CN104189849A - Traditional Chinese medicine composition for preventing adverse reaction after anesthesia and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing adverse reaction after anesthesia and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to the technical field of preventing shiver after surgical anesthesia, in particular to a traditional Chinese medicine composition for preventing an adverse reaction after anesthesia and a preparation method of the traditional Chinese medicine composition. Liquorice, panax notoginseng, a betel nut, radix puerariae, pangolin, cordate houttuynia, hedyotis diffusa, dandelion, eucommia, a persimmon leaf, pine needles, cypress bark, bighead atractylodes rhizome, curcuma zedoary, kelp, garlic, ginger, hotbed chives seeds and a sponge gourd are combined and mixed in a classification and segmentation manner, and different decocting and extraction methods are performed on the mixed raw materials; the raw materials are added at different opportunities and in different physicochemical environments, so that active ingredients of the raw materials achieve concerted reaction; the drug efficacy of the composition is further improved; and an inhibiting effect on the adverse reaction arising from the anesthesia is improved.
Description
Technical field
The present invention relates to the shiver with cold prevention technique field after surgery anesthesia, especially a kind of Chinese medicine composition of anaesthetizing rear untoward reaction and preparation method thereof that prevents.
Background technology
Before anesthesia is before performing the operation or certain medical diagnosis on disease checks, for eliminate patient misery, ensure patient safety, create the method for good surgical environments, clinically, mainly contain general anesthesia, local anesthesia and combined anesthesia and concentrate type; Therefore narcotics is also roughly divided for these three groups for this reason.But, no matter be that whole body, part or the anesthesia meeting are all that the reversibility function of the nervus centralis of human body and peripheral nervous system is suppressed, this inhibition is mainly the forfeiture of the pain sensation.Yet, in using anaesthesia process, tend to occur untoward reaction, as dizzy, happiness is slept, feel sick, vomiting, constipation, skin pruritus and excretion difficult, the untoward reaction that for this reason how to prevent and treat anaesthesia process to bring becomes one of indispensable step of operative treatment.
And in the prevention and treatment of traditional anesthesia untoward reaction, mostly take Western medicine as main, and Western medicine is difficult to eradicate, and even makes untoward reaction aggravation, and then do not reach desirable effect; So, have a large amount of researcheres to anesthesia after the prevention of untoward reaction and the medication for the treatment of that bring be studied and explore, and then for prevention and treatment, anaesthetize the untoward reaction bringing a kind of desirable prevention and medicine be provided.
As disclosing a kind of Radix Satyrii nepalensis, Herba Changnieniae amoenae and other of adopting, the capsule of shiver with cold after the patent No. < < prevention anesthesia that is CN201410170852.5 and preparation method thereof > > amounts to the Chinese medicine composition of 12 taste raw materials, through being classified, raw material decocts extraction, distillation extraction effective ingredient, after spraying is dry, the capsule of rear shiver with cold is anaesthetized in prevention encapsulated and that obtain.
Mono-kind of < < that and for example patent No. is CN201410239216.3 treat the medicine of anesthetics untoward reaction and preparation method > > disclose a kind ofly adopt Philippine Paphiopedilum (Concolor Paphiopedilum), Bin youth, Caulis Parthenocissi Laetivirentis, pick up the ears, Bulbus Allii and other amount to the Chinese medicine composition of 16 taste raw materials, in order to treat anesthetics untoward reaction.
In addition, also have that some bring about treatment anesthetics feel sick, prevention targetedly and the medicine of other untoward reaction such as vomiting.
As can be seen here, in the prior art, to the prevention of the untoward reaction bringing after anaesthetizing or treatment, it is all the extremely strong Chinese medicine composition of a kind of specific aim, and the Chinese medicine composition of the universality of the untoward reaction that anesthetics is brought prevention and treatment have not been reported, for this reason, this research worker, on the basis of existing technology, for the untoward reaction of the universality bringing after anesthesia, the untoward reaction bringing for prevention anesthesia provides a kind of medication new approaches.
