CN104161872B - Alopecia areata external is rubbed with the hands and is coated with medicated wine and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of alopecia areata external and rub painting medicated wine with the hands, take off the primary raw material stating weight proportion and be prepared from: Retinervus Luffae Fructus 16-25 part, Pericarpium Zanthoxyli 8-12 part, Fructus Gardeniae 12-22 part, Calomelas 5-9 part, fresh Flos Celosiae Cristatae 50-80 part, Camphora 0.5-3.0 part, Borneolum Syntheticum 1.2-3.0 part, brandy 400-600 part.This product is on the basis of summing up forefathers' experience, adopt pure natural draft Chinese medicine unique formula and technique to refine to form, by scalp irritation acupuncture point, can play and regulate meridians, promoting flow of QI and blood, nourishing the liver and kidney, the disease of the insufficiency of vital energy and blood caused by liver and kidney deficiency such as treatment alopecia areata, can play again and improve cerebral blood flow supply, the effect of immunity moderation.

Description

Alopecia areata external is rubbed with the hands and is coated with medicated wine and preparation method thereof

Technical field

The present invention relates to traditional Chinese medicine field.Particularly relate to alopecia areata external and rub painting medicated wine and preparation method thereof with the hands.

Background technology

Alopecia areata is a kind of non-cicatricial alopecia of autoimmunity, often betides the crinite position of health, and local skin is normal, no conscious sympton.Alopecia areata is because of more complicated.But study carefully its local disease because of, mainly local circulation obstacle, hair follicle blood supply insufficiency, causes the alopecia of patch shape.The traditional Chinese medical science thinks the common green grass or young crops of primary disease, postadolescent, contains by heat in blood, and multiple irritated by mind, seven emotions are unsuccessful, strongly fragrant fire-transformation of a specified duration, and accumulate in burning hot, intense heat bringing about wind syndrome, " pneumatic leaf falls ", hair is alopecia therefore.So teenager suffers from primary disease, mostly be caused by interior-heat, its treatment also should with clearing away heat and cooling blood, the agent of hair growth promoting of dispeling the wind.Absurdly can't take tonic.Otherwise mend hotter and hotter, more Re Zefa more falls.Spirit emotion changes is one of major reason of primary disease, and on this aspect, Chinese and western medicine is consistent.As long as keep the stable of emotion in daily life as far as possible, sufficient sleep, just can prevent the alopecia because direct stimulation, overfatigue cause.Alopecia areata (Alopeciaareata) is commonly called as " alopecia areata ", is the patchy alopecia trichopathy of a kind of limitation suddenly occurred.It has alopecia areata, alopecia totalis, alopecia universalis three kinds.Its lesion scalp is normal, NIP and subjective symptoms.The primary disease course of disease, can spontaneous remission and recurrence through slow.If whole hair of scalp all comes off, claim alopecia totalis (alopeciatotalis); The person if all hairs of whole body all do not come off, claims alopecia universalis (alopeciauniversalis).Primary disease and deficiency in both Qi and blood, deficiency of the liver and kindey, blood stasis hair key is relevant.Hair is the sign of blood condition, then blood difficulty is raw for the deficiency of vital energy, and Rhizoma Imperatae must not need to support, therefore deals with in flakes; Blood stored in the liver, kidney storing essence, asthenia of essence and blood then sends out the source without growth; Block bloody path, fresh blood can not hair care, therefore falling out.Dialectically to be divided into: heart deficiency of spleen-QI (mind is smooth, have a dizzy spell, night sleeps, and dream is many, insomnia), stagnation of liver-QI blood stasis (gas rushes down uncomfortable in chest, hepatosplenomegaly, sternal rib pain), QI and blood deficiency (after being ill or sick alopecia for a long time, god's disease is weak, pale complexion, emaciated physique), deficiency of the liver and kindey (dizziness and tinnitus, lumbago and backache, seminal emission lingering diarrhea, sexual impotence xerostomia).Their cause of disease and treat roughly the same, the degree of just clinical manifestation is different.The alopecia of head burst limitation plaque-like, circular or oval, differ in size, border is obvious, and local hair purifies and NIP, and no conscious sympton, Chang Yu stumbles on.Indivedual severe patient can be developed to alopecia totalis, and notably eyebrow, armpit hair, pubes also can come off entirely.The course of disease sustainable several months is to the several years.What have shows as the alopecia of head limitation patch shape, and rounded, oval or map shape, differs in size, sharpness of border, the smooth NIP of alopecia place scalp, and around it, hair is easily pulled out.General alopecia district no conscious sympton, minority can occur that local scalp is micro-and itch or feeling of numbness etc.In general, mostly recovery process is first have tiny soft white hair growth to go out, and sometimes can take off with personal attendant, and thicker blackening recovers normal gradually.Occur comparatively unexpected, after sometimes getting up in the morning, find head there is the circular alopecia spot differed in size.The morbidity of alopecia areata is relevant with psychoneural factor.May be because spiritual high-pressure have impact on neural regulative mechanism, directly or indirectly damage hair follicle, caused alopecia.Alopecia areata occurs that suddenly circle, oval alopecia are for feature with hair.Any position at human body can be given birth to by first alopecia district, but is common in head.Namely alopecia areata is generally multiple is born in scalp, but also other positions can occur, as the place such as eyebrow, beard.Primary disease Chang Yu stumbles on or is found by other people, and no conscious sympton, minority case at the initial stage of a disease affected part can have mile abnormality to feel.Any position at human body can be given birth to by first alopecia district, but is apt to occur in head.General at scalp, or the place such as eyebrow, beard.According to estimates, in crowd, the sickness rate of alopecia areata is less than 0.1%; The patients with alopecia areata pathological changes of 95% is about had only to be confined to scalp.Alopecia areata often shows as hair position and occurs independently circumscribed alopecia in blocks, circular or oval, edge clear, diameter 1 ~ 2cm or larger.Alopecia district skin smooth, shinny, without remarkable atrophy, but still have pore visible, infringement is hair difficult drop-off around, and the hair root come off attenuates, and ball top reduces, can be formed exclamation mark shape "! ".If infringement increase gradually, increased number, adjacent skin lesion district can be fused into mutually differ in size, patch in irregular shape.The hair that often there are some pines in the edge in alopecia district and easily take off, what have fractures, the often atrophy of proximal hair.As this hair is extracted, can see this hair upper coarse and lower fine and picture exclamation mark (! ), and the trichochromes of bottom also depigmentation.This phenomenon is the sign of progressive stage.If the state of an illness continues development, skin lesion can involve full head, so that hair all comes off.Now, scalp still can keep normal appearance, is be alopecia totalis.Serious case, except hair comes off entirely, other hairs everywhere of whole body, comprise eyebrow, eyelashes, beard, armpit hair, pubes and whole body chaeta etc., all can come off, this situation is called alopecia universalis.In male's patients with alopecia areata, the people of 10% is about had to develop into alopecia universalis.

