CN104225219A - Traditional Chinese medicine preparation for reducing blood fat and softening blood vessels and preparation method of traditional Chinese preparation - Google Patents
Traditional Chinese medicine preparation for reducing blood fat and softening blood vessels and preparation method of traditional Chinese preparation Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for reducing blood fat and softening blood vessels. The preparation is characterized that the preparation is a traditional Chinese medicine prepared from the following traditional Chinese medicines which have the functions of dissipating stasis, soothing the liver and tonifying qi and clearing and activating the channels and collaterals. The preparation according to the invention can be used for effectively reducing total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (LDL), can be used for reducing blood viscosity, softening blood vessels, enhancing blood circulation of coronary artery, resisting arrhythmia, preventing atherogenesis and preventing cerebral apoplexy and coronary heart disease. The total effective rate is 93.4%. Moreover, no remarkable adverse reactions are found, and the clinical effect is satisfactory.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation its preparation method of blood fat reducing vessel softening.
Background technology
Hyperlipidemia is a kind of systemic disease, and a large amount of research data shows, hyperlipidemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death independently important risk factor.In addition, hyperlipidemia is also the important risk factor promoting hypertension, impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.
Between nearly 20 years, the food consumption of people and diet structure there occurs very large change, and the most active effects brought thus is exactly that the sickness rate of hyperlipidemia constantly promotes, and progressively occurs becoming younger.City white collar rhythm of life is fast, and operating pressure is large, and diet is irregular, and lack motion, the people of about 40% is hyperlipidemia.According to statistics, China's hyperlipidemia number of patients is up to 1.6 hundred million, and expert estimates, in the middle of the adult in more than 30 years old, the whole nation, the sickness rate of hyperlipidemia is at about 10%-20%, and hyperlipemia number is up to 90,000,000.Investigation display, China has 250 ten thousand to 300 ten thousand people to die from cardiovascular diseases every year, and this kind of disease has become the major causes of death of harm China city and country population health.Talk about cardiovascular disease, a lot of people knows relevant with hypertension, but in fact, hides in our body, and what the moment threaten our vascular health also has more hidden, more severe " killer ", and it is exactly hyperlipidemia.Expert points out, dyslipidemia is one of important risk factor of the medium cardiovascular and cerebrovascular disease of coronary heart disease, heart infarction and ischemic cerebral apoplexy.
The present invention just for hyperlipidemia patient and establish, there is effect of removing blood stasis and activating blood flow, soothing the liver QI invigorating, dredge the meridian passage, can effectively by low total plasma cholesterol (TC), triglyceride (TG), high density lipoprotein (LDL), and blood stickiness can be reduced, vessel softening, strengthens coronary flow circulation, arrhythmia, atherosclerosis is formed, preventing brain stroke, coronary heart disease.
By clinical observation, the present invention obviously can improve hyperlipidemia patient vertigo and tinnitus, forgetful difficulty is slept, limb fiber crops are uncomfortable in chest, soreness of the waist and knees, and limb weighs the symptoms such as weak.Reduce sufferer blood fat, vessel softening function: total effective rate reaches 90%, and do not find any obvious untoward reaction, clinical effectiveness is satisfied.At present, clinically to evident in efficacy, safety good, Chinese medicine preparation easy to use still for be badly in need of.After being contrasted by the similar medicine of the present invention and existing treatment hyperlipidemia and complication thereof, we think that curative effect of the present invention is reliable, and have one's own knack on prescription medicine, are the crystallizations of clinical experience for many years.Therefore, exploitation of the present invention is expected to provide a safety, ideal Chinese medicine preparation effective, cheap, easy to use for clinical, is expected to obtain good economical, societal benefits after applying.