Summary of the invention
In order to solve the above-mentioned technical problem existing in prior art, the invention provides a kind of Chinese medicine composition of anaesthetizing rear untoward reaction and preparation method thereof that prevents, there is compatibility suitable, meet Chinese medicine and modern medical theory, each taste material medicine is synergism mutually, strengthen drug effect, and there is the effect of promoting blood circulation and stopping pain, pleasant stomach function regulating, the even certain effect of various untoward reaction that preventing narcotic is brought, this medicine compatibility amount is little, mutually collaborative between each compatibility, improved drug safety, and without any side effects.
Specifically be achieved by the following technical programs:
Prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material composition (weight portion meter) is: Radix Glycyrrhizae 2-3 part, Radix Notoginseng 4-5 part, Semen Arecae 1-2 part, Radix Puerariae 1-3 part, Squama Manis 2-4 part, Herba Houttuyniae 3-5 part, Hedyotidis Diffusae 2-3 part, Herba Taraxaci 1-3 part, Cortex Eucommiae 3-5 part, Folium Kaki 2-7 part, Folium Pini 1-3 part, Cupressaceae skin 1-3 part, Rhizoma Atractylodis Macrocephalae 0.5-1.7 part, Rhizoma Curcumae 0.7-1.3 part, Thallus Laminariae (Thallus Eckloniae) 0.1-0.5 part, Bulbus Allii 1-3 part, Rhizoma Zingiberis Recens 3-5 part, hotbed chives seed 0.3-0.7 part, Fructus Luffae 6-7 part.
Described raw material composition (weight portion meter) is: 2.5 parts, Radix Glycyrrhizae, 4.5 parts of Radix Notoginseng, 1.5 parts of Semen Arecaes, 2 parts of Radix Puerariaes, 3 parts of Squama Maniss, 4 parts of Herba Houttuyniae, 2.5 parts of Hedyotidis Diffusaes, 2 parts of Herba Taraxacis, 4 parts of the Cortexs Eucommiae, 5 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1 part of the Rhizoma Atractylodis Macrocephalae, 0.9 part of Rhizoma Curcumae, 0.3 part, Thallus Laminariae (Thallus Eckloniae), 2 parts, Bulbus Allii, 4 parts of Rhizoma Zingiberis Recens, 0.5 part of hotbed chives seed, 6.5 parts, Fructus Luffae.
Described raw material composition (weight portion meter) is: 3 parts, Radix Glycyrrhizae, 4 parts of Radix Notoginseng, 1 part of Semen Arecae, 1 part of Radix Puerariae, 3 parts of Squama Maniss, 3 parts of Herba Houttuyniae, 3 parts of Hedyotidis Diffusaes, 2 parts of Herba Taraxacis, 4 parts of the Cortexs Eucommiae, 4 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1.2 parts of the Rhizoma Atractylodis Macrocephalaes, 1.1 parts of Rhizoma Curcumae, 0.2 part, Thallus Laminariae (Thallus Eckloniae), 2 parts, Bulbus Allii, 4 parts of Rhizoma Zingiberis Recens, 0.6 part of hotbed chives seed, 7 parts, Fructus Luffae.
Its raw material composition (weight portion meter) is: 2 parts, Radix Glycyrrhizae, 5 parts of Radix Notoginseng, 1 part of Semen Arecae, 3 parts of Radix Puerariaes, 4 parts of Squama Maniss, 3 parts of Herba Houttuyniae, 3 parts of Hedyotidis Diffusaes, 3 parts of Herba Taraxacis, 5 parts of the Cortexs Eucommiae, 6 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1.4 parts of the Rhizoma Atractylodis Macrocephalaes, 0.8 part of Rhizoma Curcumae, 0.2 part, Thallus Laminariae (Thallus Eckloniae), 3 parts, Bulbus Allii, 5 parts of Rhizoma Zingiberis Recens, 0.5 part of hotbed chives seed, 6 parts, Fructus Luffae.
After adding the adjuvant that pharmaceutics is conventional, can be made into a kind of in powder, decoction, capsule, tablet.