Along with the fast development of society and the continuous quickening of rhythm of life, bring huge pressure to the life of people, many youngsters are because the pressure of life and the irregular of work and rest cause a large amount of alopecias, and this has all brought worried and puzzlement.

At present, medicine for alopecia areata also has a lot, for the problems referred to above, the Chinese patent literature of publication number CN102988582A (application number 201210406338.8) discloses a kind of Chinese medicine composition and preparation method for the treatment of alopecia areata, described Chinese medicine is made up of each crude drug of following weight/volume parts: Radix Ginseng 5-10 part, Radix Astragali 10-60 part, Radix Angelicae Sinensis 5-15 part, Radix Rehmanniae Preparata 10-30 part, Rhizoma Chuanxiong 3-10 part, Flos Carthami 3-9 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Polygoni Multiflori Preparata 10-30 part, Fructus Mori 10-15 part, Rhizoma Drynariae 10-15 part, Herba Cistanches 10-15 part, Fructus Corni 5-30 part, Fructus Ligustri Lucidi 10-15 part, Herba Ecliptae 10-15 part, Semen Sesami Nigrum 10-30 part.The Chinese patent literature of publication number CN103893508A (application number 201410156681.0) discloses a kind of Chinese medicine preparation of fast treating alopecia areata, it is by being mainly prepared from by following raw materials in parts by weight number ratio: Radix Polygalae 5-15 part, Folium fici microcarpae 5-10 part, Radix Inulae Cappae 3-5 part, Styrax 2-8 part, Semen Cuscutae 10-20 part, Herba Seu Radix Tetrastigmatis Obtecti 5-15 part, Herba Plumbagellae Micranthae 3-10 part, Caulis Spatholobi 10-20 part, Radix Ginseng 3-5 part, Flos Inulae 5-10 part, Radix Morindae Officinalis 3-8 part, Pericarpium Sesami indici 2-5 part, Flos Hibisci Rosae-Sinensis 5-10 part, Radix Asparagi 2-6 part, Semen Platycladi 2-5 part, semen juglandis 5-12 part, Rhizoma Chuanxiong 10-20 part, Spina Gleditsiae 5-15 part, Flos Rosae Rugosae 2-5 part, Cortex Moutan 5-10 part, Galium spurium L. 2-5 part, Radix Paeoniae Rubra 10-15 part, Flos Narcissi chinensis 5-12 part, Cacumen Platycladi 3-10 part.The Chinese patent literature of publication number CN102670940A (application number 201210154338.3) discloses a kind of Traditional Chinese medicine liniment for the treatment of alopecia areata, it is by being mainly prepared from by following raw materials in parts by weight number ratio: Fructus Viticis 5-10 part, Radix Angelicae Dahuricae 10-20 part, Pericarpium Sesami indici 2-5 part, Radix Et Rhizoma Rhei 3-10 part, Pericarpium Granati 2-5 part, Lignum Santali Albi 3-8 part, Herba Cistanches 5-12 part, Rhizoma Anemarrhenae 5-10 part, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 2-5 part, Rhizoma Atractylodis Macrocephalae 3-10 part, Fructus Evodiae 5-10 part, Cortex Eucommiae 10-15 part, Semen Cuscutae 10-20 part, Radix Glycyrrhizae 10-18 part, Cortex Lycii 5-15 part, Colophonium 3-10 part, Fructus Cnidii 2-6 part, Radix Aconiti 2-5 part, Fructus Caryophylli 2-6 part, Radix Angelicae Sinensis 3-8 part, Herba Tropaeoli 2-8 part, Herba Asari 5-15 part, Bulbus Narcissi Chinensis 3-10 part, Herba Lycopi 3-10 part, Borneolum Syntheticum 8-18 part.

The medicine of current treatment alopecia areata symptom, is mostly Western medicine, can brings certain toxic and side effects in patient's use procedure, therapeutic effect is not good, fundamentally can not solve the disease of patient, and drug dependence is larger, long-term taking easily causes body damage, immunity degradation.The prescription for the treatment of by Chinese herbs primary disease nourishes blood the side of enriching blood; Nourishing the liver and kidney side; Strong liver QI invigorating side; Yin nourishing removing heat from blood side; Liver-smoothing, qi-regulating side; Admittedly decorations dredging collateral side etc.The clinical effectiveness of these medicines or prescription is all undesirable, or function singleness, or toxic and side effects is large.And some medical materials used costly, adds the financial burden of common people.

Summary of the invention

For the deficiencies in the prior art, add oral drugs and be rich in hormone more, easily cause body metabolism disorderly, even Secondary cases fungus, viral infection, and hair transplant all can cause the deep lesions of hair follicle to a certain extent, cortex is totally disrupted, and cannot repair.An object of the present invention is that providing a kind of external effectively can treating alopecia areata to rub with the hands is coated with medicated wine, adopts medical material comparatively common in the localities as raw material, with low cost.Medicine can go directly patient part by the present invention, effectively ensures curative effect, reaches the object for the treatment of both the principal and secondary aspects of a disease, and more after also not easily recur, there is therapeutic effect good, have no side effect, the advantage that treatment cost is low.In addition, this external is rubbed with the hands and is coated with effect that medicated wine also has blood circulation promoting and blood stasis dispelling, yin nourishing strengthening the spleen, clearing heat and moistening dryness, dissipating rashes of regulating the flow of vital energy, Bushen Tongluo and blood hair growth promoting.Cure mainly the symptom such as alopecia areata, alopecia.Another object of the present invention is just to provide above-mentioned external and rubs the preparation method being coated with medicated wine with the hands.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Be used for the treatment of alopecia areata external and rub painting medicated wine with the hands, take off the primary raw material stating weight proportion to be prepared from: Retinervus Luffae Fructus 16-25 part, Pericarpium Zanthoxyli 8-12 part, Fructus Gardeniae 12-22 part, Calomelas 5-9 part, fresh Flos Celosiae Cristatae 50-80 part, Camphora 0.5-3.0 part, Borneolum Syntheticum 1.2-3.0 part, brandy 400-600 part is (preferred, brandy 450-550 part, is more preferably, brandy 500 parts).

