CN104189704A - Pharmaceutical composition for treating duck viral hepatitis - Google Patents
Pharmaceutical composition for treating duck viral hepatitis Download PDFInfo
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- CN104189704A CN104189704A CN201410402779.XA CN201410402779A CN104189704A CN 104189704 A CN104189704 A CN 104189704A CN 201410402779 A CN201410402779 A CN 201410402779A CN 104189704 A CN104189704 A CN 104189704A
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Abstract
The invention provides a pharmaceutical composition for treating duck viral hepatitis. The pharmaceutical composition is prepared from the following ingredients by weight: 60-90g of white hyacinth bean, 60-90g of fructus tribuli, 60-90g of giant typhonium rhizome, 60-90g of corydalis bungeana, 30-50g of golden buckwheat rhizome, 30-50g of cordate houttuynia, 30-50g of chastetree fruit, 30-50g of burdock fruit, 30-50g of reed rhizome, 30-50g of scutellaria root, 30-50g of forsythia fruit, 30-50g of rhubarb, 30-50g of herba euphorbiae humifusae, 30-50g of ash bark, 15-30g of herba Lycopodii, 15-30g of mistletoe, 15-30g of amomum fruit, 15-30g of coix seed, 10-20g of Chinese date and 10-20g of liquorice. The pharmaceutical composition is simple in preparation and convenient in use, has the effects of replenishing the liver and spleen, clearing away heat and toxic materials as well as diminishing inflammation and protecting the liver, and has a good effect on treating duck viral hepatitis.
Description
technical field:
The present invention relates to veterinary drug technical field, relate in particular to a kind of medicine compositions of Duck Hepatitis Virus.
background technology:
Duck viral hepatitis is by DHV, to be caused a kind of acute contagious disease of duckling.Clinically anxious to fall ill, propagate fast, mortality rate is high, cuing open inspection liver, to have obvious petechia and ecchymosis be feature.Clinically anxious to fall ill, propagate fast, mortality rate is high, cuing open inspection liver, to have obvious petechia and ecchymosis be feature.Duck viral hepatitis is that the kind of duckling is propagated rapidly and highly lethal infectious disease.The characteristics of lesion of liver is that volume increases and has hemorrhage speckle, and the mortality rate while starting to fall ill, up to more than 90%, causes very large loss.Primary disease mainly betides 3 weeks ducklings below age, there is not yet above morbidity report 4 week age, and on the not impact of duck of growing up, chicken and goose also have resistance.Someone finds, with duck viral hepatitis virus artificial challenge's age in days and the poult in 1 week age, young goose and galeeny, can produce symptom, pathological change and the serum neutralizing antibody of primary disease, and be separated to virus from the liver of poult.Primary disease is propagated very fast in duckling group, above will pass through digestive tract infection.Duck liver inflammation is caused by 3 kinds of different virus, is respectively DHV (DHV) I, II, III type, and modal is DHVI type, belongs to enterovirus.
Chinese traditional treatment birds has advantages of certain, as low in drug residue etc.In prior art, the prescription for the treatment of duck viral hepatitis is as square l, each 250 grams of the fresh Folium Isatidis blade root of prescription, Radix Serissae, Radix glochidionis puberi, Yellow Fructus Gardeniae root each 100 grams (500 duckling therapeutic doses).By adopting the new herbarium recentium root coming, clean, section, adds 2 liters, water, and with the medicinal liquid to 1 liter of left and right at a simmer, every sick duck gavages 1～2 milliliter.Not yet there is the duckling of symptom, before administration, cut off the water supply a few hours, when duckling feels thirsty, allow its drink-service.Observation of curative effect prince learns [< < traditional Chinese veterinary medicine magazine > > introduction, adopt antibiotic and sulfa drugs to fail to respond to any medical treatment, with sick 10 groups of this side's treatment duck viral hepatitis, received satisfied therapeutic effect.Side 2, prescription Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Fructus Forsythiae, Flos Lonicerae, Herba Ardisiae Japonicae, Herba Artemisiae Scopariae, Fructus Aurantii, each 25 grams, Radix Glycyrrhizae (for 500 duckling consumptions).Decocting juice mixes meal and feeds.The duckling not eating, drips clothes by medicine juice, 3 times on the 1st, serve on 2 days.