The preparation of its decoction comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, according to the weight ratio of mixed material and clear water, be 1:(4-6 again) ratio be placed in boiler, and add wherein the Sal of pan feeding water gross weight 1-3%, soak after 3-4h, start the boiler that heats up, make the water temperature in boiler be warming up to 70-90 ℃ at 40-50min, and after constant temperature decocting herbs 10-20min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, again boiler is carried out to hyperthermic treatment, make the water temperature in boiler be warming up to 100-110 ℃ at 10-15min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 60-80 ℃, and temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 3-5min, be warming up to 90 ℃ and carry out constant temperature and decoct 10-20min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 50-60min, stops decocting, and adopts the frozen water of 2-5 ℃ that accounts for raw medicinal material gross weight 3-5%, at 10-20s, pours in boiler, adopts agitator to stir after 10-15min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.02-0.08MPa carries out filtration treatment, obtains filtrate and filtering residue; And filtrate is concentrated into at 2/3rds o'clock, and add the Mel of the 0.5-1% that accounts for concentrated solution weight, can obtain the decoction of the Chinese medicine composition of the rear untoward reaction of prevention anesthesia.
The preparation of its powder is further comprising the steps of: by step 2) filtering residue that filter to obtain is placed in dehydrator, adopt the temperature of 50-60 ℃, dry while being filtering residue weight 1-3% to filtering residue moisture, be placed on again in pulverizer, be crushed to 100-130 order, obtain powder, after the proportioning that is 1:3 with clear water according to weight ratio by powder is again mixed homogeneously, mix suspension, add wherein again the nano-carbon powder of mixed liquor gross weight 1%, and be warming up to after 60-70 ℃, insulation is processed after 20-30min, be cooled to room temperature, and be placed in centrifugal separator, the rotating speed of adjusting centrifuge is that 1000-2000r/min carries out centrifugalize, obtain centrifugal liquid and centrifugal slag, again by centrifugal liquid and step 2) filtrate that obtains mixes, obtain mixed liquor, and mixed liquor is carried out to spray drying treatment, wherein the inlet temperature of spray drying treatment is 150-250 ℃, outlet temperature is 50-60 ℃, after spray drying treatment finishes, collects the powder in drying baker, pack, can obtain the Chinese medicine composition medicinal powder of the rear untoward reaction of prevention anesthesia.
The preparation of its capsule is further comprising the steps of: after the powder collection in drying baker is good, be loaded in the capsule body of the Testa oryzae oil that weight contains 1-2%, can obtain the Chinese medicinal composition capsules of untoward reaction after prevention anesthesia.
The preparation of its tablet is further comprising the steps of: the powder of having collected is mixed with lactose according to weight ratio 1:1, and after adjusting its moisture and being 25-35%, be pressed into the tablet of 0.45mg/ sheet, and to be placed in temperature be the environment of 30-40 ℃, baking 3-5min, can obtain the Chinese medicine composition tablet that rear untoward reaction is anaesthetized in prevention.
Compared with prior art, technique effect of the present invention is embodied in:
1. pass through Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, the Cortex Eucommiae, Folium Kaki, Folium Pini, Cupressaceae skin, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, hotbed chives seed, Fructus Luffae 19 taste raw material of Chinese medicine carry out compatibility mixing, and when mixing, the raw material segmentation of classifying is mixed, and mixed material is carried out to different decoction extracting method, and on different opportunitys, under different physicochemical environments, add, and then make the effective ingredient in various raw materials carry out concerted reaction, further strengthened the drug effect of compositions, improved the inhibitory action of the untoward reaction that anesthesia is brought.
2. by the compatibility of 19 taste raw materials is controlled, the lower antagonism of crude drug object, make between the every effective ingredient in each material medicine mutually collaborative, and in conjunction with the technical parameter in preparation technology and raw material, add the control on opportunity, make each material composition that complicated directed biochemical reaction occur, form and a kind ofly can act on the various untoward reaction that anesthesia brings, and then reach that the intestines and stomach is comfortable, pleasant, the effect of relaxing muscles and tendons to promote blood circulation.
3. 19 tastes of the present invention, by the adjustment to the control of processing step and parameter, make synergism each other stronger, and side effect is low.
The specific embodiment
Below in conjunction with concrete embodiment, technical scheme of the present invention is done to further restriction, but claimed scope is not only confined to done description.
