CN104189396B - Seven leaf mirabilite-alum lotions and preparation method thereof - Google Patents
Seven leaf mirabilite-alum lotions and preparation method thereof Download PDFInfo
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- CN104189396B CN104189396B CN201410463424.1A CN201410463424A CN104189396B CN 104189396 B CN104189396 B CN 104189396B CN 201410463424 A CN201410463424 A CN 201410463424A CN 104189396 B CN104189396 B CN 104189396B
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Abstract
The present invention relates to seven leaf mirabilite-alum lotions and preparation method thereof, belong to technical field of traditional Chinese medicines.The seven leaves mirabilite-alum lotion includes following component in parts by weight：15 18 parts of Paris polyphylla, 32 35 parts of rheum officinale, 68 parts of asarum, 15 17 parts of Cortex Phellodendri, 9 11 parts of Chinese prickly ash, 69 parts of monkshood, 9 12 parts of radix aconiti agrestis, 15 18 parts of cape jasmine, 16 17 parts of alum, 15 17 parts of semen momordicae, 38 41 parts of saltcake, 16 19 parts of kuh-seng.The preparation method of seven leaf mirabilite-alum lotions of the invention is simple, obtained seven leaves mirabilite-alum lotion has the function that well clearing heat and detoxicating, swelling and pain relieving and detoxification sore treatment, available for diseases such as contact dermatitis, subacute dermatitis, eczema, nettle rash, pruituses, also available for external piles, mixed hemorrhoid, anal fistula, eczema, the postoperative hip bath of anus.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to seven leaf mirabilite-alum lotions and preparation method thereof.
Background technology
The skin disease institute medications such as existing contact dermatitis are mostly the outer paste wiped, containing hormone, antianaphylaxis components it is more, it is for oral administration
Have and can remove damp and hot capsule, tablet etc., lotion is rare.There is Halomine ointment for hemorrhoid department, available for outer painting.
The seven leaf mirabilite-alum lotions of the present invention are external-use lotion, fill up the blank in this field.
The content of the invention
, should It is an object of the present invention to solve the deficiency of the existing technology and provide seven leaf mirabilite-alum lotions and preparation method thereof
The preparation method of seven leaf mirabilite-alum lotions is simple, and there is obtained seven leaves mirabilite-alum lotion good clearing heat and detoxicating, swelling and pain relieving to conciliate
Poison treats the effect of sore, available for diseases such as contact dermatitis, subacute dermatitis, eczema, nettle rash, pruituses, also can be used for outer
The postoperative hip bath of hemorrhoid, mixed hemorrhoid, anal fistula, anus.
The technical solution adopted by the present invention is as follows：
Seven leaf mirabilite-alum lotions, including following component in parts by weight：It is 15-18 parts of Paris polyphylla, 32-35 parts of rheum officinale, thin
6-8 parts pungent, 15-17 parts of Cortex Phellodendri, 9-11 parts of Chinese prickly ash, 6-9 parts of monkshood, 9-12 parts of radix aconiti agrestis, 15-18 parts of cape jasmine, 16-17 parts of alum,
15-17 parts of semen momordicae, 38-41 parts of saltcake, 16-19 parts of kuh-seng.
It is further preferred that the seven leaf mirabilite-alum lotions, including following component in parts by weight：Paris polyphylla
16.7 parts, 33.3 parts of rheum officinale, 6.7 parts of asarum, 16.7 parts of Cortex Phellodendri, 10 parts of Chinese prickly ash, 6.7 parts of monkshood, 10 parts of radix aconiti agrestis, cape jasmine 16.7
Part, 16.7 parts of alum, 16.7 parts of semen momordicae, 40 parts of saltcake, 16.7 parts of kuh-seng.
The present invention also provides a kind of preparation method of seven leaves mirabilite-alum lotion, include the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, puts
Put 9-13 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）What is obtained is pre-
Batch mixing carries out percolation extraction, obtains the extracting solution that parts by weight are 380-430 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, every time
When 1-2 is small, collecting decoction, weight fraction is concentrated into after standing as 580-620 parts, then again with step（2）Obtained extracting solution
Mixing, boils, is filling, being capped, labeling.
Wherein, percolation extraction is according to the percolation under liquid extract and medicinal extract item（One annex I O of Chinese Pharmacopoeia）Into
Row seepage pressure effects.
It is further preferred that the preparation method of the seven leaf mirabilite-alum lotions, includes the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, puts
Put 12 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）What is obtained is pre-
Batch mixing carries out percolation extraction, obtains the extracting solution that parts by weight are 400 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, every time
1.5 it is small when, collecting decoction, weight fraction is concentrated into after standing as 600 parts, then again with step（2）Obtained extracting solution mixing,
Boil, is filling, being capped, labeling.
