CN104206917A - Weaned pig feed containing D-ribose feed additive - Google Patents

Weaned pig feed containing D-ribose feed additive Download PDF

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Publication number
CN104206917A
CN104206917A CN201410489029.0A CN201410489029A CN104206917A CN 104206917 A CN104206917 A CN 104206917A CN 201410489029 A CN201410489029 A CN 201410489029A CN 104206917 A CN104206917 A CN 104206917A
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ribose
feed
vitamin
weanling pig
additive
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CN201410489029.0A
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Inventor
高曙光
付石军
范晓明
王娟
吕晓楠
王晓亮
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SHANDONG BINZHOU ZHISHENG SCIENCE & TECHNOLOGY INNOVATION PROMOTION CENTER
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SHANDONG BINZHOU ZHISHENG SCIENCE & TECHNOLOGY INNOVATION PROMOTION CENTER
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Priority to CN201410489029.0A priority Critical patent/CN104206917A/en
Publication of CN104206917A publication Critical patent/CN104206917A/en
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Abstract

The invention relates to a weaned pig feed containing a D-ribose feed additive. The feed is characterized by further comprising the following main raw material components: corn, bean pulp, fish meal, yeast powder, calcium hydrophosphate, shell powder, soybean oil and salt. Microelement premix and the D-ribose feed additive are further added in the main raw materials. The D-ribose additive comprises D-ribose, bran, corncob powder, medical stone and high-calcium stone powder. The premix comprises vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin 20, d-pantothenic acid, biotin, folic acid, Cu, Fe, Zn, Mn, Co, Se and iodine. By adjusting the main feed recipe and adding the D-ribose feed additive and the premix microelement in the main feed, the microbial flora balance in an animal body is improved, and the proliferative activity of intestinal bifidobacterium is promoted selectively, so that the daily gain and the propagation performance of weaned pigs are improved.

