CN1042172C - 多步免疫测定方法及其自动测量装置 - Google Patents
多步免疫测定方法及其自动测量装置 Download PDFInfo
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- G01N35/04—Details of the conveyor system
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- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
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- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
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- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
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- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- Automatic Analysis And Handling Materials Therefor (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
待测物质 | 试剂R1 | 试剂R2 | ||
hCG | Billes ESTAPOR-抗hCG单克隆抗体片段F(ab')1 | *0.1%ρ/v溶液 | PAL-抗hCG单克隆抗体片段F(ab')2 | **5毫克/升溶液 |
催乳激素 | Billes ESTAPOR-抗催乳激素单克隆抗体片段F(ab')2 | *0.1%ρ/v溶液 | PAL-抗催乳激素单克隆抗体片段F(ab')2 | **5毫克/升溶液 |
IOXO G | Billes ESTAPOR-抗弓形体病抗原 | *0.1%ρ/v溶液 | PAL-人体抗IgG.多克隆抗体 | **50微克/升溶液 |
风疹 | Billes ESTAPOR-弓形体病抗原 | *0.1%ρ/v溶液 | PAL-人体抗IgG多克隆抗体 | **50微克/升溶液 |
衣原体 | Bi lles ESTAPOR-衣原体抗原 | *0.1%ρ/v溶液 | PAL-人体抗IgG多克隆抗体 | **50微克/升溶液 |
TOXOM | Billes ESTAPOR-抗弓形体病单克隆抗体片段F(-ab') | *0.1%ρ/v溶液 | 由动物Ig标记的纯化弓体形病抗原-PAL | **20毫克/升溶液 |
物质 | 血清 | 清洗液 | 试剂1 试剂2 | PNPP | |
hcG催乳激素 | 10025 | 5050 | 300300 | 500500 | |
TOXO G风疹衣原体TOXOM | 10101010 | 50505050| | 300300300300 | 400400400400 | 500500500500 |
反应组件的位置 | hcG(管1)催乳激素(管2) | TOXO G(管3)TOXO M(管4)衣原体(管5)风诊 (管6) |
1486878889 | 加样品+清洗液加单试剂(R+R)予磁化磁化洗涤预磁化 | 加样品+清洗液加试剂R1予磁化磁化洗涤预磁化 |
反应组所转动90一圈 919293949596984828386878889反应组件转 90动第二圈 91929394959698反应组件转 82动第三圈 83 | 磁化洗涤预磁化磁化洗涤预磁化磁化加酶作用底物予磁化读结果 | 磁化洗涤预磁化磁化洗涤预磁化磁化加试剂R1预磁化磁化洗涤预磁化磁化洗涤预磁化磁化洗涤预磁化磁化加酶作用底物预磁化读结果 |
得出结果的时间 | 30分钟 | 47分钟 |
Claims (17)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8915095 | 1989-11-17 | ||
FR8915095A FR2654836B1 (fr) | 1989-11-17 | 1989-11-17 | Appareil d'execution automatique d'un immunodosage en plusieurs etapes successives d'au moins une substance biologique dans une pluralite d'echantillons biologiques, procede et reactif mettant en óoeuvre ledit appareil. |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1053682A CN1053682A (zh) | 1991-08-07 |
CN1042172C true CN1042172C (zh) | 1999-02-17 |
Family
ID=9387490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN90110354A Expired - Fee Related CN1042172C (zh) | 1989-11-17 | 1990-11-17 | 多步免疫测定方法及其自动测量装置 |
Country Status (16)
Country | Link |
---|---|
US (2) | US5559002A (zh) |
EP (2) | EP0679891A2 (zh) |
JP (1) | JP3142868B2 (zh) |
CN (1) | CN1042172C (zh) |
AT (1) | ATE133789T1 (zh) |
AU (1) | AU643732B2 (zh) |
CA (1) | CA2044588A1 (zh) |
DE (2) | DE69025175T2 (zh) |
DK (1) | DK0454826T3 (zh) |
ES (1) | ES2027631T3 (zh) |
FR (1) | FR2654836B1 (zh) |
GR (2) | GR920300051T1 (zh) |
IN (1) | IN171967B (zh) |
RU (1) | RU2102758C1 (zh) |
WO (1) | WO1991007662A1 (zh) |
ZA (1) | ZA909204B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100413594C (zh) * | 2003-06-04 | 2008-08-27 | 吉耐尔基因方案解决有限公司 | 生物材料处理装置 |
CN100427951C (zh) * | 2003-05-09 | 2008-10-22 | 财团法人工业技术研究院 | 分段收集液体的装置及其方法 |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2095785C (en) * | 1992-05-22 | 1996-12-24 | Johannes Jacobus Porte | Door-mounted wash station |
FR2695729B1 (fr) * | 1992-09-11 | 1994-11-04 | Biotrol Sa Lab | Appareil automatique de dosage immunologique. |
CA2180364A1 (fr) * | 1994-11-07 | 1996-05-17 | Michel Uzan | Appareil automatique de dosage immunologique |
FR2726652B1 (fr) * | 1994-11-07 | 1996-12-20 | Merck Clevenot Laboratoires | Appareil automatique de dosage immunologique |
GB9522056D0 (en) * | 1995-10-27 | 1996-01-03 | Dynatech Med Prod Ltd | Level sensor and washer unit |
