CN104185641A - 针对tnf和il-17的双特异性免疫结合剂 - Google Patents

针对tnf和il-17的双特异性免疫结合剂 Download PDF

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Publication number
CN104185641A
CN104185641A CN201280064228.6A CN201280064228A CN104185641A CN 104185641 A CN104185641 A CN 104185641A CN 201280064228 A CN201280064228 A CN 201280064228A CN 104185641 A CN104185641 A CN 104185641A
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seq
chain variable
structural domain
variable structural
antigen
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CN201280064228.6A
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Chinese (zh)
Inventor
C.M.斯伊
詹尼弗.佩雷兹
L.贝纳图伊
Y.库特斯科瓦
J.梅莫特
S.钟
L.伊顿
M.胡干恩
A.布里托
安卡.克拉伯斯
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AbbVie Inc
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AbbVie Inc
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Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CN104185641A publication Critical patent/CN104185641A/zh
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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CN201280064228.6A 2011-10-24 2012-10-24 针对tnf和il-17的双特异性免疫结合剂 Pending CN104185641A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550619P 2011-10-24 2011-10-24
US61/550619 2011-10-24
PCT/US2012/061686 WO2013063110A1 (en) 2011-10-24 2012-10-24 Bispecific immunobinders directed against tnf and il-17

Publications (1)

Publication Number Publication Date
CN104185641A true CN104185641A (zh) 2014-12-03

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CN201280064228.6A Pending CN104185641A (zh) 2011-10-24 2012-10-24 针对tnf和il-17的双特异性免疫结合剂

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US (2) US9655964B2 (enExample)
EP (1) EP2771361A1 (enExample)
JP (1) JP6121432B2 (enExample)
KR (1) KR20140084254A (enExample)
CN (1) CN104185641A (enExample)
AR (1) AR088514A1 (enExample)
AU (1) AU2012328917B2 (enExample)
BR (1) BR112014009810A2 (enExample)
CA (1) CA2853114A1 (enExample)
CL (1) CL2014001055A1 (enExample)
CO (1) CO7020874A2 (enExample)
CR (1) CR20140224A (enExample)
DO (1) DOP2014000084A (enExample)
EC (1) ECSP14001260A (enExample)
GT (1) GT201400077A (enExample)
HK (1) HK1200321A1 (enExample)
IL (1) IL232207A0 (enExample)
MX (1) MX2014004980A (enExample)
PE (1) PE20142245A1 (enExample)
PH (1) PH12014500903A1 (enExample)
RS (1) RS20140202A1 (enExample)
RU (1) RU2014121043A (enExample)
SG (1) SG11201401796SA (enExample)
TW (1) TW201323441A (enExample)
UY (1) UY34410A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
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CN108135913A (zh) * 2015-10-05 2018-06-08 莫佛塞斯公司 治疗和/或预防特应性皮炎的il-17c拮抗剂
CN111133001A (zh) * 2017-09-22 2020-05-08 豪夫迈·罗氏有限公司 用于分析目的的多价单或双特异性重组抗体

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JP7179464B2 (ja) 2015-01-20 2022-11-29 アイジーエム バイオサイエンシズ インコーポレイテッド 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
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JP6955507B2 (ja) 2015-12-14 2021-10-27 マクロジェニクス，インコーポレーテッド Ｐｄ‐１及びｃｔｌａ‐４との免疫応答性を有する二重特異性並びにその使用方法
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