CN104922649A - Turmeric acne eliminating external preparation and preparation method and application thereof - Google Patents
Turmeric acne eliminating external preparation and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a turmeric acne eliminating external preparation comprising turmeric, coral ginger and other components, a preparation method of the turmeric acne eliminating external preparation and the novel application in the field of pharmacy, and belongs to the technical field of traditional Chinese medicine. The turmeric acne eliminating external preparation has the effect of relieving acute injuries and swelling of soft tissue and improving pathological tissue change and can be used for treating traumatic injuries.
Description
Technical field
The present invention relates to a kind of eliminating acne turmeric external preparation containing the composition such as Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini and preparation method thereof and the novelty teabag in pharmaceutical field, belong to the technical field of Chinese medicine.
Background technology
Eliminating acne turmeric liniment is OTC (over-the-counter) class liniment, and main component is Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Polygoni cymosi, Herba Solidaginis, Herba Chenopodii, Herb Gynostemmae Pentaphylli, Rhizoma Zingiberis corallini, and exercise use is for for the acne (acne) caused by damp and hot strongly fragrant skin.The preparation method of existing product is as follows: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, and vapor distillation extracts volatile oil, for subsequent use.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, carry out percolation according to the percolation (Chinese Pharmacopoeia version in 2000 annex I O) under fluid extract and extractum item with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter, it is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to alcohol content, leave standstill 24 hours and filter, filtrate and above-mentioned liquid of filtering merge.Separately getting after volatile oil adds polyoxyethylene sorbitan monoleate emulsifying adds in above-mentioned medicinal liquid, mixing, filters, is adjusted to ormal weight, obtains final product.
Summary of the invention
The object of the present invention is to provide the new preparation method of this Chinese patent medicine and the new opplication in pharmacy.
In fact, the present invention relates to composition is Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Polygoni cymosi, Herba Solidaginis, Herba Chenopodii, Herb Gynostemmae Pentaphylli, the eliminating acne turmeric external preparation and preparation method thereof of Rhizoma Zingiberis corallini and the application in the medicine of preparation treatment traumatic injury.
Technical scheme of the present invention forms like this: described eliminating acne turmeric external preparation is made up of 50 parts, Rhizoma Curcumae Longae, Rhizoma Paridis 50 parts, Herba Polygoni cymosi 50 parts, Herba Chenopodii 25 parts, Herba Solidaginis 25 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Zingiberis corallini 50 parts.The method for making of described eliminating acne turmeric external preparation is as follows: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts, and obtains extract A, retains, Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis is ground into fine powder, medicinal residues and Herba Polygoni cymosi after merging said extracted, Herba Chenopodii, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized, the soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, add ethanol in proper amount to dissolve, be spin-dried for, add water make 10% solution, homogenizing 30 minutes again, obtain solution B, then obtained liniment, gel, Emulsion, spray, ointment.Supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g.The application of described eliminating acne turmeric external preparation in the medicine of preparation treatment traumatic injury.
Experimental example 1: acute soft tissue contusion is tested
150-200 g rat, male, 20, random packet, often organizes 10.Rats with bilateral hind leg calf shaves hair, and location survey respectively organizes the normal girth of rat hindleg shank, hits 3 times continuously, causes topical acute soft tissue injury model, often organize 20 lower limbs, totally 80 lower limbs during modeling with pounder outside mid calf.If merge fracture person to be rejected.Instant coating after modeling, each 0.5 mL, every day 4 times.After 1st coating, 8h, 24h, 48h, 72 h measure hind leg shank swelling (after modeling coating girth-normal girth), often organize simultaneously and at these 4 time points, rat cervical dislocation is put to death fast respectively, tissue is got at centre of percussion position, 10% formaldehyde is fixed, paraffin embedding, HE dyes.The inflammation swelling of optical microphotograph Microscopic observation and inflammatory cell infiltration situation.
Pharmacodynamic experiment result shows, this pharmaceutical composition has the effect alleviating acute soft tissue contusion swelling, and improves the pathological change of tissue, shows as subcutaneous tissue and muscle tissue damage alleviates, neutrophil infiltrates reduces, tissue repair is very fast.Can be used for treating traumatic injury.
