin without anaphylaxis, and has no any toxicity.
Long term toxicity test: the patch prepared by embodiment 1-2 respectively, at every turn with 2 times of children's's external application amount, 5 times, 10 times amount, is affixed on de-plucked rabbit back (two lung projection back) respectively, each subsides 4 hours, paste 1 every day, continuous 2 weeks.Its hemogram, lung, Liver and kidney function are observed, finds no toxic action; The toxic infringements of organ such as the heart, liver, spleen, lung, kidney are not found through pathological section.Therefore point out clinical recommended drug dosage use safety.
Significantly can promote that mice trachea excretion is phenol red, increase the expectoration amount of rat trachea, prompting this product has obvious phlegm-dispelling functions.
Embodiment 4
Clinical data
This group case selection accept for medical treatment out-patient totally 120 example, age 4-13 year between, 7.5 years old mean age; Stochastic averagina is divided into three groups, matched group, embodiment 1 group, embodiment 2 groups, three groups of not statistically significants (P>0.05) in sex, age, the course of disease and state of an illness distribution.
Diagnosing Asthma standard:
1, recurrent exerbation pant, out of breath, uncomfortable in chest or cough, how with to contact allergen, cold air, physics, chemical irritation and viral upper respiratory tract infection, motion etc. relevant; 2, during outbreak at two lung audible and be dispersed in or diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation; 3, above-mentioned symptom and sign can be alleviated or spontaneous remission through treatment; Panting 4, caused by other diseases, out of breath, uncomfortable in chest and cough; 5, its atypical clinical manifestations person's (as without obviously panting or sign), at least should possess following 1 the pulmonary function test positive (1) brinchial provocation test or motion activated test is positive; (2) the positive FEV1 of Bronchodilation Test increases >=12%, and FEV1 increases absolute value >=200m1; (3) (or 2 weeks) aberration rate >=20% in peak expiratory flow (PEF) day.Meet 1 ~ 4 or 4,5 persons, can asthma be diagnosed as.
Therapeutic Method
Embodiment 1 group: at the patch of Tiantu, Zhongfu, big vertebra, fei shu, the Dingchuan acupuncture point docile embodiment of the present invention 1, every cave one is pasted, the next day, is changed once, within 3 days, is a course for the treatment of, treats 3 courses for the treatment of.
Embodiment 2 groups: at the patch of Tiantu, Zhongfu, big vertebra, fei shu, the Dingchuan acupuncture point docile embodiment of the present invention 2, every cave one is pasted, the next day, is changed once, within 3 days, is a course for the treatment of, treats 3 courses for the treatment of.
Matched group: cough with asthma pastes, and each acupoint plaster one pastes, each subsides 7 are pasted, and take off, within every 7 days, stick once after 24 hours.
Efficacy assessment standard:
Cure: the symptom that diagnostic criteria provides, its symptom disappears completely, and physical recovery is healthy; Effective: the symptom that diagnostic criteria provides, symptom has clear improvement or improves, and namely asthma all has and obviously alleviates or alleviate, and needs continual cure;
Invalid: the symptom that diagnostic criteria provides, symptom is without improvement.
Concrete treatment situation sees table 1:
Table 1
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate |
| Matched group | 40 | 12 | 15 | 13 | 67.5% |
| Embodiment 1 group | 40 | 21 | 14 | 5 | 87.5％ |
| Embodiment 2 groups | 40 | 30 | 10 | 0 | 100% |
Embodiment 2 groups comparatively matched group significant difference.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (4)
1., for a patch for preventing phlegm from forming and stopping coughing, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 333g, Rhizoma Zingiberis Recens 200g.
2. patch described in claim 1, is characterized in that, preparation method is as follows:
(1) mentioned component decocts with water twice, and first time adds 8 times of weight water, decocts 2 hours, and second time adds 6 times of weight water and decocts 1 hour, is concentrated into the extractum that density is 1.2g/ml;
(2) get raw rubber 100g, after fully swelling, move into ingredients pot and stir 3 hours, add Colophonium 80g successively, zinc oxide 80g, lanoline 15g, vaseline 15g, liquid paraffin 10g, mixing, add extractum prepared by step (1) and prepare patch.