Be used for the treatment of alopecia areata external and rub painting medicated wine with the hands, preferred scheme is, take off the primary raw material stating weight proportion to be prepared from: Retinervus Luffae Fructus 18-22 part, Pericarpium Zanthoxyli 9-11 part, Fructus Gardeniae 16-18 part, Calomelas 6-8 part, fresh Flos Celosiae Cristatae 60-70 part, Camphora 1.5-2.0 part, Borneolum Syntheticum 2.0-2.2 part, brandy 450-500 part.

Be used for the treatment of alopecia areata external and rub painting medicated wine with the hands, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Retinervus Luffae Fructus 20 parts, 10 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 17 parts, Calomelas 7 parts, fresh Flos Celosiae Cristatae 65 parts, Camphora 1.8 parts, Borneolum Syntheticum 2.1 parts, brandy 475 parts.

The preparation method of the above-mentioned medicated wine for hair growth promoting, step is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, and 10-25 days is soaked in sealing, and every day shakes;

(2) add proper honey to stir, continue fermentation 10-25 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

According to preparation method recited above: the concentration that step (1) adds brandy is 45 °-65 ° (preferred concentration is 50 °-60 °, and being more preferably concentration is 55 °).

According to preparation method recited above: shake step (1) every day (preferred every day shakes 4-6 time, is more preferably and shakes 5 every day).

According to preparation method recited above: 10-25 days (preferred 16-20 days is more preferably 18 days) is soaked in step (1) sealing.

According to preparation method recited above: step (2) adds Mel (consumption of preferred Mel is the 4%-6% of brandy quality, is more preferably 5%).

According to preparation method recited above: step (2) fermentation 10-25 days (preferred 16-20 days is more preferably 18 days).

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

The present invention compared with prior art, need not take medicine, and without hospitalization, makes simple and convenient, has no side effect.Select common Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae, Calomelas, Flos Celosiae Cristatae and brandy, and Camphora and Borneolum Syntheticum, with low cost, compatibility is reasonable, easy to use, and have skin moistening and to invigorate blood circulation, promote effect of hair growth promoting, Be very effective, has good curative effect.

The pharmacological effect of each crude drug is respectively:

Retinervus Luffae Fructus: sweet in the mouth is flat.Return lung, stomach, Liver Channel.Main chemical compositions Retinervus Luffae Fructus, containing xylan and cellulose, also may contain mannan, galactan and lignin etc.The particular matters such as the saponins in the middle of Fructus Luffae, luffein, lymphatic temperament, wood glue, citrulline, xylan and interferon have certain special role.Contained by prevent the vitamin B1 of skin aging, the compositions such as the vitamin C of skin whitening, can protect skin, eliminate speckle, making skin pure white, delicate, is rare cosmetic good merchantable brand, therefore Sucus Luffae has the title of " beauty's water ".Have that dysmenorrhea is active, effect of removing heat-phlegm.Control pain in chest and hypochondrium, stomachache, lumbago, lung-heat productive cough, carbuncle, anal fistula.

Pericarpium Zanthoxyli: acrid in the mouth, temperature, poisonous.Return spleen, stomach, kidney channel.Main chemical compositions Pericarpium Zanthoxyli fruit containing volatile oil 0.7%(Guizhou produce), 2 ~ 4%(Gansu produce), 4 ~ 9%(Guangdong produce).Containing Geraniol, limonene, cumic alcohol etc. in volatile oil.Fruit is still containing sterol, unsaturated organic acid etc.Contained Geraniol, low dose can suppress the spontaneous activity of rat.To isolated rabbit small intestinal, act on non-constant during low concentration.Sometimes have slightly but motion more of a specified duration is hyperfunction, heavy dose then suppresses bowel movement.Geraniol has anthelmintic action to Cavia porcellus ascarid.According to another report, the rare alcohol liquid of Pericarpium Zanthoxyli has local anesthesia effect, and in the topical anesthesia of rabbit cornea, effect is slightly weak compared with tetracaine; In the infiltration anesthesia of Cavia porcellus, effect is better than procaine.There is warming middle-JIAO to relieve pain, effect of killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.

Fructus Gardeniae: bitter in the mouth, cold.GUIXIN, liver, lung, stomach warp.Main chemical compositions is for containing flavonoid gardenin, pectin, tannin, crocin, crocetin, PEARLITOL 25C, nonacosane, cupreol.The another glycoside containing the smelly formaldehyde structure of multiple tool ring: gardenoside, geniposide pool element-1-glycoside, lattice Tegosept P-1-β-D-gentiobioside and shanzhiside in a small amount.There is heat clearing away, pathogenic fire purging, effect of removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.

