CN104203926B - 新类型的二氮杂*衍生物螯合剂及作为mri造影剂的其与顺磁性金属的配合物 - Google Patents

新类型的二氮杂*衍生物螯合剂及作为mri造影剂的其与顺磁性金属的配合物 Download PDF

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Publication number
CN104203926B
CN104203926B CN201380014181.7A CN201380014181A CN104203926B CN 104203926 B CN104203926 B CN 104203926B CN 201380014181 A CN201380014181 A CN 201380014181A CN 104203926 B CN104203926 B CN 104203926B
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Chinese (zh)
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CN104203926A (zh
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A·马约基
M·维西加利
L·贝尔特拉米
L·西尼
L·拉图阿达
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Bracco Imaging SpA
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Bracco Imaging SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380014181.7A 2012-03-14 2013-03-13 新类型的二氮杂*衍生物螯合剂及作为mri造影剂的其与顺磁性金属的配合物 Active CN104203926B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12159378.4 2012-03-14
EP12159378.4A EP2639227A1 (en) 2012-03-14 2012-03-14 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
PCT/EP2013/055094 WO2013135750A1 (en) 2012-03-14 2013-03-13 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents

Publications (2)

Publication Number Publication Date
CN104203926A CN104203926A (zh) 2014-12-10
CN104203926B true CN104203926B (zh) 2017-12-15

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CN201380014181.7A Active CN104203926B (zh) 2012-03-14 2013-03-13 新类型的二氮杂*衍生物螯合剂及作为mri造影剂的其与顺磁性金属的配合物

Country Status (7)

Country Link
US (1) US9259491B2 (enExample)
EP (2) EP2639227A1 (enExample)
JP (1) JP6375231B2 (enExample)
CN (1) CN104203926B (enExample)
AU (1) AU2013231301B2 (enExample)
CA (1) CA2863784C (enExample)
WO (1) WO2013135750A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6251744B2 (ja) * 2012-09-07 2017-12-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． ＭＲＩ用の両親媒性錯体を含む常磁性固体脂質ナノ粒子（ｐＳＬＮ）
CN105377309A (zh) 2013-05-30 2016-03-02 伯拉考成像股份公司 荧光固体脂质纳米颗粒组合物及其制备
WO2017137477A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
DE102017129405A1 (de) 2017-12-11 2019-06-13 Universitätsklinikum Jena Neue DAZA-Chelatoren als Liganden in der Leberbildgebung
CN112996764B (zh) 2018-11-12 2023-11-21 伯拉考成像股份公司 螯合aazta缀合物及其配合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302370A (en) * 1989-09-11 1994-04-12 Institut Fur Diagnostikforschung Gmbh Chelating agents for forming complexes with radioactive isotopes, metal complexes thereof and use thereof in diagnosis and therapy
CN101233117A (zh) * 2005-06-24 2008-07-30 伯拉考成像股份公司 能够与金属离子配合的多齿氮杂配体及其在诊断和治疗中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
EP1105162A1 (en) * 1998-08-10 2001-06-13 Bracco Research S.A. Combination of a positive mri contrast agent with a negative mri contrast agent
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
FR2795412B1 (fr) * 1999-06-23 2001-07-13 Adir Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ITMI20011518A1 (it) 2001-07-17 2003-01-17 Bracco Imaging Spa Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
GB0305422D0 (en) * 2003-03-10 2003-04-16 Univ Open Detection, monitoring and treatment of cancer
US7988950B2 (en) * 2004-07-02 2011-08-02 Bracco Imaging S.P.A. Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (MRI) which contain a chelating moiety with polyhydroxylated substituents
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
FR2939318B1 (fr) * 2008-12-10 2012-07-13 Guerbet Sa Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302370A (en) * 1989-09-11 1994-04-12 Institut Fur Diagnostikforschung Gmbh Chelating agents for forming complexes with radioactive isotopes, metal complexes thereof and use thereof in diagnosis and therapy
EP0417870B1 (de) * 1989-09-11 1994-07-20 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Chelatbildner zur Komplexierung von radioaktiven Isotopen, deren Metallkomplexe sowie ihre Verwendung in Diagnostik und Therapie
CN101233117A (zh) * 2005-06-24 2008-07-30 伯拉考成像股份公司 能够与金属离子配合的多齿氮杂配体及其在诊断和治疗中的应用

Also Published As

Publication number Publication date
EP2639227A1 (en) 2013-09-18
US9259491B2 (en) 2016-02-16
US20150037261A1 (en) 2015-02-05
WO2013135750A1 (en) 2013-09-19
JP6375231B2 (ja) 2018-08-15
AU2013231301A1 (en) 2014-08-28
EP2834222B1 (en) 2016-03-09
JP2015509966A (ja) 2015-04-02
CA2863784C (en) 2018-04-17
CN104203926A (zh) 2014-12-10
CA2863784A1 (en) 2013-09-19
AU2013231301B2 (en) 2017-01-05
EP2834222A1 (en) 2015-02-11

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