CN106421155B - It is a kind of to treat allergic rhinitis medicament - Google Patents
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Abstract
The invention belongs to pharmaceutical technology fields, in particular to a kind of to treat allergic rhinitis medicament.Medicament is by fresh tabernaemontanus bulrush perfume (or spice) leaf 10g, fresh Rose Mallow Root herb 10g, Cortex Phellodendri 5g, root bark of tree peony 5g and trehalose 2g, it is obtained through water-removing, frying, crushing, ethyl alcohol extraction, distillation extraction, decoction extraction, concentration, mixing, encapsulating, sterilizing, also medicament obtained above can be configured to liposome medical fluid again.By collunarium, absorbent cotton dip in suction plug nose, atomization import nose in either method use, allergic reaction can be released rapidly, and reach curative effect.
Description
Technical field
The invention belongs to pharmaceutical technology fields, in particular to a kind of to treat allergic rhinitis medicament.
Background technique
Allergic rhinitis, i.e. allergic rhinitis refer to the medium mainly mediated by lgE after atopic individuals contact allergen
(mainly histamine) release, and there are many schneiderian membrance non-infectious inflammatory diseases of the participations such as immunocompetent cell and cell factor
Disease.There are also a kind of rhinopathy, modern medicine is known as vasomotor rhinitis, and symptom is also much like with allergic rhinitis, also has
Typical watery nasal discharge and sneeze, but its mechanism is that vegetative nerve, endocrine adjust not normal draw to blood vessel, the Intervention of schneiderian membrance
It rises.
Although modern medicine can explain the pathogenesis of above-mentioned rhinitis in more detail, can also be adopted for different pathological types
Certain curative effect is obtained with the corresponding drug therapy such as such as antihistamine, glucocorticoid, anticholinergic, but all can not thoroughly be controlled
More, and side effect is big.
Chinese medicine just had before thousands of years discusses this disease, referred to as allergic rhinitis, nasosinusitis, and doctor also develops many in the successive dynasties
Prescription and method are treated, such as the Guizhi decoction and Mahuang Tang of warming lung for dispelling cold, the Yupingfeng San of invigorating qi for consolidating superficies, the benefit for the rising Yang that replenishes qi to invigorate the spleen
Middle Qi-benefiting decoction, the Zhen Wu Tang, Decoction for strengthening the Spleen-Yang of warming yang for diuresis, the Yinqiao San of wind-dispelling heat-dissipating and various external pulvis and drop wash Chinese medicine, can not
Deny, can also be produced effects in terms of improving constitution and mitigating symptom, but anaphylactoid many symptoms of nose still can not
It eradicates, is difficult to cure.
Summary of the invention
The present inventor carries out in-depth study by the rhinitis to similar allergic rhinitis symptoms, closes in conjunction with to of all times
It is found in the analysis of the discussion of such disease, the immunocompetence and the occurrence of this disease of human body are that have the relationship of reciprocal causation, Wo Mentong
It often only emphasizes that this disease can just occur since the immunity of human body is not strong, does not pay attention to the symptom that this disease long-term morbidity occurs but
Itself, the immunity that can also make us body is constantly damaged, and yang-energy can not be able to convergence rehabilitation, forms vicious circle.Understand
This point, just should the crucial local route repair for focusing on schneiderian membrance, prevent from inducing in the appearance of ill symptom, give patient
The time of rehabilitation is obtained, because human body itself is with magical self-rehabilitation ability, as long as can give body good branch
It holds and the time, without excessive drug therapy, the rehabilitation instinct of human body is that recovery from illness may be implemented completely.However, making a general survey of
Treat the medication of above-mentioned rhinitis at all times, the blocking agent of Western medicine, Claritin, hormone or even antibiotic abuse, all repeatedly
Interfere the ecological environment of nose.Even Chinese medicine, such as wrinkled giant hyssop, Rhizoma Chuanxiong, the root of Dahurain angelica, Flos Magnoliae Liliflorae, kapur, schizonepeta, fiber crops are also commonly used
The stimulating drug of the acidities such as Huang, the achene of Siberian cocklebur, fennel, defends tenaciously the theory medication of wind dispelling cold dispelling, the result is that make schneiderian membrance by
Stimulation repeatedly, cannot not only eradicate allergic rhinitis, make the state of an illness touching refractory instead, this kind of topical agent is in the patent literature
Also it can be found everywhere, it is tangible regrettable.