Calomelas: acrid in the mouth, cold; Poisonous.Return large intestine, small intestine meridian.Main chemical compositions is calomel.Calomelas external has bactericidal action, takes orally and can prevent enteral abnormal fermentation in right amount, and can tonneau stool.There is parasite killing, counteracting toxic substances, diuretic, effect of relieving constipation.Control scabies, scrofula, syphilis, primary sore, skin ulcer, edema, tympanites, defecation is closed.

Fresh Flos Celosiae Cristatae: sweet in the mouth, puckery, cool in nature.Return liver, large intestine channel.Main chemical compositions is Kaempferitrin, amaranth glycoside, pinitol and volume potassium nitrate.Containing the multivitamin such as protein, fat, folic acid, pantothenic acid, vitamin B1, B2, B4, B12, C, D, E, K, and Kaempferitrin, amaranth glycoside, pinite, pinitol, potassium nitrate, 21 seed amino acids, 13 kinds of trace element and more than 51 kinds natural and enzyme cofactor, wherein in seed, protein content, up to 73%, can supplement the deficiency of grain content.There is astringing to arrest bleeding, leukorrhagia stopping, effect of dysentery relieving.For spitting blood, metrorrhagia, has blood in stool, hemorrhoidal bleeding, leucorrhea with red and white discharge, and chronic dysentery is more than.

Camphora: main component is pure gum camphor is a kind of terpenoid organic compound.There is orifice opening, qi stagnation removing, ward off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect, cure mainly the symptoms such as scabies pruritus, traumatic pain, toothache.Oleum Camphora forms primarily of various terpenoid.The continuous rectification under vacuum of general multi-tower type, obtains Gum Camphor and various essential oil (as cineole, linalool, Oleum Pini outer coffin, safrole) and side-product (as white camphor oil, red camphor oil, blue camphor oil) in conjunction with techniques such as freezing, distillations.

Borneolum Syntheticum: this product is the fresh skill of canella Camphor tree, leaf is through extracting the crystallization of being processed into.Acrid in the mouth, hardship, cool in nature.There is refreshment of having one's ideas straightened out, effect of clearing away heat to alleviate pain.Faint for calentura kind dusk, convulsion, apoplexy syncope due to accumulation of phlegm, infantile convulsion expectorant fan, sore throat toothache, order carbuncle sore infections, conjunctival congestion.

Brandy: be the high-quality famous brand of wine that a kind of wine is brewageed through distillation, by people are liked, its alcohol content about 40% ~ 50%.Custom is being raw material with Fructus Vitis viniferae, and the wine through fermentation, distillation, storage, allotment is called brandy.Brandy beauty and skin care good merchantable brand, has special skin effect using brandy as the skin protection cosmetics of additive.With brandy bathing, the blood circulation improving skin, reach the effect of beauty and skin care.In shampoo, add a little brandy, limit side washing massaging scalp, adheres to for a long time, and hair can be made no longer to come off.

In the present invention Retinervus Luffae Fructus invigorate blood circulation, dredging collateral, Eradicates wind, open hair sled; Calomelas, Fructus Gardeniae stimulate, activate hair, hair is female; Brandy, benefiting QI and nourishing blood, hair strengthening hair growth promoting; All medicines share, play altogether invigorate blood circulation, dredging collateral, Eradicates wind, hair growth promoting effect.Alopecia areata external of the present invention is rubbed with the hands and is coated with medicated wine, meets the theory of the traditional Chinese medical science about hair growth promoting.This product is on the basis of summing up forefathers' experience, adopt pure natural draft Chinese medicine unique formula and technique to refine to form, by scalp irritation acupuncture point, can play and regulate meridians, promoting flow of QI and blood, nourishing the liver and kidney, the disease of the insufficiency of vital energy and blood caused by liver and kidney deficiency such as treatment alopecia areata, can play again and improve cerebral blood flow supply, the effect of immunity moderation.

Technical advantage of the present invention is also embodied in:

1, selected materials is all Chinese medicine material, and curative effect is remarkable, has no side effect, and has and prepares simple, economy feature easily;

2, external stranding painting medicated wine transdermal absorption factor is high, not easily develops immunity to drugs, avoids the infringement of medicinal liquid for oral administration to Liver and kidney function, adheres to that use is evident in efficacy to preventing and treating alopecia areata

3, raw material of Chinese medicine of the present invention is through dialectical compatibility, thus effective effect playing its promotion hair growth promoting.