Embodiment 1
Prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material is: Radix Glycyrrhizae 2g, Radix Notoginseng 4g, Semen Arecae 1g, Radix Puerariae 1g, Squama Manis 2g, Herba Houttuyniae 3g, Hedyotidis Diffusae 2g, Herba Taraxaci 1g, Cortex Eucommiae 3g, Folium Kaki 2g, Folium Pini 1g, Cupressaceae skin 1g, Rhizoma Atractylodis Macrocephalae 0.5g, Rhizoma Curcumae 0.7g, Thallus Laminariae (Thallus Eckloniae) 0.1g, Bulbus Allii 1g, Rhizoma Zingiberis Recens 3g, hotbed chives seed 0.3g, Fructus Luffae 6g.
The preparation of its decoction comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, the ratio that is 1:6 according to the weight ratio of mixed material and clear water is again placed in boiler, and add wherein the Sal of pan feeding water gross weight 3%, soak after 4h, start the boiler that heats up, make the water temperature in boiler be warming up to 90 ℃ at 50min, and after constant temperature decocting herbs 20min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, then carries out hyperthermic treatment by boiler, make the water temperature in boiler be warming up to 110 ℃ at 15min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 80 ℃, temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 5min, be warming up to 90 ℃ and carry out constant temperature and decoct 20min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 60min, stops decocting, and adopts the frozen water of 5 ℃ that accounts for raw medicinal material gross weight 5%, at 20s, pours in boiler, adopts agitator to stir after 15min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.08MPa carries out filtration treatment, obtains filtrate and filtering residue; And filtrate is concentrated into at 2/3rds o'clock, and add 1% the Mel that accounts for concentrated solution weight, can obtain the decoction of the Chinese medicine composition of untoward reaction after prevention anesthesia.
Embodiment 2
Prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material is: Radix Glycyrrhizae 3g, Radix Notoginseng 5g, Semen Arecae 5g, Radix Puerariae 3g, Squama Manis 4g, Herba Houttuyniae 5g, Hedyotidis Diffusae 3g, Herba Taraxaci 3g, Cortex Eucommiae 5g, Folium Kaki 7g, Folium Pini 3g, Cupressaceae skin 3g, Rhizoma Atractylodis Macrocephalae 1.7g, Rhizoma Curcumae 1.3g, Thallus Laminariae (Thallus Eckloniae) 0.5g, Bulbus Allii 3g, Rhizoma Zingiberis Recens 5g, hotbed chives seed 0.7g, Fructus Luffae 7g.
The preparation of its powder comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, the ratio that is 1:4 according to the weight ratio of mixed material and clear water is again placed in boiler, and add wherein the Sal of pan feeding water gross weight 1%, soak after 3h, start the boiler that heats up, make the water temperature in boiler be warming up to 70 ℃ at 40min, and after constant temperature decocting herbs 10min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, then carries out hyperthermic treatment by boiler, make the water temperature in boiler be warming up to 100 ℃ at 10min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 60 ℃, temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 3min, be warming up to 90 ℃ and carry out constant temperature and decoct 10min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 50min, stops decocting, and adopts the frozen water of 2 ℃ that accounts for raw medicinal material gross weight 3%, at 10s, pours in boiler, adopts agitator to stir after 10min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.02MPa carries out filtration treatment, obtains filtrate and filtering residue, the filtering residue of acquisition is placed in to dehydrator, adopt the temperature of 50 ℃, dry while being filtering residue weight 1% to filtering residue moisture, be placed on again in pulverizer, be crushed to 100 orders, obtain powder, after the proportioning that is 1:3 with clear water according to weight ratio by powder is again mixed homogeneously, mix suspension, add wherein again the nano-carbon powder of mixed liquor gross weight 1%, and be warming up to after 60 ℃, insulation is processed after 20min, be cooled to room temperature, and be placed in centrifugal separator, the rotating speed of adjusting centrifuge is that 1000r/min carries out centrifugalize, obtain centrifugal liquid and centrifugal slag, again centrifugal liquid is mixed with the filtrate of acquisition, obtain mixed liquor, and mixed liquor is carried out to spray drying treatment, wherein the inlet temperature of spray drying treatment is 150 ℃, outlet temperature is 50 ℃, after spray drying treatment finishes, collects the powder in drying baker, pack, can obtain the Chinese medicine composition medicinal powder of the rear untoward reaction of prevention anesthesia.