Inventors believe that either medium caused by allergen discharges, or nerve, endocrine to the blood vessel of schneiderian membrance,
Intervention adjust it is not normal, all related to the stimulation that schneiderian membrance cell is subject to, the present invention has screened a large amount of Chinese herbal medicine, with it is sweet,
Light, amara be drug choice, avoid dripping of irritant drugs first, then from pharmacological property, functionally test and screen, inhibition must be reached
With block allergic reaction, convergence, cool blood, calmness, removing toxic substances, anti-inflammatory resultant effect.
Allergic rhinitis medicament is treated the object of the present invention is to provide a kind of.
The object of the present invention is achieved like this.
A kind of preparation method for treating allergic rhinitis medicament, is made of following preparation step:
(1) fresh tabernaemontanus bulrush perfume (or spice) leaf 10g and fresh Rose Mallow Root herb 10g are rinsed well with clear water, is put into microwave stove heating, makes it
Moisture rapid evaporation, achievees the effect that water-removing, until taking out when water content 1~3%, being ground into middle powder；
(2) Cortex Phellodendri 5g is ground into coarse powder, adds rice wine 5g to infiltrate, 150~155 DEG C of 3~5min of frying；
(3) root bark of tree peony 5g is got express developed completely with boiling water, 85 DEG C of drying are ground into coarse powder；
(4) whole raw materials obtained by above-mentioned steps (1), (2), (3) are mixed, obtains mixed raw material, is put into lid
In glass container, 3 times of mixed raw material weight of ethyl alcohol is added, concentration of alcohol is 70% (V/V), closed, impregnate 3 at room temperature~
It 5 days, is shaken daily in dipping process 2 times, through 200 mesh centrifugal filtrations, obtains alcohol dipping liquid, obtain alcohol extracting after being distilled to recover ethyl alcohol
Taking liquid；
(5) by 3 times of dregs of a decoction weight of deionized water is added in the resulting dregs of a decoction after 200 mesh centrifugal filtrations in step (4), add
Heat is boiled, and is collected distillate 30min with distilling apparatus, is obtained distillation medical fluid, and the medical fluid containing the dregs of a decoction boiled is filtered out through the centrifugation of 200 mesh
After the dregs of a decoction, water extraction liquid is obtained, trehalose 2g is added in water extraction liquid, to dissolving, heating evaporation is concentrated into 30g for stirring,
Obtain concentrated medicament；
(6) alcohol extracting taking liquid made from step (4) is mixed with step (5) distillation medical fluid obtained and concentrated medicament, is stirred
It mixes uniformly, with the glass ampule encapsulating of 20mL specification, 100 DEG C of 45min sterilizings are made a kind of and treat allergic rhinitis medicament.
The application method of medicament obtained above has following four application method:
(1) by the direct collunarium of medicament；
(2) suction medicament is dipped in absorbent cotton wool, alternately put into the nostril of left and right；
(3) it will spray into or import in nose after medicament sprayer or ultrasonic ultrasonic delay line memory atomization；
(4) medicament is configured to liposome medical fluid successor meaning selects one of above-mentioned three kinds of application methods method to use.
Beneficial effects of the present invention are as follows:
(1) fresh tabernaemontanus bulrush perfume (or spice) leaf belongs to the fresh leaf of magaphanerophytes' tabernaemontanus bulrush perfume (or spice) tree for Thymelaeceae agalloch eaglewood.Fresh Rose Mallow Root herb is
Herbal medicine.Quick heating by micro-wave oven to fresh tabernaemontanus bulrush perfume (or spice) leaf and fresh Rose Mallow Root, since microwave heating can be produced from the inside of raw material
Heat, therefore moisture energy rapid evaporation, while by the herbaceous taste in leaf quickly with vapor evolution, in addition high heat effect, water-removing effect
Fruit highly significant, also acts as sterilization functions.
