CA2863784C - A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents - Google Patents

A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents Download PDF

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Publication number
CA2863784C
CA2863784C CA2863784A CA2863784A CA2863784C CA 2863784 C CA2863784 C CA 2863784C CA 2863784 A CA2863784 A CA 2863784A CA 2863784 A CA2863784 A CA 2863784A CA 2863784 C CA2863784 C CA 2863784C
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Canada
Prior art keywords
compound
formula
group
mmol
preparation
Prior art date
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CA2863784A
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English (en)
French (fr)
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CA2863784A1 (en
Inventor
Alessandro Maiocchi
Massimo Visigalli
Lorena Beltrami
Loredana Sini
Luciano Lattuada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
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Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of CA2863784A1 publication Critical patent/CA2863784A1/en
Application granted granted Critical
Publication of CA2863784C publication Critical patent/CA2863784C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2863784A 2012-03-14 2013-03-13 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents Active CA2863784C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12159378.4A EP2639227A1 (en) 2012-03-14 2012-03-14 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
EP12159378.4 2012-03-14
PCT/EP2013/055094 WO2013135750A1 (en) 2012-03-14 2013-03-13 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents

Publications (2)

Publication Number Publication Date
CA2863784A1 CA2863784A1 (en) 2013-09-19
CA2863784C true CA2863784C (en) 2018-04-17

Family

ID=47846054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2863784A Active CA2863784C (en) 2012-03-14 2013-03-13 A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents

Country Status (7)

Country Link
US (1) US9259491B2 (enExample)
EP (2) EP2639227A1 (enExample)
JP (1) JP6375231B2 (enExample)
CN (1) CN104203926B (enExample)
AU (1) AU2013231301B2 (enExample)
CA (1) CA2863784C (enExample)
WO (1) WO2013135750A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602715A (zh) * 2012-09-07 2015-05-06 伯拉考成像股份公司 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN)
EP3003395B1 (en) * 2013-05-30 2019-07-17 Bracco Imaging S.p.A Fluorescent solid lipid nanoparticles composition and preparation thereof
US11370826B2 (en) 2016-02-09 2022-06-28 Bracco Suisse Sa Recombinant chimeric protein for selectins targeting
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
DE102017129405A1 (de) 2017-12-11 2019-06-13 Universitätsklinikum Jena Neue DAZA-Chelatoren als Liganden in der Leberbildgebung
EP3880635B1 (en) 2018-11-12 2023-01-04 Bracco Imaging SPA Chelating aazta conjugate, complexes thereof and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JP2002522514A (ja) * 1998-08-10 2002-07-23 ブラッコ・リサーチ・ソシエテ・アノニム ポジティブｍｒｉコントラスト剤とネガティブｍｒｉコントラスト剤との組合せ
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
FR2795412B1 (fr) * 1999-06-23 2001-07-13 Adir Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ITMI20011518A1 (it) 2001-07-17 2003-01-17 Bracco Imaging Spa Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia
US7893223B2 (en) * 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
GB0305422D0 (en) * 2003-03-10 2003-04-16 Univ Open Detection, monitoring and treatment of cancer
EP1765812B1 (en) * 2004-07-02 2009-04-29 Bracco Imaging S.p.A Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
FR2939318B1 (fr) * 2008-12-10 2012-07-13 Guerbet Sa Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2

Also Published As

Publication number Publication date
EP2834222B1 (en) 2016-03-09
CN104203926B (zh) 2017-12-15
EP2834222A1 (en) 2015-02-11
US9259491B2 (en) 2016-02-16
AU2013231301A1 (en) 2014-08-28
CN104203926A (zh) 2014-12-10
JP2015509966A (ja) 2015-04-02
WO2013135750A1 (en) 2013-09-19
US20150037261A1 (en) 2015-02-05
CA2863784A1 (en) 2013-09-19
JP6375231B2 (ja) 2018-08-15
EP2639227A1 (en) 2013-09-18
AU2013231301B2 (en) 2017-01-05

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