Embodiment 3
Prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material is: Radix Glycyrrhizae 2.5g, Radix Notoginseng 4.5g, Semen Arecae 1.5g, Radix Puerariae 2g, Squama Manis 3g, Herba Houttuyniae 4g, Hedyotidis Diffusae 2.5g, Herba Taraxaci 2g, Cortex Eucommiae 4g, Folium Kaki 5g, Folium Pini 2g, Cupressaceae skin 2g, Rhizoma Atractylodis Macrocephalae 1g, Rhizoma Curcumae 0.9g, Thallus Laminariae (Thallus Eckloniae) 0.3g, Bulbus Allii 2g, Rhizoma Zingiberis Recens 4g, hotbed chives seed 0.5g, Fructus Luffae 6.5g.
The preparation of its capsule comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, the ratio that is 1:5 according to the weight ratio of mixed material and clear water is again placed in boiler, and add wherein the Sal of pan feeding water gross weight 2%, soak after 3.5h, start the boiler that heats up, make the water temperature in boiler be warming up to 80 ℃ at 45min, and after constant temperature decocting herbs 15min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, then carries out hyperthermic treatment by boiler, make the water temperature in boiler be warming up to 105 ℃ at 13min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 70 ℃, temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 4min, be warming up to 90 ℃ and carry out constant temperature and decoct 15min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 55min, stops decocting, and adopts the frozen water of 5 ℃ that accounts for raw medicinal material gross weight 4%, at 15s, pours in boiler, adopts agitator to stir after 14min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.06MPa carries out filtration treatment, obtains filtrate and filtering residue, the filtering residue of acquisition is placed in to dehydrator, adopt the temperature of 55 ℃, dry while being filtering residue weight 2% to filtering residue moisture, be placed on again in pulverizer, be crushed to 115 orders, obtain powder, after the proportioning that is 1:3 with clear water according to weight ratio by powder is again mixed homogeneously, mix suspension, add wherein again the nano-carbon powder of mixed liquor gross weight 1%, and be warming up to after 65 ℃, insulation is processed after 25min, be cooled to room temperature, and be placed in centrifugal separator, the rotating speed of adjusting centrifuge is that 1500r/min carries out centrifugalize, obtain centrifugal liquid and centrifugal slag, centrifugal liquid is mixed with the filtrate of acquisition again, obtain mixed liquor, and mixed liquor is carried out to spray drying treatment, wherein the inlet temperature of spray drying treatment is 200 ℃, and outlet temperature is 55 ℃, after spray drying treatment finishes, collects the powder in drying baker, after again the powder collection in drying baker is good, be loaded in the capsule body that weight contains 1.5% Testa oryzae oil, can obtain the Chinese medicinal composition capsules of untoward reaction after prevention anesthesia.
Embodiment 4
Prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material is: Radix Glycyrrhizae 3g, Radix Notoginseng 4g, Semen Arecae 1g, Radix Puerariae 1g, Squama Manis 3g, Herba Houttuyniae 3g, Hedyotidis Diffusae 3g, Herba Taraxaci 2g, Cortex Eucommiae 4g, Folium Kaki 4g, Folium Pini 2g, Cupressaceae skin 2g, Rhizoma Atractylodis Macrocephalae 1.2g, Rhizoma Curcumae 1.1g, Thallus Laminariae (Thallus Eckloniae) 0.2g, Bulbus Allii 2g, Rhizoma Zingiberis Recens 4g, hotbed chives seed 0.6g, Fructus Luffae 7g.