DE69733927T2 (de) * | 1996-04-26 | 2006-05-24 | Dade Behring Inc., Deerfield | Verfahren und vorrichtung zur vorbehandlung von proben in einem chemischen analysator |
US6103193A (en) * | 1996-05-01 | 2000-08-15 | Sanko Junyaku Co., Ltd. | Automatic immunoassay method and apparatus |
FR2748569B1 (fr) * | 1996-05-07 | 1998-08-07 | Biocom Sa | Procede et installation de separation de particules magnetiques dans un fluide pour l'analyse biologique, et application dudit procede |
DE69638151D1 (de) * | 1996-05-20 | 2010-04-29 | Prec System Science Co Ltd | Prozess und apparat zur kontrolle magnetischer teilchen mit hilfe einer pipettier-maschine |
US5804436A (en) * | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
US6558916B2 (en) | 1996-08-02 | 2003-05-06 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time measurements of patient cellular responses |
US6280967B1 (en) | 1996-08-02 | 2001-08-28 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time of cellular responses |
FR2754599B1 (fr) | 1996-10-15 | 1998-12-04 | Merck Clevenot Laboratoires | Appareil automatique de dosage immunologique |
DE69818650T2 (de) | 1997-03-25 | 2004-08-12 | Immunivest Corp., Wilmington | Gerät und methoden zum einfnag und zur analyse von partikel-einheiten |
US6025189A (en) * | 1997-05-14 | 2000-02-15 | 3M Innovative Properties Company | Apparatus for reading a plurality of biological indicators |
US6833275B1 (en) * | 1997-07-22 | 2004-12-21 | Roche Diagnostics Gmbh | Gold conjugates containing detergent |
EP1340982B1 (en) | 1997-11-14 | 2009-10-21 | Gen-Probe Incorporated | Assay work station |
AU769762B2 (en) * | 1997-11-14 | 2004-02-05 | Gen-Probe Incorporated | A substance transfer device |
FR2783321B1 (fr) * | 1998-09-11 | 2000-11-24 | Biotrol Diagnostic | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
EP2000803A1 (en) | 1998-11-30 | 2008-12-10 | Nanosphere, Inc. | Nanoparticles with Polymer Shells |
US6312910B1 (en) | 1999-04-09 | 2001-11-06 | Shot, Inc. | Multistage electromagnetic separator for purifying cells, chemicals and protein structures |
US20020187133A1 (en) * | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
JP4141608B2 (ja) * | 2000-01-17 | 2008-08-27 | プレシジョン・システム・サイエンス株式会社 | 容器搬送処理システム |
US20030113740A1 (en) * | 2001-04-26 | 2003-06-19 | Mirkin Chad A. | Oligonucleotide-modified ROMP polymers and co-polymers |
GB0124341D0 (en) * | 2001-10-10 | 2001-11-28 | Randox Lab Ltd | Assay |
US20030232401A1 (en) * | 2002-06-12 | 2003-12-18 | Pugia Michael J. | Bacterial test method by glycated label binding |
FR2855614B1 (fr) | 2003-05-28 | 2005-07-08 | Biomerieux Sa | Systeme de controle de la temperature au sein d'un automate d'analyse biologique reduisant la variation thermique entre les temperatures d'entree et de sortie de l'air |
CN1793920B (zh) * | 2005-11-18 | 2010-11-10 | 中国海洋大学 | 一种全自动微藻分析仪 |
JP2009518655A (ja) * | 2005-12-08 | 2009-05-07 | パーカー・ハニフィン・コーポレーション | 分析用アプリケーションのためのシリンジ洗浄ステーション |
JP5094222B2 (ja) * | 2007-06-15 | 2012-12-12 | シスメックス株式会社 | 試料分析装置および試料分析方法 |
FR2934681B1 (fr) * | 2008-07-29 | 2011-09-30 | Bastien Karkouche | Dispositif pour la capture de particules biologiques et utilisation. |
FR2957672B1 (fr) * | 2010-03-22 | 2013-03-15 | Novacyt | Procede automatique et automate de preparation et d'analyse d'une pluralite de suspensions cellulaires |
KR101866844B1 (ko) * | 2010-07-23 | 2018-06-14 | 루미넥스 코포레이션 | 면역분석에서 시약의 반응성을 조절하기 위한 공동 결합 |
EP2690445B1 (en) * | 2011-03-25 | 2023-05-03 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Apparatus for automatic analysis and sample analysis method thereof |
