CN110680880A - Traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia and application thereof - Google Patents
Traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia and application thereof Download PDFInfo
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- CN110680880A CN110680880A CN201911010348.8A CN201911010348A CN110680880A CN 110680880 A CN110680880 A CN 110680880A CN 201911010348 A CN201911010348 A CN 201911010348A CN 110680880 A CN110680880 A CN 110680880A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Abstract
The invention discloses a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia, which comprises the following raw materials in parts by weight: 20-40 parts of achyranthes bidentata, 20-40 parts of ligusticum wallichii, 10-20 parts of gastrodia elata, 10-20 parts of uncaria, 10-20 parts of selfheal, 10-20 parts of fructus evodiae and 10-20 parts of cinnamon. Meanwhile, the invention also discloses application of the traditional Chinese medicine composition in preparing food, health-care products and medicines for treating the liver-yang hyperactivity type insomnia. The traditional Chinese medicine composition provided by the invention can effectively treat insomnia caused by hyperactivity of liver-yang, is prepared from traditional Chinese medicine raw materials, is quick in effect taking, treats both symptoms and root causes, is efficient and free of side effects, and can effectively improve symptoms of insomnia, headache, dizziness, irritability, red tongue, wiry pulse and the like of a patient.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia and application thereof.
Background
Insomnia is a physiological disorder of persistent sleep quality and/or dissatisfaction, and anxiety or fear to insomnia is the causative psychological factor in this disease. Insomnia is the most common sleep disorder, and refers to insufficient sleep, difficulty in falling asleep, and early awakening caused by various reasons. The main symptoms of insomnia are the effects on the manifestations of activities in the daytime, such as sensory fatigue, dysphoria, mood disorders, inattention and poor memory, so the ability and efficiency of insomniacs tends to decrease. The latency period of the patient generally entering sleep is prolonged, the sleep time is shortened, and the physiological arousal is increased in the sleeping process. Insomnia varies greatly in course, and can be limited to months if caused by psychological or medical stress events. Most often, insomnia is exacerbated in the first stage, which is progressive, for weeks to months, with more stable chronic sleep difficulties lasting for years. The common causes of insomnia mainly include environmental causes, individual factors, physical causes, mental factors, emotional factors and the like.
The symptoms of insomnia with hyperactivity of liver-yang are: in addition to insomnia, headache, vertigo, irritability, red tongue, wiry pulse, etc. are accompanied. At present, methods for treating insomnia caused by hyperactivity of liver-yang at home and abroad comprise western medicine treatment methods and traditional Chinese medicine treatment methods. However, satisfactory results are difficult to achieve in terms of cure rate, treatment means, treatment cost, and the like.
Disclosure of Invention
Based on the above, the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine composition for treating the liver-yang hyperactivity type insomnia, which has the advantages of quick response, treatment of both symptoms and root causes, high efficiency and no side effect.
In order to achieve the purpose, the invention adopts the technical scheme that: a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia comprises the following raw materials in parts by weight: 20-40 parts of achyranthes bidentata, 20-40 parts of ligusticum wallichii, 10-20 parts of gastrodia elata, 10-20 parts of uncaria, 10-20 parts of selfheal, 10-20 parts of fructus evodiae and 10-20 parts of cinnamon.
The achyranthes root in the formula of the traditional Chinese medicine composition is bitter in acid and neutral in nature, mainly enters liver and kidney channels, can tonify when moving, descends well in nature, is mainly used for drawing blood to descend, breaking down hyperactivity of yang, calming adverse qi and nourishing liver and kidney, and is used as a monarch drug. Only wind-herbs can be found on the vertex, Chuan Xiong can direct the herbs upward and excel in alleviating pain, so it is good at treating jueyin headache; the gastrodia elata is a nerve medicament for treating wind, the uncaria is light, clear and cool and can purge fire and calm wind, and the three medicines are ministerial medicaments; in the formula, evodia rutaecarpa, bitter in flavor and large heat directly enter liver and stomach, warms liver and stomach, and cinnamon, although pungent and hot, can induce fire to return to original place, so that yang qi descends, and selfheal, namely, selfheal, clears liver and discharges heat, and restricts a pungent and hot product, which are used as assistant drugs. The medicines are combined to play the effects of calming the liver, suppressing yang hyperactivity, soothing the nerves and aiding sleep.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of radix achyranthis bidentatae, 25-35 parts of ligusticum wallichii, 12-18 parts of gastrodia elata, 12-18 parts of uncaria, 15-18 parts of selfheal, 15-18 parts of fructus evodiae and 12-18 parts of cinnamon.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30 parts of achyranthes bidentata, 35 parts of ligusticum wallichii, 15 parts of gastrodia elata, 18 parts of uncaria, 16 parts of selfheal, 15 parts of fructus evodiae and 12 parts of cinnamon.
The invention also provides application of the traditional Chinese medicine composition in preparing food, health-care products and medicines for treating the liver-yang hyperactivity type insomnia.