The preparation of its tablet comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, the ratio that is 1:5.5 according to the weight ratio of mixed material and clear water is again placed in boiler, and add wherein the Sal of pan feeding water gross weight 2.5%, soak after 3.5h, start the boiler that heats up, make the water temperature in boiler be warming up to 75 ℃ at 44min, and after constant temperature decocting herbs 17min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, then carries out hyperthermic treatment by boiler, make the water temperature in boiler be warming up to 108 ℃ at 11min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 65 ℃, temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 4min, be warming up to 90 ℃ and carry out constant temperature and decoct 17min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 58min, stops decocting, and adopts the frozen water of 3 ℃ that accounts for raw medicinal material gross weight 3.5%, at 17s, pours in boiler, adopts agitator to stir after 13min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.05MPa carries out filtration treatment, obtains filtrate and filtering residue, the filtering residue of acquisition is placed in to dehydrator, adopt the temperature of 59 ℃, dry while being filtering residue weight 2% to filtering residue moisture, be placed on again in pulverizer, be crushed to 125 orders, obtain powder, after the proportioning that is 1:3 with clear water according to weight ratio by powder is again mixed homogeneously, mix suspension, add wherein again the nano-carbon powder of mixed liquor gross weight 1%, and be warming up to after 65 ℃, insulation is processed after 29min, be cooled to room temperature, and be placed in centrifugal separator, the rotating speed of adjusting centrifuge is that 1700r/min carries out centrifugalize, obtain centrifugal liquid and centrifugal slag, again by centrifugal liquid and step 1) filtrate that obtains mixes, obtains mixed liquor, and mixed liquor is carried out to spray drying treatment, wherein the inlet temperature of spray drying treatment is 190 ℃, outlet temperature is 57 ℃, after spray drying treatment finishes, collects the powder in drying baker, again the powder of having collected is mixed with lactose according to weight ratio 1:1, and after adjusting its moisture and being 33%, be pressed into the tablet of 0.45mg/ sheet, and to be placed in temperature be the environment of 37 ℃, baking 4min, can obtain the Chinese medicine composition tablet that rear untoward reaction is anaesthetized in prevention.
Embodiment 5
On the basis of embodiment 1, other steps are all with embodiment 1, prevent to anaesthetize a Chinese medicine composition for rear untoward reaction, its raw material is: Radix Glycyrrhizae 2g, Radix Notoginseng 5g, Semen Arecae 1g, Radix Puerariae 3g, Squama Manis 4g, Herba Houttuyniae 3g, Hedyotidis Diffusae 3g, Herba Taraxaci 3g, Cortex Eucommiae 5g, Folium Kaki 6g, Folium Pini 2g, Cupressaceae skin 2g, Rhizoma Atractylodis Macrocephalae 1.4g, Rhizoma Curcumae 0.8g, Thallus Laminariae (Thallus Eckloniae) 0.2g, Bulbus Allii 3g, Rhizoma Zingiberis Recens 5g, hotbed chives seed 0.5g, Fructus Luffae 6g.
At this, it is important to point out; above embodiment only limits to the technique effect that can reach technical scheme of the present invention and detailed regulation and elaboration are done in the concrete operations of preparation; it is not the further restriction to technical scheme of the present invention; the non-outstanding essential characteristics that those skilled in the art make on this basis and non-significant progress, all belong to protection category of the present invention.
Claims (9)
1. a Chinese medicine composition that prevents to anaesthetize rear untoward reaction, it is characterized in that, its raw material composition (weight portion meter) is: Radix Glycyrrhizae 2-3 part, Radix Notoginseng 4-5 part, Semen Arecae 1-2 part, Radix Puerariae 1-3 part, Squama Manis 2-4 part, Herba Houttuyniae 3-5 part, Hedyotidis Diffusae 2-3 part, Herba Taraxaci 1-3 part, Cortex Eucommiae 3-5 part, Folium Kaki 2-7 part, Folium Pini 1-3 part, Cupressaceae skin 1-3 part, Rhizoma Atractylodis Macrocephalae 0.5-1.7 part, Rhizoma Curcumae 0.7-1.3 part, Thallus Laminariae (Thallus Eckloniae) 0.1-0.5 part, Bulbus Allii 1-3 part, Rhizoma Zingiberis Recens 3-5 part, hotbed chives seed 0.3-0.7 part, Fructus Luffae 6-7 part.
2. the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 1, it is characterized in that, described raw material composition (weight portion meter) is: 2.5 parts, Radix Glycyrrhizae, 4.5 parts of Radix Notoginseng, 1.5 parts of Semen Arecaes, 2 parts of Radix Puerariaes, 3 parts of Squama Maniss, 4 parts of Herba Houttuyniae, 2.5 parts of Hedyotidis Diffusaes, 2 parts of Herba Taraxacis, 4 parts of the Cortexs Eucommiae, 5 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1 part of the Rhizoma Atractylodis Macrocephalae, 0.9 part of Rhizoma Curcumae, 0.3 part, Thallus Laminariae (Thallus Eckloniae), 2 parts, Bulbus Allii, 4 parts of Rhizoma Zingiberis Recens, 0.5 part of hotbed chives seed, 6.5 parts, Fructus Luffae.
