CN104208603A - Traditional Chinese medicine for treating diabetes and preventing cardio-cerebrovascular complications and preparation method thereof - Google Patents
Traditional Chinese medicine for treating diabetes and preventing cardio-cerebrovascular complications and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating diabetes and preventing cardio-cerebrovascular complications. The traditional Chinese medicine is characterized by being composed of the following components having the functions of tonifying qi, activating blood, soothing the liver, nourishing the liver, freeing the channels, and activating the collaterals: radix astragali, Chinese angelica, kudzu vine root, ligusticum wallichii, white peony root, dried radix rehmanniae, red sage root, trichosanthes root, pseudostellaria root, corn silk, wolfberry, polygonatum kingianum, and dried ginger. The traditional Chinese medicine can effectively reduce the blood sugar and blood pressure, prevent fatty liver, modulate the blood fat and blood viscosity, and prevent the atherogenesis. Through the observation in clinic, it is found that the symptoms of thirst, glycosuria, palpitation, weakness, heat intolerance, and edema are prominently improved. The traditional Chinese medicine can reduce the blood sugar content, improves the glycosylated hemoglobin (HbAlc) value, has a total effective rate of 90%, does not have any adverse reaction, and has a satisfied clinical effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation its preparation method for the treatment of diabetes mellitus prevention cardiovascular and cerebrovascular complication.
Background technology
Diabetes are a kind of common chronic diseases, along with growth in the living standard over nearly 30 years, the increase of aged tendency of population and fat incidence rate, the sickness rate of diabetes is in ascendant trend year by year, number of the infected is only second to India, be world's diabetes second big countries, the epidemiologic data display of national 14 provinces and cities 300,000 people in 1980, the prevalence of diabetes is 6.09%.Research paper publish data according to " diabetes prevalence in Chinese population " that on March 26th, 2010, " New England Journal of Medicine " was published shows, at present the existing diabetics more than 9,400 ten thousand of China.Professor Ji Linong points out, diabetics number speedup rapidly increases inseparable with city " affluenza " crowd that urbanization process is accelerated, living standards of the people improve, unsound life style increases and causes of China over 10 years.This conclusion one covers 14 provinces and cities in the whole nation, and the investigation of age more than 20 years old 54240 people, final 47325 people finally complete investigation.This investigation also shows, and diabetes have started in the Chinese youngster of 20 years old to 39 years old popular, and the prevalence of this age bracket accounts for 3.2%, and diabetes number in ill early stage reaches 9.0% especially.These " wealth and rank " diabeticss from city all with metabolic diseases such as obesity, blood fat disorder and/or fatty livers, considerably increase the risk that cardiovascular disease complication occurs mostly.Data show, and China exceedes half diabetics and is attended by obesity simultaneously, or is attended by hypertension and blood fat disorder simultaneously.Research shows that the complication of diabetes is main causes that diabetics is lethal, disable, especially cardiovascular and cerebrovascular complication has become the topmost cause of death of diabetes (up to 75%), and the diabetics of about 70% is because cardiovascular disease needs hospitalization.The diabetics of new diagnosis may have chronic complicating diseases, wherein retinopathy 16.6%, Microalbuminuria 21%.The diabetic complication investigation display that domestic 4000 people participate in: merge lower limb nerve affection person and account for 38%, cataract accounts for 44%, Microalbuminuria accounts for 33%, and severe complication (mainly referring to myocardial infarction, cerebrovas-cularaccident, renal failure, blind and amputation) is 2%-7%.Along with the progress of diabetic duration, the incidence rate of various chronic complicating diseases also progressively increases.Current expert advocates and surmounts blood glucose center mode, and reduction insulin resistant and blood sugar lowering develop simultaneously, and the control of blood glucose, blood pressure, blood fat is laid equal stress on.
The present invention is attended by the patient of the diseases such as obesity, blood fat disorder, fatty liver, hypertension for type Ⅱdiabetes mellitus and establishes just, there is effect of inrigorating qi and promoting blood circulation, soothing the liver foster kidney, dredge the meridian passage, can effectively hypoglycemia, blood pressure, anti-fatty liver, and energy regulating blood lipoid and blood stickiness, atherosclerosis is formed.
