CN104225151A - Traditional Chinese medicine preparation with heat clearing and fire purging effects and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation with heat clearing and fire purging effects. The traditional Chinese medicine preparation is characterized by being prepared by combining fructus forsythiae, fructus gardeniae, coptis chinensis and the like and being prepared into the dosage forms such as tablets, capsules, granules and the like. The traditional Chinese medicine preparation has the effects of clearing away heat and toxic materials as well as dehumidifying and eliminating swelling and is used for treating dizziness, toothache, mouth and tongue sores, swelling and pain in the throat, earache and tinnitus, constipation and reddish urine caused by wind-heat attacking upward and excess lung-stomach heat. 20 patients are treated in clinic, the total effective rate is up to 95.00%, and the symptoms of the diseases are remarkably relieved.

Description

A kind of have Chinese medicine preparation of heat clearing away and internal heat reducing effect and preparation method thereof

?

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly a kind of have Chinese medicine preparation of heat clearing away and internal heat reducing effect and preparation method thereof.

Background technology

Getting angry is TCM-related Terms, and so-called " fire " describes some hot symptom in health.And the internal fever of the unbalance rear appearance of namely yin-Yang of getting angry.It is generally acknowledged that " fire " can be divided into " excess-fire " and " asthenic fire " two large class, common symptom of getting angry then has " heart-fire " and " liver-fire ".Such as stomach-fire can have a stomach-ache, the large symptom such as dry stool, halitosis, and lung-fire can have the symptoms such as spitting of blood, cough, yellow sputum, and liver-fire has that some are irritated, insomnia, women have distending pain of the breast, and heart-fire will palpitation and insomnia, vexed.Modal is exactly heatstroke, and be all overlong time slow-witted under, hydropenia, sultry environment too high in temperature usually, then body temperature also can raise.The typical burning hot disease of diseases caused by exogenous pathogenic factor of one that Here it is.In general burning hot situation raw in is burning hoter than diseases caused by exogenous pathogenic factor many, and such as people's pressure becomes social life that is large, that add growing tension now, and growth in the living standard, often stays up late, eats maror etc., and generally cause yin-Yang unbalance, endogenous fire is vigorous.The factor of inside lighting a fire is more much bigger than in the past.A lot of people thinks that getting angry is indisposition, has some medicine or self regulation just passable once.In fact get angry relatively lighter when having, can oneself regulate.But for some special populations such as old people or have underlying diseases as the people of cardiovascular disease or should arouse attention.

By clinical observation, the present invention can obviously improve have a dizzy spell, dental pain, aphtha of the mouth and tongue, laryngopharynx swelling and pain, otalgia tinnitus, constipation, oliguria with reddish urine, total effective rate reaches 95%, and does not find any obvious untoward reaction, and clinical effectiveness is satisfied.At present, clinically to evident in efficacy, safety good, Chinese medicine preparation easy to use still for be badly in need of.Therefore, exploitation of the present invention is expected to provide a safety, ideal Chinese medicine preparation effective, cheap, easy to use for clinical, is expected to obtain good economical, societal benefits after applying.

Summary of the invention

The invention belongs to the Chinese medicine preparation with heat clearing away and internal heat reducing effect, it is characterized in that by heat-clearing and toxic substances removing, detumescence of drying, invigorating the spleen and replenishing QI, kidney tonifying Xing Yang, Chinese prescription form, comprise Fructus Forsythiae 6 ~ 21%, Fructus Gardeniae 15 ~ 35%, Radix Scutellariae 5 ~ 20%, Radix Scrophulariae 10 ~ 30%, Rhizoma Coptidis 1 ~ 8%, Rhizoma Dioscoreae 4 ~ 18%.Technical scheme of the present invention is: extract taste Chinese medicine each in the present invention, extracting solution concentrating under reduced pressure becomes concentrated solution; After concentrated solution is dried to extract dry powder by distinct methods, by adding different auxiliary material respectively, can be made into the solid preparations such as granule, capsule, tablet; Also can will add appropriate distilled water in concentrated solution, water precipitating adds adjuvant and the liquid preparation such as oral liquid and syrup made by antiseptic after filtering.The different auxiliary material added in different dosage form of the present invention, does not affect clinical effectiveness of the present invention, and these adjuvants comprise starch, microcrystalline Cellulose, magnesium stearate, dextrin, lactose, sucrose, antiseptic etc.Therefore the present invention can meet that wide wind heat is got angry, the vigorous patient of endogenous fire is to the requirement of different dosage form.