But composition is very complicated contained by Chinese medicine, both containing multiple active ingredient, have invalid element again, existing technique dosage form has certain defect, its effective ingredient should be extracted and be separated further, purification, then carry out liposomal encapsulated, so that Transdermal absorption.Preparation is made the external preparation such as liniment, gel, Emulsion, spray, ointment simultaneously.Through repeatedly testing, the technique of this product can extract the active ingredient in this prescription medical material to greatest extent, the inherent quality of this product formulation and clinical therapeutic efficacy is improved, the effect of product is played to greatest extent.
Experimental example 2: volatile oil is drawn mode is investigated
Mode is 1.: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, add 6 times amount water soaking 2 hours, then steam distillation 5 hours, collects volatile oil.
Mode is 2.: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts.Extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g.
As can be seen from result of the test above; adopt the method for supercritical extraction not only can increase the extracted amount of volatile ingredient; and part curcumin can also be extracted when low temperature by adding entrainer; be well protection to active component, therefore our extracting mode of selected volatile ingredient is supercritical extraction.
Experimental example 3: active site enrichment route screens
Route is 1.: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts, and extract retains.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis, be ground into fine powder, carry out percolation with 6 times amount 80% ethanol as solvent, collect liquid of filtering, for subsequent use.Get Herba Polygoni cymosi, Herba Chenopodii, decoct with water three times, 2 hours first times, second time 1.5 hours, 1 hour third time, collecting decoction, filter.It is 1.18 ~ 1.22(60 DEG C that filtrate is concentrated into relative density) clear paste, add ethanol and reach 50% to amount of alcohol, leave standstill 24 hours filter, filtrate and above-mentioned liquid of filtering merge, decompression recycling ethanol, concentrate drying.
Route is 2.: get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts, and extract retains.Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol to relative density is 1.05 ~ 1.10(60 DEG C), add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized.
As can be seen from result of the test above, process route 2. can effective deposition activity position, and content is significantly promoted, and the rate of transform is higher.
Experimental example 4: liposome enclose conditional filtering
(1) soybean lecithin and cholesterol consumption proportion are studied
Method: take a certain amount of soybean lecithin and cholesterol is placed in 500ml eggplant-shape bottle, add appropriate dehydrated alcohol and make dissolving, with on Rotary Evaporators, reduction vaporization (rotating speed is 80r/min) in 35 DEG C of waters bath with thermostatic control, reclaim ethanol, by the ointment powder aqueous solution aquation of 10%, rotate 10 minutes, then homogenizing 30 minutes.
Rhizoma Paridis saponin envelop rate
as can be seen from the above results, along with the increase of soybean lecithin consumption, envelop rate presents ascendant trend.But in conjunction with the ratio that the amplitude risen and consumption increase, we select soybean lecithin: cholesterol is the ratio of 8:1.
(2) ointment powder concentration affects envelop rate
Method: take a certain amount of soybean lecithin and cholesterol admixture (both ratios are 8:1), be placed in 500ml eggplant-shape bottle, add appropriate dehydrated alcohol and make dissolving, with on Rotary Evaporators, reduction vaporization (rotating speed is 80r/min) in 35 DEG C of waters bath with thermostatic control, reclaims ethanol, adds the ointment powder aqueous solution aquation of variable concentrations, rotate 10 minutes, then homogenizing 30 minutes.
Rhizoma Paridis saponin envelop rate
as can be seen from the above results, medicated powder excessive concentration, cause dispersion insufficient, envelop rate obviously declines; But as can be seen from process of the test, concentration is too low, makes volumes of formulation too huge, have considerable influence for preparations shaping, therefore drug of choice amidin concentration is 10%.