By clinical observation, the present invention obviously can improve the thirsty polydipsia of diabetes patient, glycosuria, the symptoms such as nervous weak, To Be Protected from Heat, edema.Reduce sufferer blood glucose, improve glycolated hemoglobin (HbA1c) value: total effective rate reaches 90%, and do not find any obvious untoward reaction, clinical effectiveness is satisfied.At present, clinically to evident in efficacy, safety good, Chinese medicine preparation easy to use still for be badly in need of.After being contrasted by the similar medicine of the present invention and existing treatment diabetes and complication thereof, we think that curative effect of the present invention is reliable, and have one's own knack on prescription medicine, are the crystallizations of clinical experience for many years.Therefore, exploitation of the present invention is expected to provide a safety, ideal Chinese medicine preparation effective, cheap, easy to use for clinical, is expected to obtain good economical, societal benefits after applying.
Summary of the invention
The invention belongs to a kind of Chinese medicine preparation for the treatment of diabetes mellitus prevention cardiovascular and cerebrovascular complication, it is characterized in that the Chinese prescription of inrigorating qi and promoting blood circulation, soothing the liver foster kidney, dredge the meridian passage forms, comprise the Radix Astragali (12-36%), Radix Angelicae Sinensis (8-25%), Radix Puerariae (14-30%), Rhizoma Chuanxiong (3-25%), the Radix Paeoniae Alba (5-25%), the Radix Rehmanniae (6-25%), Radix Salviae Miltiorrhizae (5-25%), Radix Trichosanthis (5-22%), Radix Pseudostellariae (3-12%), Stigma Maydis (8-28%), Fructus Lycii (5-12%), Rhizoma Polygonati (4-13%), Rhizoma Zingiberis (4-25%).
Technical scheme of the present invention is: extract taste Chinese medicine each in the present invention, extracting solution concentrating under reduced pressure becomes concentrated solution; After concentrated solution is dried to extraction dry powder by distinct methods, by adding different auxiliary material respectively, can be made into the solid preparations such as granule, capsule, tablet; Can also will add appropriate distilled water in concentrated solution, water precipitating adds adjuvant and oral liquid made by antiseptic after filtering; Instill after concentrated solution can also being added proper amount of matrix mixing in condensed fluid, shrink cooling and make drop pill.The different auxiliary material that different dosage form of the present invention adds, does not affect clinical effectiveness of the present invention, and these adjuvants comprise the starch, microcrystalline Cellulose, magnesium stearate, dextrin, lactose, oligomeric xylose, antiseptic etc. that diabetes patient is suitable for.Therefore the present invention can meet the requirement of diabetics to different dosage form.
The object of this invention is to provide and a kind ofly treat diabetes and its cardiovascular and cerebrovascular complication had to the Chinese medicine preparation of obvious curative effects and control action.The Pharmacodynamics experimental result of this preparation shows: this preparation can make glycolated hemoglobin (HbA1c) decline 1%-2% and can make weight loss, reduce cardiovascular and cerebrovascular vessel resistance simultaneously, and patients' blood, heart rate, liver function, electrocardiogram indices are all had no adverse effect, and take and above index was improved significantly in more than three months.Use Granules in Treating patients with NIDDM 20 of the present invention example clinically, basic recovery 4 example, account for 20%, marked improvement 9 example, accounts for 45%, progressive 5 examples, 25%, total effective rate 90%.Tcm symptom improves total effective rate: edema 91.97%, shortness of breath and fatigue 77.8%, frequent micturition 87.1%, thirsty polydipsia 82.3%, cardiopalmus 76.78%, hyperhidrosis 80.15%, complexion 83%.Illustrate that the present invention obviously can improve diabetic symptom.Compare P<0.001 before and after the treatment of tcm symptom total mark value and have significant differences.14.65 ± 5.72 days average onset times, the shortest 5 days, most elder 23 days.After treatment, random plasma glucose, cholesterol, triglyceride, blood pressure have obvious decline (equal P<0.001).Also observe the impact of granule of the present invention on the safety indexes of Liver and kidney function in clinical experiment process simultaneously, find Non Apparent Abnormality change before and after treatment.Clinical taking in process has not reported gastrointestinal tract and other untoward reaction yet, illustrates that the present invention takes safety.
Prescription of the present invention, on the basis of above-mentioned 13 taste medicines, can also add other and have blood sugar lowering inrigorating qi and promoting blood circulation, the Chinese medicine of soothing the liver dissipating blood stasis.