WO2013099660A1 (ja) | 2011-12-26 | 2013-07-04 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料分注プローブ洗浄方法 |
JP5977085B2 (ja) * | 2012-01-12 | 2016-08-24 | 株式会社ユニフレックス | ベッセル洗浄装置 |
CN114137240A (zh) | 2013-03-15 | 2022-03-04 | 雅培制药有限公司 | 具有后面可进入轨道系统的自动化诊断分析仪及相关方法 |
ES2934684T3 (es) | 2013-03-15 | 2023-02-24 | Abbott Lab | Analizadores de diagnóstico automatizados que tienen carruseles dispuestos verticalmente y métodos relacionados |
WO2014149118A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
ES2724537T3 (es) * | 2013-12-03 | 2019-09-11 | Immunodiagnostic Systems Ltd | Procedimiento para cuantificar un analito, y un dispositivo analítico automático configurado para poner en práctica dicho procedimiento |
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WO2020076659A1 (en) * | 2018-10-08 | 2020-04-16 | Accure Health Inc. | Automated assay processing methods and systems |
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CA3162684A1 (en) * | 2020-02-27 | 2021-09-02 | Molarray Research Inc. | System and apparatus for automated sample extracting of biological specimens |
CN114001997A (zh) * | 2021-10-22 | 2022-02-01 | 广州检验检测认证集团有限公司 | 一种甲醛测试的取样清洗装置 |
CN114236129B (zh) * | 2021-12-20 | 2022-09-23 | 江苏集萃中科纳米科技有限公司 | 一种体外免疫诊断试剂背景发光处理系统 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4058367A (en) * | 1976-05-19 | 1977-11-15 | Gilford Instrument Laboratories Inc. | Automatic asynchronous fluid processing apparatus |
EP0216026A1 (en) * | 1985-06-26 | 1987-04-01 | Japan Tectron Instruments Corporation | Automatic analysis apparatus |
WO1988002866A1 (en) * | 1986-10-14 | 1988-04-21 | Serono Diagnostics Partners | Automated analytical apparatus for measuring antigens or antibodies in biological fluids |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4157323A (en) * | 1976-06-09 | 1979-06-05 | California Institute Of Technology | Metal containing polymeric functional microspheres |
US4169804A (en) * | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
US4265855A (en) * | 1978-11-03 | 1981-05-05 | Electro-Nucleonics, Inc. | System for performing immunochemical and other analyses involving phase separation |
US4335094A (en) * | 1979-01-26 | 1982-06-15 | Mosbach Klaus H | Magnetic polymer particles |
US4369226A (en) * | 1979-03-19 | 1983-01-18 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
EP0030087A1 (en) * | 1979-11-13 | 1981-06-10 | Technicon Instruments Company Limited | Immunoassay method and apparatus and kit for carrying out the method |
FR2480764B1 (fr) * | 1980-04-18 | 1985-10-04 | Rhone Poulenc Spec Chim | Latex de polymeres magnetiques et procede de preparation |
NZ201901A (en) * | 1981-09-25 | 1986-11-12 | Commw Serum Lab Commission | An apparatus suitable for performing automated heterogeneous immunoassays in a plurality of samples |
US4628037A (en) * | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4624923A (en) * | 1984-06-08 | 1986-11-25 | Yeda Research And Development Company Limited | Metal-coated polyaldehyde microspheres |
GB8501671D0 (en) * | 1985-01-23 | 1985-02-27 | Allen G J | Immunoassay |
GB8507706D0 (en) * | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
FI851702A0 (fi) * | 1985-04-29 | 1985-04-29 | Labsystems Oy | Foerfarande och anordning foer utfoering immunobestaemningar. |
US5200270A (en) * | 1986-02-25 | 1993-04-06 | Toyo Soda Manufacturing Co., Ltd. | Carrier for a biologically active component for immunoassay or enzymatic reaction |
GB8614084D0 (en) * | 1986-06-10 | 1986-07-16 | Serono Diagnostics Ltd | Immunoassay |
US5091206A (en) * | 1987-10-26 | 1992-02-25 | Baxter Diagnostics Inc. | Process for producing magnetically responsive polymer particles and application thereof |