Summary of the invention
The invention belongs to a kind of Chinese medicine preparation of blood fat reducing vessel softening, it is characterized in that the Chinese prescription of removing blood stasis and activating blood flow, soothing the liver QI invigorating, dredge the meridian passage forms, comprise Cortex Cinnamomi (12-30%), Radix Salviae Miltiorrhizae (8-25%), Rhizoma Chuanxiong (14-36%), Radix Angelicae Sinensis (3-28%), Radix Pseudostellariae (5-25%), Radix Polygoni Multiflori Preparata (6-25%), Radix Salviae Miltiorrhizae (5-25%), Rhizoma Polygonati Odorati (5-26%), Folium Nelumbinis (8-28%).
Technical scheme of the present invention is: extract taste Chinese medicine each in the present invention, extracting solution concentrating under reduced pressure becomes concentrated solution; After concentrated solution is dried to extraction dry powder by distinct methods, by adding different auxiliary material respectively, can be made into the solid preparations such as granule, capsule, tablet; Can also will add appropriate distilled water in concentrated solution, water precipitating adds adjuvant and oral liquid made by antiseptic after filtering; Instill after concentrated solution can also being added proper amount of matrix mixing in condensed fluid, shrink cooling and make drop pill.The different auxiliary material that different dosage form of the present invention adds, does not affect clinical effectiveness of the present invention, and these adjuvants comprise the starch, microcrystalline Cellulose, magnesium stearate, dextrin, lactose, oligomeric xylose, antiseptic etc. that diabetes patient is suitable for.Therefore the present invention can meet the requirement of diabetics to different dosage form.
The object of this invention is to provide the Chinese medicine preparation that a kind of blood fat reducing vessel softening has obvious curative effects and control action.The Pharmacodynamics experimental result of this preparation shows: this preparation can make hyperlipidemic conditions obviously improve, vessel softening simultaneously, strengthen coronary flow circulation, reduce cardiovascular and cerebrovascular vessel resistance, and patients' blood, heart rate, liver function, electrocardiogram indices are all had no adverse effect.Use Granules in Treating hyperlipemic patients 30 of the present invention example clinically, basic recovery 14 example, account for 46.7%, marked improvement 11 example, accounts for 36.7%, progressive 3 examples, 10%, total effective rate 93.4%.Tcm symptom improves total effective rate: TC, TG reduce by 91.97%, HDL and reduce by 89.7%, dizzy 77.8%, limb fiber crops 87.1%, insomnia 76.78%, uncomfortable in chest 80.15%, complexion 83%.Illustrate that the present invention obviously can improve hypertension symptom.Compare P<0.001 before and after the treatment of tcm symptom total mark value and have significant differences.16.85 ± 7.82 days average onset times, the shortest 5 days, most elder 23 days.After treatment, TC has obvious decline (equal P<0.001), and TG obviously declines (equal P<0.001), and HDL declines obviously (P<0.003).Also observe the impact of granule of the present invention on the safety indexes of blood pressure, liver, kidney, cardiac function in clinical experiment process simultaneously, find Non Apparent Abnormality change before and after treatment.Clinical taking in process has not reported gastrointestinal tract and other untoward reaction yet, illustrates that the present invention takes safety.
Prescription of the present invention, on the basis of above-mentioned nine taste medicines, can also add other and have blood sugar lowering inrigorating qi and promoting blood circulation, the Chinese medicine of soothing the liver dissipating blood stasis.
Using method of the present invention: oral, every day three times, each 1-2 bag granule (or 2-4 capsules, or 2-4 sheet tablet, or 1-2 props up oral liquid, or 1-2 drop pill).It within 30 days, is a course for the treatment of.