(2) Cortex Phellodendri, be Chinese medicine, bitter is cold in nature, by crushing, plus rice wine infiltration and 150~155 DEG C of fryings 3~
5min can significantly reduce the cold of Cortex Phellodendri, reach modified purpose, create condition for cooperation prescription medicine.
(3) root bark of tree peony is got express developed with boiling water, can greatly reduce bacterium and impurity, and 85 DEG C dry both property of traditional Chinese without prejudice,
It can further sterilize again and be conducive to crush.
(4) alcohol dipping that the raw material of above-mentioned preliminary treatment is passed through to 70% (V/V) concentration, by the alcohol in prescription raw material
Dissolubility functional activity substance is leached out, and the dregs of a decoction add boiling boiling distillation, extracts volatility functional mass, while will boil and mention medical fluid
Filtering, concentration, obtain water-solubility function active material, by three kinds of different extracting modes, comprehensively sufficiently extract raw material
Whole effective components.
(5) trehalose is added and mixes concentration with water extraction liquid, then is mixed with distillation medical fluid and alcohol extracting taking liquid, encapsulating is gone out
Bacterium can be such that the functional activity substance in medical fluid is protected to greatest extent.
(6) each raw material in prescription of the present invention, tests prove that, not but not stimulation schneiderian membrance and generate allergic effect
Reaction, effectively can inhibit allergic effect to react instead, wherein fresh tabernaemontanus bulrush spiceleaf slightly warm in nature, it can tranquilizing and allaying excitement inhibition allergic effect reaction；Cortex Phellodendri wine
Cold nature after system can be dehumidified, be invigorated blood circulation, anti-inflammatory, repairing damaged cell；Root bark of tree peony energy cool blood, anti-inflammatory, inhibits allergic effect reaction at promoting blood circulation；It is fresh
Rose Mallow Root herb is sweet in flavor, light, mild-natured, enters the heart, lung channel, can expelling wind and removing dampness, clearing heat and detoxicating, elimination oedema.Above-mentioned four traditional Chinese medicine object is former
After material combination, no acidity penetrating odor is sweet in flavor, bitter and gas perfume (or spice) is refined, produce mild wind-dispelling, it is antipruritic, dampness removing consumer edema, disappear
Except inflammatory symptoms, calm convergence, the resultant effect for inhibiting allergic effect reaction, prescription is simplified and effect highly significant.
(7) trehalose is in playing protection medical fluid while functional activity substance, moreover it is possible to enhance drug and schneiderian membrance cell
Compatibility, in addition, play the slow releasing function of regulating medicine since it forms one layer of micro- coating function to drug molecule, this
Effect produces following the utility model has the advantages that 1. making a small amount of drug, constant, constantly being absorbed by schneiderian membrance cell, will not be because of mucous membrane
Cell instantaneous touch high concentration medicine and cause stimulate the reaction；2. making medication constant, persistently release, persistent is stablized.
(8) after trehalose being added, when being fabricated to liposome medical fluid, encapsulation rate can be made to greatly improve, so that medicament be made to send out
Wave better curative effect.