Description

A kind of weanling pig feed that contains D-ribose feed addictive
Technical field
The present invention relates to weanling pig field of feed, be specifically related to a kind of weanling pig feed that contains D-ribose feed addictive.
Background technology
Huge contribution has been made in the development that antibiotic extensive use was once produced to herding, feeding antibiotic can suppress the logical interior harmful microbe growth and reproduction of livestock and poultry digestion, reduce the consumption of endotrophic material, promote the breeding of the profitable strain of the essential nutriment of synthetic animal in alimentary canal, make the synthetic increase of nutriment, suppress or kill some pathogenic microorganism, the resistance against diseases that strengthens livestock and poultry, prevents disease, makes the attenuation of intestines wall, thereby the infiltration of favourable nutrient and absorption, improve a poor appetite.But, antibiotic being applied in when bringing the very big interests of people, its abuse has also brought increasing trouble to the mankind, abuse of antibiotics meeting makes bacterium develop immunity to drugs, use for a long time antibiotic to cause the immunity degradation of livestock and poultry body, thereby the inoculation of vaccine is produced harmful effect, can cause livestock and poultry autogenous infection, use antibiotic also can cause residual at livestock products and environment for a long time for a long time with antibiotic.
D-ribose (D-ribose) is a kind of pentose, is mRNA, tRNA, the composition sugar of the various RNA such as rRNA, is also the composition sugar of various nucleotide coenzymes, is again reduced form inducer, ribose and phosphoric acid in vivo together with running, there is very important physiological action.Can be compared with glucose in physiological importance.Its molecular formula is C 5h 10o 5, relative molecular weight 150.13, fusing point 86-87 DEG C.Sterling D-ribose is white crystalline powder, and the very easily moisture absorption is water-soluble, is slightly soluble in ethanol, is insoluble to ether, propiophenone and chloroform etc.
D-ribose can be converted into nucleotides freshener and riboflavin, is applied to pharmacy, medicine, cosmetics, healthy food and animal feed aspect.In recent years, the development of nucleic acid drug, driven by D-ribose synthetic antiviral, the research of antitumor nucleotides medicine.D-ribose also can be used for treating myocardial ischemia, improves heart to ischemic patience and improves cardiac function, and for lacking adenylate, what dehydrogenase caused is tetanic hard, and because in cell, lacks the myalgia that phosphorylation causes.F-methylinosine phosphoric acid is that a kind of purine derivative of being prepared by D-ribose can weaken the immunosuppressive action that human immunodeficiency virus causes, and some ameliorative nucleotides are antiviral all to be synthesized by ribose with anticancer preparation.The 2-vinyl iodide being derived by D-ribose can change into taxol and homologue thereof, is the active drug of the newborn nest cancer for the treatment of.
In modern pig industry, early weaning piglet is owing to having the advantage such as production effect, nutritional need, reduction feeding cost that improves sow, and obtains promotion and application widely.But early weaning piglet stress cause piglet functional disturbances of gastrointestinal tract, bring out early weaning piglet syndrome, cause piglet growth to slow down or stagnate, even dead, the stress of baby pigs caused ablaction syndrome causing thus increases, and has all brought huge negative effect also to piglet growth and Swine Production simultaneously.Therefore, research stress of baby pigs caused ablaction and adopt rationally effectively prevention and control measure to promote pig industry even the development of animal husbandry have great importance, and before the application there are no D-ribose additive research and the relevant report for weanling pig feed.
Summary of the invention
Technical problem to be solved by this invention, be exactly for the deficiencies in the prior art, and a kind of weanling pig feed that contains D-ribose feed addictive providing, by adjusting staple food grain formula, and in staple food grain, add D-ribose feed addictive and increase premix trace element, improve microorganism species balance in animal body, optionally promote the proliferation activity of intestinal bifidobacteria, thereby improve weanling pig daily gain and production performance.
The solution of the present invention is achieved by the following technical measures:
A kind of weanling pig feed that contains D-ribose feed addictive, it is characterized in that: this weanling pig feed comprises following primary raw material component: corn, dregs of beans, fish meal, dusty yeast, calcium monohydrogen phosphate, oyster shell whiting, soya-bean oil, salt are also added with microelement pre-mix material and D-ribose additive in above primary raw material.