Product composition of the present invention differentiates：
（1）Take product 20ml of the present invention, be evaporated, residue adds 2mol/L hydrochloric acid 20ml, be heated to reflux 1 it is small when, filtering, filtrate
Add diatomite 2g, stir evenly, extracted with ether 2ml, divide and take ether solution to steam to 1ml, as test solution.Separately take diosgenin
Reference substance, adds diethyl ether and solution of the 1ml containing 2mg is made, as reference substance solution.According to thin-layered chromatography（One annex of Chinese Pharmacopoeia
VI B）Experiment, draws each 10 μ l of above two solution, puts respectively on same silica gel g thin-layer plate, with chloroform system-methanol（Body
Product is than being 95：5）For solvent, it is unfolded, takes out, dry, spray and dried about 10 minutes at 105 DEG C with 5% phosphomolybdic acid ethanol solution, supplies
In test product chromatography, the spot of same color is shown on position corresponding with reference substance chromatography.
（2）Product 20ml of the present invention is taken, ammonification test solution is adjusted to alkalescence, adds sodium chloride to saturation, quiet with ether 25ml extractions
Layering is put, divides and takes ether layer（Such as ether layer emulsification, emulsion layer is split in beaker, heating water bath to emulsion layer disappears, then pours into
In separatory funnel, divide and take ether layer）, water-bath steamed to 1ml as test solution.Aconitine reference substance separately is taken, is made of ether
Per solution of the 1ml containing 2mg, as reference substance solution, according to thin-layered chromatography（One annex VI B of Chinese Pharmacopoeia）Test, in absorption
Each 10 μ l of two kinds of solution are stated, are put respectively on same silica gel g thin-layer plate, with thiacyclohexane-diethylamine（Volume ratio is 8：2）Solution
For solvent, it is unfolded, takes out, dry, spray with dilute bismuth potassium iodide solution, in test sample chromatography, corresponding with reference substance chromatography
On position, the spot of same color is shown.
In this product chromatography, with corresponding reference substance chromatography relevant position, showing the spot of same color.
Compared with prior art, the present invention its advantage is：（1）The preparation method of seven leaf mirabilite-alum lotions is simple, is made
Seven leaf mirabilite-alum lotions there is good clearing heat and detoxicating, swelling and pain relieving and detoxification sore treatment；（2）Product of the present invention is used to connect
The diseases such as property dermatitis, subacute dermatitis, eczema, nettle rash, pruitus are touched, also available for external piles, mixed hemorrhoid, anal fistula, eczema, anus
The postoperative hip bath of door.
Embodiment
With reference to embodiment, the present invention is described in further detail.
Embodiment 1
Seven leaf mirabilite-alum lotions, including following component in parts by weight：15 parts of Paris polyphylla, 32 parts of rheum officinale, 6 parts of asarum,
15 parts of Cortex Phellodendri, 9 parts of Chinese prickly ash, 6 parts of monkshood, 9 parts of radix aconiti agrestis, 15 parts of cape jasmine, 16 parts of alum, 15 parts of semen momordicae, 38 parts of saltcake, kuh-seng 16
Part.
The present invention also provides a kind of preparation method of seven leaves mirabilite-alum lotion, include the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, puts
Put 9 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）What is obtained is pre-
Batch mixing carries out percolation extraction, obtains the extracting solution that parts by weight are 380 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, every time 1
Hour, collecting decoction, weight fraction is concentrated into after standing as 620 parts, then again with step（2）Obtained extracting solution mixing, is boiled
Boiling, filling, capping, labeling；
Wherein, the coarse granularity is that medicinal powder granularity requirements are coarse powder, and percolation extraction is according to liquid extract and medicinal extract
Percolation under（One annex I O of Chinese Pharmacopoeia）Carry out seepage pressure effects.
Embodiment 2
Seven leaf mirabilite-alum lotions, including following component in parts by weight：18 parts of Paris polyphylla, 35 parts of rheum officinale, 6 parts of asarum,
15 parts of Cortex Phellodendri, 9 parts of Chinese prickly ash, 6 parts of monkshood, 9 parts of radix aconiti agrestis, 15 parts of cape jasmine, 16 parts of alum, 15 parts of semen momordicae, 38 parts of saltcake, kuh-seng 16
Part.
The preparation method of seven leaf mirabilite-alum lotion of the present embodiment, includes the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, puts
Put 13 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）What is obtained is pre-
Batch mixing carries out percolation extraction, obtains the extracting solution that parts by weight are 430 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, every time 2
Hour, collecting decoction, weight fraction is concentrated into after standing as 580 parts, then again with step（2）Obtained extracting solution mixing, is boiled
Boiling, filling, capping, labeling；
Wherein, the coarse granularity is that medicinal powder granularity requirements are coarse powder, and percolation extraction is according to liquid extract and medicinal extract
Percolation under（One annex I O of Chinese Pharmacopoeia）Carry out seepage pressure effects.
Embodiment 3
Seven leaf mirabilite-alum lotions, including following component in parts by weight：16.7 parts of Paris polyphylla, 33.3 parts of rheum officinale, asarum
6.7 parts, 16.7 parts of Cortex Phellodendri, 10 parts of Chinese prickly ash, 6.7 parts of monkshood, 10 parts of radix aconiti agrestis, 16.7 parts of cape jasmine, 16.7 parts of alum, semen momordicae 16.7
Part, 40 parts of saltcake, 16.7 parts of kuh-seng.