The traditional Chinese medicine composition provided by the invention can be used for preparing food, health-care products and medicines for treating liver-yang hyperactivity type insomnia.
The invention also provides a health-care product for treating the liver-yang hyperactivity type insomnia, which comprises the traditional Chinese medicine composition and auxiliary materials acceptable in the field of health-care products.
Preferably, the health product dosage forms include powders, granules, capsules, tablets and solutions.
The invention also provides a medicine for treating the liver-yang hyperactivity type insomnia, which comprises the traditional Chinese medicine composition and a pharmaceutically acceptable carrier.
Preferably, the medicament is in an oral dosage form.
Preferably, the oral dosage forms include powders, granules, capsules, tablets, pills and solutions.
Through a large amount of researches and statistical analysis, the inventor discovers that radix achyranthis bidentatae, ligusticum wallichii, gastrodia elata, uncaria, selfheal, fructus evodiae and cinnamon are compounded together, the insomnia caused by hyperactivity of liver-yang can be effectively treated, the cure rate is high, the effect is fast, the relapse is avoided, and the usage amount of all raw materials in the application range can ensure that a patient has no adverse reaction, is safe and has no toxic or side effect.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine composition provided by the invention can effectively treat insomnia caused by hyperactivity of liver-yang, is prepared from traditional Chinese medicine raw materials, is quick in effect taking, treats both symptoms and root causes, is efficient and free of side effects, and can effectively improve symptoms of insomnia, headache, dizziness, irritability, red tongue, wiry pulse and the like of a patient.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
The invention relates to an embodiment of a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia, which comprises the following raw materials in parts by weight: 20 parts of achyranthes bidentata, 30 parts of ligusticum wallichii, 10 parts of gastrodia elata, 20 parts of uncaria, 12 parts of selfheal, 10 parts of fructus evodiae and 15 parts of cinnamon.
Example 2
The invention relates to an embodiment of a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia, which comprises the following raw materials in parts by weight: 25 parts of achyranthes bidentata, 20 parts of ligusticum wallichii, 20 parts of gastrodia elata, 15 parts of uncaria, 10 parts of selfheal, 20 parts of fructus evodiae and 10 parts of cinnamon.
Example 3
The invention relates to an embodiment of a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia, which comprises the following raw materials in parts by weight: 40 parts of achyranthes bidentata, 40 parts of ligusticum wallichii, 18 parts of gastrodia elata, 10 parts of uncaria, 20 parts of selfheal, 18 parts of fructus evodiae and 20 parts of cinnamon.
Example 4
The invention relates to an embodiment of a traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia, which comprises the following raw materials in parts by weight: 30 parts of achyranthes bidentata, 35 parts of ligusticum wallichii, 15 parts of gastrodia elata, 18 parts of uncaria, 16 parts of selfheal, 15 parts of fructus evodiae and 12 parts of cinnamon.
Example 5
The present example studies the treatment effect of the traditional Chinese medicine composition of examples 1 to 4 on insomnia with hyperactivity of liver-yang.
(I) Experimental method
230 patients diagnosed with insomnia with hyperactivity of liver-yang were selected, randomly divided into 4 groups (experimental groups 1-4), and the traditional Chinese medicine compositions of examples 1-4 were respectively taken, and the usage was: the traditional Chinese medicine composition in the embodiment 1-4 is prepared into decoction by a conventional method in the field, the decoction is taken 2 times a day, once in the morning and at night, for 2 weeks continuously, and other medicines are forbidden to be taken in the test period. The patients in each group have no statistical difference in age, sex and disease course and are comparable. After 2 weeks, the treatment effect of each group of patients was evaluated according to the criteria in table 1 (drawn up according to the guidelines on clinical research of new drugs for Chinese medicine treatment of insomnia):
TABLE 1 evaluation criteria for therapeutic effects
(II) results of the experiment
The results of the experiment are shown in table 2:
TABLE 2 results of the experiment
The experimental results show that the traditional Chinese medicine composition has the cure rate of over 45 percent for the liver-yang hyperactivity type insomnia and the total treatment effective rate of over 85 percent. In particular, the traditional Chinese medicine composition of example 4 has the best treatment effect on insomnia with hyperactivity of liver-yang, the cure rate reaches 56.45%, and the total treatment effective rate reaches 91.9%. And all tested patients have no adverse reaction in the reaction process of taking the traditional Chinese medicine composition, and the traditional Chinese medicine composition is safe, has no side effect and basically has no relapse.
Example 6
The traditional Chinese medicine composition disclosed by the embodiment 1 of the invention is used for treating clinical cases of liver-yang hyperactivity type insomnia.