US5051238A (en) * | 1987-11-20 | 1991-09-24 | Hitachi, Ltd. | Automatic analyzing system |
US5147529A (en) * | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
US5104808A (en) * | 1988-08-26 | 1992-04-14 | Laska Paul F | Method and apparatus for effecting a plurality of assays on a plurality of samples in an automatic analytical device |
IE900688A1 (en) * | 1989-03-08 | 1991-02-13 | Becton Dickinson Co | Signal enhancement in magnetic immunoassay by inhibition of¹enzymatic catalysis |
-
1989
- 1989-11-17 FR FR8915095A patent/FR2654836B1/fr not_active Expired - Fee Related
-
1990
- 1990-11-16 DE DE69025175T patent/DE69025175T2/de not_active Expired - Fee Related
- 1990-11-16 AT AT90917219T patent/ATE133789T1/de not_active IP Right Cessation
- 1990-11-16 WO PCT/FR1990/000823 patent/WO1991007662A1/fr active IP Right Grant
- 1990-11-16 CA CA002044588A patent/CA2044588A1/en not_active Abandoned
- 1990-11-16 DE DE199090917219T patent/DE454826T1/de active Pending
- 1990-11-16 RU SU5001490A patent/RU2102758C1/ru active
- 1990-11-16 EP EP95110811A patent/EP0679891A2/fr not_active Withdrawn
- 1990-11-16 DK DK90917219.9T patent/DK0454826T3/da active
- 1990-11-16 ES ES90917219T patent/ES2027631T3/es not_active Expired - Lifetime
- 1990-11-16 AU AU67548/90A patent/AU643732B2/en not_active Ceased
- 1990-11-16 JP JP03500162A patent/JP3142868B2/ja not_active Expired - Fee Related
- 1990-11-16 EP EP90917219A patent/EP0454826B1/fr not_active Expired - Lifetime
- 1990-11-17 ZA ZA909204A patent/ZA909204B/xx unknown
- 1990-11-17 CN CN90110354A patent/CN1042172C/zh not_active Expired - Fee Related
-
1991
- 1991-01-01 IN IN2/MAS/91A patent/IN171967B/en unknown
-
1992
- 1992-08-31 GR GR92300051T patent/GR920300051T1/el unknown
-
1994
- 1994-01-10 US US08/179,543 patent/US5559002A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/463,812 patent/US5736413A/en not_active Expired - Fee Related
-
1996
- 1996-04-30 GR GR960401189T patent/GR3019803T3/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4058367A (en) * | 1976-05-19 | 1977-11-15 | Gilford Instrument Laboratories Inc. | Automatic asynchronous fluid processing apparatus |
EP0216026A1 (en) * | 1985-06-26 | 1987-04-01 | Japan Tectron Instruments Corporation | Automatic analysis apparatus |
WO1988002866A1 (en) * | 1986-10-14 | 1988-04-21 | Serono Diagnostics Partners | Automated analytical apparatus for measuring antigens or antibodies in biological fluids |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100427951C (zh) * | 2003-05-09 | 2008-10-22 | 财团法人工业技术研究院 | 分段收集液体的装置及其方法 |
CN100413594C (zh) * | 2003-06-04 | 2008-08-27 | 吉耐尔基因方案解决有限公司 | 生物材料处理装置 |
Also Published As
Publication number | Publication date |
---|---|
ATE133789T1 (de) | 1996-02-15 |
JPH04503117A (ja) | 1992-06-04 |
DE69025175D1 (de) | 1996-03-14 |
GR3019803T3 (en) | 1996-07-31 |
IN171967B (zh) | 1993-02-20 |
US5736413A (en) | 1998-04-07 |
AU643732B2 (en) | 1993-11-25 |
ES2027631T3 (es) | 1996-06-01 |
EP0679891A2 (fr) | 1995-11-02 |
ES2027631T1 (es) | 1992-06-16 |
CA2044588A1 (en) | 1991-05-18 |
DE69025175T2 (de) | 1996-09-12 |
EP0454826B1 (fr) | 1996-01-31 |
EP0679891A3 (zh) | 1995-11-29 |
WO1991007662A1 (fr) | 1991-05-30 |
FR2654836A1 (fr) | 1991-05-24 |
DE454826T1 (de) | 1992-04-09 |
DK0454826T3 (da) | 1996-05-28 |
JP3142868B2 (ja) | 2001-03-07 |
RU2102758C1 (ru) | 1998-01-20 |
AU6754890A (en) | 1991-06-13 |
FR2654836B1 (fr) | 1994-01-28 |
GR920300051T1 (en) | 1992-08-31 |
CN1053682A (zh) | 1991-08-07 |
EP0454826A1 (fr) | 1991-11-06 |
US5559002A (en) | 1996-09-24 |
ZA909204B (en) | 1991-09-25 |
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