The preparation method of seven leaf mirabilite-alum lotion of the present embodiment, includes the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, puts
Put 12 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）What is obtained is pre-
Batch mixing carries out percolation extraction, obtains the extracting solution that parts by weight are 400 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, every time
1.5 it is small when, collecting decoction, weight fraction is concentrated into after standing as 600 parts, then again with step（2）Obtained extracting solution mixing,
Boil, is filling, being capped, labeling；
Wherein, the coarse granularity is that medicinal powder granularity requirements are coarse powder, and percolation extraction is according to liquid extract and medicinal extract
Percolation under（One annex I O of Chinese Pharmacopoeia）Carry out seepage pressure effects.
Product of the present invention is yellowish-brown liquid, on inspection, its pH value：3.0~5.0（Annex of Chinese Pharmacopoeia 2010 edition
VII G）；Remaining：Related every regulation under lotion item should be met（Annex I V of Chinese Pharmacopoeia 2010 edition）
Usage and dosage of the present invention：External application.Cutaneous pruritus：This product about 100ml humidification boiling water one is taken to wash affected part again.Hemorrhoid are sat
Bath：Each 200ml one times of warm water hip baths 20 minutes.Or this product is taken directly to apply affected part on a small quantity.
Product storage practice of the present invention：It is closed, put shady place.The term of validity is 12 months.
To the itchy skin eruption patient of different symptoms, affected part is washed using product of the present invention, it is specific such as table 1.
Table 1
Affected part is washed to 100 contact dermatitis patients using product of the present invention at the same time, it is specific such as table 2.
Claims (4)
1. a kind of lotion for treating contact dermatitis, it is characterised in that be made of the following raw material medicine in parts by weight：Weight
Building 15-18 parts, 32-35 parts of rheum officinale, 6-8 parts of asarum, 15-17 parts of Cortex Phellodendri, 9-11 parts of Chinese prickly ash, 6-9 parts of monkshood, 9-12 parts of radix aconiti agrestis,
15-18 parts of cape jasmine, 16-17 parts of alum, 15-17 parts of semen momordicae, 38-41 parts of saltcake, 16-19 parts of kuh-seng.
2. it is according to claim 1 treatment contact dermatitis lotion, it is characterised in that by parts by weight as
Lower bulk pharmaceutical chemicals are made：16.7 parts of Paris polyphylla, 33.3 parts of rheum officinale, 6.7 parts of asarum, 16.7 parts of Cortex Phellodendri, 10 parts of Chinese prickly ash, 6.7 parts of monkshood, grass
10 parts of crow, 16.7 parts of cape jasmine, 16.7 parts of alum, 16.7 parts of semen momordicae, 40 parts of saltcake, 16.7 parts of kuh-seng.
3. the preparation method of the lotion of the treatment contact dermatitis described in claim 1, it is characterised in that include the following steps：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, places 9-
13 it is small when, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）Obtained pre-composition
Material carries out percolation extraction, obtains the extracting solution that parts by weight are 380-430 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, each 1-2 is small
When, collecting decoction, weight fraction is concentrated into after standing as 580-620 parts, then again with step（2）Obtained extracting solution mixing,
Boil, is filling, being capped, labeling.
4. the preparation method of the lotion for the treatment of contact dermatitis according to claim 3, it is characterised in that including following step
Suddenly：
Step（1）, rheum officinale, asarum, Cortex Phellodendri and Chinese prickly ash are ground into coarse powder together, are then sufficiently humidified so as to water, is capped, places 12
Hour, obtain premix material；
Step（2）, add the mixed liquor after boiling boiling as solvent is leached by the use of alum and saltcake, to step（1）Obtained pre-composition
Material carries out percolation extraction, obtains the extracting solution that parts by weight are 400 parts；
Step（3）, asarum, monkshood, radix aconiti agrestis, cape jasmine, semen momordicae and kuh-seng are cut into slices together, add boiling to carry secondary, 1.5 is small every time
When, collecting decoction, weight fraction is concentrated into after standing as 600 parts, then again with step（2）Obtained extracting solution mixing, boil,
Filling, capping, labeling.
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| CN104189396B true CN104189396B (en) | 2018-04-27 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218682A (en) * | 1998-10-12 | 1999-06-09 | 范永昌 | Bathing medicine for preventing and curing vulva disease |
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2014
- 2014-09-12 CN CN201410463424.1A patent/CN104189396B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218682A (en) * | 1998-10-12 | 1999-06-09 | 范永昌 | Bathing medicine for preventing and curing vulva disease |
Non-Patent Citations (2)
| Title |
|---|
| 七叶硝矾洗剂的微生物限度检查方法验证;梅群等;《大理学院学报》;20080630;第7卷(第06期);17-18 * |
| 中医洗浴疗法的应用;王曙东等;《时珍国医国药》;20010630;第12卷(第06期);565-566 * |
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