(9) common such a phenomenon in clinic, if being applied to red, swollen, hot, pain the positive sore patient of a trouble pungent
The phenomenon that red, swollen, hot, pain symptoms obviously aggravate can occur quickly in hot herbal mediciment, patient, if using bitter cold instead at once
Cool blood, removing toxic substances, heat-clearing Chinese herbal medicine, patient has a refrigerant comfortable feeling at once, it is seen then that pharmacological property, the compatibility of human body of drug
And adaptability is extremely important and significant, although current science remains difficult to make detailed explanation, its mechanism must be
It is existing.Prescription of the invention is to inspire by the theory of traditional Chinese medicine, searches out and schneiderian membrance is enabled to have good affinity, adaptability, phase
The drug of melting property is combined, and effect can shield resistance sensibiligen, inhibit allergic effect reaction, restrains inflammatory reaction symptom, after use, meeting
Feel comfortable immediately, the congested prompt resolution of the redness of schneiderian membrance.From this phenomenon, an important proposition also is disclosed for us: right
The understanding of traditional Chinese medicine mechanism and probing into still shoulders heavy responsibilities！It but is also inexhaustible medicine source.
(10) using after medicament of the invention, either allergic rhinitis or vasomotor rhinitis, sneeze, stream are clear
Tears, nasal obstruction symptom can significantly improve, and achieve the purpose that " stopping loss " first, so that patient body be allowed to be able to slowly restore strong
Strong, health, endocrine restore normal, and immunity improves, the adaptability enhancing of body, then, along with benefiting for this medicament
Effect, schneiderian membrance functional status can be repaired and be fully recovered, if being able to cooperate traditional Chinese medicine for oral administration conditioning and reinforcing body kinematics, rhinitis
Complex velocity is faster.Because of continuous watery nasal discharge, substantially it is excessive secretion, that is, a kind of consumption, healthy tendency, energy can be enabled continuous
Therefore loss as long as the allergic effect reaction of nose can be pacified, be restrained, can be only achieved the effect stopped loss, to realize the mesh of rehabilitation again
, if effect of the invention is that weight lifting is light, change numerous to simple.
Specific embodiment
Below by specific embodiment, the invention will be further described.
Embodiment.
A kind of preparation method for treating allergic rhinitis medicament, is made of following preparation step:
(1) fresh tabernaemontanus bulrush perfume (or spice) leaf 10g and fresh Rose Mallow Root herb 10g are rinsed well with clear water, is put into microwave stove heating, makes it
Moisture rapid evaporation, achievees the effect that water-removing, until taking out when water content 1~3%, being ground into middle powder；
(2) Cortex Phellodendri 5g is ground into coarse powder, adds rice wine 5g to infiltrate, 150~155 DEG C of 3~5min of frying；
(3) root bark of tree peony 5g is got express developed completely with boiling water, 85 DEG C of drying are ground into coarse powder；
(4) whole raw materials obtained by above-mentioned steps (1), (2), (3) are mixed, obtains mixed raw material, is put into lid
In glass container, 3 times of mixed raw material weight of ethyl alcohol is added, concentration of alcohol is 70% (V/V), closed, impregnate 3 at room temperature~
It 5 days, is shaken daily in dipping process 2 times, through 200 mesh centrifugal filtrations, obtains alcohol dipping liquid, obtain alcohol extracting after being distilled to recover ethyl alcohol
Taking liquid；
(5) by 3 times of dregs of a decoction weight of deionized water is added in the resulting dregs of a decoction after 200 mesh centrifugal filtrations in step (4), add
Heat is boiled, and is collected distillate 30min with distilling apparatus, is obtained distillation medical fluid, and the medical fluid containing the dregs of a decoction boiled is filtered out through the centrifugation of 200 mesh
After the dregs of a decoction, water extraction liquid is obtained, trehalose 2g is added in water extraction liquid, to dissolving, heating evaporation is concentrated into 30g for stirring,
Obtain concentrated medicament；
(6) alcohol extracting taking liquid made from step (4) is mixed with step (5) distillation medical fluid obtained and concentrated medicament, is stirred
It mixes uniformly, with the glass ampule encapsulating of 20mL specification, 100 DEG C of 45min sterilizings are made a kind of and treat allergic rhinitis medicament.