[this disease of < < traditional Chinese veterinary medicine magazine > > is at present without specific treatment medicine for observation of curative effect Hu Xuanwen.Adopt this side to feed afternoon on the same day, do not find dead duck next day, then take 1 dose, the whole rehabilitations of remaining duck.This side on probation only controls duckling more than 1.500, good results.Side's 3 Yiganlings, the prescription Radix Rehmanniae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Gentianae, Rhizoma Imperatae, Caulis Akebiae, Cortex Phellodendri, Fructus Gardeniae, Herba Artemisiae Scopariae, Radix Isatidis, Herba Lysimachiae, Herba Hyperici Japonici, Herba Abri.Decocting is for oral administration.Every part of adult's dosage can be fed 40～50 ducklings, 1 dose of every day.Serve on 3～5 days.[< < traditional Chinese veterinary medicine magazine > > introduces observation of curative effect Ke Yi, applies this side only with 3～5 days, and its effect is very satisfied.As inject duck liver egg yolk liquid and add Yiganling simultaneously, effect is better, protective rate 100%.Side's 4 " the lucid yang sending up soup " add 50 grams of taste prescription Radix Isatidis, 50 grams of Folium Isatidiss, 50 grams of Radix Arnebiae (Radix Lithospermi)s, 40 grams of Rhizoma Cimicifugaes, 30 grams of Radix Puerariaes, 30 grams of Radix Bupleuri, 30 grams of Fructus Gardeniaes, 25 grams of Radix Et Rhizoma Rhei, 20 grams of dried Alumens, 40 grams, Radix Glycyrrhizae (being 200 duckling consumptions above).Usage grinds to the powder or decocts soup mix fodder and feed, and 1 dose of every day, every 2～3 hours 1 time, serve on 3～5 doses.Observation of curative effect Zhang Zhaolun [< Chinese veterinarian < medical magazine > >] introduces, application the lucid yang sending up Tonga taste, divide different condition of illness addition or subtraction of changes, 2 558 sick ducks and the duck that carries disease germs are tried to control, effective 1 988, effective 221, invalid 349, satisfactory effect.For duck viral hepatitis, the experience that Chinese veterinarian among the people develops in practice also has certain effect in treatment.As: each 12 grams of Rhizoma Et Radix Notopterygii, Radix Saposhnikoviaes, respectively 10 grams, Ramulus Uncariae Cum Uncis, Rhizoma Atractylodis, Herba Schizonepetae, Herba Menthae, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, each 6 grams of Radix Peucedani, Flos Loniceraes, each 30 grams of Fructus Hordei Germinatus, six songs, 15 grams of Fructus Crataegis (every 100 duckling consumptions).Decocting water mixes meal and feeds.For another example: 30 grams of LIUYI SAN, six 1 of song, respectively 15 grams of Spica Prunellae, Radix Glycyrrhizae, Flos Loniceraes, each 7 grams of Pericarpium Citri Reticulatae, Cortex Phellodendris, respectively 10 grams of Herba Lophatheri, Radix Angelicae Sinensis, Rhizoma Osmundae, Radix Codonopsis, Radix Et Rhizoma Rhei, Radix Scutellariaes.Decoct water and feed (100 duckling consumptions).And for example: 30 grams of Radix Scutellariaes, 50 grams of Cortex Phellodendris, 30 grams of Fructus Forsythiaes, 30 grams of Indigo Naturaliss, 20 grams of Flos Loniceraes, 40 grams of Herba Ardisiae Japonicaes, 30 grams of Herba Artemisiae Scopariaes, 40 grams of Herba Lysimachiaes, 30 grams of Fructus Mumes.Decoct juice, spice is fed.Trencherman does not splash into medicine in mouth, every day 3 times.The record of periodical literature is as ' prevention effect of mattress Pu Liver-Clearing Powder to Duck Hepatitis Virus ', < Chinese veterinarian < medical magazine > >, 05 year the 5th disclosed prescription of phase: mattress Pu Liver-Clearing Powder: Herba Artemisiae Scopariae 200 g, Herba Taraxaci 200 g, Herba Hedyotidis Diffusae 200 g, Radix Isatidis 50 g, Flos Lonicerae 60 g, Rhizoma Coptidis 35 g, Fructus Gardeniae 35 g, Radix Gentianae 35 g, Radix Bupleuri 30 g, Radix Saposhnikoviae 30 g, Ramulus Uncariae Cum Uncis 30 g, the Radix Astragali 40 g, Fructus Hordei Germinatus 35 g, Radix Glycyrrhizae 20 g.For another example, ' test of Chinese medicinal formulae to Duck Hepatitis Virus prevention effect ', < < traditional Chinese veterinary medicine magazine > > the 1st phase of calendar year 2001 disclosed prescription Herba Artemisiae Scopariae 50g, Radix Gentianae 20g, Radix Scutellariae 20g, Rhizoma Coptidis 20g, Radix Astragali 20g, Radix Isatidis 20g, Radix Bupleuri Seedling 20g, Massa Medicata Fermentata 50g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 20g.By retrieval, find, the prescription that the Herba Artemisiae Scopariae of take is treated this type of disease as monarch drug is more, and Herba Artemisiae Scopariae is damp-excreting anti-icteric medicinal, eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.