The object of this invention is to provide a kind of Chinese medicine preparation with heat clearing away and internal heat reducing effect.The Pharmacodynamic test of active extract result of this preparation shows: this preparation can obviously improve have a dizzy spell, dental pain, aphtha of the mouth and tongue, laryngopharynx swelling and pain, otalgia tinnitus, constipation, oliguria with reddish urine.Acute toxicity test of the present invention and long term toxicity test result show to have no overt toxicity reaction.Use vigorous patient 20 example of Granules in Treating endogenous fire of the present invention clinically, basic recovery 2 example, accounts for 10. 00 %; Remarkable recovery 17 example, accounts for 85 00 %, total effective rate 95. 00 %.Tcm symptom improves total effective rate: oral ulcer is 82.86 %, gingival swelling and pain is 90.00 %, xerostomia is 84.36 %, oliguria with reddish urine is 84.6%, susceptible to lose temper due to restlessness is 67.78 %, sleep disorder is 75.00 %, dysphoria with feverish sensation in the chest palms and soles is 91.97 %, pharynx pain hoarseness is 93.00 %.Illustrate that the present invention obviously can improve symptom of getting angry, especially to having a dizzy spell, the improvement of the symptom such as dental pain, aphtha of the mouth and tongue, laryngopharynx swelling and pain, oliguria with reddish urine is obvious.Also observe the impact of granule of the present invention on safety indexes such as hematuria routine, Liver and kidney function in clinical trial process simultaneously, find Non Apparent Abnormality change before and after treatment.Clinical taking in process has not also reported gastrointestinal tract and other untoward reaction, illustrates that the present invention takes safety.Prescription of the present invention, on the basis of above-mentioned Six-element medicine, also can add the Chinese medicine that other have invigorating vital QI effect.Using method of the present invention: oral, every day three times, each 1 one 2 bags of granules (or 3 one 6 capsules, or 3-6 tablets of tablets, or 1-2 oral liquids or 10-20 ml syrup).It within 30 days, is a course for the treatment of.

embodiment 1:

Fructus Forsythiae, Fructus Gardeniae, Radix Scutellariae, Radix Scrophulariae, Rhizoma Coptidis, Rhizoma Dioscoreae powder are broken into coarse powder, decoct with water three times, collecting decoction, filter, filtrate is condensed into the concentrated solution that relative density is 1.20 one 1.22, continues to be condensed into thick paste, differently can do bath, pulverize, sieve, be the dry medicated powder of extraction of the present invention;

embodiment 2:

Fructus Forsythiae, Fructus Gardeniae, Radix Scutellariae, Radix Scrophulariae, Rhizoma Coptidis, Rhizoma Dioscoreae powder are broken into coarse powder, decoct with water three times, collecting decoction, and filter, filtrate is condensed into the concentrated solution that relative density is 1.20 one 1.22, continues to be condensed into thick paste, is extraction medicinal liquid of the present invention;

embodiment 3: tablet

Adding starch, dextrin, magnesium stearate mixing by extracting in above-described embodiment in dry medicated powder, granulating, drying, sieve, be pressed into 1000, be tablet of the present invention.

embodiment 4: capsule

Adding starch, dextrin by extracting in above-described embodiment in dry medicated powder, mixing, granulate, sieving, fill 1000 capsules, be capsule of the present invention. embodiment 5: granuleadding dextrin, microcrystalline Cellulose, magnesium stearate, lactose, sucrose by extracting in above-described embodiment in dry medicated powder, granulation, granulate, to sieve, make granule, granule of the present invention. embodiment 6: oral liquidadd 400ml distilled water by extracting in above-described embodiment in medicinal liquid, sterilization, fill, makes 1000ml oral liquid, oral liquid of the present invention.

Present people's pressure becomes social life that is large, that add growing tension, and growth in the living standard, often stays up late, eats maror etc., and generally cause yin-Yang unbalance, endogenous fire is vigorous.The factor of inside lighting a fire is more much bigger than in the past.A lot of people thinks that getting angry is indisposition, has some medicine or self regulation just passable once.In fact get angry relatively lighter when having, can oneself regulate.But for some special populations such as old people or have underlying diseases as the people of cardiovascular disease or should arouse attention.

Therefore development of the present invention is faced with wide market, wherein contains great social benefit and huge economic benefit.

Claims (2)

1. a Chinese medicine preparation with heat clearing away and internal heat reducing effect, is characterized in that it is made up of the raw material comprising following dosage proportioning: Fructus Forsythiae 6 ~ 21%, Fructus Gardeniae 15 ~ 35%, Radix Scutellariae 5 ~ 20%, Radix Scrophulariae 10 ~ 30%, Rhizoma Coptidis 1 ~ 8%, Rhizoma Dioscoreae 4 ~ 18%..

2. the preparation method with the Chinese medicine preparation of heat clearing away and internal heat reducing effect according to claim 1, it is characterized in that the technological process of described preparation is: Fructus Forsythiae, Fructus Gardeniae, Radix Scutellariae, Radix Scrophulariae, Rhizoma Coptidis, Rhizoma Dioscoreae powder are broken into coarse powder, decoct with water three times, collecting decoction, filter, filtrate is condensed into the concentrated solution that relative density is 1.20-1.22, continue to be condensed into thick paste, differently can do bath, pulverize, sieve, be the dry medicated powder of extraction of the present invention; By adding starch, dextrin, microcrystalline Cellulose, magnesium stearate, lactose, sucrose, xanthan gum adjuvant, make granule, capsule, tablet.