Application examples 1: Zhang, female 39 years old, have suffered from allergic rhinitis 6 years, when air quality is slightly worse, i.e., frequently play spray
It sneezes, watery nasal discharge, leads to concha swelling gradually, nasal obstruction symptom occur, can cause alliteration, attention that cannot concentrate when serious, once use
A variety of Western medicine kimonos Chinese patent drug Yupingfeng San are crossed, though can temporarily alleviate, are can not be restored always, product of the present invention is tried out,
It is used, is dripped 4 times with direct collunarium method within 1st, 3 drops are respectively dripped in each left and right nostril, and feel is comfortable after drop, and rhiocnesmus does not occur, hence it is evident that
Few sneezing, after one month, the symptom of allergic reaction disappears substantially, then adheres to not having over the past half year using fully recovering after 2 months
There is recurrence.
Application examples 2: Chen, male, 52 years old, after every morning gets up, the cold and Warm Changes in Northern of temperature, or the cold water for washing one's face, washing one's hands
Stimulation, i.e. initiation sneeze is continuous, and nose stream clear water shape tears lead to nasal obstruction, eyelid edema, with all over Chinese and Western drug for treating rhinitis in the market, also
It can not be restored.Medicament 50g made from above-described embodiment is taken, the glass equipped with 80g adipose membrane as made from lecithin, cholesterol is added to
It in glass bottle, is stirred with blender, liposome medical fluid is made, sprayed into nose with sprayer, 1 time a day, after 6 days, symptom is big
It is big to improve, without stream clear water shape nasal mucus, continue to use 12 days, and sentence Guizhi decoction and close the decoction of Yupingfeng prescription, the next day take it is one,
6 doses are taken, after above-mentioned treatment, all symptoms disappear, and recovery from illness is paid a return visit, no recurrence after 3 months.
Better embodiment of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as, the scope of protection of the patent of the present invention is with appended claims
It is quasi-.
Claims (3)
1. a kind of preparation method for treating allergic rhinitis medicament, which is characterized in that be made of following preparation step:
(1) fresh tabernaemontanus bulrush perfume (or spice) leaf 10g and fresh Rose Mallow Root herb 10g are rinsed well with clear water, is put into microwave stove heating, makes its moisture
Rapid evaporation achievees the effect that water-removing, until taking out when water content 1~3%, being ground into middle powder；
(2) Cortex Phellodendri 5g is ground into coarse powder, adds rice wine 5g to infiltrate, 150~155 DEG C of 3~5min of frying；
(3) root bark of tree peony 5g is got express developed completely with boiling water, 85 DEG C of drying are ground into coarse powder；
(4) whole raw materials obtained by above-mentioned steps (1), (2), (3) are mixed, obtains mixed raw material, is put into the glass of lid
In container, 3 times of mixed raw material weight of ethyl alcohol, concentration of alcohol 70%(V/V is added), it is closed, it impregnates 3~5 days at room temperature,
It is shaken daily in dipping process 2 times, through 200 mesh centrifugal filtrations, obtains alcohol dipping liquid, obtain alcohol extracting medicine after being distilled to recover ethyl alcohol
Liquid；
(5) by resulting 3 times of dregs of a decoction weight of dregs of a decoction addition of deionized water, heating are boiled after 200 mesh centrifugal filtrations in step (4)
Boiling collects distillate 30min with distilling apparatus, obtains distillation medical fluid, and the medical fluid containing the dregs of a decoction boiled is filtered out the dregs of a decoction through the centrifugation of 200 mesh
Afterwards, water extraction liquid is obtained, trehalose 2g is added in water extraction liquid, to dissolving, heating evaporation is concentrated into 30g, obtains dense for stirring
Contracting medical fluid；
(6) alcohol extracting taking liquid made from step (4) is mixed with step (5) distillation medical fluid obtained and concentrated medicament, stirring is equal
Even, with the glass ampule encapsulating of 20mL specification, 100 DEG C of 45min sterilizings are made a kind of and treat allergic rhinitis medicament.
2. a kind for the treatment of allergic rhinitis medicament that preparation method as described in claim 1 is prepared.
3. medicament, is configured to liposome medicament by treatment allergic rhinitis medicament according to claim 2 again.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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