CN104258023B - Traditional Chinese medicine composition for treating depressive disorder - Google Patents
Traditional Chinese medicine composition for treating depressive disorder Download PDFInfo
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- CN104258023B CN104258023B CN201410579885.5A CN201410579885A CN104258023B CN 104258023 B CN104258023 B CN 104258023B CN 201410579885 A CN201410579885 A CN 201410579885A CN 104258023 B CN104258023 B CN 104258023B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating depressive disorder and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by mixing coptis chinensis, astragalus membranaceus, bighead atractylodes rhizome, dried tangerine peel, tuber fleeceflower stems, nacre, asparagus fern, pinellia ternate and ginseng, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is rigorous, simple and reasonable in formulas, and has a good treatment effect on depressive disorder caused by liver depression and qi stagnation, vital energy and phlegm stagnation, heart and spleen insufficiency, liver and kidney deficiency, heart and lung yin deficiency and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of Cure of depression.
Background technology
Depression is a kind of common emotion and mental disorder disease, is Psychology Dept. commonly encountered diseases.Along with the quickening of social life rhythm, depression has become the disease occurred frequently of society.Low for main clinical characteristics with remarkable and lasting mental state, be the main Types of mood disorders.Its main manifestations be depressed, speech minimizing, slow, the normal self-accusation of psychomotor, from crime even suicide attempts etc.Even each outbreak continues at least 2 weeks more than, elder's several years, majority of cases has the tendency of recurrent exerbation, and each outbreak great majority can be alleviated, and part can have residual symptoms or transfer to chronic.
Current Cure of depression many employings western medical treatment, but Western medicine dependency is large, and there is withdrawal symptom greatly, easily in treatment toxic and side effects, taking for a long time can major injury hepatic and renal function.At present the 7 class antidepressants such as piperazine azatropylidene class sends at total 5-hydroxy tryptamine reuptake depressant, monoamine oxidase inhibitor, phenyl piperazines, 5-hydroxy tryptamine-norepinephrine reuptake inhibitor, aminoketones, tricyclic antidepressants, Fourth Ring, in various degree have that toxic and side effects is large, drug price is high and easily recur after healing, need the defects such as long term administration maintenance.
Depression belongs to the strongly fragrant disease category of the traditional Chinese medical science, and disease is complicated and changeable.Medicine typing common clinically has depression of liver-QI: spirit depressing, and the breast side of body is done swollen, or gastral cavity painful abdominal mass, and belch is done frequently, sighing frequently, menoxenia.Thin white fur of tongue, stringy pulse; Stagnated QI transforming into fire: being irritable and getting angry easily, feeling of oppression over the chest and distention of hypochondrium, headache conjunctival congestion, bitter taste, noisy pantothenic acid, constipation yellowish urine.Red tongue, yellow fur, wiry and frequent pulse; Melancholy is overtaxed one's nerves: staring spells is uneasy, and ambition is unhappy, dreaming often and waking easily, and sad melancholy is kind cries.Red tip of the tongue white and thin fur, stringy and thready pulse; Deficiency of both the heart and spleen: kind think of is worried too much puzzled, chest distress and palpitation symptoms, insomnia forgetfulness, shallow complexion, dizzy, tired, easy antiperspirant, weak digestive function of the spleen and stomach.Light red tongue, white and thin fur, stringy and thready pulse or count accurately; Hyperactivity of fire caused by deficiency of YIN: sick prolonged deficiency is tired sleeps less, irritable, dizzy cardiopalmus, flushed cheeks, feverish sensation in the palms and soles, dry mouth and throat, or sees night sweat.Red tongue, thin fur, stringy and thready pulse or count accurately.The most common is stagnation of QI due to depression of the liver, syndrome of deficiency of both heart and spleen, how to cause because feelings will is upset, that its pathogenesis is mainly depression of liver-QI, the heart is become homeless is foster, dysfunction of the spleen in transportation clinical normal to regulate the flow of vital energy, to eliminate the phlegm, to calm the nerves, to have one's ideas straightened out, invigorating the heart and spleen treatment.As loose in ease pill, resolving depression Herba Albiziae, A son is a comfort to the mother soup etc.
Summary of the invention
The present invention, according to theory of Chinese medical science, on the basis of prescription handed down from one's ancestors, provides a kind of Chinese medicine composition of Cure of depression.