Experimental example 5: acute soft tissue contusion contrast experiment
150-200 g rat, male, 20, random packet, often organizes 10.Rats with bilateral hind leg calf shaves hair, and location survey respectively organizes the normal girth of rat hindleg shank, hits 3 times continuously, causes topical acute soft tissue injury model, often organize 20 lower limbs, totally 80 lower limbs during modeling with pounder outside mid calf.If merge fracture person to be rejected.Instant coating after modeling, each 0.5 mL, every day 4 times.After 1st coating, 8h, 24h, 48h, 72 h measure hind leg shank swelling (after modeling coating girth-normal girth), often organize simultaneously and at these 4 time points, rat cervical dislocation is put to death fast respectively, tissue is got at centre of percussion position, 10% formaldehyde is fixed, paraffin embedding, HE dyes.The inflammation swelling of optical microphotograph Microscopic observation and inflammatory cell infiltration situation.
Rhizoma Paridis saponin preparation technology: Rhizoma Paridis medical material, pulverize, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol to relative density is 1.05 ~ 1.10(60 DEG C), add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, then with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized.
As can be seen from the above results, this pharmaceutical composition deposition activity position, comparatively one-component (Rhizoma Paridis saponin) better effects if.The technique provided is separated active ingredient further, purification, then carries out liposomal encapsulated, so that Transdermal absorption.The exterior-applied liquid medicine gel that we provide, can extend administration time, plays the effect of slow release.
Comprehensive above-mentioned experimental result, can draw and the invention has the advantages that:
(1) preparation technology's enrichment active ingredient of the present invention, easier Transdermal absorption, the effect of product has remarkable lifting.
(2) the present invention has excavated new medical application to known Chinese patent medicine eliminating acne turmeric liniment, has opened up a new application.
Concrete embodiment
Embodiment 1: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g), obtain extract A, retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized.The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, adds ethanol in proper amount and dissolves, be spin-dried for, add water make 10% solution, homogenizing 30 minutes, obtains solution B, adds the 940 type carbomers of 1%, stir 1 hour, after again extract A being dissolved with 2 times amount propylene glycol, to join in mixed solution homogenizing 30 minutes, regulate pH=6 ~ 7 with triethanolamine, homogenizing 30 minutes, obtains gel again.
Usage and dosage: external.Ointment is applied to affected part, outer wiping every day 2-3 time.
Embodiment 2: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g), obtain extract A, retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 10% solution, homogenizing 30 minutes, obtains solution B.Separately get extract A and add Tween-80 and glycerol mix homogeneously, in 70 DEG C of homogenizing 10 minutes, cool to room temperature, then add propylene glycol emulsifying 10 minutes, emulsifier proportion is extract A: Tween-80: glycerol: propylene glycol (1:4:1:1
) finally add in above-mentioned solution B, add the ethyl hydroxybenzoate of 0.1%, mixing, leave standstill and filter, namely standardize solution obtains Emulsion.
Embodiment 3: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g), obtain extract A, retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 10% solution, homogenizing 30 minutes, obtains solution B; Extract A adds 2 times of dissolve with ethanols, then mixs homogeneously with solution B, and adjustment concentration of alcohol is 30%, mixing, and filter, filtrate is dispensed in pressure vessel, pours compressed nitrogen and namely obtains spray.
Embodiment 4: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g), obtain extract A and retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 10% solution, homogenizing 30 minutes, obtains solution B; Extract A adds 2 times of propylene glycol and dissolves, then mixs homogeneously with solution B, and adjustment concentration of alcohol is 30%, mixing, and filter, filtrate is dispensed in pressure vessel, pours compressed nitrogen and namely obtains spray.
Embodiment 5: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g), obtain extract A and retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 10% solution, homogenizing 30 minutes, obtains solution B; Said extracted thing A is added 2 times of tween 80 emulsifyings, then adds 2 times amount glycerol mix homogeneously, then add solution B mix homogeneously, adjustment concentration of alcohol is 40%, homogenizing 20 minutes, and filter, filtrate fill, obtains liniment.
Experimental example 6: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 25MPa; Extraction temperature is: 50 DEG C; CO
2flow: 30L/h; Extraction time: 4 hours; Entrainer is ethanol, and consumption is 0.8ml/g), obtain extract A and retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 3 times amount of getting it filled: the mixture of cholesterol=9:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 6% solution, homogenizing 30 minutes, obtains solution B; Above-mentioned supercritical extract is added 2 times of tween 80 emulsifyings, then add 2 times amount glycerol mix homogeneously, then add solution B mix homogeneously, adjustment concentration of alcohol is 40%, homogenizing 20 minutes, and filter, filtrate fill, obtains liniment.