3., for a patch for preventing phlegm from forming and stopping coughing, it is prepared by following raw material and obtains:
Herba Ephedrae 200g, Semen Sinapis 200g, Flos Caryophylli 33g, Herba Asari 100g, Herba Ardisiae Japonicae 100g,
Rhizoma Zingiberis Recens 50g, Cortex Moutan 50g, Pericarpium Citri Reticulatae 30g, Fructus Trichosanthis 30g, Cortex Mori 20g,
Cortex Cinnamomi 20g, Fructus Ligustri Lucidi 20g, Fructus Lycii 20g, Rhizoma Dioscoreae 20g, Cortex Phellodendri 20g,
Flos Lonicerae 20g, Herba Artemisiae Scopariae 15g, Radix Salviae Miltiorrhizae 15g, Fructus Aurantii 15g, Folium Ginkgo 15g,
Herba Cistanches 10g, Radix Ophiopogonis 10g, Bulbus Lilii 10g, Semen Coicis 10g, Fructus Arctii 10g,
Raw rubber 100g, Colophonium 80g, zinc oxide 80g, lanoline 15g, vaseline 15g,
Liquid paraffin 10g.
4. patch as claimed in claim 3, it is characterized in that, the preparation method of described patch comprises the steps:
(1) get Herba Ephedrae, Semen Sinapis, Flos Caryophylli, Herba Asari, Herba Ardisiae Japonicae, Rhizoma Zingiberis Recens, mixing, decocts with water twice, and first time adds 8 times of weight water, decocts 2 hours, and second time adds 6 times of weight water and decocts 1 hour, is concentrated into the extractum A that density is 1.2g/ml;
(2) Cortex Moutan, Pericarpium Citri Reticulatae, Fructus Trichosanthis, Cortex Mori, Cortex Cinnamomi, Fructus Ligustri Lucidi, Fructus Lycii, Rhizoma Dioscoreae, Cortex Phellodendri, Flos Lonicerae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, Fructus Aurantii, Folium Ginkgo, Herba Cistanches, Radix Ophiopogonis, Bulbus Lilii, Semen Coicis, Fructus Arctii is got, mixing, add the ethanol of 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum B that density is 1.2g/ml;
(3) get raw rubber, abundant swelling rear immigration ingredients pot stirs 3 hours, adds Colophonium successively, zinc oxide, lanoline, vaseline, liquid paraffin, and mixing, then adds the extractum A of step (1) and the extractum B of step (2), be prepared into patch.
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| CN201510675968.9A CN105267915A (en) | 2015-10-19 | 2015-10-19 | Patch for eliminating phlegm and stopping cough and process for preparing patch |
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| CN201510675968.9A CN105267915A (en) | 2015-10-19 | 2015-10-19 | Patch for eliminating phlegm and stopping cough and process for preparing patch |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106819283A (en) * | 2016-12-30 | 2017-06-13 | 六安市裕安区天缘中药材种植专业合作社 | A kind of phlegm-dampness constitution nurses one's health gardenia tea drink |
| CN107670004A (en) * | 2017-10-13 | 2018-02-09 | 翔宇药业股份有限公司 | A kind of pharmaceutical preparation for being used for asthma, bronchitis and preparation method thereof |
| CN108434413A (en) * | 2018-03-22 | 2018-08-24 | 翔宇药业股份有限公司 | Fragrant fiber crops cold asthma patch and its application and quality determining method |
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| CN102085337A (en) * | 2009-12-07 | 2011-06-08 | 罗谦 | Patch for treating bronchial asthma of children |
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| CN107670004A (en) * | 2017-10-13 | 2018-02-09 | 翔宇药业股份有限公司 | A kind of pharmaceutical preparation for being used for asthma, bronchitis and preparation method thereof |
| CN108434413A (en) * | 2018-03-22 | 2018-08-24 | 翔宇药业股份有限公司 | Fragrant fiber crops cold asthma patch and its application and quality determining method |
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Application publication date: 20160127 |