3. the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 1, it is characterized in that, described raw material composition (weight portion meter) is: 3 parts, Radix Glycyrrhizae, 4 parts of Radix Notoginseng, 1 part of Semen Arecae, 1 part of Radix Puerariae, 3 parts of Squama Maniss, 3 parts of Herba Houttuyniae, 3 parts of Hedyotidis Diffusaes, 2 parts of Herba Taraxacis, 4 parts of the Cortexs Eucommiae, 4 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1.2 parts of the Rhizoma Atractylodis Macrocephalaes, 1.1 parts of Rhizoma Curcumae, 0.2 part, Thallus Laminariae (Thallus Eckloniae), 2 parts, Bulbus Allii, 4 parts of Rhizoma Zingiberis Recens, 0.6 part of hotbed chives seed, 7 parts, Fructus Luffae.
4. the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 1, it is characterized in that, its raw material composition (weight portion meter) is: 2 parts, Radix Glycyrrhizae, 5 parts of Radix Notoginseng, 1 part of Semen Arecae, 3 parts of Radix Puerariaes, 4 parts of Squama Maniss, 3 parts of Herba Houttuyniae, 3 parts of Hedyotidis Diffusaes, 3 parts of Herba Taraxacis, 5 parts of the Cortexs Eucommiae, 6 parts of Folium Kaki, 2 parts of Folium Pinis, 2 parts of Cupressaceae skins, 1.4 parts of the Rhizoma Atractylodis Macrocephalaes, 0.8 part of Rhizoma Curcumae, 0.2 part, Thallus Laminariae (Thallus Eckloniae), 3 parts, Bulbus Allii, 5 parts of Rhizoma Zingiberis Recens, 0.5 part of hotbed chives seed, 6 parts, Fructus Luffae.
5. the Chinese medicine composition of untoward reaction after the prevention as described in claim 1-4 any one anesthesia, is characterized in that, after adding the adjuvant that pharmaceutics is conventional, can be made into a kind of in powder, decoction, capsule, tablet.
6. the preparation method of the Chinese medicine composition of untoward reaction after prevention anesthesia as claimed in claim 5, is characterized in that, the preparation of its decoction comprises the following steps:
(1) raw material is processed: according to proportioning raw materials, by Radix Glycyrrhizae, Radix Notoginseng, Semen Arecae, Radix Puerariae, Squama Manis, the Cortex Eucommiae, after Cupressaceae skin mix homogeneously, according to the weight ratio of mixed material and clear water, be 1:(4-6 again) ratio be placed in boiler, and add wherein the Sal of pan feeding water gross weight 1-3%, soak after 3-4h, start the boiler that heats up, make the water temperature in boiler be warming up to 70-90 ℃ at 40-50min, and after constant temperature decocting herbs 10-20min, then in boiler, add successively the Rhizoma Atractylodis Macrocephalae according to proportioning, Rhizoma Curcumae, hotbed chives seed, after to be added completing, again boiler is carried out to hyperthermic treatment, make the water temperature in boiler be warming up to 100-110 ℃ at 10-15min, constant temperature decocts 30min, then the water temperature in boiler is cooled to 60-80 ℃, and temperature fall time is 40min, and after constant temperature decoction 10min, then add successively wherein Herba Houttuyniae, Hedyotidis Diffusae, Herba Taraxaci, Folium Kaki, Folium Pini, and at 3-5min, be warming up to 90 ℃ and carry out constant temperature and decoct 10-20min, then add successively wherein Thallus Laminariae (Thallus Eckloniae), Bulbus Allii, Rhizoma Zingiberis Recens, Fructus Luffae, continues constant temperature and decocts after 50-60min, stops decocting, and adopts the frozen water of 2-5 ℃ that accounts for raw medicinal material gross weight 3-5%, at 10-20s, pours in boiler, adopts agitator to stir after 10-15min, stand-by,
(2) decoction slag liquid vacuum filtration: by step 1) completing is placed in vacuum filter, and the vacuum of adjusting vacuum filter is that 0.02-0.08MPa carries out filtration treatment, obtains filtrate and filtering residue; And filtrate is concentrated into at 2/3rds o'clock, and add the Mel of the 0.5-1% that accounts for concentrated solution weight, can obtain the decoction of the Chinese medicine composition of the rear untoward reaction of prevention anesthesia.