4, the experiment proved that, active ingredient is stablized, persistent, long shelf-life.

5, medicine source is easy to get, with low cost, can relieve patient ' s burden.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1alopecia areata external is rubbed with the hands and is coated with medicated wine, takes off and states primary raw material and be prepared from (every part of 25g): Retinervus Luffae Fructus 16 parts, 8 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 12 parts, Calomelas 5 parts, fresh Flos Celosiae Cristatae 50 parts, Camphora 0.5 part, Borneolum Syntheticum 1.2 parts, brandy 400 parts.

The preparation process that painting medicated wine is rubbed in alopecia areata external with the hands is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, sealing immersion 10 days, and every day shakes;

(2) add proper honey to stir, continue fermentation 10 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

model case one:zhao XX, man, 30, family is in provincial capital, and typical urban resident, father and mother have saved bit by bit a little family property previously, have room to have car, and Mr. Zhao itself also has portion to compare decent work.Can Mr. Zhao but due to serious alopecia areata situation, look for a partner in marriage always talk one blow one.When asking about the reason of departure, the wife's side is not kept away and is said separatedly: " Xiao Zhao of 30 years old is extremely old for one's age because of alopecia areata, looks like quadragenarian people, and the girl friend with twenties mismatches together! " afterwards, he liked the migrant job-hunting girl having gone up rural area, Mr. Zhao thinks the identity of oneself " urban resident ", and the other side should be unable to refuse.But he is when it comes to the subject of a talk or essay, other girl has looked sidelong at and has waved that good-by at a glance, and clearly the alopecia areata image of oneself is exactly think that what is said or talked about rural area girl is very difficult .

Once accidental, Mr. Zhao has heard that from colleague there alopecia areata external of the present invention is rubbed with the hands and has been coated with medicated wine, and this is exactly the people of a rationality, and he thinks oneself as half alopecia expert, but after he son have studied several raw material of the present invention, admits especially.So determine to make a try, after the external of use embodiment 1 gained alopecia areata is rubbed with the hands and is coated with a course for the treatment of of medicated wine, hair has just less fallen; Continue to use the external of embodiment 1 gained alopecia areata to rub with the hands and be coated with a course for the treatment of of medicated wine, the place of alopecia areata starts to grow hair; Adhere to using the external of embodiment 1 gained alopecia areata to rub the time being coated with 4 courses for the treatment of of medicated wine with the hands, on head, two major parts speckle just cannot see substantially, long not only black but also close of hair.Adhere to using the external of embodiment 1 gained alopecia areata to rub with the hands and be coated with 6 courses for the treatment of of medicated wine, the place of alopecia areata is thoroughly long good.Till now, all pass by more than 1 year, alopecia areata recurred never again.Erect image Mr. Zhao say: " alopecia areata solves not difficult in fact, looks for right method, is only most critical.”

embodiment 2alopecia areata external is rubbed with the hands and is coated with medicated wine, takes off and states primary raw material and be prepared from (every part of 15g): Retinervus Luffae Fructus 25 parts, 12 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 22 parts, Calomelas 9 parts, fresh Flos Celosiae Cristatae 80 parts, Camphora 3.0 parts, Borneolum Syntheticum 3.0 parts, brandy 600 parts.

The preparation process that painting wine is rubbed in alopecia areata external with the hands is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, sealing immersion 25 days, and every day shakes;

(2) add proper honey to stir, continue fermentation 25 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

model case two:king XX, female, 18 years old, student was people from Binzhou.Patient's front left in January frontal eminence top hair comes off suddenly, area 2cmX3cm, therefore comes inventor place on November 8th, 2010.Disease is seen: the unexpected alopecia in left frontal eminence top, ovalize, area 2cmX3cm, the occipitalia alopecia of right top, rounded, area 1cmX1cm, alopecia district skin Lightening, there is the hair of frangibility at edge, time have nervous, breathe hard, fatigue and weakness, anorexia, pale tongue, white and thin fur, thready and weak pulse.: because learning anxiety, ponder over the impairment of the spleen of working with one's mind.Dark consumption painstaking effort, blood deficiency can not go up honor, and hair loses in moistening foster and comes off suddenly.The heart is become homeless foster, therefore has palpitation, breathes hard.Deficiency-weakness of spleen-QI, then anorexia, cause the biochemical weary source of QI and blood then, therefore fatigue and weakness.Pale tongue, white and thin fur, thready and weak pulse, be levying of insufficiency of vital energy and blood.Be diagnosed as alopecia areata (deficiency of qi and blood).Use the external of embodiment 2 gained alopecia areata to rub painting medicated wine 6 Zhou Hou alopecia district hair with the hands and all grow new sending out.All the other all diseases disappear.Advise and continue to take, with after treatment recovery from illness in February.Through repeatedly following up a case by regular visits to, so far without recurrence.