Primary disease is analyzed the cause of disease with theory of Chinese medical science, duckling " the spleen tending to insufficiency usually ", appetite is prosperous strong, and digestive function is poor in addition, easily suffer from enteritis, the diseases such as diarrhoea, and " the liver being liable to excess ", heat-transformation in ill rear easy biography, Chang Yindong liver-wind, easy ill virus hepatitis, other internal organs are ill also tends to cause mixed infection, harm liver, intestinal, spleen, each internal organs of stomach.The ill virus hepatitis of duckling, card belongs to epidemic febrile disease scope, for experiencing due to the heresy of epidemic disease.According to differentiation of disease according to pathological changes of the viscera and their analysis, duck experiences virus attack liver, causes deficiency of heart-QI, can not preside over blood circulation each warp of circulating, YIN nourishing whole body, alluvial heat-dissipating, heat in blood is withered, as now of a specified duration, its Therapeutic Principle causes death, so should be " heat-clearing and toxic substances removing, antiinflammatory protects the liver ".
summary of the invention:
The object of the invention is to take prior art as basis, provide a kind of proportioning simple, easy to use, invigorating liver and spleen, heat-clearing and toxic substances removing, antiinflammatory protects the liver, the medicine compositions of the Duck Hepatitis Virus that treatment duck viral hepatitis is effective.
To achieve these goals, the invention provides a kind of medicine compositions of Duck Hepatitis Virus, wherein, according to unit of weight, configure following each component:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60-90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30-50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15-30g of Semen Coicis, Fructus Jujubae, each 10-20g of Radix Glycyrrhizae.
Or, according to unit of weight, configure following each component:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60-80g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30-40g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15-20g of Semen Coicis, Fructus Jujubae, each 10-15g of Radix Glycyrrhizae.
Or, according to unit of weight, configure following each component:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 80-90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 40-50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 20-30g of Semen Coicis, Fructus Jujubae, each 15-20g of Radix Glycyrrhizae.
Or, according to unit of weight, configure following each component:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 65-85g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 35-45g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 18-28g of Semen Coicis, Fructus Jujubae, each 12-18g of Radix Glycyrrhizae.
The preparation method of the medicine compositions of Duck Hepatitis Virus is as follows:
Each crude drug component in above-mentioned Chinese medicine composition is ground to form respectively to fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.
Using method, mixing in water for oral taking, the medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:15-20.Rush to obtain aqueous solution, according to every duckling 2-5ml, gavage, three times on the one.
It is monarch drug that Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, Herba Violae are take in the present invention, take Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, Cortex Fraxini is ministerial drug, take Herba Lycopodii, Herba Taxilli, Fructus Amomi, Semen Coicis is adjuvant drug, with Fructus Jujubae, Radix Glycyrrhizae tying-in for making medicine.This proportioning is simple, easy to use, invigorating liver and spleen, and heat-clearing and toxic substances removing, antiinflammatory protects the liver, and treatment duck viral hepatitis is effective.
the specific embodiment:
Experimental data:
One, medicine grouping:
Group 1, Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 30g of Semen Coicis, Fructus Jujubae, each 20g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:20.Every gavages 3ml.