Described this weanling pig feed comprises following raw material by weight: corn 60%~70%, dregs of beans 15%~25%, fish meal 5%~10%, dusty yeast 1%~5%, calcium monohydrogen phosphate 1%~5%, oyster shell whiting 0.1%~1.5%, soya-bean oil 1%~5%, salt 0.1%~1.5%, microelement pre-mix material 0.5%~5%, D-ribose additive is by adding 200mg~500mg in every kilogram of above-mentioned feed.
In above-described microelement pre-mix material, comprise vitamin A, neo dohyfral D3, vitamin E, prokayvit, vitamin B1, vitamin B2, pyridoxamine, cobalamin, nicotinic acid 20, d-pantothenic acid, biotin, folic acid, Cu, Fe, Zn, Mn, Co, Se, iodine.
In above-described microelement pre-mix material, comprise cost by containing vitamin A 2000~2500IU in every kilogram of feed, neo dohyfral D3 200~250IU, vitamin E 15~20mg, prokayvit 0.3~0.8mg, vitamin B1 1~2mg, vitamin B2 3.0~5.0mg, pyridoxamine 1.0~3.0mg, cobalamin 0.01~0.03mg, nicotinic acid 16~25mg, d-pantothenic acid 10~15mg, biotin 0.05~1.00mg, folic acid 0.10~0.50 mg, Cu 150~250mg, Fe 100~150mg, Zn 30~80mg, Mn 30~70mg, Co 1.0~5.0 mg, Se 0.1~0.5mg, iodine 0.30~0.60 mg.
Above-described D-ribose additive comprises D-ribose, wheat bran, maize cob meal, medical stone, high calcium stone flour.
In above-described D-ribose additive, composition comprises by weight: D-ribose 40%~55%, wheat bran 8%~15%, maize cob meal 8%~18%, medical stone 5%~15%, high calcium stone flour 10%~20%.
The formulation that above-described D-ribose additive can be made into is tablet, capsule, granule, oral liquid.
The trophic level of the above this weanling pig feed is: crude protein 18.00%~22%, calcium 1.00%~3%, available phosphorus 0.50%~1.00%, lysine 1.00%~3.00%.
Useful technique effect of the present invention is: weanling pig feed of the present invention optionally promotes the propagation of gut flora, improve microorganism species balance in poultry body, promote beneficial bacterium breeding in animal alimentary canal, suppress harmful bacteria growth, reduce the incidence of disease of Other diseases, promote growth.Pollution-free, have no side effect, noresidue, can disease resistance, improve food utilization efficiency, can increase substantially again the production performance of poultry.And supplementary material is easy to obtain, preparation technology is simple, being beneficial to extension and producing.
D-ribose is a kind of pentose being present in all living cells, it is the important composition material of inhereditary material nucleic acid in organism, there is substantial connection with the formation of adenylate and the regeneration of ATP, can enter into the salvage route of ATP, create condition for generating rapidly ATP, it is one of the most basic energy source of life metabolism, in heart and muscle metabolism, play a crucial role, can promote the recovery of local organization ischemic, anoxic, play and supplement weanling pig energy i (in vivo), fatigue-relieving, effect of rear antisecosis time of shortening campaign.
Detailed description of the invention
For clearly demonstrating the present invention program's technical characterstic, below in conjunction with specific embodiment, the present invention is set forth, but described embodiment to be not as a limitation of the invention, protection scope of the present invention is as the criterion with claims.
(1) preparation of D-ribose additive
Embodiment 1:
In every 100g feed addictive, contain: D-ribose 55g, wheat bran 10g, maize cob meal 8g, medical stone 10g, high calcium stone flour 17g pulverizes above material in pulverizer, crosses 60 mesh sieves, evenly mixes according to described weight, makes feed addictive.
Embodiment 2:
In every 100g feed addictive, contain: D-ribose 40g, wheat bran 15g, maize cob meal 15g, medical stone 15g, high calcium stone flour 15g pulverizes above material in pulverizer, crosses 60 mesh sieves, evenly mixes according to described weight, makes feed addictive.
Embodiment 3:
In every 100g feed addictive, contain: D-ribose 50g, wheat bran 17g, maize cob meal 13g, medical stone: 8g, high calcium stone flour 12g.Above material is pulverized in pulverizer, crossed 60 mesh sieves, evenly mix according to described weight, make feed addictive.(2) application of feed of the present invention on weanling pig
1, experiment purpose
The impact of research D-ribose on Growth Performance of Weaning Piglets and Biochemical Indices In Serum.
2, experimental animal and experimental design