embodiment 3alopecia areata external is rubbed with the hands and is coated with medicated wine, takes off and states primary raw material and be prepared from (every part of 25g): Retinervus Luffae Fructus 18 parts, 9 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 16 parts, Calomelas 6 parts, fresh Flos Celosiae Cristatae 60 parts, Camphora 1.5 parts, Borneolum Syntheticum 2.0 parts, brandy 450 parts.

The preparation process that painting medicated wine is rubbed in alopecia areata external with the hands is as follows:

(Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag by (1), and fresh Flos Celosiae Cristatae tears up, and are together placed in airtight non iron container, add brandy, sealing immersion 16 days, and every day shakes;

(2) add proper honey to stir, continue fermentation 16 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

model case three:liu XX, man, 42 years old, people from Hebei, the boss of a foreign trade corporation, to the eye very honourable, others envies him very much, goes home evening to be Mr. Liu's the most painful thing when taking postiche head facing to mirror, may be because the reason of Inheritance, Mr. Liu obtained alopecia areata, 40 how old hair just fallen similar, people can only be seen by periwigging.In order to treat alopecia areata, Mr. Liu does not know to use how many methods, tries how many products, once attempts hair transplant yet, but effect is also undesirable.Look at the scalp of light light before mirror, just incomparable disappointment.

Once treat with courtesy, be unintentionally familiar with bald boss the same as him before, but what be presented in his at the moment is that hair is grown neat, Mr. Liu also thought and periwigged at that time.Careful one asks and just learns, employed alopecia areata external of the present invention and rub with the hands and be coated with medicated wine before 2 years, afterwards hair make one's wish fulfilled longer.This is for Mr. Liu, can be regarded as large good news.So he brings into use the external of the embodiment of the present invention 3 gained alopecia areata to rub with the hands be coated with medicated wine, after 3 courses for the treatment of, alopecia areata all has new sending out to grow everywhere, covers scalp.Continue to use the external of the embodiment of the present invention 3 gained alopecia areata to rub with the hands and be coated with 4 courses for the treatment of of medicated wine, hair looks not only black but also close, a bit do not see the vestige of alopecia, Mr. Wang is very delight, adheres to that again using the external of the embodiment of the present invention 3 gained alopecia areata to rub painting medicated wine with the hands consolidates 3 courses for the treatment of.Pay a return visit after 3 years, hair is dense, reaches clinical cure object.。

embodiment 4alopecia areata external is rubbed with the hands and is coated with medicated wine, takes off and states primary raw material and be prepared from (every part of 15g): Retinervus Luffae Fructus 22 parts, 11 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 18 parts, Calomelas 8 parts, fresh Flos Celosiae Cristatae 70 parts, Camphora 2.0 parts, Borneolum Syntheticum 2.2 parts, brandy 500 parts.

The preparation process that painting medicated wine is rubbed in alopecia areata external with the hands is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, sealing immersion 20 days, and every day shakes;

(2) add proper honey to stir, continue fermentation 20 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

embodiment 5alopecia areata external is rubbed with the hands and is coated with medicated wine, takes off and states primary raw material and be prepared from (every part of 20g): Retinervus Luffae Fructus 20 parts, 10 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 17 parts, Calomelas 7 parts, fresh Flos Celosiae Cristatae 65 parts, Camphora 1.8 parts, Borneolum Syntheticum 2.1 parts, brandy 475 parts.