embodiment 1
get Cortex Cinnamomi 120g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues
Radix Angelicae Sinensis 600g decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, filtrate concentrates, and adds ethanol and makes alcohol content reach 60%, precipitate with ethanol in concentrated solution, cold preservation (-2 ~ 2 DEG C) 24 hours, filters, filtrate recycling ethanol and to be condensed into relative density be 1.21 ~ 1.22(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 700g again, Radix Polygoni Multiflori Preparata 340g, Radix Pseudostellariae 120g, Radix Salviae Miltiorrhizae 360g, Rhizoma Polygonati Odorati 160g, Semen Cassiae 240g, Folium Nelumbinis 280g, add 60% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.22 ~ 1.23; Separately get volatile oil inclusion complex 4.6g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 200ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 2get Cortex Cinnamomi 180g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues
Radix Angelicae Sinensis 800g decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, filtrate concentrates, and adds ethanol and makes alcohol content reach 70%, precipitate with ethanol in concentrated solution, cold preservation (-2 ~ 2 DEG C) 24 hours, filters, filtrate recycling ethanol and to be condensed into relative density be 1.21 ~ 1.22(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 880g again, Radix Polygoni Multiflori Preparata 300g, Radix Pseudostellariae 140g, Radix Salviae Miltiorrhizae 380g, Rhizoma Polygonati Odorati 180g, Semen Cassiae 260g, Folium Nelumbinis 300g, add 75% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.22 ~ 1.23; Separately get volatile oil inclusion complex 6.2g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 300ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 3
Get Cortex Cinnamomi 200g, extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues
Radix Angelicae Sinensis 860g decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, filtrate concentrates, and adds ethanol and makes alcohol content reach 75%, precipitate with ethanol in concentrated solution, cold preservation (-2 ~ 2 DEG C) 24 hours, filters, filtrate recycling ethanol and to be condensed into relative density be 1.21 ~ 1.22(60 DEG C) concentrated solution; Get Rhizoma Chuanxiong 820g again, Radix Polygoni Multiflori Preparata 280g, Radix Pseudostellariae 160g, Radix Salviae Miltiorrhizae 320g, Rhizoma Polygonati Odorati 220g, Semen Cassiae 280g, Folium Nelumbinis 320g, add 80% ethanol extraction secondary, 2 hours first times, second time 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.22 ~ 1.23; Separately get volatile oil inclusion complex 8.5g, be ground into fine powder, sieve, mixing.Get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 500ml distilled water and make dissolving, water precipitating (-2 ~ 2 DEG C) 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
embodiment 4: tablet
Add 130g starch, 20g microcrystalline Cellulose by the various embodiments described above in the dry medicated powder of any extract, mixing, granulate, dry, sieve, add 1.5g magnesium stearate, mixing, is pressed into 1000 and is Tablets.
embodiment 5: capsule
Add 180g starch by the various embodiments described above in the dry medicated powder of any extract, mixing, granulate, dry, sieve, fill 1000 capsules, be capsule of the present invention.
embodiment 6: granule
Add lactose 180g, dextrin 600g by the various embodiments described above in the dry medicated powder of any extract, granulate, granulate, sieves, and makes 1000g granule, is granule of the present invention.
embodiment 7: oral liquid
Add 0.3% sodium benzoate, 400ml distilled water by the various embodiments described above in the dry medicated powder of any extract, sterilization, fill, makes 1000ml oral liquid, is oral liquid of the present invention.
According to formula of the present invention, the preparation of other dosage forms such as suspensoid, drop pill, syrup can also be made.
Hyperlipidemia is one of China's frequently-occurring disease, in China's people with hyperlipidemia, in the middle of the adult of state more than 30 years old, the sickness rate of hyperlipidemia is at about 10%-20%, a statistical data display, the annual morbidity of China's hyperlipidemia is 5,63/,100,000, and prevalence is 76,81/,100,000.According to statistics, more than nearly 3600 people of cardiovascular and cerebrovascular disease death toll that whole world every day causes because of hyperlipidemia, hypertension, cerebral infarction, apoplexy, heart infarction, hemiplegia that China causes because of hyperlipidemia every year, disable, lethal number rises with the speed of average annual growth 12%.
The present invention adopts Chinese medical discrimination therapy, and link closely pathogenesis, treating both the principal and secondary aspects of a disease, with removing blood stasis and activating blood flow, soothing the liver QI invigorating, dredge the meridian passage for principle for the treatment of, flavour of a drug refine, compatibility is orderly, medicine letter power is special, reduce blood fat, blood stickiness, vessel softening, strengthen coronary flow circulation, arrhythmia, atherosclerosis is formed, the good recipe of preventing brain stroke, coronary heart disease.