192 of the young boars of 28 ± 2 age in days wean " Du × long × large " are chosen in test, are divided at random 4 groups, every group of 6 repetitions, 8 pigs of every repetition, the 4 kinds of daily rations of feeding respectively: (1) basal diet (control group); (2) basal diet+200mgD-ribose additive/kg basal diet; (3) basal diet+300mgD-ribose additive/kg basal diet; (4) basal diet+500mgD-ribose additive/kg basal diet.Experimental basis Diet Formula and trophic level are in table 1, and testing material is powder.Each subfield that repeats is fed, and records just starting weight of piglet, and piglet starting weight Analysis of variance difference is not remarkable.
Table 1 basal diet formula and trophic level
The metabolizable energy of above daily ration is 13.89MJ/kg.
Note: microelement pre-mix material (every kg feed) contains: vitamin A 2200 IU; Neo dohyfral D3 220IU; Vitamin E 16mg; Prokayvit 0.50 mg; Vitamin B1 1.50 mg; Vitamin B2 4.00 mg; Pyridoxamine 2.0 mg; Cobalamin 0.020 mg; Nicotinic acid 20 mg; D-pantothenic acid 12.00 mg; Biotin 0.08mg; Folic acid 0.30 mg; Cu 200 mg; Fe 120 mg; Zn 50 mg; Mn 50mg; Co 2.0 mg; Se 0.3 mg; Iodine 0.45 mg.
3, feeding and management
Test is carried out in same closed standard pig house, examination pig free choice feeding and drinking-water.Immunity disinfectant program is undertaken by pig farm conventional method.Test is responsible for by special messenger, manages in strict accordance with test requirements document.Feeding and management is carried out with reference to the feeding and management code of this product boar.Pig is entered behind hurdle with basal diet 7 d that feed, and the formal test time is 28 d.
4, production performance index
When experiment starts and finishes, piglet on an empty stomach after 12 h in the morning next day individuality weigh, record in detail each group of feed intake, calculate the average daily gain (ADG) of each processed group, average daily ingestion amount (ADFI) and feedstuff-meat ratio (F/G).
5, diarrhea rate
Record in detail each repetition grice diarrhoea situation, calculate diarrhea rate, computing formula is as follows:
Diarrhea frequency=(diarrhoea piglet × diarrhoea number of days)/(test piglet number × test number of days) × 100%
6, Biochemical Indices In Serum
Experiment finishes, and on an empty stomach 12 h of piglet often repeat to choose 1, and vena cava anterior blood sampling, for measuring Biochemical Indices In Serum.Blood sample leaves standstill 0.5 h, centrifugal 10 min of 3000 r/min, separation of serum in 37 DEG C.Total serum protein (TP), T-CHOL (TC), triglycerides (TG), HDL (HDL), glutamic-pyruvic transaminase (GPT), glutamic-oxalacetic transaminease (GOT) content adopt full-automatic biochemical analyzer to measure.
7, data statistic analysis
Test data is carried out preliminary treatment with Excel, adopts SPSS 13 softwares to add up, and carries out significance test of difference and multiple ratio with the one-factor analysis of variance, and result represents with average ± standard error.
8, results and analysis
(1) impact of D-ribose on Growth Performance of Weaning Piglets and diarrhea rate
The impact of table 2 D-ribose on piglet growth performance and diarrhea rate
Note: colleague's lowercase difference represents significant difference (P<O.05).
As shown in Table 2, with control group comparison, in daily ration, add the D-ribose average daily gain (P<0.05) that has been significantly increased, reduced diarrhea rate (P<0.05).Average daily ingestion amount and the control group of 200 mg/kg D-ribose interpolation groups relatively significantly improve (P<0.05), and are significantly higher than 300 mg/kg, 500 mg/kg D-ribose interpolation group (P (O.05).Result shows, the D-ribose that daily ration adds certain level can significantly affect piglet daily gain, feed intake, feed conversion rate and diarrhoea situation.
(2) impact of D-ribose on weanling pig Biochemical Indices In Serum
The impact of table 3 D-ribose on weanling pig biochemical indicator
Note: with representing significant difference (P<0.05) after column data between different lowercases.
From table 3,200mg/kg group, 300mg/kg group total protein content and control group reduce more respectively 6.7%(P<O.05), 5.9%(P>0.05); 500mg/kg group total protein content and control group relatively improve 1.4% (P>O.05), and are significantly higher than 200mg/kg group and 300mg/kg group (P<O.05).With control group comparison, add 500mg/kg group and significantly reduced T-CHOL and triglyceride concentration (P<0.05), between 200mg/kg group and 300mg/kg group without significant difference (P>0.05).200mg/kg group hdl concentration is significantly higher than control group and 300mg/kg group (P<O.05).Between each group, glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease content are without significant difference (P>0.05).The D-ribose that shows daily ration interpolation certain level significantly affects piglet protein metabolism, and lipid (T-CHOL, triglycerides) metabolism, and the D-ribose of high dose has promotion same-action to improving piglet the Total albumen content.