Group 2, Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15g of Semen Coicis, Fructus Jujubae, each 10g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:18.Every gavages 4ml.
Group 3, Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 80g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 40g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 20g of Semen Coicis, Fructus Jujubae, each 15g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:15.Every gavages 5ml.
Group 4, in background technology, < Chinese veterinarian < medical magazine > >, 05 year the 5th disclosed prescription of phase: mattress Pu Liver-Clearing Powder: Herba Artemisiae Scopariae 200 g, Herba Taraxaci 200 g, Herba Hedyotidis Diffusae 200 g, Radix Isatidis 50 g, Flos Lonicerae 60 g, Rhizoma Coptidis 35 g, Fructus Gardeniae 35 g, Radix Gentianae 35 g, Radix Bupleuri 30 g, Radix Saposhnikoviae 30 g, Ramulus Uncariae Cum Uncis 30 g, the Radix Astragali 40 g, Fructus Hordei Germinatus 35 g, Radix Glycyrrhizae 20 g.Be decocted in water for oral dose, every feeding 3-5ml.
Group 5, in background technology, ' test of Chinese medicinal formulae to Duck Hepatitis Virus prevention effect ', < < traditional Chinese veterinary medicine magazine > > the 1st phase of calendar year 2001 disclosed prescription Herba Artemisiae Scopariae 50g, Radix Gentianae 20g, Radix Scutellariae 20g, Rhizoma Coptidis 20g, Radix Astragali 20g, Radix Isatidis 20g, Radix Bupleuri Seedling 20g, Massa Medicata Fermentata 50g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 20g.Be decocted in water for oral dose, every feeding 3-5ml.
Group 6, in background technology, " the lucid yang sending up soup " adds 50 grams of taste prescription Radix Isatidis, 50 grams of Folium Isatidiss, 50 grams of Radix Arnebiae (Radix Lithospermi)s, 40 grams of Rhizoma Cimicifugaes, 30 grams of Radix Puerariaes, 30 grams of Radix Bupleuri, 30 grams of Fructus Gardeniaes, 25 grams of Radix Et Rhizoma Rhei, 20 grams of dried Alumens, 40 grams, Radix Glycyrrhizae, is decocted in water for oral dose, every feeding 3-5ml.
Group 7, folk remedy in background technology: each 12 grams of Rhizoma Et Radix Notopterygii, Radix Saposhnikoviaes, respectively 10 grams, Ramulus Uncariae Cum Uncis, Rhizoma Atractylodis, Herba Schizonepetae, Herba Menthae, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, each 6 grams of Radix Peucedani, Flos Loniceraes, each 30 grams of Fructus Hordei Germinatus, six songs, 15 grams of Fructus Crataegis, are decocted in water for oral dose, every feeding 3-5ml.
Group 8, duck liver Trane Western medicine only carry out intramuscular injection 0.5ml/.
The grouping of experiment thing:
The nonimmune white duckling of test duck 3 age in days, before test, random its serum of sampling observation DVH antibody, checks maternal antibody with agar gel diffusion test, all negative.
Get nonimmune white duckling 360 plumages of 3 age in days, be divided at random 9 groups (1 to 8 is test group, and 9 groups is blank group), 40 every group, isolation is conventional raises.Experimental group 1-8 counteracting toxic substances, with (500 ELD50/0.1ml) intramuscular injection of the strong poison of DHV D2000-1.After counteracting toxic substances 6 hours, liver is dissected and is found: hepatomegaly, be yellowish red color or graniphyric, and there are petechia and ecchymosis in surface, and gallbladder enlargement, is full of bile.Spleen is enlargement sometimes, and outward appearance is the piebaldism of similar liver also.Kidney is congested, swelling, and cardiac muscle is as boiled shape.External sign duckling twitches, wryneck, and foot spasm, head are to swinging back, having loose bowels.
Administration:
Experimental group 1-7 group is used respectively the medicine in medicine grouping 1-7 to feed, and experimental group 8 is used duck liver Trane Western medicine only to carry out intramuscular injection 0.5ml/, within 3 days, observes afterwards.Cure number of elements (duckling, is calculated and cures to the symptom of swinging back, having loose bowels without tic, wryneck, foot spasm, head)
Result:
Duckling sign after healing is consistent with blank group.To sum up, effective percentage of the present invention (medicine group 1-group 3) 82.5-87.5%, medicine group 4 effective percentage 72.5%, medicine group 5 effective percentage 67.5%.Medicine group 6 effective percentage 65%.Medicine group 7 effective percentage 65%.Medicine 8 effective percentage 80%.