The technical solution used in the present invention is as follows: a kind of Chinese medicine composition of Cure of depression, is characterized in that, this Chinese medicine composition is prepared from by Rhizoma Coptidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Caulis Polygoni Multiflori, Concha Margaritifera, Radix Asparagi, the Rhizoma Pinelliae and ginseng compatibility.
Particularly, the Chinese medicine composition of Cure of depression of the present invention adopts the material medicine of following weight proportion to be prepared from:
Rhizoma Atractylodis Macrocephalae 30-60 part, Pericarpium Citri Reticulatae 30-60 part, Rhizoma Coptidis 16-40 part, Radix Astragali 6-20 part, Caulis Polygoni Multiflori 10-24 part, Concha Margaritifera 12-24 part, Radix Asparagi 8-24 part, Rhizoma Pinelliae 8-24 part, Radix Ginseng 1-6 part.
Preferably, the Chinese medicine composition of compound Cure of depression of the present invention adopts the material medicine of following weight proportion to be prepared from:
The Rhizoma Atractylodis Macrocephalae 40 parts, Pericarpium Citri Reticulatae 40 parts, Rhizoma Coptidis 24 parts, the Radix Astragali 18 parts, Caulis Polygoni Multiflori 18 parts, Concha Margaritifera 16 parts, Radix Asparagi 12 parts, the Rhizoma Pinelliae 12 parts, Radix Ginseng 3 parts.
Fang Xie:
Rhizoma Coptidis: nature and flavor, bitter, cold.Gui Jing, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly, heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.Concocting method: removing impurity, runs through rear shave, dry, or smashs to pieces the used time.
The Radix Astragali: nature and flavor, sweet, temperature.Gui Jing, returns lung, spleen channel.Function cures mainly, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Concocting method: removing impurity, size separately, is cleaned, is run through, cut sheet, dry.
The Rhizoma Atractylodis Macrocephalae: nature and flavor, bitter, sweet, temperature.Gui Jing, returns spleen, stomach warp.Function cures mainly, invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Concocting method: be sprinkled into by processed with honey wheat bran in hot pot, add Rhizoma Atractylodis Macrocephalae sheet in time smoldering, fry to coke yellow, effusion burnt odor gas, take out, sieve removes processed with honey wheat bran.Every 100kg Rhizoma Atractylodis Macrocephalae sheet, with processed with honey wheat bran 10kg.
Pericarpium Citri Reticulatae: nature and flavor, bitter, pungent, temperature.Gui Jing, returns lung, spleen channel.Function cures mainly, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Concocting method: removing impurity, shower water, runs through, and shredding is dried in the shade.
Caulis Polygoni Multiflori: nature and flavor, sweet micro-hardship, flat.Gui Jing, the heart; Liver Channel.Function cures mainly, tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Main insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus.Concocting method: clear water is cleaned, and slightly soak, pull out, after running through, cutting, dries.
Radix Ginseng: nature and flavor, sweet, micro-hardship, flat.Gui Jing, returns spleen, lung, heart channel.Function cures mainly, strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.Concocting method: run through, shave, dry.
Concha Margaritifera: nature and flavor is salty, cold.Gui Jing, returns liver, heart channel.Function cures mainly, suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.Concocting method: removing impurity, smashes.
Radix Asparagi: nature and flavor is sweet, bitter, cold.Gui Jing, returns lung, kidney channel.Function cures mainly, nourishing YIN to relieve dryness, and lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.Concocting method: removing impurity, cleans rapidly, shave, dry.
The Rhizoma Pinelliae: nature and flavor, pungent, temperature; Poisonous.Gui Jing, returns spleen, stomach, lung meridian.Function cures mainly, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.Concocting method: get the clean Rhizoma Pinelliae, size separately, is dipped to interior without the dry heart with 8% white alum solution, mouth is tasted and micro-ly had numb feeling in the tongue, takes out, cleans, cut sheet, drying.Every 100kg Rhizoma Pinelliae, uses Alumen 20kg.