Claims (8)

1. a weanling pig feed that contains D-ribose feed addictive, it is characterized in that: this weanling pig feed comprises following primary raw material component: corn, dregs of beans, fish meal, dusty yeast, calcium monohydrogen phosphate, oyster shell whiting, soya-bean oil, salt are also added with microelement pre-mix material and D-ribose additive in above primary raw material.
2. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 1, it is characterized in that, this weanling pig feed comprises following raw material by weight: corn 60%~70%, dregs of beans 15%~25%, fish meal 5%~10%, dusty yeast 1%~5%, calcium monohydrogen phosphate 1%~5%, oyster shell whiting 0.1%~1.5%, soya-bean oil 1%~5%, salt 0.1%~1.5%, microelement pre-mix material 0.5%~5%, D-ribose additive is by adding 200mg~500mg in every kilogram of above-mentioned feed.
3. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 1 and 2, is characterized in that comprising vitamin A, neo dohyfral D3, vitamin E, prokayvit, vitamin B1, vitamin B2, pyridoxamine, cobalamin, nicotinic acid 20, d-pantothenic acid, biotin, folic acid, Cu, Fe, Zn, Mn, Co, Se, iodine in described microelement pre-mix material.
4. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 3, it is characterized in that: in described microelement pre-mix material, comprise cost by containing vitamin A 2000~2500IU in every kilogram of feed, neo dohyfral D3 200~250IU, vitamin E 15~20mg, prokayvit 0.3~0.8mg, vitamin B1 1~2mg, vitamin B2 3.0~5.0mg, pyridoxamine 1.0~3.0mg, cobalamin 0.01~0.03mg, nicotinic acid 16~25mg, d-pantothenic acid 10~15mg, biotin 0.05~1.00mg, folic acid 0.10~0.50 mg, Cu 150~250mg, Fe 100~150mg, Zn 30~80mg, Mn 30~70mg, Co 1.0~5.0 mg, Se 0.1~0.5mg, iodine 0.30~0.60 mg.
5. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 1 and 2, is characterized in that: described D-ribose additive comprises D-ribose, wheat bran, maize cob meal, medical stone, high calcium stone flour.
6. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 5, is characterized in that in described D-ribose additive, composition comprises by weight: D-ribose 40%~55%, wheat bran 8%~15%, maize cob meal 8%~18%, medical stone 5%~15%, high calcium stone flour 10%~20%.
7. according to a kind of weanling pig feed that contains D-ribose feed addictive described in claim 1 or 2 or 6, it is characterized in that: the formulation that described D-ribose additive can be made into is tablet, capsule, granule, oral liquid.
8. a kind of weanling pig feed that contains D-ribose feed addictive according to claim 1 and 2, is characterized in that the trophic level of this weanling pig feed is: crude protein 18.00%~22%, calcium 1.00%~3%, available phosphorus 0.50%~1.00%, lysine 1.00%~3.00%.
CN201410489029.0A 2014-09-23 2014-09-23 Weaned pig feed containing D-ribose feed additive Pending CN104206917A (en)

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CN106805243A (en) * 2017-02-28 2017-06-09 吉林省清评科技有限公司 A kind of high-valued method of comprehensive utilization of Ginseng under Forest
CN107950750A (en) * 2017-11-24 2018-04-24 定远县金胜农业开发有限公司 A kind of mixed feed that can improve meat quality without antibiotic

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CN106306456A (en) * 2016-08-17 2017-01-11 严铭 Pig feed
CN106805243A (en) * 2017-02-28 2017-06-09 吉林省清评科技有限公司 A kind of high-valued method of comprehensive utilization of Ginseng under Forest
CN107950750A (en) * 2017-11-24 2018-04-24 定远县金胜农业开发有限公司 A kind of mixed feed that can improve meat quality without antibiotic

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Application publication date: 20141217