Antiviral experimental data:
Experimental group 1-8 after DHV D2000-1 counteracting toxic substances, takes medicine 3 days, randomly draws one, takes after body weight fixingly, dissects, and gets liver and calculates liver exponential quantity, calculates liver index suppression ratio.
Heavy (the g)/body weight (g) * 100 of liver index=liver
Liver index suppression ratio=(virus control group liver Mean value of index-experimental group liver Mean value of index)/virus control group liver Mean value of index * 100%
Liver index is larger, represents that liver pathological changes degree is serious,
Hepatic tissue is fixed with 10% formaldehyde, ethanol series dehydration, dimethylbenzene is transparent, paraffin embedding, slice thickness 4-5 micron, HE dyeing, observes blood lipid with ordinary optical microscope and changes, with the liver of Normal group as a comparison.
The impact (n=10) of liver's checking (virus is observed)
Can find, the present invention (experimental group 1-3) to viral DHV D2000-1 suppression ratio apparently higher than other experimental grouies, prove that effect of the present invention is better.
The experiment of toxicity to rat:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD 50) > 2000mg/kg,
Belong to low toxicity.
Object lesson 1
Kong Jiayi cultivation base, 2500 of meat-type duck of cultivation, during 5 age in days, find that there is duckling when dying head to back, swing back, spasm, is opisthotonus shape, spirit is depressed, appetite is absolutely useless.Eyes semi-closure, stupor, diarrhoea, movement disorder, health is swung to a side, bipod spasm, a few hours, back was to layback and dead.3-4 days dead more than 100, dissect to find hepatomegaly to be yellowish red color or graniphyric, there are petechia and ecchymosis in surface, gallbladder enlargement, is full of bile.Spleen is enlargement sometimes, and outward appearance is the piebaldism of similar liver also.Kidney is congested, swelling, for viral duck liver inflammation, applicable the present invention: Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 30g of Semen Coicis, Fructus Jujubae, each 20g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:20.
To have 462 isolation of sick duck of disease symptom, every gavages 3ml treatment.Every of asymptomatic duckling gavages 1ml prevention.Every day 2 times, after 3 days, 462 sick ducks are cured 382, and dead 80, effective percentage 82.68%.After healthy duck feeding prevention, only have 59 to only have disease symptom, all the other are in good health.
Example 2, Qin Jia cultivation base, cultivation meat-type duck 1800 plumages, during 7 age in days, find that there is duckling when dying head to back, swing back, spasm, is opisthotonus shape, spirit is depressed, appetite is absolutely useless.Eyes semi-closure, stupor, diarrhoea, movement disorder, health is swung to a side, bipod spasm, a few hours back to layback and dead, therefore dead more than 200 only, dissect and find hepatomegaly in 2 days, be yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gallbladder enlargement, is full of bile.Spleen is enlargement sometimes, and outward appearance is the piebaldism of similar liver also.Kidney is congested, swelling, is diagnosed as duck viral hepatitis.Use prescription: group 2, Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15g of Semen Coicis, Fructus Jujubae, each 10g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:18.To have 408 isolation of sick duck of disease symptom, every gavages 4ml.Every of asymptomatic duckling gavages 1ml prevention.Every day 2 times, after 3 days, 408 sick ducks are cured 356, and dead 52, effective percentage 87.25%.After healthy duck feeding prevention, only have 52 to only have disease symptom, all the other are in good health.