Development of the present invention is faced with wide market, wherein contains great social benefit and huge economic benefit.
Claims (6)
1. a Chinese medicine preparation for blood fat reducing vessel softening, is characterized in that said preparation is made up of following raw material: Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Folium Nelumbinis.
2. there is the Chinese medicine preparation of blood fat reducing vessel softening as claimed in claim 1, it is characterized in that each Ingredient Amount is respectively: Cortex Cinnamomi 12-30%, Radix Salviae Miltiorrhizae 8-25%, Rhizoma Chuanxiong 14-36%, Radix Angelicae Sinensis 3-28%, Radix Pseudostellariae 5-25%, Radix Polygoni Multiflori Preparata 6-25%, Radix Salviae Miltiorrhizae 5-25%, Rhizoma Polygonati Odorati 5-26%, Folium Nelumbinis 8-28%.
3. the Chinese medicine preparation with blood fat reducing vessel softening as described in claim 1,2, is characterized in that making Chinese patent medicine, and dosage form is the preparations such as oral tablet, granule, capsule, oral liquid, drop pill.
4. the preparation method with the Chinese medicine preparation of blood fat reducing vessel softening as described in claim 1,2,3, is characterized in that the technological process of described preparation is: get Cortex Cinnamomi, and extract volatile oil, volatile oil is drawn liquid beta-schardinger dextrin-inclusion becomes inclusion complex; Medicinal residues Radix Angelicae Sinensis decocts with water 2 times, each 1.5 hours, merge extractive liquid, filters, filtrate concentrates, and adds ethanol and makes alcohol content reach 60 ~ 75%, precipitate with ethanol in concentrated solution, cold preservation 24 hours, filter, filtrate recycling ethanol is also condensed into the concentrated solution that relative density is 1.21 ~ 1.22; Get Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Semen Cassiae, Folium Nelumbinis again, add 60 ~ 80% ethanol extraction secondaries, 2 hours first times, second time 1 hour, merge extractive liquid, filters, filtrate recycling ethanol, and the concentrated solution being condensed into that relative density is 1.22 ~ 1.23; Separately get volatile oil inclusion complex, be ground into fine powder, sieve, mixing.
5. get above-mentioned two kinds of concentrated solutions, merge, continue to be condensed into thick paste, dry, pulverize, add above-mentioned fine powder, evenly sieve, be the dry medicated powder of extraction of the present invention; Or get above-mentioned two kinds of concentrated solutions merging, add above-mentioned fine powder, add 200 ~ 500ml distilled water and make dissolving, water precipitating 24 hours, filter, filtrate is the present invention and extracts medicinal liquid.
6., by adding starch, dextrin, microcrystalline Cellulose, magnesium stearate, lactose, oligomeric xylose, antiseptic adjuvant, make granule, capsule, tablet, oral liquid, drop pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017180174A1 (en) * | 2016-04-15 | 2017-10-19 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297917A (en) * | 2008-06-16 | 2008-11-05 | 广东宏兴集团股份有限公司宏兴制药厂 | Chinese medicinal composition for treating hyperlipemia and preparation thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297917A (en) * | 2008-06-16 | 2008-11-05 | 广东宏兴集团股份有限公司宏兴制药厂 | Chinese medicinal composition for treating hyperlipemia and preparation thereof |
Non-Patent Citations (1)
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| 良石: "《高血脂患者宜与忌》", 31 August 2008 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017180174A1 (en) * | 2016-04-15 | 2017-10-19 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
| US9913871B2 (en) | 2016-04-15 | 2018-03-13 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
| US9919018B2 (en) | 2016-04-15 | 2018-03-20 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
| US10357527B2 (en) | 2016-04-15 | 2019-07-23 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
| US11419909B2 (en) | 2016-04-15 | 2022-08-23 | Fairhaven Health, Llc | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
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