More than the present invention Rhizoma Atractylodis Macrocephalae enriching spleen-QI in nine taste medical materials, Pericarpium Citri Reticulatae reason temper, the two one mends a reason, can burnt the source of vital function in benefit, and make blood life to some extent, blood deficiency must be mended, and gains in depth of comprehension institute is supported, and the mind is pacified certainly.Rhizoma Coptidis, bitter cold, goes vexed, except damp and hot, Radix Astragali benefiting QI for strengthening the superficies, inducing diuresis to remove edema, Radix Asparagi, clearing away heart-fire and moistening the lung; The Rhizoma Pinelliae reduces phlegm, suppressing the hyperactive liver, the therapeutic method to keep the adverse QI flowing downwards; Caulis Polygoni Multiflori, Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, tranquilizing by nourishing the heart; Radix Ginseng promotes the production of body fluid, and calms the nerves.All medicine medical material 5 use, can depressed liver-energy dispersing and QI regulating, tranquillization with heavy prescription, consciousness-restoring and orifice-opening, clearing away heat and eliminating phlegm.Chinese medicine composition prescription of the present invention is rigorous, simplify, rationally, therapeutic dose is low, has no side effect, and has good therapeutic effect to the depression that stagnation of QI due to depression of the liver, mental disorder pent-up, deficiency of both the heart and spleen, deficiency of the liver and kindey and YIN-deficiency of both the heart and lung etc. cause.
Detailed description of the invention
Technical scheme of the present invention is further illustrated below by specific embodiment.
Embodiment 1
Rhizoma Atractylodis Macrocephalae 400g, Pericarpium Citri Reticulatae 400g, Rhizoma Coptidis 240g, Radix Astragali 180g, Caulis Polygoni Multiflori 180g, Concha Margaritifera 160g, Radix Asparagi 120g, Rhizoma Pinelliae 120g, Radix Ginseng 30g.
Get above medical material, pulverize respectively, cross 150 mesh sieves, mix homogeneously, adds appropriate amount of starch, dehydrated alcohol soft material, and 60 DEG C of oven dry, add appropriate Pulvis Talci, magnesium stearate, tabletting, and packaging, obtains Chinese medicinal tablet of the present invention, and every sheet is containing crude drug 0.5g.
Embodiment 2
Rhizoma Atractylodis Macrocephalae 400g, Pericarpium Citri Reticulatae 400g, Rhizoma Coptidis 240g, Radix Astragali 180g, Caulis Polygoni Multiflori 180g, Concha Margaritifera 160g, Radix Asparagi 120g, Rhizoma Pinelliae 120g, Radix Ginseng 30g.
Get above medical material, pulverize respectively, cross 150 mesh sieves, mix homogeneously, add appropriate lactose, appropriate Pulvis Talci, mix homogeneously, is filled in capsule, obtains Chinese medicine capsules of the present invention, and every capsules is containing crude drug 0.5g.
Embodiment 3
Rhizoma Atractylodis Macrocephalae 400g, Pericarpium Citri Reticulatae 400g, Rhizoma Coptidis 240g, Radix Astragali 180g, Caulis Polygoni Multiflori 180g, Concha Margaritifera 160g, Radix Asparagi 120g, Rhizoma Pinelliae 120g, Radix Ginseng 30g.
Get above medical material, pulverize respectively, cross 150 mesh sieves, mix homogeneously, adds appropriate amount of starch, dehydrated alcohol, sucrose, stirs, and through fluidized bed granulation, obtains dried particles, subpackage, obtains Chinese medicine granules of the present invention, and every bag containing crude drug 2.5g.
Embodiment 4 clinical data
1 physical data
The present invention selects 188 routine patients with depression to our hospital to be the object of observation.Wherein man 70 example, female 118 example; Age 23-56 year, average 38.5 years old; Course of disease 1-7, average 5.2 years.Be divided into treatment group and matched group at random, often organize 94 examples.The age of two groups of patients, sex, the equal not statistically significant of course of disease difference (P>0.05), have comparability.
2 diagnostic criterias
2.1 Western medicine diagnose standards, the diagnostic criteria of all cases meet " Chinese Spirit Obstacles classification and diagnostic criteria " (CCMD-3) depression:
(1) low based on mental state, and have following 4 at least: 1. hebetude, without happy sense; 2. energy goes down or tired sense; 3. psychomotor activity is sluggish or intense; 4. self evaluation too low, self-accusation or have feeling of guilt; 5. association difficulty or conscious elaborative faculty decline; 6. repeatedly there is the thought of wanting to die or have suicide, autolesionism; 7. sleep disorder, as insomnia, early awakening or hypersomnia; 8. appetite reduction or body weight obviously alleviate; 9. hyposexuality.