7. the preparation method of the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 6, it is characterized in that, the preparation of its powder is further comprising the steps of: by step 2) filtering residue that filter to obtain is placed in dehydrator, adopt the temperature of 50-60 ℃, dry while being filtering residue weight 1-3% to filtering residue moisture, be placed on again in pulverizer, be crushed to 100-130 order, obtain powder, after the proportioning that is 1:3 with clear water according to weight ratio by powder is again mixed homogeneously, mix suspension, add wherein again the nano-carbon powder of mixed liquor gross weight 1%, and be warming up to after 60-70 ℃, insulation is processed after 20-30min, be cooled to room temperature, and be placed in centrifugal separator, the rotating speed of adjusting centrifuge is that 1000-2000r/min carries out centrifugalize, obtain centrifugal liquid and centrifugal slag, again by centrifugal liquid and step 2) filtrate that obtains mixes, obtain mixed liquor, and mixed liquor is carried out to spray drying treatment, wherein the inlet temperature of spray drying treatment is 150-250 ℃, outlet temperature is 50-60 ℃, after spray drying treatment finishes, collects the powder in drying baker, pack, can obtain the Chinese medicine composition medicinal powder of the rear untoward reaction of prevention anesthesia.
8. the preparation method of the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 7, it is characterized in that, the preparation of its capsule is further comprising the steps of: after the powder collection in drying baker is good, be loaded in the capsule body of the Testa oryzae oil that weight contains 1-2%, can obtain the Chinese medicinal composition capsules of untoward reaction after prevention anesthesia.
9. the preparation method of the Chinese medicine composition of rear untoward reaction is anaesthetized in prevention as claimed in claim 7, it is characterized in that, the preparation of its tablet is further comprising the steps of: the powder of having collected is mixed with lactose according to weight ratio 1:1, and after adjusting its moisture and being 25-35%, be pressed into the tablet of 0.45mg/ sheet, and to be placed in temperature be the environment of 30-40 ℃, baking 3-5min, can obtain the Chinese medicine composition tablet of untoward reaction after prevention anesthesia.
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| CN104524286A (en) * | 2014-12-19 | 2015-04-22 | 刘瑞全 | Traditional Chinese medicinal liquid for treating adverse reaction after anesthesia and preparation method |
| CN104623433A (en) * | 2015-01-12 | 2015-05-20 | 王槐照 | Traditional Chinese medicine for preventing postanesthesia shivering and preparation method of traditional Chinese medicine |
| CN105920270A (en) * | 2016-06-12 | 2016-09-07 | 谭英 | Traditional Chinese medicine injection applied to nursing postoperative anesthetic adverse reactions and preparation method thereof |
| CN108079220A (en) * | 2018-02-09 | 2018-05-29 | 重庆医科大学附属永川医院 | A kind of preparation for alleviating arcotic adverse reaction and preparation method thereof |
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| CN103432369A (en) * | 2013-08-29 | 2013-12-11 | 王冉 | Medicament for treating narcotic adverse reactions |
| CN103948800A (en) * | 2014-04-28 | 2014-07-30 | 彭英华 | Capsule for preventing chill after anesthesia and preparation method thereof |
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| CN104524286A (en) * | 2014-12-19 | 2015-04-22 | 刘瑞全 | Traditional Chinese medicinal liquid for treating adverse reaction after anesthesia and preparation method |
| CN104623433A (en) * | 2015-01-12 | 2015-05-20 | 王槐照 | Traditional Chinese medicine for preventing postanesthesia shivering and preparation method of traditional Chinese medicine |
| CN105920270A (en) * | 2016-06-12 | 2016-09-07 | 谭英 | Traditional Chinese medicine injection applied to nursing postoperative anesthetic adverse reactions and preparation method thereof |
| CN108079220A (en) * | 2018-02-09 | 2018-05-29 | 重庆医科大学附属永川医院 | A kind of preparation for alleviating arcotic adverse reaction and preparation method thereof |
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