Wu female, 46 years old, suffers from insomnia for five years, and has been diagnosed as insomnia with hyperactivity of liver yang, with symptoms including difficulty in falling asleep, early awakening, headache, vertigo and the like. The decoction prepared by the traditional Chinese medicine composition in the embodiment 1 is taken 2 times a day, once in the morning and at night, after the decoction is continuously taken for 3 weeks, the sleep condition is obviously improved, the sleep is deep, the sleep time per day is increased by 3-4 hours, and the symptoms of morning awakening, headache and dizziness disappear. After 3 months of follow-up visit, insomnia does not relapse, sleep quality is greatly improved, and spirit is greatly improved.
Example 7
The traditional Chinese medicine composition provided by the embodiment 3 is used for treating clinical cases of liver-yang hyperactivity type insomnia.
Mr. Zhang, age 26, insomnia due to severe working stress in the near day, is diagnosed as insomnia with hyperactivity of liver-yang, and has symptoms including difficulty in falling asleep, early awakening, feeling fatigue, dysphoria, inattention and poor memory. After the decoction prepared by the traditional Chinese medicine composition in the embodiment 3 is taken for 2 times a day, the insomnia symptoms are greatly improved after the decoction is taken for 2 weeks continuously, the sleeping time is prolonged compared with the original sleeping time, the sleeping depth is increased, the energy is vigorous after the sleep is waken, and the memory is improved. After 2 months, the follow-up visit is carried out, the insomnia does not relapse, the fatigue feeling and the dysphoria state disappear, and the working state is obviously improved.
Example 8
The traditional Chinese medicine composition provided by the embodiment 4 is used for treating clinical cases of liver-yang hyperactivity type insomnia.
Sunwood female, age 57, insomnia, headache, vertigo, irritability, red tongue, and fatigue. After the decoction prepared by the traditional Chinese medicine composition in the embodiment 4 is taken 2 times a day, once in the morning and evening, the insomnia symptom is greatly improved after the decoction is continuously taken for 2 weeks, the sleeping condition is obviously improved, the headache and dizziness are avoided, the sleeping time is prolonged compared with the original sleeping time, and the sleeping depth is increased. After 6 months of follow-up visit, insomnia does not relapse, the fatigue feeling and the impatience and irritability state are greatly improved, and the life quality is obviously improved.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for treating liver-yang hyperactivity type insomnia is characterized by comprising the following raw materials in parts by weight: 20-40 parts of achyranthes bidentata, 20-40 parts of ligusticum wallichii, 10-20 parts of gastrodia elata, 10-20 parts of uncaria, 10-20 parts of selfheal, 10-20 parts of fructus evodiae and 10-20 parts of cinnamon.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 25-35 parts of radix achyranthis bidentatae, 25-35 parts of ligusticum wallichii, 12-18 parts of gastrodia elata, 12-18 parts of uncaria, 15-18 parts of selfheal, 15-18 parts of fructus evodiae and 12-18 parts of cinnamon.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 30 parts of achyranthes bidentata, 35 parts of ligusticum wallichii, 15 parts of gastrodia elata, 18 parts of uncaria, 16 parts of selfheal, 15 parts of fructus evodiae and 12 parts of cinnamon.
4. Use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in preparation of food, health care products and medicines for treating insomnia caused by hyperactivity of liver-yang.
5. A health product for treating insomnia caused by hyperactivity of liver-yang, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3 and auxiliary materials acceptable in the field of health products.
6. The health product for treating insomnia caused by hyperactivity of liver-yang according to claim 5, wherein the dosage form of the health product comprises powder, granules, capsules, tablets and solutions.
7. A medicine for treating insomnia caused by hyperactivity of liver-yang, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3 and a pharmaceutically acceptable carrier.
8. The medicine for treating insomnia due to hyperactivity of liver-yang as claimed in claim 7, wherein said medicine is in oral dosage form.
9. The medicament for treating the insomnia caused by the hyperactivity of liver-yang as claimed in claim 8, wherein the oral dosage forms include powders, granules, capsules, tablets, pills and solutions.
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| Application Number | Priority Date | Filing Date | Title |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115501283A (en) * | 2022-11-10 | 2022-12-23 | 广州白云山奇星药业有限公司 | Application of Huatuo Zaizao pill in preparing medicine for treating insomnia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766759A (en) * | 2008-12-30 | 2010-07-07 | 戴建国 | Medicinal footbath liquor |
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2019
- 2019-10-22 CN CN201911010348.8A patent/CN110680880A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766759A (en) * | 2008-12-30 | 2010-07-07 | 戴建国 | Medicinal footbath liquor |
Non-Patent Citations (1)
| Title |
|---|
| 陈建兴: "邓铁涛浴足方对高血压病肝阳上亢型的疗效观察及机制探讨", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115501283A (en) * | 2022-11-10 | 2022-12-23 | 广州白云山奇星药业有限公司 | Application of Huatuo Zaizao pill in preparing medicine for treating insomnia |
| CN115501283B (en) * | 2022-11-10 | 2023-09-26 | 广州白云山奇星药业有限公司 | Application of Huatuo reconstruction pill in preparation of medicine for treating insomnia |
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Application publication date: 20200114 |