(2) order of severity standard (having one of following situation at least): 1. social function is impaired; 2. cause suffering or adverse consequences to me.
(3) course of disease standard: symptom at least continues 2 weeks;
(4) compliance is good, agrees to the person of following up a case by regular visits to.
2.2 tcm diagnosis standards, all cases meet the strongly fragrant sick diagnostic criteria of the formulation of " Chinese medical disease Standardization of diagnosis and curative effect ":
Strongly fragrant cause of disease feelings will is not relaxed, depression and stagnation of QI and causing a disease.Be apt to melancholy with depression, irritable emotion, or irritability is apt to cry as primary symptom.Be more common in neurosis, hysteria.Diagnosis basis: 1. melancholy is not smooth, lassitude, feeling of oppression over the chest and distention of hypochondrium, sighing frequently.Or anorexia, insomnia and dreamful sleep, irritability is apt to diseases such as crying.2. have disgruntled, worry too much, the feelings will such as grieved, worried hinders history.3. organic disease can be got rid of through each systems inspection and lab testing.
3. medication:
Matched group: give maprotiline treatment, every day 3 times, a 25-100mg, takes 60 days continuously.
Treatment group: use the granule that the embodiment of the present invention 3 is obtained, 3 times on the one, each 1 bag, 15 days courses for the treatment of.Take 4 courses for the treatment of continuously.
4. evaluation criterion
4.1 doctor trained in Western medicine criterions of therapeutical effect:
Do 17 Hamilton depressive scales (HAMD) at pre-treatment and after treatment respectively, using front and back deduction as the observation index of curative effect, deduction rate >=80% is recovery from illness, deduction rate is marked improvement between 50-79%, deduction rate is at 25-49% for progressive, and deduction rate is less than 25% for invalid.
4.2 Efficacy of Traditional Chinese Medicine standards
Cure: transference cure, emotion is normal.
Take a turn for the better: symptom alleviates, and emotion is basicly stable.
Do not heal: symptom, emotion are all without improvement.
5. statistical method
Data acquisition SPSS19.0 software carries out statistical analysis, measurement data with
represent, before and after treatment, Indexes Comparison adopts t inspection; Enumeration data adopts X
2inspection.P < 0.05 represents that difference has statistical significance.
6. result
After treating 4 courses for the treatment of, matched group and treatment group treatment front and back HAMD total score compare, see table 1
Before and after table 1 liang group treatment, HAMD total score compares
| Group | Case load | Before treatment | After treatment |
| Matched group | 94 | 23.08±3.87 | 15.66±4.87 |
| Treatment group | 94 | 22.71±5.62 | 7.03±1.74* |
* compare with matched group, p<0.01;
Table 1 is pointed out, and through the treatment of 4 courses for the treatment of, treatment group HAMD total score deduction is maximum, and compared with matched group, p<0.01, has pole significant difference.
After treating 4 courses for the treatment of, two groups of Comparison of therapeutic are in table 2.
Table 2 liang group Comparison of therapeutic table
| Group | Case load | Recovery from illness | Marked improvement | Progressive | Invalid | Total effective rate |
| Treatment group | 94 | 57(60.6％) | 26 | 10 | 1 | 98.9％ |
| Matched group | 94 | 31(33.0％) | 32 | 19 | 12 | 87.2％ |
Compared with matched group, Chinese medicine composition of the present invention, in Cure of depression, reaches the cure rate of 60.6%.And matched group is only the cure rate of 33.0%, total effective rate aspect, treatment group is also significantly higher than matched group, reaches 98.9%, and matched group is only 87.2%.After treatment group patient recovery from illness, 1 course for the treatment of of after treatment, rear drug withdrawal, pay a return visit after 1 year, no case was recurrence.
In therapeutic process, matched group few patients has drowsiness, dizzy, xerostomia in various degree, trembles, tachycardia, skin allergy, constipation are uncomfortable.Treatment group does not find any untoward reaction.
Claims (2)
1. a Chinese medicine composition for Cure of depression, is characterized in that, is prepared from by the material medicine of following weight proportion:
2. the Chinese medicine composition of Cure of depression as claimed in claim 1, is characterized in that, be prepared from by the material medicine of following weight proportion:
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