Using method of the present invention: oral, every day three times, each 1-2 bag granule (or 2-4 capsules, or 2-4 sheet tablet, or 1-2 props up oral liquid, or 1-2 drop pill).It within 30 days, is a course for the treatment of.
embodiment 1
get Rhizoma Zingiberis 120g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues and Radix Astragali 700g, Radix Angelicae Sinensis 320g, Radix Rehmanniae 140g, Rhizoma Polygonati 120g, Stigma Maydis 240g, Radix Trichosanthis 200g, Fructus Lycii 120g, decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, and filtrate concentrates, adding ethanol in concentrated solution makes alcohol content reach 60%, precipitate with ethanol, cold preservation (-2 ~ 2 DEG C) 24 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.22 ~ 1.23(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 280g again, Radix Puerariae 600g, Radix Paeoniae Alba 200g, Radix Salviae Miltiorrhizae 360g, Radix Pseudostellariae 120g, adds 60% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filters, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.21 ~ 1.22; Separately get volatile oil inclusion complex 4.6g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 300ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 2get Rhizoma Zingiberis 180g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues and Radix Astragali 900g, Radix Angelicae Sinensis 280g, Radix Rehmanniae 160g, Rhizoma Polygonati 140g, Stigma Maydis 260g, Radix Trichosanthis 180g, Fructus Lycii 140g, decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, and filtrate concentrates, adding ethanol in concentrated solution makes alcohol content reach 70%, precipitate with ethanol, cold preservation (-2 ~ 2 DEG C) 24 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.22 ~ 1.23(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 220g again, Radix Puerariae 640g, Radix Paeoniae Alba 220g, Radix Salviae Miltiorrhizae 380g, Radix Pseudostellariae 140g, adds 75% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filters, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.21 ~ 1.22; Separately get volatile oil inclusion complex 6.2g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 400ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 3
Get Rhizoma Zingiberis 200g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues and Radix Astragali 800g, Radix Angelicae Sinensis 380g, Radix Rehmanniae 180g, Rhizoma Polygonati 160g, Stigma Maydis 280g, Radix Trichosanthis 220g, Fructus Lycii 160g, decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, and filtrate concentrates, adding ethanol in concentrated solution makes alcohol content reach 50%, precipitate with ethanol, cold preservation (-2 ~ 2 DEG C) 24 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.22 ~ 1.23(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 360g again, Radix Puerariae 880g, Radix Paeoniae Alba 240g, Radix Salviae Miltiorrhizae 400g, Radix Pseudostellariae 160g, adds 80% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filters, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.21 ~ 1.22; Separately get volatile oil inclusion complex 8.5g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 600ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 4
Add 130g starch, 20g microcrystalline Cellulose by the various embodiments described above in the dry medicated powder of any extract, mixing, granulate, dry, sieve, add 1.5g magnesium stearate, mixing, is pressed into 1000 and is Tablets.
embodiment 5: capsule
Add 180g starch by the various embodiments described above in the dry medicated powder of any extract, mixing, granulate, dry, sieve, fill 1000 capsules, be capsule of the present invention.
embodiment 6: granule
Add lactose 180g, dextrin 600g by the various embodiments described above in the dry medicated powder of any extract, granulate, granulate, sieves, and makes 1000g granule, is granule of the present invention.
embodiment 7: oral liquid
Add 0.3% sodium benzoate, 400ml distilled water by the various embodiments described above in the dry medicated powder of any extract, sterilization, fill, makes 1000ml oral liquid, is oral liquid of the present invention.
embodiment 8: drop pill
Add 300ml polyethylene glycol 6000 by the various embodiments described above in the dry medicated powder of any extract, make suspension, add liquid Paraffin, put into grinding tool, shrink condensation, make 1000 drop pill, be drop pill of the present invention.
According to formula of the present invention, the preparation of other dosage forms such as suspensoid can also be made.