Experimental example 7: Rhizoma Curcumae Longae 50g, Rhizoma Paridis 50g, Herba Polygoni cymosi 50g, Herba Chenopodii 25g, Herba Solidaginis 25g, Herb Gynostemmae Pentaphylli 25g, Rhizoma Zingiberis corallini 50g, gets Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopts supercritical CO
2fluids extraction extracts (supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 35MPa; Extraction temperature is: 40 DEG C; CO
2flow: 50L/h; Extraction time: 4 hours; Entrainer is ethanol, and consumption is 1.2ml/g), obtain extract A and retain; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 5 times amount of getting it filled: the mixture of cholesterol=10:1, add ethanol in proper amount dissolve, be spin-dried for, add water make 12% solution, homogenizing 30 minutes, obtains solution B; Extract A is added 2 times of tween 80 emulsifyings, then add 2 times amount glycerol mix homogeneously, then add solution B mix homogeneously, adjustment concentration of alcohol is 40%, homogenizing 20 minutes, and filter, filtrate fill, obtains liniment.
Claims (4)
1. the preparation method of eliminating acne turmeric external preparation, it is characterized in that: described eliminating acne turmeric external preparation is made up of 50 parts, Rhizoma Curcumae Longae, Rhizoma Paridis 50 parts, Herba Polygoni cymosi 50 parts, Herba Chenopodii 25 parts, Herba Solidaginis 25 parts, Herb Gynostemmae Pentaphylli 25 parts, Rhizoma Zingiberis corallini 50 parts, get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini is ground into coarse powder, adopt supercritical CO
2fluids extraction extracts, and obtains extract A; Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are ground into fine powder, medicinal residues and Herba Polygoni cymosi, Herba Chenopodii after merging said extracted, with 6 times amount 80% alcohol reflux 2 times, extracting liquid filtering, filtrate recycling ethanol is 1.05 ~ 1.10 to relative density 60 DEG C, add 2 times of water gagings and stir evenly rear filtration, filtrate crosses AB-8 macroporous adsorptive resins with the flow velocity of per kilogram medical material 250ml per hour, again with 10% ethanol remove impurity of 4 times of resin volumes, finally use 50% ethanol desorbing of 4 times of resin volumes, collect stripping liquid, decompression recycling ethanol, concentrate drying is pulverized; The soybean lecithin of powder 4 times amount of getting it filled: the mixture of cholesterol=8:1, adds ethanol in proper amount and dissolves, be spin-dried for, add water make 10% solution, then homogenizing 30 minutes, obtains solution B, then obtained liniment, gel, Emulsion, spray.
2., according to the preparation method of eliminating acne turmeric external preparation described in claim 1, it is characterized in that: supercritical CO
2fluid extraction condition is as follows: extracting pressure is: 30MPa; Extraction temperature is: 45 DEG C; CO
2flow: 40L/h; Extraction time: 3 hours; Entrainer is ethanol, and consumption is 1ml/g.
3. eliminating acne turmeric external preparation, is characterized in that: be made up of the preparation method described in claim 1 or 2.
4. the application of eliminating acne turmeric external preparation in the medicine of preparation treatment traumatic injury according to claim 3.
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| CN108903541A (en) * | 2018-09-25 | 2018-11-30 | 四川新绿色药业科技发展有限公司 | A kind of medicine-filled pillow and preparation method thereof for wind-expelling pain-stopping |
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Non-Patent Citations (1)
| Title |
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| 国家药品监督管理局编: "《国家药品中药标准（眼科，耳鼻喉科皮肤科分册）》", 31 December 2002 * |
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| CN108903541A (en) * | 2018-09-25 | 2018-11-30 | 四川新绿色药业科技发展有限公司 | A kind of medicine-filled pillow and preparation method thereof for wind-expelling pain-stopping |
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