CN104225678A - 一种医用钛金属材料及其制备方法 - Google Patents
一种医用钛金属材料及其制备方法 Download PDFInfo
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- CN104225678A CN104225678A CN201410521019.0A CN201410521019A CN104225678A CN 104225678 A CN104225678 A CN 104225678A CN 201410521019 A CN201410521019 A CN 201410521019A CN 104225678 A CN104225678 A CN 104225678A
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- Prior art keywords
- titanium
- metal material
- polyethylene glycol
- titanium metal
- adhesive layer
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 239000010936 titanium Substances 0.000 title claims abstract description 85
- 229910052719 titanium Inorganic materials 0.000 title claims abstract description 85
- 239000007769 metal material Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 32
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 31
- 210000000963 osteoblast Anatomy 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 24
- 150000002334 glycols Chemical class 0.000 claims abstract description 22
- 230000008569 process Effects 0.000 claims abstract description 8
- 239000012790 adhesive layer Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 230000000844 anti-bacterial effect Effects 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 21
- 239000012153 distilled water Substances 0.000 claims description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 17
- -1 3-(methacryloxypropyl) propyl Chemical group 0.000 claims description 14
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 10
- QZSKYMMIFBLVGO-UHFFFAOYSA-N ethane-1,2-diol;2-methylprop-2-enoic acid Chemical compound OCCO.CC(=C)C(O)=O QZSKYMMIFBLVGO-UHFFFAOYSA-N 0.000 claims description 10
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims description 9
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 102000029816 Collagenase Human genes 0.000 claims description 8
- 108060005980 Collagenase Proteins 0.000 claims description 8
- 229960002424 collagenase Drugs 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- CRZQGDNQQAALAY-UHFFFAOYSA-N Methyl benzeneacetate Chemical class COC(=O)CC1=CC=CC=C1 CRZQGDNQQAALAY-UHFFFAOYSA-N 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 7
- 238000004132 cross linking Methods 0.000 claims description 7
- 229910021589 Copper(I) bromide Inorganic materials 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 210000002449 bone cell Anatomy 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 229940093476 ethylene glycol Drugs 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- NICYNNGYHJJJMJ-UHFFFAOYSA-N propan-2-one;titanium Chemical compound [Ti].CC(C)=O NICYNNGYHJJJMJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 claims description 3
- 230000010261 cell growth Effects 0.000 claims description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
- 230000001582 osteoblastic effect Effects 0.000 claims description 3
- 238000012805 post-processing Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 13
- 229910052751 metal Inorganic materials 0.000 abstract description 13
- 239000002184 metal Substances 0.000 abstract description 13
- 230000006870 function Effects 0.000 abstract description 9
- 230000012010 growth Effects 0.000 abstract description 8
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- NBXZNTLFQLUFES-UHFFFAOYSA-N triethoxy(propyl)silane Chemical compound CCC[Si](OCC)(OCC)OCC NBXZNTLFQLUFES-UHFFFAOYSA-N 0.000 abstract 1
- 239000000047 product Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000007943 implant Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000000181 anti-adherent effect Effects 0.000 description 2
- 230000010065 bacterial adhesion Effects 0.000 description 2
- 239000003519 biomedical and dental material Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000007822 coupling agent Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004513 dentition Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
细菌 | ATCC 6538 | ATCC 25922 | ATCC 10231 | ATCC 9372 |
抗细菌粘附率 | 99.99% | 99.98% | 100% | 99.98% |
钛片 | 本发明产物 | |
LDH活性 | 236 | 205 |
Claims (8)
Priority Applications (1)
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CN201410521019.0A CN104225678B (zh) | 2014-09-30 | 2014-09-30 | 一种医用钛金属材料及其制备方法 |
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CN201410521019.0A CN104225678B (zh) | 2014-09-30 | 2014-09-30 | 一种医用钛金属材料及其制备方法 |
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CN104225678A true CN104225678A (zh) | 2014-12-24 |
CN104225678B CN104225678B (zh) | 2016-05-11 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105543820A (zh) * | 2015-12-25 | 2016-05-04 | 武汉迪赛新材料有限公司 | 一种不锈钢医疗器械表面抗细菌粘附涂层的制备方法 |
CN106512106A (zh) * | 2016-11-02 | 2017-03-22 | 北京大学口腔医学院 | 抗菌牙科材料及其制备方法 |
Citations (5)
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---|---|---|---|---|
CN1613434A (zh) * | 2003-11-03 | 2005-05-11 | 北京天助畅运医疗技术研究所 | 动物组织生长诱导支架 |
WO2009058351A2 (en) * | 2007-10-31 | 2009-05-07 | Chameleon Scientific Corporation | Spinulose surfaces |
KR20140090962A (ko) * | 2013-01-10 | 2014-07-18 | 한양대학교 에리카산학협력단 | 항균 티타늄 임플란트의 제조방법 및 그에 따라 제조된 항균 티타늄 임플란트 |
CN104005016A (zh) * | 2014-06-06 | 2014-08-27 | 重庆大学 | 一种兼具抗菌及促成骨细胞功能的医用钛合金及其制备方法 |
CN104028742A (zh) * | 2014-05-27 | 2014-09-10 | 华南理工大学 | 钛纳米棒-聚多巴胺-共掺杂锌和银复合材料及其制备与应用 |
-
2014
- 2014-09-30 CN CN201410521019.0A patent/CN104225678B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1613434A (zh) * | 2003-11-03 | 2005-05-11 | 北京天助畅运医疗技术研究所 | 动物组织生长诱导支架 |
WO2009058351A2 (en) * | 2007-10-31 | 2009-05-07 | Chameleon Scientific Corporation | Spinulose surfaces |
KR20140090962A (ko) * | 2013-01-10 | 2014-07-18 | 한양대학교 에리카산학협력단 | 항균 티타늄 임플란트의 제조방법 및 그에 따라 제조된 항균 티타늄 임플란트 |
CN104028742A (zh) * | 2014-05-27 | 2014-09-10 | 华南理工大学 | 钛纳米棒-聚多巴胺-共掺杂锌和银复合材料及其制备与应用 |
CN104005016A (zh) * | 2014-06-06 | 2014-08-27 | 重庆大学 | 一种兼具抗菌及促成骨细胞功能的医用钛合金及其制备方法 |
Non-Patent Citations (4)
Title |
---|
FAN ZHANG等: "Functionalization of Titanium Surfaces via Controlled Living Radial Polymerization: From Antibacterial Surface to Surface for Osteoblast Adhesion", 《IND. ENG. CHEM. RES.》 * |
MARCO MORRA: "Biochemical modification of titanium surfaces: peptides and ECM proteins", 《EUROPEAN CELLS AND MATERIALS》 * |
廖娟等: "纯钛种植体表面抗菌改性的研究进展", 《国际口腔医学杂志》 * |
杨隽等: "硅烷化甲氧基聚乙二醇接枝改性镍钛合金", 《功能材料》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105543820A (zh) * | 2015-12-25 | 2016-05-04 | 武汉迪赛新材料有限公司 | 一种不锈钢医疗器械表面抗细菌粘附涂层的制备方法 |
CN105543820B (zh) * | 2015-12-25 | 2017-11-24 | 武汉迪赛新材料有限公司 | 一种不锈钢医疗器械表面抗细菌粘附涂层的制备方法 |
CN106512106A (zh) * | 2016-11-02 | 2017-03-22 | 北京大学口腔医学院 | 抗菌牙科材料及其制备方法 |
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CN104225678B (zh) | 2016-05-11 |
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