Diabetes are one of China's frequently-occurring diseases, and in China, type 2 diabetes mellitus patient accounts for 93.7%, and type 1 diabetes patient accounts for 5.6%, and other types only account for 0.7%.The up-to-date epidemiological survey result of China shows, total patient of diabetes patient number reaches more than 9,200 ten thousand, and prediabetes number reaches more than 1.48 hundred million.IDF (IDF) up-to-date prediction world diabetes patient groups will press on towards 500,000,000 in the year two thousand thirty.The situation is tense for China's diabetes control.Family of the present invention acts on modern expert and advocates surmount blood glucose center mode, reduces insulin resistant and blood sugar lowering and develops simultaneously, the pattern that the control of blood glucose, blood pressure, blood fat is laid equal stress on, from Chinese medical discrimination theory, TCM theory links closely pathogenesis, giving consideration to both the incidental and fundamental, and flavour of a drug refine, compatibility is orderly, medicine letter power is special, is treatment type Ⅱdiabetes mellitus, depressed liver-energy dispersing and QI regulating, dredge the meridian passage, improves the good recipe of cardiovascular and cerebrovascular vessel health status.
Development of the present invention is faced with wide market, wherein contains great social benefit and huge economic benefit.
Claims (6)
1. treat a Chinese medicine preparation for diabetes mellitus prevention cardiovascular and cerebrovascular complication, it is characterized in that said preparation is made up of following raw material: the Radix Astragali, Radix Angelicae Sinensis, Radix Puerariae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Radix Pseudostellariae, Stigma Maydis, Fructus Lycii, Rhizoma Polygonati, Rhizoma Zingiberis.
2. there is the Chinese medicine preparation for the treatment of diabetes mellitus prevention cardiovascular and cerebrovascular complication as claimed in claim 1, it is characterized in that each Ingredient Amount is respectively: Radix Astragali 12-36%, Radix Angelicae Sinensis 8-25%, Radix Puerariae 14-30%, Rhizoma Chuanxiong 3-25%, Radix Paeoniae Alba 5-25%, Radix Rehmanniae 6-25%, Radix Salviae Miltiorrhizae 5-25%, Radix Trichosanthis 5-22%, Radix Pseudostellariae 3-12%, Stigma Maydis 8-28%, Fructus Lycii 5-12%, Rhizoma Polygonati 4-13%, Rhizoma Zingiberis 4-25%.
3. the Chinese medicine preparation with treatment diabetes mellitus prevention cardiovascular and cerebrovascular complication as described in claim 1,2, it is characterized in that making Chinese patent medicine, dosage form is the preparations such as oral tablet, granule, capsule, oral liquid, drop pill.
4. the preparation method with the Chinese medicine preparation for the treatment of diabetes mellitus prevention cardiovascular and cerebrovascular complication as described in claim 1,2,3, it is characterized in that the technological process of described preparation is: Rhizoma Zingiberis is extracted volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues and the Radix Astragali, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Polygonati, Stigma Maydis, Radix Trichosanthis, Fructus Lycii, decoct with water 2 times, each 1.5 hours, merge extractive liquid, filter, filtrate concentrates, and adds ethanol and make alcohol content reach 50 ~ 75% in concentrated solution, precipitate with ethanol, cold preservation 24 hours, filter, filtrate recycling ethanol is also condensed into the concentrated solution that relative density is 1.22 ~ 1.23; Get Rhizoma Chuanxiong, Radix Puerariae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Pseudostellariae again, add 60 ~ 80% ethanol extraction secondaries, 2 hours first times, second time 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.21 ~ 1.22; Separately get volatile oil inclusion complex, be ground into fine powder, sieve, mixing.
5. get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 300 ~ 600ml distilled water and make dissolving, water precipitating 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
6., by adding starch, dextrin, microcrystalline Cellulose, magnesium stearate, lactose, oligomeric xylose, antiseptic adjuvant, make granule, capsule, tablet, oral liquid, drop pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104605269A (en) * | 2015-03-04 | 2015-05-13 | 段英兰 | Healthy porridge conducive to people with diabetes and preparation method thereof |
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| CN101934030A (en) * | 2010-08-28 | 2011-01-05 | 郑沛 | Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934030A (en) * | 2010-08-28 | 2011-01-05 | 郑沛 | Medicinal composition for treating symptom-complex of excessive eating (diabetes) and method for preparing same |
Non-Patent Citations (1)
| Title |
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| 庞健丽，等: "糖尿病性冠心病中医用药特点及思路", 《中华中医药学刊》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104605269A (en) * | 2015-03-04 | 2015-05-13 | 段英兰 | Healthy porridge conducive to people with diabetes and preparation method thereof |
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Application publication date: 20141217 |