The preparation process that painting medicated wine is rubbed in alopecia areata external with the hands is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, sealing immersion 18 days, and every day shakes;

(2) add proper honey to stir, continue fermentation 18 days, filter and remove residue, get upper strata clarification medicated liquor;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

Using method: dip medicated wine with absorbent cotton and put it on the skin, every day 4-6 time, 10 days courses for the treatment of.

test example:being coated with medicated wine to verify that the external of embodiment 5 gained alopecia areata is rubbed with the hands, We conducted contrast test.Patients with alopecia areata 240 people is selected in experiment, male 150 example, women 90 example.In age 18-50 year, 35.6 years old mean age, the course of disease is all within half a year, and average course of disease 4.5 months, skin lesion 1-5 place, alopecia area is within 8cm × 8cm.Get rid of pseudopelade, androgenetic alopecia etc.Patient is divided into matched group and treatment group randomly, treatment group 130 example, matched group 110 example.Two groups all have comparability in sex, age, the course of disease and the state of an illness.Treatment group: our every days same equal time, use under square one absorbent cotton dip the external of embodiment 5 gained alopecia areata rub with the hands be coated with medicated wine put it on the skin, every day 4-6 time, 10 days courses for the treatment of.Matched group: with experimental group under identical time and environment, uses the product (as 10% speckle insect destructive of the roots of seedlings tincture, Alopecia Pill etc.) of other treatment alopecia areata, every day 4-6 time, 10 days courses for the treatment of.And observe simultaneously, record the natural on-off cycles of hair growth situation of every group patient.Curative effect situation criterion: recovery from illness: alopecia areata district terminal hair newly sends out growth whole.Effective: alopecia areata district terminal hair coverage rate >=60%.Progressive: alopecia areata district terminal hair coverage rate >=30%, fine hair on birds or animals hair grows, but poor growth, color and luster is black or white.Invalid: alopecia areata phenomenon is not eased or continues alopecia.Wherein effective percentage adds effective in healing.

Result is as shown in the table:

Table 1

efficacy analysis:as can be seen from Table 1, use the external of embodiment 5 gained alopecia areata to rub the treatment group being coated with medicated wine with the hands and only have 1 people invalid, and matched group is invalid up to 10 people.And use the external of embodiment 5 gained alopecia areata to rub the cure rate of painting medicated wine with the hands up to 90.7%, total effective rate reaches 98.5%, and uses the cure rate of the matched group of the product of other treatment alopecia areata only to reach 45.5%.Experiment show to use the external of embodiment 5 gained alopecia areata to rub with the hands and be coated with medicated wine compared with using the product of other treatment alopecia areata, its curative effect increases substantially, and effective percentage significantly promotes.

Table 2

Also can find out significantly from table 2, use the external of the embodiment of the present invention 5 gained alopecia areata to rub with the hands to be coated with medicated wine all remarkable for the effect of various types of alopecia, Most patients symptom after 6 courses for the treatment of of medication is clearly better.Alopecia areata external of the present invention is rubbed with the hands and is coated with that medicated wine has good blood circulation promoting and blood stasis dispelling, promotion of blood circulation, improves hair follicle nutrition, hair follicle stimulating growth, promote new effect sending out regeneration, has good curative effect to alopecia.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (6)

1. the preparation method being coated with medicated wine is rubbed in alopecia areata external with the hands, it is characterized in that, takes off the primary raw material stating weight proportion: Retinervus Luffae Fructus 20 parts, 10 parts, Pericarpium Zanthoxyli, Fructus Gardeniae 17 parts, Calomelas 7 parts, fresh Flos Celosiae Cristatae 65 parts, Camphora 1.8 parts, Borneolum Syntheticum 2.1 parts, brandy 475 parts; Step is as follows:

(1) Retinervus Luffae Fructus, Pericarpium Zanthoxyli, Fructus Gardeniae and Calomelas are put into airtight cotton bag, fresh Flos Celosiae Cristatae tears up, and is together placed in airtight non iron container, adds brandy, and 16-20 days is soaked in sealing, and every day shakes 4-6 time; The concentration of brandy is 50 °-60 °;

(2) add proper honey to stir, continue fermentation 16-20 days, filter and remove residue, get upper strata clarification medicated liquor; The consumption of Mel is the 4%-6% of brandy quality;

(3) Camphora and Borneolum Syntheticum are ground, join in the medicated liquor of step (2) gained, sterile packaged.

2. preparation method according to claim 1, is characterized in that: the concentration of step (1) brandy is 55 °.

3. preparation method according to claim 1, is characterized in that: step (1) every day shakes 5 times.

4. preparation method according to claim 1, is characterized in that: step (1) sealing immersion 18 days.

5. preparation method according to claim 1, is characterized in that: the consumption of step (2) Mel is 5% of brandy quality.

6. preparation method according to claim 1, is characterized in that: step (2) fermentation 18 days.