Example 3, the raiser of king family, 800 of cultivation meat-type duck, moist dark because of cage house, during 8 age in days, find that there is duckling spasm, be opisthotonus shape, spirit is depressed, and appetite is absolutely useless.Eyes semi-closure, stupor, diarrhoea, movement disorder, health is swung to a side, bipod spasm, a few hours back to layback and dead, be dead 100 to have a surplus within one day, dissect and find hepatomegaly, be yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gallbladder enlargement, is full of bile.Spleen is enlargement sometimes, and outward appearance is the piebaldism of similar liver also.Kidney is congested, swelling, is viral duck liver inflammation.Use prescription is as follows: Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 80g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 40g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 20g of Semen Coicis, Fructus Jujubae, each 15g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form respectively fine powder, mix, obtain mixture, mixture is joined in the water of 6 ~ 8 times of amounts and decoct, each decoction 2 ~ 4 hours, decoct 3 times, decocted rear filtration at every turn, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, extractum is joined in the alcoholic solution that the determining alcohol with respect to 2 ~ 3 times of amounts of mixture quality is 90% ~ 95%, stir completely and dissolve, subsequently 4 ℃ of following standing over night of temperature, subsequent filtration, filtrate is carried out to concentrating under reduced pressure and remove ethanol, the mastic obtaining is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, stir by ultraviolet radiation disinfection 10 seconds, obtain the medicine compositions of Duck Hepatitis Virus of the present invention.The medicine compositions of the Duck Hepatitis Virus of the powdery mixing in water for oral taking of heating, the mass ratio of control medicine and water is 1:15.To have 179 isolation of sick duck of disease symptom, every gavages 5ml.Every of asymptomatic duckling gavages 1ml prevention.Every day 2 times, after 3 days, 179 sick ducks are cured 152, and dead 27, effective percentage 84.91%.After healthy duck feeding prevention, only have 29 to only have disease symptom, all the other are in good health.
It is monarch drug that Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, Herba Violae are take in the present invention, take Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, Cortex Fraxini is ministerial drug, take Herba Lycopodii, Herba Taxilli, Fructus Amomi, Semen Coicis is adjuvant drug, with Fructus Jujubae, Radix Glycyrrhizae tying-in for making medicine.This proportioning is simple, easy to use, invigorating liver and spleen, and heat-clearing and toxic substances removing, antiinflammatory protects the liver, and treatment duck viral hepatitis is effective.
Claims (4)
1. a medicine compositions for Duck Hepatitis Virus, is characterized in that, according to unit of weight, configures following each component:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60-90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30-50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15-30g of Semen Coicis, Fructus Jujubae, each 10-20g of Radix Glycyrrhizae.
2. the medicine compositions of Duck Hepatitis Virus according to claim 1, is characterized in that, according to following each component of unit of weight configuration:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 60-80g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 30-40g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 15-20g of Semen Coicis, Fructus Jujubae, each 10-15g of Radix Glycyrrhizae.
3. the medicine compositions of Duck Hepatitis Virus according to claim 1, is characterized in that, according to following each component of unit of weight configuration:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 80-90g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 40-50g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 20-30g of Semen Coicis, Fructus Jujubae, each 15-20g of Radix Glycyrrhizae.
4. the medicine compositions of Duck Hepatitis Virus according to claim 1, is characterized in that, according to following each component of unit of weight configuration:
Semen Lablab Album, Fructus Tribuli, Rhizoma Typhonii, each 65-85g of Herba Violae, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Fructus Viticis, Fructus Arctii, Rhizoma Phragmitis, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Euphorbiae Humifusae, each 35-45g of Cortex Fraxini, Herba Lycopodii, Herba Taxilli, Fructus Amomi, each 18-28g of Semen Coicis, Fructus Jujubae, each 12-18g of Radix Glycyrrhizae.
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| CN105853627A (en) * | 2016-05-30 | 2016-08-17 | 宿州瑞泰农业发展有限公司 | Chinese and western medicine complex formula for treating duck virus hepatitis |
| CN106955344A (en) * | 2016-01-11 | 2017-07-18 | 天津嘉创生物科技有限公司 | A kind of Chinese medicine composition for preventing and treating Duck Hepatitis Virus and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103272200A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating duck viral hepatitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103272200A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating duck viral hepatitis and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106955344A (en) * | 2016-01-11 | 2017-07-18 | 天津嘉创生物科技有限公司 | A kind of Chinese medicine composition for preventing and treating Duck Hepatitis Virus and preparation method thereof |
| CN105853627A (en) * | 2016-05-30 | 2016-08-17 | 宿州瑞泰农业发展有限公司 | Chinese and western medicine complex formula for treating duck virus hepatitis |
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